专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07501157B2 Hydroxyl functional surface coating 失效
标题翻译：羟基官能表面涂层
公开(公告)号：US07501157B2
公开(公告)日：2009-03-10
申请号：US11035849
申请日：2005-01-13
申请人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead , David A. Goldberg , Charles H. Greef , David W. Grainger
发明人： Guoqiang Mao , Steven W. Metzger , Michael J. Lochhead , David A. Goldberg , Charles H. Greef , David W. Grainger
IPC分类号： B05D3/02
CPC分类号： G01N33/54393 , A61L27/34 , A61L29/085 , A61L31/10 , G01N33/5306 , G01N2035/00158
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

2. 发明授权

US06306348B1 Inorganic permeation layer for micro-electric device 失效
标题翻译：微电子器件无机渗透层
公开(公告)号：US06306348B1
公开(公告)日：2001-10-23
申请号：US09354931
申请日：1999-07-15
申请人： John R. Havens , Michael K. Krihak , Charles H. Greef , Daniel E. Raymond , Michael J. Heller
发明人： John R. Havens , Michael K. Krihak , Charles H. Greef , Daniel E. Raymond , Michael J. Heller
IPC分类号： G01N1500
CPC分类号： B01L3/502761 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00853 , B01L3/502707 , B01L3/50273 , B01L3/508 , B01L3/5085 , B01L2200/0647 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2400/0415 , B01L2400/0421 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C07K1/24 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L24/95 , H01L25/50 , H01L51/0595 , H01L2924/10253 , H01L2924/14 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： The present invention pertains to a method of, and a device created by, depositing an inorganic permeation layer on a micro-electronic device for molecular biological reactions. The permeation layer is preferably sol-gel. The sol-gel permeation layer can be created with pre-defined porosity, pore size distribution, pore morphology, and surface area. The sol-gel permeation layer may also function as the attachment layer of the micro-electric device.
摘要翻译：本发明涉及通过在用于分子生物反应的微电子器件上沉积无机渗透层而产生的方法和装置。渗透层优选为溶胶 - 凝胶。溶胶 - 凝胶渗透层可以产生具有预定孔隙率，孔径分布，孔形态和表面积。溶胶 - 凝胶渗透层也可以用作微电子装置的附着层。

3. 发明授权

US08288155B2 Biomolecular attachment sites on microelectronic arrays and methods thereof 有权
标题翻译：微电子阵列上的生物分子附着位点及其方法
公开(公告)号：US08288155B2
公开(公告)日：2012-10-16
申请号：US11777919
申请日：2007-07-13
申请人： John R. Havens , Thomas J. Onofrey , Charles H. Greef , Gregory J. Kevorkian , Jain Krotz , Kristie L. Lykstad , Daniel E. Raymond , Howard R. Reese , Regina Rooney , John J. Scott
发明人： John R. Havens , Thomas J. Onofrey , Charles H. Greef , Gregory J. Kevorkian , Jain Krotz , Kristie L. Lykstad , Daniel E. Raymond , Howard R. Reese , Regina Rooney , John J. Scott
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/0072 , C07B2200/11 , C07C319/02 , C07H21/00 , C40B40/06 , G01N33/54353 , G01N33/545 , C07C323/60
摘要： Methods of addressing a biomolecule to a selectively addressable electrode are described. A permeation layer overlying a plurality of selectively addressable electrodes is provided. The permeation layer includes a reactive group that is adapted to bond to a biomolecule and that requires activation through a chemical transformation before bonding to the biomolecule. At least one selectively addressable electrode is biased such that a pH change occurs in an overlying solution of the at least one selectively addressable electrode. The reactive group in a portion of the permeation layer above the at least one selectively addressable electrode is then chemically transformed to an activated reactive group as a result of the pH change. A biomolecule is then bound to the permeation layer overlying the at least one selectively addressable electrode through the activated reactive group.
摘要翻译：描述了将生物分子寻址到选择性寻址电极的方法。提供了覆盖多个选择性寻址电极的渗透层。渗透层包括适于结合生物分子的反应性基团，并且在结合到生物分子之前需要通过化学转化的活化。至少一个选择性寻址的电极被偏压，使得在所述至少一个选择性寻址电极的上覆溶液中发生pH变化。作为pH变化的结果，将至少一个可选寻址电极上方的渗透层的一部分中的反应基团化学转化成活化的反应性基团。然后将生物分子与穿过活化的反应性基团的至少一个选择性寻址电极重叠的渗透层结合。

