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1. 发明申请

WO2007002126A1 ALKYL SULFONAMIDE DERIVATIVES 审中-公开
标题翻译：亚苄基磺酰胺衍生物
公开(公告)号：WO2007002126A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024043
申请日：2006-06-21
申请人： H. LUNDBECK A/S , JUBIAN, Vrej , PACKIARAJAN, Mathivanan , JIMENEZ, Hermogenes , REINHARD, Emily
发明人： JUBIAN, Vrej , PACKIARAJAN, Mathivanan , JIMENEZ, Hermogenes , REINHARD, Emily
IPC分类号： C07D277/20 , A61K31/426
CPC分类号： C07D417/04
摘要： This invention is directed to alkyl sulfonamide derivatives which are ligands at the NPY Y5 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention.
摘要翻译：本发明涉及作为NPY Y5受体的配体的烷基磺酰胺衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症的受试者的方法，其包括给予受试者一定量的本发明化合物。本发明还提供了治疗患有焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。

2. 发明申请

WO2006083536A1 AMINOALKOXYPHENYL INDOLONE DERIVATIVES 审中-公开
标题翻译：氨基羟基苯酚吲哚酮衍生物
公开(公告)号：WO2006083536A1
公开(公告)日：2006-08-10
申请号：PCT/US2006/001522
申请日：2006-01-18
申请人： H. LUNDBECK A/S , KONKEL, Michael , PACKIARAJAN, Mathivanan , CHEN, Heidi , TOPIWALA, Upendra , JIMENEZ, Hermogenes , TALISMAN, Jamie
发明人： KONKEL, Michael , PACKIARAJAN, Mathivanan , CHEN, Heidi , TOPIWALA, Upendra , JIMENEZ, Hermogenes , TALISMAN, Jamie
IPC分类号： C07D209/40
CPC分类号： C07D209/34 , C07D403/12 , C07D405/12
摘要： This invention is directed to aminoalkoxyphenyl indolone derivatives, which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the subject invention.
摘要翻译：本发明涉及作为GAL3受体的配体的氨基烷氧基苯基吲哚酮衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。

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