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1. 发明授权

US4808622A Circulation active methionine-substituted 1,4-dihydropyridines 失效
标题翻译：循环活性甲硫氨酸取代的1,4-二氢吡啶类
公开(公告)号：US4808622A
公开(公告)日：1989-02-28
申请号：US1496
申请日：1987-01-07
申请人： Gunther Kinast , Eckhard Schwenner , Stanislav Kazda , Andreas Knorr , Michael Kayser
发明人： Gunther Kinast , Eckhard Schwenner , Stanislav Kazda , Andreas Knorr , Michael Kayser
IPC分类号： A61K31/455 , A61P9/10 , A61P9/12 , C07D211/90 , C07D413/04 , C07D211/86
CPC分类号： C07D413/04 , C07D211/90
摘要： Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.
摘要翻译：循环活跃，例如其中R1是苯基或杂环基的式“IMAGE”的抗高血压新型甲硫氨酸取代的二氢吡啶或其生理上可接受的盐。

2. 发明授权

US5063239A Amino-esters of dihydropyridines useful for improving circulation in patients 失效
标题翻译：有助于改善患者循环的二羟基吡啶的氨基酸
公开(公告)号：US5063239A
公开(公告)日：1991-11-05
申请号：US520419
申请日：1990-05-08
申请人： Eckhard Schwenner , Hartmut Stegelmeier , Stanislav Kazda , Andreas Knorr
发明人： Eckhard Schwenner , Hartmut Stegelmeier , Stanislav Kazda , Andreas Knorr
IPC分类号： C07D319/00 , A61K31/455 , A61P9/12 , C07D211/90 , C07D405/12 , C07D405/14 , C07D455/06
CPC分类号： C07D405/12 , C07D211/90 , C07D405/14 , C07D455/06
摘要： Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,R.sup.2 is optionally substituted alkyl or other radicalR.sup.3 and R.sup.5 are hydrogen, methyl or other radicals,R.sup.4 is hydrogen or optionally substituted alkyl,X is from 2 to 15, andR.sup.6 is ##STR2## and physiologically acceptable salts thereof.

3. 发明授权

US4950676A Amino-esters of dihydropyridines, and their use as circulatory agents for treating ischaemic heart diseases 失效
标题翻译：二氢吡啶的氨基酯，以及它们作为治疗缺血性心脏病的循环剂的用途
公开(公告)号：US4950676A
公开(公告)日：1990-08-21
申请号：US317313
申请日：1989-03-01
申请人： Eckhard Schwenner , Hartmut Stagelmeier , Stanislav Kazda , Andreas Knorr
发明人： Eckhard Schwenner , Hartmut Stagelmeier , Stanislav Kazda , Andreas Knorr
IPC分类号： C07D319/00 , A61K31/455 , A61P9/12 , C07D211/90 , C07D405/12 , C07D405/14 , C07D455/06
CPC分类号： C07D405/12 , C07D211/90 , C07D405/14 , C07D455/06
摘要： Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,R.sup.2 is optionally substituted alkyl or other radicalR.sup.3 and R.sup.5 are hydrogen, methyl or other radicals,R.sup.4 is hydrogen or optionally substituted alkyl,X is from 2 to 15, andR.sup.6 is ##STR2## and physiologically acceptable salts thereof.

4. 发明授权

US4861782A Certain 2h-benzo[a]quinolizin-2-yl-aminoalkyl esters of 1,4-dihydro-3,5-pyridinedicarboxylates useful for treating circulation disorders 失效
标题翻译：用于治疗循环障碍的1,4-二氢-3,5-吡啶二羧酸酯的某些2-苯并[a]喹嗪酮-2-基 - 氨基烷基酯
公开(公告)号：US4861782A
公开(公告)日：1989-08-29
申请号：US018652
申请日：1987-02-25
申请人： Eckhard Schwenner , Hartmut Stegelmeier , Stanislav Kazda , Andreas Knorr
发明人： Eckhard Schwenner , Hartmut Stegelmeier , Stanislav Kazda , Andreas Knorr
IPC分类号： C07D319/00 , A61K31/455 , A61P9/12 , C07D211/90 , C07D405/12 , C07D405/14 , C07D455/06
CPC分类号： C07D405/12 , C07D211/90 , C07D405/14 , C07D455/06
摘要： Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,R.sup.2 is optionally substituted alkyl or other radicalR.sup.3 and R.sup.5 are hydrogen, methyl or other radicals,R.sup.4 is hydrogen or optionally substituted alkyl,X is from 2 to 15, andR.sup.6 is ##STR2## and physiologically acceptable salts thereof.
摘要翻译：其中R1是苯基或被硝基，三氟甲基或其它基团取代的杂环基的式“IMAGE”的循环活性化合物，R 2是任选取代的烷基或其它基团R 3和R 5是氢，甲基或其它基团，R 4是氢或任选被取代的烷基，X为2至15，并且R 6为其生理上可接受的盐。

