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1. 发明授权

US09612236B2 Multi epitope assay 有权
公开(公告)号：US09612236B2
公开(公告)日：2017-04-04
申请号：US13704258
申请日：2011-06-14
申请人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
发明人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.

2. 发明申请

US20130095495A1 MULTI EPITOPE ASSAY 有权
标题翻译：多重抗生素测定
公开(公告)号：US20130095495A1
公开(公告)日：2013-04-18
申请号：US13704258
申请日：2011-06-14
申请人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
发明人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.
摘要翻译：本发明涉及亲和测定中生物靶标检测方法，该方法包括以下步骤：提供含生物靶的生物样品体积，向包含生物靶标的生物样品体积添加第一捕获部分，其中所述第一捕获部分被粘附到颗粒上，所捕获的生物靶的浓度在步骤a）中小于生物样品体积的洗脱体积，从所述颗粒切割所述第一捕获部分或所述生物靶，并直接或间接检测和/或以三明治或竞争亲和测定格式定量生物学靶标，其中生物靶标与至少一个捕获部分，优选至少两个捕获部分相关联。

3. 发明申请

US20130109106A1 SYSTEM FOR SELECTIVELY PROCEEDING A SAMPLE 审中-公开
标题翻译：选择一个样品的系统
公开(公告)号：US20130109106A1
公开(公告)日：2013-05-02
申请号：US13808522
申请日：2011-07-04
申请人： Derk Jan Wilfred Klunder , Jeroen Hans Nieuwehuis , Menno Willem Jose Prins , Toon Hendrik Evers
发明人： Derk Jan Wilfred Klunder , Jeroen Hans Nieuwehuis , Menno Willem Jose Prins , Toon Hendrik Evers
IPC分类号： G01N1/10
CPC分类号： G01N1/10 , B01L3/0275 , B01L3/527 , B01L7/52 , B01L2200/04 , B01L2200/0684 , B01L2200/16 , B01L2300/027 , B01L2300/044 , B01L2300/0627 , B01L2300/0654 , B01L2300/087 , B01L2400/043 , G01N35/00029 , G01N35/0098 , G01N35/1002 , G01N2035/00158 , G01N2035/0436 , Y10T436/2575
摘要： The invention relates to a method and a system (100) for selectively processing a sample (130) according to one of a plurality of different assays, for example for detecting a certain target component in the sample. The system comprises a plurality of “specific reagent reservoirs” (120) that contain different sets of reagents, wherein each set is required for one of the assays. Moreover, the system (100) comprises a “universal reagent reservoir” in which reagents for several assays are provided, preferably reagents for all assays. The universal reagent reservoir may preferably be a cartridge (110) in which the processing of a sample (130) can take place and which comprises a plurality of binding sites that are selective for different target components. Depending on the assay to be performed with a sample (130) at hand, the appropriate specific reagent reservoir (121b) is chosen and processed in the universal cartridge (110). This can particularly be done by a manipulator (140) in a high-throughput automated laboratory system.
摘要翻译：本发明涉及用于根据多种不同测定中的一种选择性处理样品（130）的方法和系统（100），例如用于检测样品中某一目标成分。该系统包括多个含有不同试剂组的“特异性试剂储存器”（120），其中每种试剂均需要每组。此外，系统（100）包括“通用试剂储库”，其中提供用于几种测定的试剂，优选用于所有测定的试剂。通用试剂储存器可以优选地是其中样品（130）的处理可以发生并且包括对不同目标组分具有选择性的多个结合位点的盒（110）。根据将要用手的样品（130）进行的测定，在通用盒（110）中选择并处理适当的特定试剂储存器（121b）。这可以通过高通量自动化实验室系统中的机械手（140）来进行。

