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1. 发明申请

WO2015154883A8 NEOSORAPHENS 审中-公开
公开(公告)号：WO2015154883A8
公开(公告)日：2015-10-15
申请号：PCT/EP2015/000757
申请日：2015-04-10
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH , TWINCORE ZENTRUM FÜR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH
发明人： MUELLER, Rolf , HUEHN, Jochen , STEINMETZ, Heinrich , KECK, Matthias , KRUG, Daniel , HARMROLFS, Kirsten , SPARWASSER, Tim , LOCHNER, Matthias , NANDAN, Amrita , KOUTSOUDAKIS, George , MEYERHANS, Andreas , DIEZ, Juana , MARTINEZ, Javier , BRÖNSTRUP, Mark
IPC分类号： C07D493/08 , C07D493/18 , A61K31/365 , A61P29/00 , A61P31/12 , A61P37/00
摘要： The present invention relates to compounds according to general formula (I); to compositions, including a pharmaceutical formulation and a combination preparation comprising one or more of the compound (s); to a process for their preparation; to uses thereof, including the use in the treatment or prevention of a viral infection or a Thl7-associated inflammatory and/or autoimmune disease.

2. 发明申请

WO2015154883A1 NEOSORAPHENS 审中-公开
公开(公告)号：WO2015154883A1
公开(公告)日：2015-10-15
申请号：PCT/EP2015/000757
申请日：2015-04-10
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH , TWINCORE ZENTRUM FÜR EXPERIMENTELLE UND KLINISCHE
发明人： MUELLER, Rolf , HUEHN, Jochen , STEINMETZ, Heinrich , KECK, Matthias , HARMROLFS, Kirsten , SPARWASSER, Tim , LOCHNER, Matthias , NANDAN, Amrita , KOUTSOUDAKIS, George , MEYERHANS, Andreas , DIEZ, Juana , MARTINEZ, Javier , BRÖNSTRUP, Mark
IPC分类号： C07D493/08 , C07D493/18 , A61K31/365 , A61P29/00 , A61P31/12 , A61P37/00
CPC分类号： C07D493/08 , A61K31/365 , A61K31/4188 , A61K45/06 , C07D493/18 , C07D495/04 , C12P17/181 , C12P17/186
摘要： The present invention relates to compounds according to general formula (I); to compositions, including a pharmaceutical formulation and a combination preparation comprising one or more of the compound (s); to a process for their preparation; to uses thereof, including the use in the treatment or prevention of a viral infection or a Thl7-associated inflammatory and/or autoimmune disease.
摘要翻译：本发明涉及通式（I）的化合物，包括药物制剂和包含一种或多种化合物的组合制剂; 一个准备过程; 包括用于治疗或预防病毒感染或Th17相关炎性和/或自身免疫性疾病的用途。

3. 发明申请

WO2019038405A1 NOVEL CYSTOBACTAMIDE DERIVATIVES 审中-公开
公开(公告)号：WO2019038405A1
公开(公告)日：2019-02-28
申请号：PCT/EP2018/072817
申请日：2018-08-23
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
发明人： TESTOLIN, Giambattista , BRÖNSTRUP, Mark , PROCHNOW, Hans-Peter , HERRMANN, Jennifer , MÜLLER, Rolf
IPC分类号： C07C237/44
摘要： The present invention relates to novel derivatives of cystobactamides of formula (lb) and the use thereof for the treatment or prophylaxis of bacterial infections.

4. 发明申请

WO2023280970A1 INHIBITORS OF ALPHA-HEMOLYSIN OF STAPHYLOCOCCUS AUREUS 审中-公开
公开(公告)号：WO2023280970A1
公开(公告)日：2023-01-12
申请号：PCT/EP2022/068862
申请日：2022-07-07
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH , LEAD DISCOVERY CENTER GMBH
发明人： DILUCREZIA, Raffaella , BRÖNSTRUP, Mark , BILITEWSKI, Ursula , DEGENHART, Carsten , DINKEL, Klaus , JERYE, Karoline , KALAWY FANSA, Eyad , KOROTKOV, Vadim , MEDINA, Eva , ROX, Katharina , SHEKHAR, Aditya , WEICH, Herbert
IPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D515/04 , A61K31/4985 , A61P31/04
摘要： The present invention relates to novel inhibitors of α-hemolysin of formula (I) and the use thereof for the prophylaxis and treatment of infections caused by Staphylococcus aureus; especially S. aureus lung infections.

