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1. 发明公开

EP1804796A2 AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES 审中-公开
标题翻译：氨基取代的芳氧基苯基哌啶衍生物
公开(公告)号：EP1804796A2
公开(公告)日：2007-07-11
申请号：EP05804433.0
申请日：2005-09-20
申请人： H.Lundbeck A/S
发明人： MARZABADI, Mohammad, R. , CHEN, Chien-An , JIANG, Yu , LU, Kai , ANDERSEN, Kim
IPC分类号： A61K31/4427 , C07D401/06
CPC分类号： C07D211/26 , C07D401/12 , C07D403/12
摘要： This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/ or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体配体的氨基取代的芳氧基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了通过混合治疗有效量的本发明化合物和药学上可接受的载体制成的药物组合物。本发明进一步提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的对象的方法，该方法包括给对象施用治疗有效量的本发明化合物。

2. 发明申请

WO2006041636A3 AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES 审中-公开
公开(公告)号：WO2006041636A3
公开(公告)日：2006-04-20
申请号：PCT/US2005/033891
申请日：2005-09-20
申请人： H.LUNDBECK A/S , MARZABADI, Mohammad, R. , CHEN, Chien-An , YU, Jiang , LU, Kai , ANDERSEN, Kim
发明人： MARZABADI, Mohammad, R. , CHEN, Chien-An , YU, Jiang , LU, Kai , ANDERSEN, Kim
IPC分类号： A61K31/4427 , C07D401/06
摘要： This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/ or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.

3. 发明公开

EP1799223A2 ARYLTHIOBENZYLPIPERIDINE DERIVATES 审中-公开
标题翻译：芳基硫代苯基哌啶衍生物
公开(公告)号：EP1799223A2
公开(公告)日：2007-06-27
申请号：EP05806054.2
申请日：2005-09-21
申请人： H.Lundbeck A/S
发明人： MARZABADI, Mohammad, R. , JIANG, Yu , CHEN, Chien-An , LU, Kai , ANDERSEN, Kim
IPC分类号： A61K31/5377 , A61K31/445 , C07D211/06 , C07D413/12
CPC分类号： C07D211/60 , C07D211/26 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体配体的芳硫基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了通过混合治疗有效量的本发明化合物和药学上可接受的载体制成的药物组合物。本发明进一步提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的对象的方法，该方法包括给对象施用治疗有效量的本发明化合物。

4. 发明公开

EP1708704A2 4-ARYL PIPERIDINES 审中-公开
标题翻译： 4-芳基哌啶
公开(公告)号：EP1708704A2
公开(公告)日：2006-10-11
申请号：EP05711430.8
申请日：2005-01-13
申请人： H.Lundbeck A/S
发明人： MARZABADI, Mohammad, R. , WETZEL, John, M. , CHEN, Chien-An , DELEON, John, E. , JIANG, Yu , LU, Kai
IPC分类号： A61K31/445 , C07D211/68 , C07D401/04 , C07D401/10
CPC分类号： C07D211/26
摘要： This invention is directed to 4-aryl piperidines and related heterocyclic compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject’s depression and/or anxiety.

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