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1. 发明授权

US4114314A Process for the production of thebaine 失效
标题翻译：生产蒂巴因的方法
公开(公告)号：US4114314A
公开(公告)日：1978-09-19
申请号：US770307
申请日：1977-02-22
申请人： Ali Shafiee , Iraj Lalezari , Narges Yassa
发明人： Ali Shafiee , Iraj Lalezari , Narges Yassa
IPC分类号： C07D489/02 , C12N5/00 , A01G1/00
CPC分类号： C07D489/02 , C12N5/0025
摘要： Tissue cultures of cells from seed heads of Papaver bracteatum Lindl, Population Arya II, are grown in artificial nutrient media to produce thebaine which is then extracted therefrom. An example of an artificial nutrient medium used for the tissue culture is revised tobacco medium supplemented with 1% agar and 1ppm 2,4-dichlorophenoxyacetic acid.
摘要翻译：来自罂粟藜种子头的细胞的组织培养物在人造营养培养基中生长，从而提取蒂巴因。用于组织培养的人造营养培养基的实例是补充有1％琼脂和1ppm 2,4-二氯苯氧基乙酸的烟草培养基。

2. 发明申请

US20050234128A1 Process for preparing fluoroleucine alkyl esters 失效
标题翻译：氟代烷基酯的制备方法
公开(公告)号：US20050234128A1
公开(公告)日：2005-10-20
申请号：US11106214
申请日：2005-04-14
申请人： Paul Devine , John Limanto , Ali Shafiee , Veena Upadhyay
发明人： Paul Devine , John Limanto , Ali Shafiee , Veena Upadhyay
IPC分类号： A61K31/198
CPC分类号： C07C249/02 , C07C229/20 , C12P13/02 , C07C251/24
摘要： This invention relates to a stereoselective preparation of fluoroleucine alkyl esters.
摘要翻译：本发明涉及一种立体选择性制备氟代烷基酯。

3. 发明授权

US5612217A Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors 失效
标题翻译：链霉菌属用于微生物合成HIV蛋白酶抑制剂的MA 7074（ATCC 55605）
公开(公告)号：US5612217A
公开(公告)日：1997-03-18
申请号：US328221
申请日：1994-10-25
申请人： Ali Shafiee , Shieh-Shung T. Chen , Byron H. Arison , Randall R. Miller , George M. Garrity , Brian Heimbuch
发明人： Ali Shafiee , Shieh-Shung T. Chen , Byron H. Arison , Randall R. Miller , George M. Garrity , Brian Heimbuch
IPC分类号： C12P17/16 , A61K31/495 , A61P31/12 , A61P37/04 , C07D401/06 , C12N1/20 , C12N7/00 , C12R1/465
CPC分类号： C07D401/06 , Y10S435/886
摘要： Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译：具有培养物MA7074的发酵的生物转化产物是有效的HIV蛋白酶抑制剂。这些产品可用于预防或治疗艾滋病毒和艾滋病感染，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。

4. 发明授权

US07429674B2 Process for preparing fluoroleucine alkyl esters 失效
标题翻译：氟代烷基酯的制备方法
公开(公告)号：US07429674B2
公开(公告)日：2008-09-30
申请号：US11106214
申请日：2005-04-14
申请人： Paul Devine , John Limanto , Ali Shafiee , Veena Upadhyay
发明人： Paul Devine , John Limanto , Ali Shafiee , Veena Upadhyay
IPC分类号： C07C229/00 , C07C205/00
CPC分类号： C07C249/02 , C07C229/20 , C12P13/02 , C07C251/24
摘要： This invention relates to a stereoselective preparation of fluoroleucine alkyl esters.
摘要翻译：本发明涉及一种立体选择性制备氟代烷基酯。

5. 发明授权

US06177008B1 Dual compartment solid phase extraction cartridge 失效
标题翻译：双室固相萃取筒
公开(公告)号：US06177008B1
公开(公告)日：2001-01-23
申请号：US09190503
申请日：1998-11-12
申请人： Laszlo R. Treiber , Ali Shafiee
发明人： Laszlo R. Treiber , Ali Shafiee
IPC分类号： B01D1508
CPC分类号： B01D15/08 , B01D15/22 , G01N30/6082
摘要： There is disclosed a dual compartment solid phase extraction cartridge comprising a container divided into a top volume and a bottom volume by a porous filter or frit, the top and bottom volumes having a quantity of sorbent. The cartridge is useful in the separation of components of a liquid and solid mixture.
摘要翻译：公开了一种双室固相萃取柱，其包括通过多孔过滤器或玻璃料分成顶部体积和底部体积的容器，顶部和底部体积具有一定数量的吸附剂。墨盒可用于分离液体和固体混合物的组分。

6. 发明授权

US6110716A HIV integrase inhibitors 失效
公开(公告)号：US6110716A
公开(公告)日：2000-08-29
申请号：US18684
申请日：1998-02-04
申请人： Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Ana M. Teran , Sheo Bux Singh , Deborah L. Zink
发明人： Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Ana M. Teran , Sheo Bux Singh , Deborah L. Zink
IPC分类号： A61K31/335 , A61K31/352 , A61K31/365 , C07D311/92 , C07D407/04 , C12P17/16 , A61K31/35 , C07D311/78 , C07D321/10
CPC分类号： C07D407/04 , A61K31/335 , A61K31/352 , A61K31/365 , C07D311/92 , C12P17/162
摘要： Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

