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1. 发明授权

EP1660568B1 HYDROPHOBER GEGENSTAND MIT RASTER HYDROPHILER BEREICHE, DESSEN HERSTELLUNG UND VERWENDUNG 有权
标题翻译：并网亲水区的生产和使用疏水OBJECT
公开(公告)号：EP1660568B1
公开(公告)日：2011-10-12
申请号：EP04764621.1
申请日：2004-08-30
申请人： Helmholtz-Zentrum für Infektionsforschung GmbH
发明人： FRANK, Ronald , ZANDER, Norbert , BEUTLING, Ulrike , SWISTOWSKI, Andrzej , BIALEK, Krzysztof
IPC分类号： B01L3/00 , C08J7/12
CPC分类号： B01L3/5088 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5085 , B01L2200/12 , B01L2300/0636 , B01L2300/0819 , B01L2300/165 , C08J7/12 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/54386
摘要： The invention relates to a plastic object having a plane surface provided with a plurality of hydrophilic regions that are separated from each other by hydrophobic barriers. The invention also relates to methods for producing said object and to uses of the same.

2. 发明授权

EP1745063B1 VERFAHREN ZUR HERSTELLUNG VON CHEMISCHEN MIKROARRAYS 有权转让
标题翻译：用于生产化学微阵列
公开(公告)号：EP1745063B1
公开(公告)日：2008-11-12
申请号：EP05739879.4
申请日：2005-05-12
申请人： Helmholtz-Zentrum für Infektionsforschung GmbH
发明人： RONALD, Frank , BEUTLING, Ulrike , SWISTOWSKI, Andrzej , DIKMANS, Antonius , GUPTE, Varsha , THIELE, Sabine
IPC分类号： C07K1/04 , C07H21/00 , G01N33/68
CPC分类号： C07K1/047
摘要： The invention concerns a method for producing a microarray, the microarray itself and the use of the microarray for detecting interactions between probe molecules and analyte molecules from a sample. The method comprises the following steps: two- to multistage synthesising of probe molecules on a polymer support, forming bonds between the probe molecules and the polymer support; dissolving the polymer support with the synthetic probe molecules, maintaining the bonds between the polymer support and the probe molecules; optional cleaning of the probe molecules bonded to the polymer support; detaching the polymer support with the bonded probe molecules; and applying the solution containing the polymer support with the bonded probe molecules as microdrops to a planar surface.

3. 发明公开

EP3249407A1 METHOD FOR DETERMINING HERPES B VIRUS AND ASSAY SYSTEM THEREFORE 审中-公开
标题翻译：确定疱疹病毒B的方法及其测定系统
公开(公告)号：EP3249407A1
公开(公告)日：2017-11-29
申请号：EP17172988.2
申请日：2017-05-26
申请人： Helmholtz-Zentrum für Infektionsforschung GmbH
发明人： HOTOP, Sven-Kevin , ABD EL WAHED, Ahmed , BRÖNSTRUP, Mark , BEUTLING, Ulrike , SIEVERS, Claudia , CZERNY, Florian , DIEDERICHSEN, Ulf , CZERNY, Claus-Peter , STAHL-HENNING, Christiane , FRITZ, Hans-Joachim , HUNSMANN, Gerhard , FRANK, Ronald
IPC分类号： G01N33/569
CPC分类号： G01N33/56994 , G01N2333/03 , G01N2469/20
摘要： In a first aspect, the present invention relates to a method for determining the presence of herpes B virus, or for determining the status of herpes B virus infection in primates based on detection of antibodies against herpes B virus. In particular, the present invention relates to a method wherein at least two different peptides of short amino acid sequences with 4 to 40 amino acid residues present in the herpes B virus glycoproteins B, C, D, G, H and/or L are detected representing target regions of antibodies being specific against herpes B virus allowing determination of the presence of herpes B virus or determining the status of the herpes B virus infection in primates based on the presence and/or amount of the antibodies accordingly. In a further aspect, the present invention relates to an assay system for determining the presence of herpes B virus comprising at least said two different peptides derived from the herpes B virus glycoproteins B, C, D, G, H and/or L representing target regions of antibodies being specific against herpes B virus as well as means for determining the presence of said antibodies binding specifically to said peptides. Finally, the present invention relates to the use of at least two peptides comprising short amino acid sequences with 4 to 40 amino acids containing at least two different epitopes derived from herpes B glycoproteins B, C, D, G, H and/or L for determining the presence of herpes B virus or for determining the status of herpes B virus infection in primates.
摘要翻译：在第一方面，本发明涉及基于检测抗疱疹B病毒的抗体来确定疱疹B病毒存在或确定灵长类动物疱疹B病毒感染状态的方法。具体而言，本发明涉及一种方法，其中检测到存在于疱疹B病毒糖蛋白B，C，D，G，H和/或L中的具有4至40个氨基酸残基的至少两种不同的短氨基酸序列肽代表针对疱疹B病毒的特异性抗体的靶区域，从而允许确定疱疹B病毒的存在或基于相应抗体的存在和/或量确定灵长类动物中疱疹B病毒感染的状态。另一方面，本发明涉及用于确定疱疹B病毒存在的测定系统，其包含至少所述两种不同的衍生自表示靶标的疱疹B病毒糖蛋白B，C，D，G，H和/或L的肽针对疱疹B病毒的抗体区域以及用于确定与所述肽特异性结合的所述抗体的存在的手段。最后，本发明涉及至少两种包含具有4-40个氨基酸的短氨基酸序列的肽，其含有源自疱疹B糖蛋白B，C，D，G，H和/或L的至少两种不同表位确定疱疹B病毒的存在或确定灵长类动物中疱疹B病毒感染的状态。

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