4. 发明申请

US20090069198A1 Biomolecular Attachment Sites on Microelectronic Arrays and Methods Thereof 有权
标题翻译：微电子阵列上的生物分子附着点及其方法
公开(公告)号：US20090069198A1
公开(公告)日：2009-03-12
申请号：US11777919
申请日：2007-07-13
申请人： John R. Havens , Thomas J. Onofrey , Charles H. Greef , Gregory J. Kevorkian , Jain Krotz , Kristie L. Lykstad , Daniel E. Raymond , Howard R. Reese , Regina Rooney , John J. Scott
发明人： John R. Havens , Thomas J. Onofrey , Charles H. Greef , Gregory J. Kevorkian , Jain Krotz , Kristie L. Lykstad , Daniel E. Raymond , Howard R. Reese , Regina Rooney , John J. Scott
IPC分类号： C40B50/18
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/0072 , C07B2200/11 , C07C319/02 , C07H21/00 , C40B40/06 , G01N33/54353 , G01N33/545 , C07C323/60
摘要： Methods of addressing a biomolecule to a selectively addressable electrode are described. A permeation layer overlying a plurality of selectively addressable electrodes is provided. The permeation layer includes a reactive group that is adapted to bond to a biomolecule and that requires activation through a chemical transformation before bonding to the biomolecule. At least one selectively addressable electrode is biased such that a pH change occurs in an overlying solution of the at least one selectively addressable electrode. The reactive group in a portion of the permeation layer above the at least one selectively addressable electrode is then chemically transformed to an activated reactive group as a result of the pH change. A biomolecule is then bound to the permeation layer overlying the at least one selectively addressable electrode through the activated reactive group.
摘要翻译：描述了将生物分子寻址到选择性寻址电极的方法。提供了覆盖多个选择性寻址电极的渗透层。渗透层包括适于结合生物分子的反应性基团，并且在结合到生物分子之前需要通过化学转化的活化。至少一个选择性寻址的电极被偏压，使得在所述至少一个选择性寻址电极的上覆溶液中发生pH变化。作为pH变化的结果，将至少一个选择性寻址电极上方的渗透层的一部分中的反应基团化学转化成活化的反应性基团。然后将生物分子与穿过活化的反应性基团的至少一个选择性寻址电极重叠的渗透层结合。

5. 发明授权

US07129229B2 Hydrazide building blocks and hydrazide modified biomolecules 有权
标题翻译：酰肼结构单元和酰肼改性生物分子
公开(公告)号：US07129229B2
公开(公告)日：2006-10-31
申请号：US10344092
申请日：2001-08-10
申请人： Stefan Raddatz , Jochen Müller-Ibeler , Markus Schweitzer , Christoph Brücher , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles H. Greef , Daguang Wang
发明人： Stefan Raddatz , Jochen Müller-Ibeler , Markus Schweitzer , Christoph Brücher , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles H. Greef , Daguang Wang
IPC分类号： A61K31/66 , C07F9/02
CPC分类号： A61K31/66 , C07F9/2408 , C07F9/2429
摘要： This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment chemistries involving branched or linear structures having one or more hydrazide attachment moieties for binding the macromolecules to a substrate surface, or for other conjugation reactions. Novel modifying reagents are provided for the introduction of protected hydrazide attachment moieties or precursor forms of such hydrazides to the macromolecule, either as a single hydrazide or as multiple hydrazides.
摘要翻译：本发明涉及用于将大分子结合到底物表面或其它共轭靶的附着化学物质。更具体地说，本发明涉及包含具有一个或多个用于将大分子结合到底物表面或其它共轭反应的一个或多个酰肼连接部分的支链或线性结构的附着化学物质。提供了新的改性试剂，用于将受保护的酰肼连接部分或这种酰肼的前体形式引入高分子，作为单酰肼或多个酰肼。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式