5. 发明授权

US4885303A Circulation-active tetrahydropyridine-3-carbonitrile derivatives 失效
标题翻译：循环活性四氢吡啶-3-腈衍生物
公开(公告)号：US4885303A
公开(公告)日：1989-12-05
申请号：US141363
申请日：1988-01-04
申请人： Horst Meyer , Eckhard Schwenner , Andreas Knorr
发明人： Horst Meyer , Eckhard Schwenner , Andreas Knorr
IPC分类号： C07D211/78 , C07D409/04
CPC分类号： C07D409/04 , C07D211/78
摘要： Circulation active tetrahydropyridines of the formula ##STR1## in which R.sup.1 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 20 carbon atoms and can be interrupted in the chain by an oxygen atom or a sulphur atom and/or can be substituted by halogen, cyano, hydroxyl, acyloxy, nitro or nitrooxy, or by a phenyl, phenoxy, phenylthio or phenylsulphonyl group which is optionally substituted by halogen, cyano, dialkylamino with in each case 1 or 2 carbon atoms per alkyl group, alkoxy with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms, trifluoromethyl or nitro, or by an .alpha.-, .beta.- or .gamma.-pyridyl group, or by an amino group, this amino group carrying 2 identical or different substituents from the group comprising alkyl with up to 4 carbon atoms, alkoxyalkyl with up to 4 carbon atoms, phenyl and aralkyl, and these substitutents optionally forming, with the nitrogen atom, a 5- to 7-membered ring which can contain, as a further hetero atom, an oxygen or sulphur atom or an N-phenyl or N-alkyl grouping, this alkyl group containing 1 to 3 carbon atoms,R.sup.2 represents phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, indolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzoxadiazolyl, benzothiadiazolyl, quinolyl, isoquinolyl, quinazolyl or quinoxalyl;whereinm denotes a number from 0 to 2 and alkyl contains 1 to 4 carbon atoms with optionally 1 to 3 fluorine atoms,R.sup.3 represents a group of the formula --CN or --COOR.sup.5, whereinR.sup.5 has the same meaning as R.sup.1 and can be identical to or different from this radical, andR.sup.4 represents hydrogen, or represents phenyl or naphthyl, and their pharmaceutically acceptable acid addition salts.
摘要翻译：式“IMAGE”的循环活性四氢吡啶，其中R1表示直链，支链或环状，饱和或不饱和的烃基，其具有至多20个碳原子并且可以被氧原子或硫原子中断，或可以被卤素，氰基，羟基，酰氧基，硝基或硝基氧基取代，或被任选被卤素，氰基，二烷基氨基取代的苯基，苯氧基，苯硫基或苯基磺酰基，在每种情况下，每个烷基具有1或2个碳原子具有1至4个碳原子的烷氧基，具有1至4个碳原子的烷基，三氟甲基或硝基，或由α，β或γ-吡啶基或氨基组成，该氨基带有2个相同或不同的含有至多4个碳原子的烷基，至多4个碳原子的烷氧基烷基，苯基和芳烷基的取代基，这些取代基任选地与氮原子一起形成5-至7-元环，其可以含有作为 furt 其杂原子，氧或硫原子或N-苯基或N-烷基，该含有1至3个碳原子的烷基，R 2表示苯基，萘基，噻吩基，呋喃基，吡咯基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，吡啶基，哒嗪基，嘧啶基，吡嗪基，吲哚基，苯并咪唑基，苯并恶唑基，苯并异恶唑基，苯并恶二唑基，苯并噻二唑基，喹啉基，异喹啉基，喹唑啉基或喹喔啉基。其中m表示0至2的数，烷基含有1至4个碳原子，可选地具有1至3个氟原子，R 3表示式-CN或-COOR 5的基团，其中R 5具有与R 1相同的含义并且可以相同 R 4表示氢，或表示苯基或萘基，以及它们的药学上可接受的酸加成盐。

