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1. 发明申请

WO2008150118A3 NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS 审中-公开
标题翻译：用于抑制癌细胞生长的新型催化剂
公开(公告)号：WO2008150118A3
公开(公告)日：2009-01-29
申请号：PCT/KR2008003162
申请日：2008-06-05
申请人： HANMI PHARM IND CO LTD , LEE KWANG-OK , CHA MI YOUNG , KIM MI RA , JUNG YOUNG HEE , LEE CHANG GON , KIM SE YOUNG , BANG KEUKCHAN , PARK BUM WOO , CHOI BO IM , CHAE YUN JUNG , KO MI YOUNG , KIM HAN KYONG , AHN YOUNG-GIL , KIM MAENG SUP , LEE GWAN SUN
发明人： LEE KWANG-OK , CHA MI YOUNG , KIM MI RA , JUNG YOUNG HEE , LEE CHANG GON , KIM SE YOUNG , BANG KEUKCHAN , PARK BUM WOO , CHOI BO IM , CHAE YUN JUNG , KO MI YOUNG , KIM HAN KYONG , AHN YOUNG-GIL , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D403/12
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D403/14
摘要： The present invention provides a novel amide derivative and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase, and a pharmaceutical composition comprising same as an active ingredient.
摘要翻译：本发明提供了一种新颖的酰胺衍生物及其药学上可接受的盐，其选择性和有效地抑制由表皮生长因子受体过表达诱导的癌细胞的生长，并且还防止由EGFR酪氨酸激酶突变引起的耐药性的发展，以及含有活性成分的药物组合物。

2. 发明公开

EP2167492A4 NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS 有权转让
标题翻译：新的抑制癌细胞生长的AMID衍生物
公开(公告)号：EP2167492A4
公开(公告)日：2010-12-15
申请号：EP08766124
申请日：2008-06-05
申请人： HANMI PHARM IND CO LTD
发明人： LEE KWANG-OK , CHA MI YOUNG , KIM MI RA , JUNG YOUNG HEE , LEE CHANG GON , KIM SE YOUNG , BANG KEUKCHAN , PARK BUM WOO , CHOI BO IM , CHAE YUN JUNG , KO MI YOUNG , KIM HAN KYONG , AHN YOUNG-GIL , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D403/12 , A61K31/517 , A61P35/00 , C07D301/14 , C07D401/12 , C07D403/14
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D403/14

3. 发明公开

EP1844022A4 QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF 有权
标题翻译：喹唑啉衍生物抑制的生长癌细胞和方法及其
公开(公告)号：EP1844022A4
公开(公告)日：2009-10-28
申请号：EP05819138
申请日：2005-12-20
申请人： HANMI PHARM IND CO LTD
发明人： HAM YOUNG JIN , CHA MI YOUNG , GONG JI HYEON , KIM CHANG IN , SONG JI YEON , KIM EUN YOUNG , KIM MAENG SUP , KIM JONG WOO , LEE GWAN SUN , KIM SE YOUNG
IPC分类号： C07D239/94
CPC分类号： C07D403/12 , C07D239/94 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12

4. 发明公开

EP1711490A4 NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新的P-GLYCOPROTEININHIBITOR，对于其方法和药物组合物包含此
公开(公告)号：EP1711490A4
公开(公告)日：2007-04-04
申请号：EP04774781
申请日：2004-10-07
申请人： HANMI PHARM IND CO LTD
发明人： CHA MI YOUNG , BANG KEUK CHAN , AHN YOUNG GIL , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D405/12
CPC分类号： C07D405/12

5. 发明公开

EP1678162A4 P-GLYCOPROTEIN INHIBITOR, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权转让
标题翻译： P-糖蛋白抑制剂，其方法和药物组合物包含此
公开(公告)号：EP1678162A4
公开(公告)日：2008-07-02
申请号：EP04774778
申请日：2004-10-06
申请人： HANMI PHARM IND CO LTD
发明人： BANG KEUK CHAN , CHA MI YOUNG , AHN YOUNG GIL , HAM YOUNG JIN , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D401/14 , C07D257/04 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C04B35/632 , C07D257/04 , C07D401/12 , C07D405/12 , C07D409/12

6. 发明专利

CA2687180C NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS 未知
公开(公告)号：CA2687180C
公开(公告)日：2012-07-24
申请号：CA2687180
申请日：2008-06-05
申请人： HANMI PHARM IND CO LTD
发明人： LEE KWANG-OK , CHA MI YOUNG , KIM MI RA , JUNG YOUNG HEE , LEE CHANG GON , KIM SE YOUNG , BANG KEUKCHAN , PARK BUM WOO , CHOI BO IM , CHAE YUN JUNG , KO MI YOUNG , KIM HAN KYONG , AHN YOUNG-GIL , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D403/12
摘要： The present invention provides a novel amide derivative of formula (I): (see formula I) and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase, and a pharmaceutical composition comprising same as an active ingredient.