5. 发明申请

WO2019030284A1 NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF 审中-公开
公开(公告)号：WO2019030284A1
公开(公告)日：2019-02-14
申请号：PCT/EP2018/071507
申请日：2018-08-08
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
发明人： KLAHN, Philipp , BRÖNSTRUP, Mark , FETZ, Verena , COLLISI, Wera , MOHR, Katrin I. , HÜTTEL, Stephan , TEGGE, Werner
IPC分类号： C07D309/30 , A61K47/65 , A61K47/55 , A61K47/64 , A61K47/68
摘要： The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.

6. 发明申请

WO2016097316A1 METHOD AND MEASURING DEVICE FOR DETERMINATION OF THE GROWTH RATE OF BIOFILM 审中-公开
标题翻译：用于确定生物膜生长速率的方法和测量装置
公开(公告)号：WO2016097316A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080540
申请日：2015-12-18
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
发明人： VAN DUUREN, Jost , KARGE, Bianka , WITTMANN, Christoph , BRÖNSTRUP, Mark
IPC分类号： G01N33/483
CPC分类号： G01N33/4836 , C12Q1/02 , C12Q1/025 , G01N27/041 , G01N2333/21
摘要： A method for determination of the growth rate of biofilm (7) using an electrical impedance analyses is disclosed. The method comprises the steps of: bringing a culture medium fluid (3) in contact to an electrode structure (4a, 4b), having biofilm (7) grown within the fluid culture medium (3) with the biofilm (7) arranged in distance to the electrodes structure (4a, 4b), so that the fluid culture medium (3) is placed between the growing biofilm (7) and the electrode structure (4a, 4b); measuring the impedance of the electrodes structure (4a, 4b) over a monitoring time, and determining the growth rate of the biofilm (7) as a function of the reduction rate of the impedance values measured on the electrode structure (4a, 4b).
摘要翻译：公开了一种使用电阻抗分析法确定生物膜生长速率（7）的方法。该方法包括以下步骤：使生物膜（7）远离排列的流体培养基（3）中生长的具有生物膜（7）的电极结构（4a，4b）接触培养液（3）（4a，4b），使得流体培养基（3）放置在生长生物膜（7）和电极结构（4a，4b）之间; 在监测时间内测量电极结构（4a，4b）的阻抗，以及根据在电极结构（4a，4b）上测量的阻抗值的减小率来确定生物膜（7）的生长速率。

7. 发明申请

WO2017085257A1 LABYRINTHOPEPTINS AS ANTI-VIRAL AGENTS 审中-公开
标题翻译：作为抗病毒药物的LABYRINTHOPEPTINS
公开(公告)号：WO2017085257A1
公开(公告)日：2017-05-26
申请号：PCT/EP2016/078143
申请日：2016-11-18
申请人： HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH , MEDIZINISCHE HOCHSCHULE HANNOVER , TWINCORE, ZENTRUM FÜR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH
发明人： BRÖNSTRUP, Mark , PROCHNOW, Hans-Peter , BIRUDUKOTA, N.V. Suryanarayana , SCHULZ, Thomas , MESSERLE, Martin , PIETSCHMANN, Thomas , HAID, Sibylle , BLOCKUS, Sebastian , LAQMANI-GOFFINET, Christine , FRANZ, Sergej , BANDA, Dominic Howard
IPC分类号： C07K14/36 , A61K38/04 , A61K38/16 , C07K7/08
CPC分类号： C07K14/36 , A61K38/00 , C07K7/08 , Y02A50/385 , Y02A50/391 , Y02A50/395
摘要： The present invention relates to novel labyrinthopeptin derivatives. These labyrinthopeptin derivatives are useful for the treatment of infectious diseases, such as an infectious disease caused by an infection with human respiratory syncytial virus (RSV), Kaposi sarcoma-associated herpesvirus (KSHV), cytomegalovirus (CMV/HCMV), dengue virus (DENV), chikungunya virus (CHIKV), tick-borne encephalitis virus (TBEV; FSME virus), vesicular stomatitis Indiana virus (VSV), zika virus (ZIKV) and/or hepatitis C virus (HCV). Said labyrinthopeptin derivatives are also useful for analyzing the mode of action of labyrinthopeptins. Also encompassed by the present invention are labyrinthopeptins for use in treating an infectious disease, in particular an infectious disease caused by an infection with any one of the viruses selected from RSV, KSHV, CMV, CHIKV, TBEV, VSV, ZIKV and HCV. The invention further relates to a combination of labyrinthopeptin A1 and A2 for use as a medicament, e.g. for treating an infectious disease caused by an infection with RSV, KSHV, CMV, DENV, CHIKV, TBEV, VSV, ZIKV and/or HCV.
摘要翻译：本发明涉及新颖的迷路肽素衍生物。这些迷路肽素衍生物可用于治疗感染性疾病，例如由人呼吸道合胞病毒（RSV），卡波西肉瘤相关疱疹病毒（KSHV），巨细胞病毒（CMV / HCMV），登革热病毒（DENV）），基孔肯雅病毒（CHIKV），蜱传脑炎病毒（TBEV; FSME病毒），水泡性口炎印第安纳病毒（VSV），zika病毒（ZIKV）和/或丙型肝炎病毒（HCV）。所述迷路肽素衍生物也可用于分析迷路肽素的作用模式。本发明还包括用于治疗感染性疾病，特别是由选自RSV，KSHV，CMV，CHIKV，TBEV，VSV，ZIKV和HCV的任何一种病毒感染引起的感染性疾病的迷路活检蛋白。本发明进一步涉及用作药物例如迷迭香素肽A1和A2的组合。用于治疗由RSV，KSHV，CMV，DENV，CHIKV，TBEV，VSV，ZIKV和/或HCV感染引起的感染性疾病。

