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1. 发明申请

WO2006086321A3 ANTIMICROBIAL HEXAPEPTIDES 审中-公开
标题翻译：抗生素下一代
公开(公告)号：WO2006086321A3
公开(公告)日：2007-02-22
申请号：PCT/US2006004147
申请日：2006-02-07
申请人： HELIX BIOMEDIX INC , FALLA TIMOTHY J , ZHANG LIJUAN , HARRIS SCOTT M
发明人： FALLA TIMOTHY J , ZHANG LIJUAN , HARRIS SCOTT M
IPC分类号： C07K7/06 , A61K38/08 , A61P31/00
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (NaI), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such a mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.
摘要翻译：本发明包括由位置2,4和6处的交替的疏水性残基（B），位置1和3的亲水性，亲水性，带电荷的残基（X）和萘丙氨酸（NaI），脂族或芳族残基（O ），通常由式XBXBOB表示，其表现出针对由各种病原体引起的感染的抗微生物活性。这些病原体可包括革兰氏阳性或阴性细菌，耐酸细菌如分枝杆菌，寄生虫，皮肤真菌或真菌病原体。典型的真菌病原体包括白色念珠菌和典型的皮肤癣菌，包括红色毛癣菌和引发毛癣菌。本发明的六肽对接受治疗的哺乳动物具有抗真菌活性，抗菌活性，所需的稳定性和缺乏毒性。

2. 发明申请

WO2007146269A3 PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 审中-公开
标题翻译：诱导细胞基质蛋白合成的肽片段
公开(公告)号：WO2007146269A3
公开(公告)日：2008-08-14
申请号：PCT/US2007013748
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC , HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K14/78 , C07K5/10
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K38/00 , A61K2121/00 , A61K2300/00 , A61Q19/00 , A61Q19/08 , C07K5/1002 , C07K5/1008 , C07K5/1024 , C07K14/78
摘要： [0049] Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
摘要翻译：公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。公开了生产四肽的异源制剂的快速，低成本的方法。

3. 发明申请

WO2011063090A2 PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY 审中-公开
标题翻译：抗紫外线防紫外线防毒素
公开(公告)号：WO2011063090A2
公开(公告)日：2011-05-26
申请号：PCT/US2010057177
申请日：2010-11-18
申请人： HELIX BIOMEDIX INC , ZHANG LIJUAN , FALLA TIMOTHY J
发明人： ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K8/64 , A61K9/0014 , A61Q7/00 , A61Q19/004 , A61Q19/08
摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.
摘要翻译：公开了具有生物和治疗活性的短肽。具体地，所公开的肽的活性是针对减少或防止诱变剂诱导的细胞/组织毒性（即，化学预防）。例如，所公开的肽可防止由紫外线（UV）曝光引起的皮肤毒性和/或诱变。所公开的肽还阻断某些细胞周期调节蛋白如Chk2的活化。这样的肽的实例是Ser-Leu-Tyr-Gln-Ser（SEQ ID NO：10）。所公开的肽也可用于降低或防止细胞毒性和突变积累的方法，否则在诱变剂暴露后会发生。绘制一种这样的方法以向皮肤施加肽以防止或减少由UV光（例如阳光）暴露引起的诱变性损伤。

4. 发明公开

EP2512498A4 PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY 有权转让
标题翻译：肽保护，禁止毒性紫外线
公开(公告)号：EP2512498A4
公开(公告)日：2013-06-05
申请号：EP10832158
申请日：2010-11-18
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： A61K38/08 , A61K8/64 , A61K9/00 , A61P17/16 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07K7/06
CPC分类号： A61K38/08 , A61K8/64 , A61K9/0014 , A61Q7/00 , A61Q19/004 , A61Q19/08
摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.

5. 发明专利

CA2835369C PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 未知
公开(公告)号：CA2835369C
公开(公告)日：2017-01-31
申请号：CA2835369
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K5/117 , A61K8/64 , A61K38/17 , A61P17/00 , A61P17/02 , A61Q19/00 , A61Q19/08
摘要： Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

6. 发明专利

CA2655116C PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 未知
公开(公告)号：CA2655116C
公开(公告)日：2016-12-13
申请号：CA2655116
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K14/78 , A61K8/64 , A61K38/07 , A61P17/02 , A61Q19/08 , C07K5/10 , C07K5/103 , C07K5/117
摘要： [0049] Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

7. 发明专利

AU2011271466B2 N-acyl amino acid derivatives for treating skin conditions such as cellulite 未知
公开(公告)号：AU2011271466B2
公开(公告)日：2013-08-22
申请号：AU2011271466
申请日：2011-06-28
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： A61K31/20 , A61K8/44
摘要： The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.

8. 发明专利

HK1170419A1 PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY 未知
公开(公告)号：HK1170419A1
公开(公告)日：2013-03-01
申请号：HK12111216
申请日：2012-11-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： A61P20060101 , A61K20060101 , A61Q20060101 , C07K20060101
摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.

9. 发明专利

PL1853620T3 Heksapeptydy przeciwdrobnoustrojowe 未知
公开(公告)号：PL1853620T3
公开(公告)日：2012-07-31
申请号：PL06720369
申请日：2006-02-07
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY J , ZHANG LIJUAN , HARRIS SCOTT M
IPC分类号： C07K7/06

10. 发明专利

CA2947353A1 PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 未知
公开(公告)号：CA2947353A1
公开(公告)日：2007-12-21
申请号：CA2947353
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K14/78 , A61K38/07 , A61P17/02 , C07K5/103
摘要： Short biologically active tetrapeptides are disclosed that are comprised of the sequence GxGP, where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

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