7. 发明授权

US5264355A Methlating enzyme from streptomyces MA6858 失效
标题翻译：来自链霉菌MA6858的浓缩酶
公开(公告)号：US5264355A
公开(公告)日：1993-11-23
申请号：US908244
申请日：1992-07-02
申请人： Ali Shafiee , Patricia M. Cameron , David A. Boulton , Louis Kaplan , Haideh Motamedi
发明人： Ali Shafiee , Patricia M. Cameron , David A. Boulton , Louis Kaplan , Haideh Motamedi
IPC分类号： C12N9/10 , C12N9/08
CPC分类号： C12N9/1007
摘要： Described is a new enzyme, 31-O-desmethyl-FK-506 O-methyltransferase (FKMT) and its N-terminal amino acid sequence. This enzyme can specifically and preferentially methylate the C-31 hydroxy group in 31-O-desmethyl FK-506/FR-900506 and other 31-O-desmethyl analogs of FK-506/FR-900506 and related compounds such as 31-O-desmethyl immunomycin type molecules, also designated FK-520 and FR-900520 by Fujisawa. The enzyme can be isolated from a FK-506 producing microorganism Streptomyces sp. (Merck Culture Collection No. MA 6858) ATCC No. 55098. Employing the enzyme in its active form, supplemented with Mg.sup.+2 ion, in the presence of the methyl donor, S-adenosyl methionine (SAM), derivatives of 31-O-desmethyl FK-506, 31-O-desmethyl FK-520 and related 31-O-desmethyl compounds may be prepared.
摘要翻译：描述了一种新的酶，31-O-去甲基-FK-506 O-甲基转移酶（FKMT）及其N-末端氨基酸序列。该酶可以特异地和优先地甲基化31-O-脱甲基FK-506 / FR-900506中的C-31羟基和FK-506 / FR-900506的其它31-O-脱甲基类似物和相关化合物如31-O 也称为Fujisawa的FK-520和FR-900520。该酶可以从FK-506产生的微生物链霉菌（Streptomyces sp。）中分离出来。（Merck Culture Collection No.MA6858）ATCC No.55098.在甲基供体存在下使用活性形式的补充了Mg + 2离子的酶，S-腺苷甲硫氨酸（SAM），31-O的衍生物 - 甲基FK-506,31-O-去甲基FK-520和相关的31-O-脱甲基化合物。

8. 发明授权

US5622866A Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces 失效
标题翻译：用于构建链霉菌综合和复制表达载体的表达盒
公开(公告)号：US5622866A
公开(公告)日：1997-04-22
申请号：US264861
申请日：1994-06-23
申请人： Haideh Motamedi , Ali Shafiee
发明人： Haideh Motamedi , Ali Shafiee
IPC分类号： C12N9/10 , C12N15/76 , C12P17/18 , C12N15/63 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1007 , C12N15/76 , C12P17/188
摘要： The present invention is directed to expression cassettes useful in gene expression studies in both homologous and heterologous Streptomyces strains. More specifically the present invention is directed to the construction of two Streptomyces lividans-recombinant strains capable of producing 31-O-desmethylFK-506 O:methyltransferase, which methvlates 31-O-desmethylFK-506 to FK-506. In addition, the present invention is directed to a process for the specific methylation of 31-desmethyl-FK506 to FK506.
摘要翻译：本发明涉及用于同源和异源链霉菌属菌株的基因表达研究中的表达盒。更具体地，本发明涉及两种能产生31-O-去甲基FK-506 O：甲基转移酶的变色链霉菌 - 重组菌株的构建，其将31-O-去甲基FK-506转化为FK-506。此外，本发明涉及31-去甲基FK506至FK506的特异性甲基化的方法。

9. 发明授权

US5491077A Microbial method 失效
标题翻译：微生物法
公开(公告)号：US5491077A
公开(公告)日：1996-02-13
申请号：US277728
申请日：1994-07-20
申请人： Michel M. Chartrain , Shieh-Shung T. Chen , George M. Garrity , Brian Heimbuch , Christopher Roberge , Ali Shafiee
发明人： Michel M. Chartrain , Shieh-Shung T. Chen , George M. Garrity , Brian Heimbuch , Christopher Roberge , Ali Shafiee
IPC分类号： C12N1/20 , C12P17/12 , C12P17/18 , C12R1/01 , C12P17/16
CPC分类号： C12R1/01 , C12P17/12 , C12P17/185
摘要： The present invention provides a process for the stereoselective reduction of phenylalkyl ketones to their corresponding (S)-hydroxy compounds. The process utilizes the novel microorganism Microbacterium MB 5614 to effectuate the chiral reduction. The present invention also provides said novel Microbacterium, which has been deposited with the ATCC and assigned the accession number ATCC 55557.
摘要翻译：本发明提供了苯基烷基酮立体选择性还原成其相应的（S） - 羟基化合物的方法。该方法利用新型微生物微杆菌MB 5614实现手性还原。本发明还提供了所述新型微杆菌，其已经保藏在ATCC并且分配了登录号ATCC 55557。

10. 发明授权

US5427933A Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834 失效
标题翻译：将苯基烷基酮还原成相应的（S） - 羟基衍生物，使用粘膜高密度IFO 5834
公开(公告)号：US5427933A
公开(公告)日：1995-06-27
申请号：US277727
申请日：1994-07-20
申请人： Shieh-Shung T. Chen , Ali Shafiee
发明人： Shieh-Shung T. Chen , Ali Shafiee
IPC分类号： C12P7/22 , C12P17/12 , C07B57/00 , C12N1/14
CPC分类号： C12P17/12 , C12P7/22 , Y10S435/931
摘要： A process for reducing a phenylalkyl ketone to the corresponding (S)-hydroxy derivative is disclosed. The process comprises contacting the phenylalkyl ketone with Mucor hiemalis IFO 5834 and recovering the (S)-hydroxy derivative.
摘要翻译：公开了将苯基烷基酮还原成相应的（S） - 羟基衍生物的方法。该方法包括使苯基烷基酮与毛毛霉（IFuc）5834接触并回收（S） - 羟基衍生物。

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