8. 发明公开

EP3377519A1 LABYRINTHOPEPTINS AS ANTI-VIRAL AGENTS 有权转让
公开(公告)号：EP3377519A1
公开(公告)日：2018-09-26
申请号：EP16809653.5
申请日：2016-11-18
申请人： Helmholtz-Zentrum für Infektionsforschung GmbH , Medizinische Hochschule Hannover , Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH
发明人： BRÖNSTRUP, Mark , PROCHNOW, Hans-Peter , BIRUDUKOTA, N.V. Suryanarayana , SCHULZ, Thomas , MESSERLE, Martin , PIETSCHMANN, Thomas , HAID, Sibylle , BLOCKUS, Sebastian , LAQMANI-GOFFINET, Christine , FRANZ, Sergej , BANDA, Dominic Howard
IPC分类号： C07K14/36 , A61K38/04 , A61K38/16 , C07K7/08
CPC分类号： C07K14/36 , A61K38/00 , C07K7/08 , Y02A50/382 , Y02A50/385 , Y02A50/391 , Y02A50/395
摘要： The present invention relates to novel labyrinthopeptin derivatives. These labyrinthopeptin derivatives are useful for the treatment of infectious diseases, such as an infectious disease caused by an infection with human respiratory syncytial virus (RSV), Kaposi sarcoma-associated herpesvirus (KSHV), cytomegalovirus (CMV/HCMV), dengue virus (DENV), chikungunya virus (CHIKV), tick-borne encephalitis virus (TBEV; FSME virus), vesicular stomatitis Indiana virus (VSV), zika virus (ZIKV) and/or hepatitis C virus (HCV). Said labyrinthopeptin derivatives are also useful for analyzing the mode of action of labyrinthopeptins. Also encompassed by the present invention are labyrinthopeptins for use in treating an infectious disease, in particular an infectious disease caused by an infection with any one of the viruses selected from RSV, KSHV, CMV, CHIKV, TBEV, VSV, ZIKV and HCV. The invention further relates to a combination of labyrinthopeptin A1 and A2 for use as a medicament, e.g. for treating an infectious disease caused by an infection with RSV, KSHV, CMV, DENV, CHIKV, TBEV, VSV, ZIKV and/or HCV.

