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1. 发明申请

WO2006086321A3 ANTIMICROBIAL HEXAPEPTIDES 审中-公开
标题翻译：抗生素下一代
公开(公告)号：WO2006086321A3
公开(公告)日：2007-02-22
申请号：PCT/US2006004147
申请日：2006-02-07
申请人： HELIX BIOMEDIX INC , FALLA TIMOTHY J , ZHANG LIJUAN , HARRIS SCOTT M
发明人： FALLA TIMOTHY J , ZHANG LIJUAN , HARRIS SCOTT M
IPC分类号： C07K7/06 , A61K38/08 , A61P31/00
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (NaI), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such a mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.
摘要翻译：本发明包括由位置2,4和6处的交替的疏水性残基（B），位置1和3的亲水性，亲水性，带电荷的残基（X）和萘丙氨酸（NaI），脂族或芳族残基（O ），通常由式XBXBOB表示，其表现出针对由各种病原体引起的感染的抗微生物活性。这些病原体可包括革兰氏阳性或阴性细菌，耐酸细菌如分枝杆菌，寄生虫，皮肤真菌或真菌病原体。典型的真菌病原体包括白色念珠菌和典型的皮肤癣菌，包括红色毛癣菌和引发毛癣菌。本发明的六肽对接受治疗的哺乳动物具有抗真菌活性，抗菌活性，所需的稳定性和缺乏毒性。

2. 发明申请

WO2007146269A3 PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 审中-公开
标题翻译：诱导细胞基质蛋白合成的肽片段
公开(公告)号：WO2007146269A3
公开(公告)日：2008-08-14
申请号：PCT/US2007013748
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC , HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K14/78 , C07K5/10
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K38/00 , A61K2121/00 , A61K2300/00 , A61Q19/00 , A61Q19/08 , C07K5/1002 , C07K5/1008 , C07K5/1024 , C07K14/78
摘要： [0049] Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
摘要翻译：公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。公开了生产四肽的异源制剂的快速，低成本的方法。

3. 发明申请

WO2011063090A2 PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY 审中-公开
标题翻译：抗紫外线防紫外线防毒素
公开(公告)号：WO2011063090A2
公开(公告)日：2011-05-26
申请号：PCT/US2010057177
申请日：2010-11-18
申请人： HELIX BIOMEDIX INC , ZHANG LIJUAN , FALLA TIMOTHY J
发明人： ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K8/64 , A61K9/0014 , A61Q7/00 , A61Q19/004 , A61Q19/08
摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.
摘要翻译：公开了具有生物和治疗活性的短肽。具体地，所公开的肽的活性是针对减少或防止诱变剂诱导的细胞/组织毒性（即，化学预防）。例如，所公开的肽可防止由紫外线（UV）曝光引起的皮肤毒性和/或诱变。所公开的肽还阻断某些细胞周期调节蛋白如Chk2的活化。这样的肽的实例是Ser-Leu-Tyr-Gln-Ser（SEQ ID NO：10）。所公开的肽也可用于降低或防止细胞毒性和突变积累的方法，否则在诱变剂暴露后会发生。绘制一种这样的方法以向皮肤施加肽以防止或减少由UV光（例如阳光）暴露引起的诱变性损伤。

4. 发明专利

JP2014129369A Peptide fragments for inducing synthesis of extracellular matrix proteins 有权
标题翻译：诱导细胞基质蛋白合成的肽片段
公开(公告)号：JP2014129369A
公开(公告)日：2014-07-10
申请号：JP2014025001
申请日：2014-02-13
申请人： Helix Biomedix Inc , ヘリックスバイオメディックス,インコーポレイテッドHelix Biomedix,Inc.
发明人： SCOTT M HARRIS , TIMOTHY J FALLA , ZHANG LIJUAN
IPC分类号： C07K5/10 , A61K8/64 , A61K9/06 , A61K9/08 , A61K9/107 , A61K38/00 , A61P9/12 , A61P17/00 , A61P17/02 , A61Q19/00 , C07K5/103 , C07K5/117
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K38/00 , A61K2121/00 , A61K2300/00 , A61Q19/00 , A61Q19/08 , C07K5/1002 , C07K5/1008 , C07K5/1024 , C07K14/78
摘要： PROBLEM TO BE SOLVED: To provide peptide compositions that stimulate production of extracellular matrix (ECM) proteins in skin and can be used in formulations for repairing damaged skin or maintaining healthy skin.SOLUTION: Provided are tetrapeptides that stimulate production of collagen in human skin. The tetrapeptides are PEKP, PKGP, PGQP, PGTP, and PGNP, with P(proline), E(glutamic acid), K(lysine), G(glycine), Q(glutamine), T(threonine), and N(asparagine). The tetrapeptides are either a free acid or amidated on the carboxyl terminus.
摘要翻译：要解决的问题：提供刺激皮肤中细胞外基质（ECM）蛋白质生成的肽组合物，可用于修复受损皮肤或维持健康皮肤的制剂。解决方案：提供刺激人皮肤胶原蛋白生成的四肽。四肽是P（脯氨酸），E（谷氨酸），K（赖氨酸），G（甘氨酸），Q（谷氨酰胺），T（苏氨酸）和N（天冬酰胺）的PEKP，PKGP，PGQP，PGTP和PGNP ）。四肽是游离酸或在羧基末端酰胺化。

5. 发明公开

EP2512498A4 PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY 有权转让
标题翻译：肽保护，禁止毒性紫外线
公开(公告)号：EP2512498A4
公开(公告)日：2013-06-05
申请号：EP10832158
申请日：2010-11-18
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： A61K38/08 , A61K8/64 , A61K9/00 , A61P17/16 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07K7/06
CPC分类号： A61K38/08 , A61K8/64 , A61K9/0014 , A61Q7/00 , A61Q19/004 , A61Q19/08
摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.