6. 发明授权

US4898877A Circulation-active cyclohexenecarboxylates 失效
标题翻译：循环活性环己烯羧酸酯
公开(公告)号：US4898877A
公开(公告)日：1990-02-06
申请号：US157678
申请日：1988-02-18
申请人： Horst Meyer , Eckhard Schwenner , Martin Bechem , Rainer Gross , Matthias Schramm , Michael Kayser , Siegbert Hebisch
发明人： Horst Meyer , Eckhard Schwenner , Martin Bechem , Rainer Gross , Matthias Schramm , Michael Kayser , Siegbert Hebisch
IPC分类号： C07D213/30 , A61K31/215 , A61K31/23 , A61K31/235 , A61K31/275 , A61K31/33 , A61K31/395 , A61K31/40 , A61K31/44 , A61P3/08 , A61P9/00 , A61P9/06 , C07C67/00 , C07C69/757 , C07C201/00 , C07C205/55 , C07C205/56 , C07C227/00 , C07C227/16 , C07C229/48 , C07C235/40 , C07C253/00 , C07C255/45 , C07C255/46 , C07C311/12 , C07C311/15 , C07C311/19 , C07C311/20 , C07C313/00 , C07C315/04 , C07C317/14 , C07C317/18 , C07C317/22 , C07C317/46 , C07C323/12 , C07C323/62 , C07C323/65 , C07C323/67 , C07D295/22
CPC分类号： C07C255/00 , C07C205/56 , C07C309/00 , C07C317/00
摘要： Novel circulation-active cyclohexenecarboxylates of the formula ##STR1## in which R.sup.1 is an organic radical,R.sup.2 is an optionally substituted aryl radical,R.sup.3 is an optionally substituted alkyl or aryl radical,X and Y are --CN, --COR.sup.4, --SO.sub.2 R.sup.4, --COOR.sup.5, --CONR.sup.6 R.sup.7 or --SO.sub.2 NR.sup.6 R.sup.7, andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 are various organic radicals.
摘要翻译：式（I）的新型循环活性环己烯羧酸酯，其中R 1是有机基团，R 2是任选取代的芳基，R 3是任选取代的烷基或芳基，X和Y是-CN，-COR 4， -SO 2 R 4，-COOR 5，-CONR 6 R 7或-SO 2 NR 6 R 7，R4，R5，R6和R7是各种有机基团。

7. 发明授权

US5849893A Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics 失效
标题翻译：具有C支化的核酸结合寡聚体用于治疗和诊断
公开(公告)号：US5849893A
公开(公告)日：1998-12-15
申请号：US719048
申请日：1996-09-24
申请人： Antonius Lobberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten Potter
发明人： Antonius Lobberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten Potter
IPC分类号： C12N15/09 , A61K31/40 , A61K31/495 , A61K31/505 , A61K38/00 , A61K38/10 , A61P31/12 , C07C271/22 , C07C309/66 , C07D207/16 , C07D239/46 , C07D239/47 , C07D239/54 , C07D403/04 , C07D403/12 , C07D473/18 , C07D473/30 , C07D473/34 , C07K5/00 , C07K5/062 , C07K5/078 , C07K5/097 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/00 , C07H21/04
CPC分类号： C07D239/47 , C07C309/66 , C07D239/54 , C07D403/04 , C07K14/003 , C07K7/06 , C07K7/08 , A61K38/00
摘要： The invention relates to nucleic acid-binding oligomers possessing C-branching of the general formula (I) ##STR1## and to the corresponding monomers, whose radicals have the meaning given in the description, and to their use as medicaments or diagnostic aids.
摘要翻译：本发明涉及具有通式（I）C支化的核酸结合低聚物（I）和相应的单体，其基团具有说明书中给出的含义，以及它们作为药物或诊断用途艾滋病。