9. 发明公开

EP3249407A1 METHOD FOR DETERMINING HERPES B VIRUS AND ASSAY SYSTEM THEREFORE 审中-公开
标题翻译：确定疱疹病毒B的方法及其测定系统
公开(公告)号：EP3249407A1
公开(公告)日：2017-11-29
申请号：EP17172988.2
申请日：2017-05-26
申请人： Helmholtz-Zentrum für Infektionsforschung GmbH
发明人： HOTOP, Sven-Kevin , ABD EL WAHED, Ahmed , BRÖNSTRUP, Mark , BEUTLING, Ulrike , SIEVERS, Claudia , CZERNY, Florian , DIEDERICHSEN, Ulf , CZERNY, Claus-Peter , STAHL-HENNING, Christiane , FRITZ, Hans-Joachim , HUNSMANN, Gerhard , FRANK, Ronald
IPC分类号： G01N33/569
CPC分类号： G01N33/56994 , G01N2333/03 , G01N2469/20
摘要： In a first aspect, the present invention relates to a method for determining the presence of herpes B virus, or for determining the status of herpes B virus infection in primates based on detection of antibodies against herpes B virus. In particular, the present invention relates to a method wherein at least two different peptides of short amino acid sequences with 4 to 40 amino acid residues present in the herpes B virus glycoproteins B, C, D, G, H and/or L are detected representing target regions of antibodies being specific against herpes B virus allowing determination of the presence of herpes B virus or determining the status of the herpes B virus infection in primates based on the presence and/or amount of the antibodies accordingly. In a further aspect, the present invention relates to an assay system for determining the presence of herpes B virus comprising at least said two different peptides derived from the herpes B virus glycoproteins B, C, D, G, H and/or L representing target regions of antibodies being specific against herpes B virus as well as means for determining the presence of said antibodies binding specifically to said peptides. Finally, the present invention relates to the use of at least two peptides comprising short amino acid sequences with 4 to 40 amino acids containing at least two different epitopes derived from herpes B glycoproteins B, C, D, G, H and/or L for determining the presence of herpes B virus or for determining the status of herpes B virus infection in primates.
摘要翻译：在第一方面，本发明涉及基于检测抗疱疹B病毒的抗体来确定疱疹B病毒存在或确定灵长类动物疱疹B病毒感染状态的方法。具体而言，本发明涉及一种方法，其中检测到存在于疱疹B病毒糖蛋白B，C，D，G，H和/或L中的具有4至40个氨基酸残基的至少两种不同的短氨基酸序列肽代表针对疱疹B病毒的特异性抗体的靶区域，从而允许确定疱疹B病毒的存在或基于相应抗体的存在和/或量确定灵长类动物中疱疹B病毒感染的状态。另一方面，本发明涉及用于确定疱疹B病毒存在的测定系统，其包含至少所述两种不同的衍生自表示靶标的疱疹B病毒糖蛋白B，C，D，G，H和/或L的肽针对疱疹B病毒的抗体区域以及用于确定与所述肽特异性结合的所述抗体的存在的手段。最后，本发明涉及至少两种包含具有4-40个氨基酸的短氨基酸序列的肽，其含有源自疱疹B糖蛋白B，C，D，G，H和/或L的至少两种不同表位确定疱疹B病毒的存在或确定灵长类动物中疱疹B病毒感染的状态。

10. 发明授权

EP3129385B1 NEOSORAPHENS AND THEIR USE IN THE TREATMENT OR PREVENTION OF A VIRAL INFECTION OR OF A TH17-ASSOCIATED INFLAMMATORY AND/OR AUTOIMMUNE DISEASE 有权
公开(公告)号：EP3129385B1
公开(公告)日：2018-06-06
申请号：EP15718442.5
申请日：2015-04-10
申请人： Helmholtz-Zentrum für Infektionsforschung GmbH , Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH
发明人： MUELLER, Rolf , HUEHN, Jochen , STEINMETZ, Heinrich , KECK, Matthias , HARMROLFS, Kirsten , SPARWASSER, Tim , LOCHNER, Matthias , NANDAN, Amrita , KOUTSOUDAKIS, George , MEYERHANS, Andreas , DIEZ, Juana , MARTINEZ, Javier , BRÖNSTRUP, Mark , KRUG, Daniel
IPC分类号： C07D493/08 , C07D493/18 , A61K31/365 , A61P29/00 , A61P31/12 , A61P37/00
CPC分类号： C07D493/08 , A61K31/365 , A61K31/4188 , A61K45/06 , C07D493/18 , C07D495/04 , C12P17/181 , C12P17/186
摘要： The present invention relates to compounds according to general formula (I); to compositions, including a pharmaceutical formulation and a combination preparation comprising one or more of the compound (s); to a process for their preparation; to uses thereof, including the use in the treatment or prevention of a viral infection or a Thl7-associated inflammatory and/or autoimmune disease.

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