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1. 发明申请

US20090184002A1 BIOSENSOR DEVICE 审中-公开
标题翻译：生物传感器设备
公开(公告)号：US20090184002A1
公开(公告)日：2009-07-23
申请号：US12299126
申请日：2007-04-24
申请人： Yukiko Furukawa , Joukje Garrelina Orsel , Hendrik Roelof Stapert
发明人： Yukiko Furukawa , Joukje Garrelina Orsel , Hendrik Roelof Stapert
IPC分类号： G01N27/26 , B23P17/00
CPC分类号： G01N33/5438 , G01N27/3275 , Y10T29/49002
摘要： A biosensor device (10) for detecting of molecules of an analyte in a sample (23) comprising: an identification element (18) comprising at least one self assembling monolayer (26) having a first surface, a transducer element (20) comprising a metal electrode (34) for receiving an electric signal from the reaction of the molecules in the sample with the at least one self assembling monolayer (26), and at least one electronic element (14, 16) for receiving the electric signal from the transducer element (20), for processing, and/or storing the electric signal. The at least one self-assembling monolayer (26) comprises at least one carboxylic acid-group for coupling the at least one self-assembling monolayer (26) to the surface (32) of the metal electrode (34).
摘要翻译：一种用于检测样品（23）中分析物的分子的生物传感器装置（10），包括：识别元件（18），包括至少一个具有第一表面的自组装单层（26），换能器元件（20）金属电极（34），用于从样品中的分子与至少一个自组装单层（26）的反应接收电信号;以及至少一个电子元件（14,16），用于从换能器接收电信号元件（20），用于处理和/或存储电信号。所述至少一个自组装单层（26）包含至少一个用于将所述至少一个自组装单层（26）耦合到所述金属电极（34）的表面（32）的羧酸基团。

2. 发明授权

US09612236B2 Multi epitope assay 有权
公开(公告)号：US09612236B2
公开(公告)日：2017-04-04
申请号：US13704258
申请日：2011-06-14
申请人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
发明人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.

3. 发明申请

US20130095495A1 MULTI EPITOPE ASSAY 有权
标题翻译：多重抗生素测定
公开(公告)号：US20130095495A1
公开(公告)日：2013-04-18
申请号：US13704258
申请日：2011-06-14
申请人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
发明人： Gwenola Sabatte , Menno Willem Jose Prins , Toon Hendrik Evers , Wilhelmina Maria Hardeman , Joukje Garrelina Orsel
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.
摘要翻译：本发明涉及亲和测定中生物靶标检测方法，该方法包括以下步骤：提供含生物靶的生物样品体积，向包含生物靶标的生物样品体积添加第一捕获部分，其中所述第一捕获部分被粘附到颗粒上，所捕获的生物靶的浓度在步骤a）中小于生物样品体积的洗脱体积，从所述颗粒切割所述第一捕获部分或所述生物靶，并直接或间接检测和/或以三明治或竞争亲和测定格式定量生物学靶标，其中生物靶标与至少一个捕获部分，优选至少两个捕获部分相关联。

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