7. 发明专利

SI1678162T1 INHIBITOR P-GLIKOPROTEINA, POSTOPEK PRIPRAVE LE-TEGA IN FARMACEVTSKI SESTAVEK, KI GA VSEBUJE 未知
公开(公告)号：SI1678162T1
公开(公告)日：2010-07-30
申请号：SI200431434
申请日：2004-10-06
申请人： HANMI PHARM IND CO LTD
发明人： BANG KEUK CHAN , CHA MI YOUNG , AHN YOUNG GIL , HAM YOUNG JIN , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D401/00 , C07D257/04 , C07D401/14 , C07D401/12 , C07D405/12 , C07D409/12

8. 发明专利

NZ546257A P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same 未知
公开(公告)号：NZ546257A
公开(公告)日：2009-09-25
申请号：NZ54625704
申请日：2004-10-06
申请人： HANMI PHARM IND CO LTD
发明人： BANG KEUK CHAN , CHA MI YOUNG , AHN YOUNG GIL , HAM YOUNG JIN , KIM MAENG SUP , LEE GWAN SUN
IPC分类号： C07D401/14 , C07D257/04 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The disclosure relates to an effective p-glycoprotein inhibitor compound of formula (I) and a pharmaceutically acceptable salt thereof, a method for preparing the same and a pharmaceutical composition containing the same as an active ingredient. The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof by suppressing p-glycoprotein.

9. 发明专利

AR110003A2 DERIVADO DE AMIDA 未知
公开(公告)号：AR110003A2
公开(公告)日：2019-02-13
申请号：ARP170103011
申请日：2017-10-30
申请人： HANMI PHARM IND CO LTD
发明人： LEE GWAN SUN , KIM MAENG SUP , AHN YOUNG , GIL - KIM HAN KYOUNG , KO MI YOUNG , CHAE YUN JUNG , CHOI BO IM , PARK BUM WOO , BANG KEUKCHAN , KIM SE YOUNG , LEE CHANG GON , JUNG YOUNG HEE , KIM MI RA , CHA MI YOUNG , LEE KWANG-OK
IPC分类号： C07D239/34 , A61K31/517 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： Reivindicación 1: Un derivado de amida de fórmula (1), o una sal farmacéuticamente aceptable del mismo, caracterizado porque: A es un resto de fórmula (2) ó (3) siendo R⁴, R⁵, R⁶ y R⁷ cada uno independientemente hidrógeno, halógeno, N-alquilo C₁₋₆ o N-hidroxi amido o C-alquilo C₁₋₆ amido inverso (-NHCOC₁₋₆), hidroxicarbonilo (-COOH), alquiloxicarbonilo C₁₋₆ (-COOC₁₋₆), alquilo C₁₋₆, o alquilo C₁₋₆ substituido con un grupo hidroxi, dialquilamina C₁₋₆ o grupo heterocíclico; R¹ es un grupo arilo o heterocíclico substituido con uno a cinco X, o alquilo C₁₋₆ substituido con arilo; R² es hidrógeno, hidroxi, alcoxi C₁₋₆, o alcoxi C₁₋₆ substituido con un grupo alcoxi C₁₋₆ o heterocíclico; R³ es hidrógeno, -COOH, alquiloxicarbonilo C₁₋₆, o amido N-no substituido o N-substituido con Y; nₐ y nᵇ son cada uno un entero que oscila entre 0 y 6; en donde: X es hidrógeno, halógeno, hidroxi, ciano, nitro, (mono-, di-, o trihalógeno)metilo, mercapto, alquiltio C₁₋₆, acrilamido, alquilo C₁₋₆, alquenilo C₁₋₆, alquinilo C₁₋₆, alcoxi C₁₋₆, ariloxi, dialquilamino C₁₋₆, o alquilo C₁₋₆ o alcoxi C₁₋₆ substituido con Z, con la condiciona de que cuando el número de X es dos o más, los grupos X pueden fusionarse entre sí para formar una estructura de anillo; Y es hidroxi, alquilo C₁₋₆ o alquilo C₁₋₆ substituido con Z, conteniendo el alquilo C₁₋₆ una a cuatro de la parte seleccionada entre el grupo que consiste en N, O, S, SO y SO₂; y Z es un grupo alquilo C₁₋₆, arilo o heterocíclico, siendo dicho grupo arilo un grupo aromático monocíclico o bicíclico C₅₋₁₂, siendo dicho grupo heterocíclico un grupo aromático o no aromático monocíclico o bicíclico C₅₋₁₂ que contiene una a cuatro de la parte seleccionada entre el grupo que consiste en N, O, S, SO y SO₂ y siendo dichos grupos arilo y heterocíclico no substituidos o substituidos con substituyente seleccionados entre el grupo que consiste en halógeno, hidroxilo, amino, nitro, ciano, alquilo C₁₋₆, alquenilo C₁₋₆, alquinilo C₁₋₆, alcoxi C₁₋₆, monoalquilamino C₁₋₆ y dialquilamino C₁₋₆.

10. 发明专利

CA2592286C QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF 未知
公开(公告)号：CA2592286C
公开(公告)日：2012-05-29
申请号：CA2592286
申请日：2005-12-20
申请人： HANMI PHARM IND CO LTD
发明人： HAM YOUNG JIN , GONG JI HYEON , CHA MI YOUNG , KIM JONG WOO , KIM MAENG SUP , KIM EUN YOUNG , SONG JI YEON , KIM CHANG IN , KIM SE YOUNG , LEE GWAN SUN
IPC分类号： C07D239/94
摘要： The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof for inhibiting the growth of cancer cells, a method for the preparation thereof and a pharmaceutical composition comprising same as an active ingredient.

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