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1. 发明申请

WO2009120655A1 INDOLE DERIVATIVES 审中-公开
标题翻译： INDOLE DORIVATIVES
公开(公告)号：WO2009120655A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038022
申请日：2009-03-24
申请人： H. LUNDBECK A/S , JIANG, Yu , HONG, Sang-Phyo , CHEN, Bin , ELDEMENKY, Eman , HUSAIN, Arifa , WU, Lingyun , LU, Kai , MA, Gil , LABELLE, Marc , MARZABADI, Mohammad , SABIO, Michael , WHITE, Andrew , MAZZA, Christine , PACKIARAJAN, Mathivanan
发明人： JIANG, Yu , HONG, Sang-Phyo , CHEN, Bin , ELDEMENKY, Eman , HUSAIN, Arifa , WU, Lingyun , LU, Kai , MA, Gil , LABELLE, Marc , MARZABADI, Mohammad , SABIO, Michael , WHITE, Andrew , MAZZA, Christine , PACKIARAJAN, Mathivanan
IPC分类号： C07D403/02 , C07D209/04
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to indole derivatives which bind to the MCHl receptor. In separate aspects, the subject invention is directed to uses of said compounds in the preparation of a pharmaceutical composition for the treatment of obesity and CNS related disorders and to methods of treating said disorders comprising administering a therapeutically effective amount of a compound of the invention.
摘要翻译：本发明涉及与MCH1受体结合的吲哚衍生物。在单独的方面，本发明涉及所述化合物在制备用于治疗肥胖症和CNS相关疾病的药物组合物中的用途以及治疗所述病症的方法，包括施用治疗有效量的本发明化合物。

2. 发明申请

WO2006083538A1 AMINOALKYLPHENYL INDOLONE DERIVATIVES 审中-公开
标题翻译：氨基苯酚吲哚酮衍生物
公开(公告)号：WO2006083538A1
公开(公告)日：2006-08-10
申请号：PCT/US2006/001527
申请日：2006-01-18
申请人： H. LUNDBECK A/S , KONKEL, Michael , PACKIARAJAN, Mathivanan , CHEN, Heidi
发明人： KONKEL, Michael , PACKIARAJAN, Mathivanan , CHEN, Heidi
IPC分类号： A61K31/41 , C07D209/40
CPC分类号： C07D209/40 , C07D403/10
摘要： This invention is directed to aminoalkylphenyl indolone derivatives, which are ligands at the GAL 3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/ or anxiety which comprises administering to the subject an amount of a compound of the subject invention.
摘要翻译：本发明涉及作为GAL 3受体的配体的氨基烷基苯基吲哚酮衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。

3. 发明申请

WO2011050063A1 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME 审中-公开
标题翻译： 2-取代的乙酰基噻唑衍生物及其用途
公开(公告)号：WO2011050063A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053379
申请日：2010-10-20
申请人： H. LUNDBECK A/S , PACKIARAJAN, Mathivanan , HOPPER, Allen , SAMS, Anette, Graven , MIKKELSEN, Gitte, Kobberoee , GRENON, Michel
发明人： PACKIARAJAN, Mathivanan , HOPPER, Allen , SAMS, Anette, Graven , MIKKELSEN, Gitte, Kobberoee , GRENON, Michel
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D277/24 , A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/496 , A61K31/5377 , C07D277/56 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/10 , C07D491/107 , C07D495/04
摘要： The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R 1 , R 2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and uses of the same.
摘要翻译：本发明提供式（I）的2-取代的乙炔基噻唑衍生物：其中R1，R2和X如本文所定义，或其药学上可接受的盐; 和药物组合物及其用途。

4. 发明申请

WO2007103295A3 HALOGENATED SULFONAMIDE DERIVATIVES 审中-公开
公开(公告)号：WO2007103295A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005563
申请日：2007-03-05
申请人： H. LUNDBECK A/S , JUBIAN, Vrej , PACKIARAJAN, Mathivanan , REINHARD, Emily
发明人： JUBIAN, Vrej , PACKIARAJAN, Mathivanan , REINHARD, Emily
IPC分类号： A01N41/06 , A61K31/18
摘要： This invention is directed to halogenated sulfonamide derivatives which are ligands at the NPY Y5 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, the present invention is directed to use of a compound of the invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.

5. 发明申请

WO2007002126A1 ALKYL SULFONAMIDE DERIVATIVES 审中-公开
标题翻译：亚苄基磺酰胺衍生物
公开(公告)号：WO2007002126A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024043
申请日：2006-06-21
申请人： H. LUNDBECK A/S , JUBIAN, Vrej , PACKIARAJAN, Mathivanan , JIMENEZ, Hermogenes , REINHARD, Emily
发明人： JUBIAN, Vrej , PACKIARAJAN, Mathivanan , JIMENEZ, Hermogenes , REINHARD, Emily
IPC分类号： C07D277/20 , A61K31/426
CPC分类号： C07D417/04
摘要： This invention is directed to alkyl sulfonamide derivatives which are ligands at the NPY Y5 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention.
摘要翻译：本发明涉及作为NPY Y5受体的配体的烷基磺酰胺衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症的受试者的方法，其包括给予受试者一定量的本发明化合物。本发明还提供了治疗患有焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。

6. 发明申请

WO2006083536A1 AMINOALKOXYPHENYL INDOLONE DERIVATIVES 审中-公开
标题翻译：氨基羟基苯酚吲哚酮衍生物
公开(公告)号：WO2006083536A1
公开(公告)日：2006-08-10
申请号：PCT/US2006/001522
申请日：2006-01-18
申请人： H. LUNDBECK A/S , KONKEL, Michael , PACKIARAJAN, Mathivanan , CHEN, Heidi , TOPIWALA, Upendra , JIMENEZ, Hermogenes , TALISMAN, Jamie
发明人： KONKEL, Michael , PACKIARAJAN, Mathivanan , CHEN, Heidi , TOPIWALA, Upendra , JIMENEZ, Hermogenes , TALISMAN, Jamie
IPC分类号： C07D209/40
CPC分类号： C07D209/34 , C07D403/12 , C07D405/12
摘要： This invention is directed to aminoalkoxyphenyl indolone derivatives, which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the subject invention.
摘要翻译：本发明涉及作为GAL3受体的配体的氨基烷氧基苯基吲哚酮衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。

7. 发明公开

EP2490541A1 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME 审中-公开
标题翻译： 2-取代 - 乙炔基噻唑衍生物及其用途
公开(公告)号：EP2490541A1
公开(公告)日：2012-08-29
申请号：EP10825591.0
申请日：2010-10-20
申请人： H. Lundbeck A/S
发明人： PACKIARAJAN, Mathivanan , HOPPER, Allen , SAMS, Anette, Graven , MIKKELSEN, Gitte, Kobberoee , GRENON, Michel
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D277/24 , A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/496 , A61K31/5377 , C07D277/56 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/10 , C07D491/107 , C07D495/04
摘要： The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R
1 , R
2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and uses of the same.
摘要翻译：本发明提供式（I）的2-取代的乙炔基噻唑衍生物或其药学上可接受的盐：其中R 1，R 2和X如本文所定义。及其药物组合物和用途。

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