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1. 发明申请

WO2008093999A1 MRI T1 CONTRASTING AGENT COMPRISING MANGANESE OXIDE NANOPARTICLE 审中-公开
标题翻译： MRI T1对比剂包含锰氧化物纳米颗粒
公开(公告)号：WO2008093999A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000574
申请日：2008-01-30
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , AN, Kwangjin , NA, Hyon Bin , LEE, Junghee
发明人： HYEON, Taeghwan , AN, Kwangjin , NA, Hyon Bin , LEE, Junghee
IPC分类号： A61K49/08
CPC分类号： A61K49/08 , A61K49/126 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , B82Y5/00 , Y10T428/2982
摘要： The present invention relates to the use of and method for using MnO nanoparticles as MRI Tl contrasting agents which reduces Tl of tissue. More specifically, the present invention is directed to MRI Tl contrasting agent comprising MnO nanoparticle coated with a biocompatible material bound to a biologically active material such as a targeting agent, for example tumor marker etc., and methods for diagnosis and treatment of tumor etc. using said MRI Tl contrasting agent, thereby obtaining more detailed images than the conventional MRI Tl-weighted images. The MRI Tl contrasting agent of the present invention allows a high resolution anotomic imaging by emphasizing Tl contrast images between tissues based on the difference of accumulation of the contarsting agent in tissues. Also, the MRI Tl contrasting agent of the present invention enables to visualize cellular distibution due to its high intracellular uptake. The MRI Tl contrasting agent of the present invention can be used for target-specific diagnosis and treatment of various diseases such as tumor etc. when targeting agents binding to disease- specific biomarkers are conjugated to the surface of nanoparticles.
摘要翻译：本发明涉及使用MnO纳米颗粒作为降低组织T1的MRI T1对比剂的用途和方法。更具体地，本发明涉及包含结合生物活性物质如靶向剂例如肿瘤标志物等的生物相容性材料的MnO纳米颗粒的MRI Tl造影剂，以及用于诊断和治疗肿瘤等的方法。使用所述MRI T1对比剂，从而获得比常规MRI T1加权图像更详细的图像。本发明的MRI T1造影剂基于组织中对比剂的积累差异，通过强调组织之间的T1对比度图像，可以进行高分辨率的插入成像。此外，本发明的MRI T1对比剂能够由于其高细胞内摄取而可视化细胞分布。当与疾病特异性生物标志物结合的靶向剂与纳米颗粒的表面缀合时，本发明的MRI Tl造影剂可用于靶向特异性诊断和治疗各种疾病如肿瘤等。

2. 发明申请

WO2008048074A1 USE OF CORE-SHELL GOLD NANOPARTICLE WHICH CONTAINS MAGNETIC NANOPARTICLES FOR MRI T2 CONTRAST AGENT, CANCER DIAGNOSTIC AND THERAPY 审中-公开
标题翻译：含有磁性纳米粒子的核心金纳米颗粒用于MRI T2对比剂，癌症诊断和治疗
公开(公告)号：WO2008048074A1
公开(公告)日：2008-04-24
申请号：PCT/KR2007/005154
申请日：2007-10-19
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , KIM, Jae Yoon , CHO, Myung-Haing , KIM, Seong Keun , LEE, Junghee
发明人： HYEON, Taeghwan , KIM, Jae Yoon , CHO, Myung-Haing , KIM, Seong Keun , LEE, Junghee
IPC分类号： A61K49/06 , A61P43/00
CPC分类号： A61K49/1887 , B82Y5/00
摘要： The present invention relates to the use of magnetic gold nanoshells consisted of gold nanoshells embedded with magnetic nanoparticles and spherical silica cores for use in MRI T2 contrast agent, cancer diagnosis and cancer therapy. More particularly, the present invention is directed to the use of an MRI T2 contrast agent using the magnetic properties of the magnetic nanoparticles embedded with the gold nanoshell, a cancer diagnostic agent for treating cancer using the cancer binding properties of target-specific ligands bonded to the surface of the magnetic gold nanoparticles and a therapeutic agent for treating cancer using the heat released form the gold nanoshell absorbed from the energy of near infrared ray range electromagnetic pulses to destroy the cancer cells, and methods for the diagnosis and treatment of cancer using the magnetic gold nanoparticles.
摘要翻译：本发明涉及包含磁性纳米颗粒的金纳米壳和用于MRI T2造影剂，癌症诊断和癌症治疗的球形二氧化硅核心的磁性金纳米壳的应用。更具体地说，本发明涉及使用嵌入有金纳米壳的磁性纳米颗粒的磁特性的MRI T2造影剂，癌症诊断剂使用与靶结合特异性配体结合的癌症结合特性磁性金纳米颗粒的表面和用于治疗癌症的治疗剂，使用从近红外线射线范围电磁脉冲的能量吸收的金纳米壳释放的热量来破坏癌细胞，以及用于诊断和治疗癌症的方法磁性金纳米颗粒。

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