专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07629029B2 Functional surface coating 有权
标题翻译：功能性表面涂层
公开(公告)号：US07629029B2
公开(公告)日：2009-12-08
申请号：US10964845
申请日：2004-10-13
申请人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead
发明人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead
IPC分类号： B05D3/02
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

2. 发明授权

US08178602B2 Functional surface coating 有权
标题翻译：功能性表面涂层
公开(公告)号：US08178602B2
公开(公告)日：2012-05-15
申请号：US12632609
申请日：2009-12-07
申请人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead
发明人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead
IPC分类号： C08K5/15 , C08K5/1535 , A61K8/73 , C08L83/00
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

3. 发明授权

US07501157B2 Hydroxyl functional surface coating 失效
标题翻译：羟基官能表面涂层
公开(公告)号：US07501157B2
公开(公告)日：2009-03-10
申请号：US11035849
申请日：2005-01-13
申请人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead , David A. Goldberg , Charles H. Greef , David W. Grainger
发明人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead , David A. Goldberg , Charles H. Greef , David W. Grainger
IPC分类号： B05D3/02
CPC分类号： G01N33/54393 , A61L27/34 , A61L29/085 , A61L31/10 , G01N33/5306 , G01N2035/00158
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

4. 发明授权

US06844028B2 Functional surface coating 有权
公开(公告)号：US06844028B2
公开(公告)日：2005-01-18
申请号：US10180199
申请日：2002-06-25
申请人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
发明人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
IPC分类号： B05D7/24 , G01N33/53 , G01N33/543 , G01N33/547 , G01N35/00 , G01N37/00 , B05D1/00
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

5. 发明申请

US20120288717A1 FUNCTIONAL SURFACE COATING 审中-公开
标题翻译：功能表面涂料
公开(公告)号：US20120288717A1
公开(公告)日：2012-11-15
申请号：US13468841
申请日：2012-05-10
申请人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
发明人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
IPC分类号： B32B9/00
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

6. 发明授权

US07067194B2 Functional surface coating 有权
公开(公告)号：US07067194B2
公开(公告)日：2006-06-27
申请号：US10718880
申请日：2003-11-21
申请人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
发明人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
IPC分类号： B32B9/00
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

7. 发明申请

US20100081735A1 FUNCTIONAL SURFACE COATING 有权
标题翻译：功能表面涂料
公开(公告)号：US20100081735A1
公开(公告)日：2010-04-01
申请号：US12632609
申请日：2009-12-07
申请人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
发明人： Guoqiano Mao , Steven W. Metzger , Michael J. Lochhead
IPC分类号： C09D105/00
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

8. 发明授权

US08697435B2 Integrated sample preparation and analyte detection 有权
标题翻译：综合样品制备和分析物检测
公开(公告)号：US08697435B2
公开(公告)日：2014-04-15
申请号：US12871402
申请日：2010-08-30
申请人： James R. Heil , Michael J. Lochhead , Kevin D. Moll , Christopher J. Myatt
发明人： James R. Heil , Michael J. Lochhead , Kevin D. Moll , Christopher J. Myatt
IPC分类号： C12M1/34 , G01N33/543
CPC分类号： G01N33/54326 , G01N33/54373 , G01N33/585 , Y10S435/808 , Y10S436/805 , Y10S436/806
摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.
摘要翻译：用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二型颗粒，其包括对目标分析物特异性的结合部分并且能够产生信号。当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

9. 发明授权

US6039897A Multiple patterned structures on a single substrate fabricated by elastomeric micro-molding techniques 失效
标题翻译：通过弹性体微型成型技术制造的单个基底上的多个图案化结构
公开(公告)号：US6039897A
公开(公告)日：2000-03-21
申请号：US919464
申请日：1997-08-28
申请人： Michael J. Lochhead , Paul Yager
发明人： Michael J. Lochhead , Paul Yager
IPC分类号： B29C33/40 , B29C33/42 , B29C39/24 , B81C1/00 , G03F7/00 , B29D11/00
CPC分类号： B82Y10/00 , B29C33/405 , B29C33/42 , B29C39/24 , B81C1/00373 , B82Y40/00 , G03F7/0002 , B81C2201/0187
摘要： A method for patterning a material onto a substrate including the steps of: providing a micro-mold having a plurality of non-communicating independent channels and having a plurality of reservoirs for receiving a micro-molding fluid each of which reservoirs communicates with a channel, the micro-mold including an elastomeric master having a surface with a plurality of recesses therein and a substrate; introducing a micro-molding fluid into the micro-mold reservoirs filling said communicating channels; and solidifying the fluid in the micro-mold and removing the elastomeric master thereby generating a pattern of material on the substrate. The micro-mold is formed by contacting the surface of the elastomeric master with the substrate such that the recesses in the surface form the plurality of reservoirs and channels.
摘要翻译：一种用于将材料图案化到衬底上的方法，包括以下步骤：提供具有多个不连通的独立通道的微型模具，并具有多个用于容纳每个储存器与沟道连通的微型模塑流体的储存器，所述微型模具包括弹性体主体，所述弹性体主体具有其中具有多个凹部的表面和基板; 将微型流体引入到填充所述连通通道的微型模具储存器中; 并固化微型模具中的流体并且移除弹性体主体，从而在衬底上产生材料图案。微型模具通过使弹性体主体的表面与基底接触而形成，使得表面中的凹部形成多个储存器和通道。

10. 发明申请

US20110012026A1 PLANAR OPTICAL WAVEGUIDE WITH CORE OF LOW-INDEX-OF-REFRACTION INTERROGATION MEDIUM 审中-公开
公开(公告)号：US20110012026A1
公开(公告)日：2011-01-20
申请号：US12883724
申请日：2010-09-16
申请人： Kevin D. Moll , Kurt R. Vogel , Marie J. Delaney , Michael J. Lochhead , Christopher J. Myatt
发明人： Kevin D. Moll , Kurt R. Vogel , Marie J. Delaney , Michael J. Lochhead , Christopher J. Myatt
IPC分类号： G01N21/64 , G02B6/32
CPC分类号： G01N21/552 , G02B6/124 , G02B6/4206
摘要： An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式