8. 发明授权

US5623049A Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics 失效
标题翻译：具有N-支化用于治疗和诊断的核酸结合寡聚体
公开(公告)号：US5623049A
公开(公告)日：1997-04-22
申请号：US300884
申请日：1994-09-06
申请人： Antonius L obberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten P otter
发明人： Antonius L obberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten P otter
IPC分类号： C07D239/47 , A61K31/195 , A61K31/40 , A61K31/401 , A61K38/00 , A61K38/10 , A61P31/12 , C07D239/54 , C07D403/06 , C07D403/12 , C07D473/18 , C07D473/30 , C07D473/34 , C07K5/00 , C07K5/06 , C07K5/062 , C07K7/06 , C07K14/00 , C07K19/00 , C07K7/00 , C07D239/00 , C07H5/04 , C07H21/04
CPC分类号： C07D239/54 , C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/003 , C07K5/06026 , A61K38/00
摘要： The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diagnostics.
摘要翻译：本发明涉及具有通式（I）的N-支化的核酸结合寡聚体及其单体，其中各个基团具有说明书中给出的含义，以及它们作为药物或作为诊断的辅助工具。

9. 发明授权

US5461054A Anthracene-spiro-pyrrolindines 失效
标题翻译：蒽 - 螺吡咯啉
公开(公告)号：US5461054A
公开(公告)日：1995-10-24
申请号：US164511
申请日：1993-12-09
申请人： Eckhard Schwenner , Gaetan Ladouceur , Thomas M. Aune
发明人： Eckhard Schwenner , Gaetan Ladouceur , Thomas M. Aune
IPC分类号： A61K31/495 , A61P37/00 , A61P43/00 , C07D209/96 , C07D403/06
CPC分类号： C07D209/96
摘要： The anthracene-spiro-pyrrolidines according to the invention are prepared by reacting either anthracene-spiro-furans or unsubstituted anthracene-spiropyrrolidines with appropriately substituted amines or by reacting unsubstituted anthracene derivatives with appropriately substituted methylenepyrrolidines. The substances can be used as active agents in medicaments, in particular for the production of immunomodulating medicaments.
摘要翻译：根据本发明的蒽 - 螺 - 吡咯烷通过使蒽 - 螺 - 呋喃或未取代的蒽 - 螺吡咯烷与适当取代的胺反应或通过使未取代的蒽衍生物与适当取代的亚甲基吡咯烷酮反应来制备。这些物质可以用作药物中的活性剂，特别是用于生产免疫调节药物。

10. 发明授权

US5051433A Pharmaceutically active basic nitro-phenyl-dihydropyridine amides 失效
标题翻译：药用活性碱性硝基苯基 - 二氢吡啶酰胺
公开(公告)号：US5051433A
公开(公告)日：1991-09-24
申请号：US413510
申请日：1989-09-27
申请人： Jurgen Stoltefuss , Eckhard Schwenner , Rainer Gross , Siegbert Hebisch , Matthias Schramm , Martin Bechem , Claudia Hirth , Johannes-Peter Stasch
发明人： Jurgen Stoltefuss , Eckhard Schwenner , Rainer Gross , Siegbert Hebisch , Matthias Schramm , Martin Bechem , Claudia Hirth , Johannes-Peter Stasch
IPC分类号： A61K31/445 , A61K31/451 , A61P9/06 , A61P9/12 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D211/90
摘要： Hypertension and cardiac insufficiency can be controlled by 4-nitrophenyl-dihydropyridine amides of the formula ##STR1## in which X can be ethylene or the like,Y is pyridyl or --NR.sup.9 R.sup.10, andR.sup.9 and R.sup.10 each independently is hydrogenor an organic group, or together form a ring, and physiologically tolerated salts thereof. Compounds in which R.sup.5 and R.sup.6 are not aryl or aralkyl are new.
摘要翻译：高血压和心功能不全可以通过其中X可以是乙烯或类似物的式“IMAGE”的4-硝基苯基 - 二氢吡啶酰胺控制，Y是吡啶基或-NR9R10，R9和R10各自独立地是氢或有机基团，或一起形成环，以及其生理上耐受的盐。 R5和R6不是芳基或芳烷基的化合物是新的。

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