6. 发明专利

MY173174A SHORT BIO-ACTIVE PEPTIDES FOR PROMOTING WOUND HEALING 未知
公开(公告)号：MY173174A
公开(公告)日：2020-01-02
申请号：MYPI2015702327
申请日：2014-01-21
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
摘要： Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB- 107 (MPKEKVFLKIEKMGRNIRN), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory and migratory properties. The inventive peptides comprise four to six contiguous amino acid residues located between position 11 and 16 of HB107 (MPKEKVFLKIEKMGRNIRN), namely EKMGRN. The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.

7. 发明专利

ES2680022T3 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular 未知
公开(公告)号：ES2680022T3
公开(公告)日：2018-09-03
申请号：ES15188894
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT , FALLA TIMOTHY , ZHANG LIJUAN
IPC分类号： C07K14/78 , A61K38/00 , A61Q19/00 , C07K5/10
摘要： Un tetrapéptido que comprende la SEQ. ID NO: 10 (PKGP) o la SEQ ID NO: 9 (PEKP) para su uso como medicamento.

8. 发明专利

CY1119191T1 ΤΕΤΡΑΠΕΠΤΙΔΙΑ ΤΑ ΟΠΟΙΑ ΠΑΡΑΓΟΝΤΑΙ ΑΠΟ ΑΝΘΡΩΠΙΝΕΣ C-X-C ΧΗΜΕΙΟΚΙΝΕΣ ΧΡΗΣΙΜΑ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΔΙΑΦΟΡΩΝ ΠΑΘΗΣΕΩΝ ΤΟΥ ΔΕΡΜΑΤΟΣ 未知
公开(公告)号：CY1119191T1
公开(公告)日：2018-02-14
申请号：CY171100663
申请日：2017-06-22
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/00 , A61K8/64 , A61K38/07 , A61Q7/02 , A61Q19/02 , A61Q19/08 , C07K14/52
摘要： Τετραπεπτίδιαταοποίααποτελούνταιαπό (I ή V)-X1-K-X2, όπουτοΧ1 μπορείναεπιλέγεταιαπόΕ, Q ήΚ, καιτοΧ2 μπορείναεπιλέγεταιαπόΜ, F, I, W ή V επιδεικνύουνδιάφορεςβιοδραστικότητες. Είναιπολυλειτουργικάμόριατελεστήγιαναδιεγείρουντημετανάστευσηκερατινοκυττάρωνναεξουδετερώνουντοπρο-φλεγμονώδεςαποτέλεσματωνβακτηριακώνσυστατικώνκυτταρικούτοιχώματοςόπωςταλιποτεϊχοϊκάοξέατουθετικούκατά Gram S. Aureus· καιναεπάγουναγγειογένεσησεκαλλιεργημέναανθρώπιναενδοθηλιακάκύτταρατηςομφαλικήςφλέβας. Ρύθμισηπροςτακάτωτηςφλεγμονώδουςπάθησηςεπιδεικνύεταιεπίσηςμετηχρήσητουμοντέλουδέρματοςψωρίασης SOR-300-FT γιααντιπροσωπευτικόπεπτίδιο. Ηβιοδραστικότηταυποστηρίζεταιεπίσηςαπότημελέτησχηματισμούπροφίλγονιδίουμετάαπόαγωγήκανονικώνιστώνδέρματοςμετηχρήσηυποκατάστατωνδέρματος EPIDERM™. Ταεφευρετικάπεπτίδιαμεδιάφορεςβιοδραστικότητεςείναιχρήσιμαγιατηναγωγήδιαφόρωνπαθήσεωντουδέρματος, όπουσυμπεριλαμβάνονται, μεταξύάλλων, οξείεςή χρόνιεςπληγές, striae disensae, γήρανσητουδέρματος, έλεγχοςτωντριχών, φλεγμονώδεςδέρμαόπωςψωρίαση, ατοπικήδερματίτιδακαιροδόχρουςακμήκαιγιααπομάκρυνσηανεπιθύμητωντριχώνή γιαπαθήσειςόπωςαπομάκρυνσηδερματοϊνωμάτων.

9. 发明专利

ES2631804T3 Tetrapéptidos derivados de quimiocinas humanas C-X-C útiles para el tratamiento de diversas afecciones de la piel 未知
公开(公告)号：ES2631804T3
公开(公告)日：2017-09-05
申请号：ES14730697
申请日：2014-05-14
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/00 , A61K8/64 , A61K38/07 , A61Q7/02 , A61Q19/02 , A61Q19/08 , C07K14/52
摘要： Un tetrapéptido aislado que presenta actividad de reparación y regeneración de heridas que consiste en la secuencia peptídica (I o V)-X1-K-X2, donde X1 es E, Q o K, y X2 es M, F, I, W, V o L.

10. 发明专利

ZA201405950B SHORT ANTIMICROBIAL LIPOPEPTIDES 未知
公开(公告)号：ZA201405950B
公开(公告)日：2017-08-30
申请号：ZA201405950
申请日：2014-08-13
申请人： HELIX BIOMEDIX INC
发明人： CARMICHAEL ROBIN , ZHANG LIJUAN
摘要： Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

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