4. 发明申请

US20140127722A1 MOLECULAR ARCHITECTURE ON MAGNETIC PARTICLES FOR AFFINITY ASSAYS WITH LOW NON-SPECIFIC BINDING 审中-公开
标题翻译：具有低非特异性结合的亲和力测定用磁性颗粒的分子结构
公开(公告)号：US20140127722A1
公开(公告)日：2014-05-08
申请号：US14128031
申请日：2012-06-26
申请人： Andrea Ranzoni , Gwenola Sabatte , Menno Willem Jose Prins
发明人： Andrea Ranzoni , Gwenola Sabatte , Menno Willem Jose Prins
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N33/54326 , G01N33/54393
摘要： The present invention relates to a coating for preventing non-specific binding of molecules to a surface layer comprising an affinity molecule, said coating comprises single layer comprising non-affine spacer molecules forming a mesh; or a shell structure, wherein said shell structure comprises a first layer comprising one or more affinity molecules and further a second layer, which is coupled to the first layer, and wherein said first and second layer comprise non-affine spacer molecules forming a mesh. The present invention further relates to a particle, a flat structure or a matrix comprising such a coating. In a further aspect the present invention relates to the use of the coating, coated particle, coated flat structure or coated matrix for detection and/or purification of a specific target biomolecule from a sample and/or determination of the concentration of the specific target biomolecule. The present invention further relates to an assay for the detection of specific target biomolecules from a sample and/or determination of the concentration of specific target biomolecules comprising the use of such coating, coated particle, coated flat structure or coated matrix, in particular coated nanoparticles.
摘要翻译：本发明涉及一种用于防止分子与包含亲和分子的表面层的非特异性结合的涂层，所述涂层包括单层，其包含形成网的非仿射间隔分子; 或壳结构，其中所述壳结构包括包含一个或多个亲和分子的第一层，以及第二层，其耦合到第一层，并且其中所述第一层和第二层包含形成网的非仿射间隔分子。本发明还涉及包含这种涂层的颗粒，平面结构或基体。在另一方面，本发明涉及涂层，包被颗粒，涂覆的扁平结构或包被基质用于从样品中检测和/或纯化特异性目标生物分子和/或确定特异性靶标生物分子浓度的用途。本发明还涉及用于从样品中检测特异性目标生物分子和/或确定特异性靶生物分子的浓度的测定法，其包括使用这种涂层，涂覆的颗粒，涂覆的平面结构或涂覆的基质，特别是涂覆的纳米颗粒。

5. 发明授权

US08981772B2 Rotating magnetic field for improved detection in cluster assays 有权
标题翻译：旋转磁场用于集群测定中的改进检测
公开(公告)号：US08981772B2
公开(公告)日：2015-03-17
申请号：US13060804
申请日：2009-09-04
申请人： Andrea Ranzoni , Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko
发明人： Andrea Ranzoni , Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01R33/02 , G01N33/553 , G01N33/543 , G01N27/74
CPC分类号： G01N33/54333 , G01N27/745
摘要： In a method of performing a cluster assay, a suspension (14) of superparamagnetic particles in a fluid to be analyzed is provided, wherein the superparamagnetic particles are coated with a bioactive agent. The particles are then allowed to form clusters due to an analyte present within the fluid. Subsequently, clusters of superparamagnetic particles are selectively actuated by applying a rotating magnetic field, wherein the amplitude of the magnetic field varies over time. Finally, the selectively actuated clusters are detected. An apparatus for performing a cluster assay comprises means for accommodating a sample (12) and means for applying a rotating magnetic field (11), the magnetic field being adapted for selectively actuating clusters of superparamagnetic particles. The apparatus further comprises means for detecting the selectively actuated clusters.
摘要翻译：在进行聚集测定的方法中，提供了待分析流体中超顺磁性颗粒的悬浮液（14），其中超顺磁性颗粒用生物活性剂涂覆。然后由于存在于流体内的分析物，使颗粒形成簇。随后，通过施加旋转磁场来选择性地致动超顺磁性颗粒簇，其中磁场的振幅随时间而变化。最后，检测到选择性地致动的簇。用于进行聚集测定的装置包括用于容纳样品（12）的装置和用于施加旋转磁场（11）的装置，所述磁场适于选择性地致动超顺磁颗粒簇。该装置还包括用于检测选择性地致动的簇的装置。

6. 发明授权

US08970215B2 Sensor device for and a method of sensing particles 有权
标题翻译：传感器装置和感测颗粒的方法
公开(公告)号：US08970215B2
公开(公告)日：2015-03-03
申请号：US12521905
申请日：2007-07-26
申请人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
发明人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
IPC分类号： G01N33/558 , G01R33/12 , B82Y25/00 , G01R33/09 , G01N15/06 , G01N11/00 , G01N15/00
CPC分类号： G01R33/12 , B82Y25/00 , G01N15/0656 , G01N2011/008 , G01N2015/0053 , G01R33/093 , G01R33/1284
摘要： A sensor device for sensing particles of a sample, the sensor device including a sensing unit adapted for sensing a detection signal indicative of the presence of the particles, a viscosity measurement unit adapted for measuring the viscosity of the sample, and a correction unit adapted for correcting the detection signal based on the measured viscosity.
摘要翻译：一种用于感测样品颗粒的传感器装置，所述传感器装置包括适于感测指示颗粒存在的检测信号的感测单元，适于测量样品粘度的粘度测量单元，以及适用于基于测量的粘度校正检测信号。

7. 发明授权

US08349274B2 Microfluidic device 有权
标题翻译：微流控装置
公开(公告)号：US08349274B2
公开(公告)日：2013-01-08
申请号：US13120456
申请日：2009-10-01
申请人： Menno Willem Jose Prins , Pieter Jan Van Der Zaag , Remco Christiaan Den Dulk
发明人： Menno Willem Jose Prins , Pieter Jan Van Der Zaag , Remco Christiaan Den Dulk
IPC分类号： G01N33/00
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/086
摘要： A microfluidic device includes chambers for performing chemical, biochemical, or physical processes and a flow path connecting the chambers. A magnetic particle is moved through the chambers which are separated by a valve-like structure that enables passing-through of the magnetic particle from one chamber to another. At least one delaying structure delays movement of the magnetic particle along the flow path.
摘要翻译：微流体装置包括用于进行化学，生物化学或物理过程的腔室和连接腔室的流路。磁性颗粒被移动通过这样的腔室，它们被使得磁性颗粒从一个腔室传递到另一个腔室的阀状结构分开。至少一个延迟结构延迟了磁性颗粒沿着流动路径的移动。

8. 发明授权

US08084270B2 Device for analyzing fluids 失效
标题翻译：液体分析装置
公开(公告)号：US08084270B2
公开(公告)日：2011-12-27
申请号：US12161715
申请日：2007-01-15
申请人： Menno Willem Jose Prins , Ralph Kurt
发明人： Menno Willem Jose Prins , Ralph Kurt
IPC分类号： G01N1/00 , G01N33/553 , G01N33/50 , G01N21/01
CPC分类号： G01N27/745 , B01F13/0809 , G01N35/0098 , Y10T436/143333 , Y10T436/25
摘要： It is an object of the invention to provide for an alternative for analyzing fluids. To this end a device for analyzing fluids comprising magnetic particles is provided, the device comprising magnetic means for generating a magnetic field designed for exerting a magnetic force to the magnetic particles creating a movement of the fluid comprising targets and a membrane with an array for moving the fluid through or along the array.
摘要翻译：本发明的目的是提供用于分析流体的替代方案。为此，提供了一种用于分析包含磁性颗粒的流体的装置，该装置包括用于产生设计用于向磁性颗粒施加磁力的磁场的磁性装置，其产生包含靶的流体和具有用于移动的阵列的膜的运动流体通过或沿着阵列。

9. 发明申请

US20110116153A1 DISPLAY DEVICE 有权
标题翻译：显示设备
公开(公告)号：US20110116153A1
公开(公告)日：2011-05-19
申请号：US13014292
申请日：2011-01-26
申请人： Bokke Johannes Feenstra , Robert Andrew Hayes , Menno Willem Jose Prins
发明人： Bokke Johannes Feenstra , Robert Andrew Hayes , Menno Willem Jose Prins
IPC分类号： G02F1/23
CPC分类号： G02B26/005 , G02F1/167 , G02F1/17 , G09F9/372
摘要： Display device is based on layer break up or layer displacement having at least two different states, in which one of the fluids, e.g., oil in a first state, adjoins at least a first support plate and, in the second state, the other fluid at least partly adjoins the first support plate. In one embodiment, a picture element corresponds to a substantially closed space and, in the first state, the other fluid layer substantially completely adjoins both support plates and is divided in two sub-layers. This makes it possible, on the one hand, to use lower voltages to make displacement occur. On the other hand, this opens the opportunity to color displays.
摘要翻译：显示装置基于具有至少两种不同状态的层破裂或层位移，其中流体（例如，处于第一状态的油）中的一种与至少第一支撑板相邻，并且在第二状态下，另一种流体至少部分地邻接第一支撑板。在一个实施例中，像素对应于基本上封闭的空间，并且在第一状态下，另一流体层基本上完全邻接两个支撑板并被分成两个子层。这使得一方面可以使用较低的电压来产生位移。另一方面，这为彩色显示屏打开了机会。

10. 发明申请

US20100173290A1 MONITORING OF ENZYMATIC PROCESSES BY USING MAGNETIZABLE OR MAGNETIC OBJECTS AS LABELS 审中-公开
标题翻译：通过使用可磁化或磁性物体作为标签来监测加工过程
公开(公告)号：US20100173290A1
公开(公告)日：2010-07-08
申请号：US12377167
申请日：2007-08-10
申请人： Menno Willem Jose Prins
发明人： Menno Willem Jose Prins
IPC分类号： C12Q1/68 , C12Q1/00 , C12M1/00
CPC分类号： C12Q1/6853 , C12Q2563/143 , C12Q2561/113 , C12Q2537/125 , C12Q2531/143
摘要： The present invention provides a method and device for monitoring an enzymatic process of a biological molecule by, at least once, during the enzymatic process determining an amount of magnetic particles attached to a sensor surface. The method and device according to embodiments of the present invention may be used for monitoring an enzymatic process as a function of time.
摘要翻译：本发明提供了一种用于通过在酶过程中至少一次测定生物分子的酶促过程来确定连接到传感器表面的磁性颗粒的量来监测酶过程的方法和装置。根据本发明的实施方案的方法和装置可用于监测作为时间的函数的酶促过程。

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