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1. 发明授权

US4677060A Process for determining the pH value in the interior of a cell 失效
标题翻译：确定细胞内部pH值的方法
公开(公告)号：US4677060A
公开(公告)日：1987-06-30
申请号：US680078
申请日：1984-12-10
申请人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
发明人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
IPC分类号： G01N21/75 , C07C255/51 , C07C255/53 , C07C271/06 , C12Q1/00 , C12Q1/02 , C12Q1/37 , C12Q1/44 , G01N21/64 , G01N21/80 , G01N33/84 , C12Q1/38
CPC分类号： C07C255/00 , G01N33/84
摘要： A process for determining the pH value in the interior of a cell is descrd. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.
摘要翻译：描述了确定细胞内部的pH值的方法。这是通过测量通过在溶液中孵育而被细胞吸收的荧光物质的发射来实现的。该溶液含有所述荧光物质的化合物; 通过存在于细胞中的酶将荧光物质从细胞中的该化合物中分离出来。选择的荧光物质是这样的，使得发射最大值的频率取决于pH值。所选择的荧光物质的化合物是膜渗透的化合物。荧光的测量是基于测量发射最大值的频率的原理。适用于此目的的荧光物质是2,3-二氰基-1,4-对苯二酚。合适的膜渗透化合物是1,4-二乙酰氧基-2,3-二氰基苯或1,4-二丁酰氧基-2,3-二氰基苯或1,4-二（叔丁氧基羰基-1-烷氧基）二氰基苯。

2. 发明授权

US4515730A Compounds for determining the pH value in the interior of a cell 失效
标题翻译：用于测定细胞内部pH值的化合物
公开(公告)号：US4515730A
公开(公告)日：1985-05-07
申请号：US394784
申请日：1982-07-02
申请人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
发明人： Gunter Valet , Gerhard Ruhenstroth-Bauer , Erich Wunsch , Luis Moroder
IPC分类号： G01N21/75 , C07C255/51 , C07C255/53 , C07C271/06 , C12Q1/00 , C12Q1/02 , C12Q1/37 , C12Q1/44 , G01N21/64 , G01N21/80 , G01N33/84 , C07C121/75
CPC分类号： C07C255/00 , G01N33/84
摘要： A process for determining the pH value in the interior of a cell is described. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.
摘要翻译：描述了确定细胞内部的pH值的方法。这是通过测量通过在溶液中孵育而被细胞吸收的荧光物质的发射来实现的。该溶液含有所述荧光物质的化合物; 通过存在于细胞中的酶将荧光物质从细胞中的该化合物中分离出来。选择的荧光物质是这样的，使得发射最大值的频率取决于pH值。所选择的荧光物质的化合物是膜渗透的化合物。荧光的测量是基于测量发射最大值的频率的原理。适用于此目的的荧光物质是2,3-二氰基-1,4-对苯二酚。合适的膜渗透化合物是1,4-二乙酰氧基-2,3-二氰基苯或1,4-二丁酰氧基-2,3-二氰基苯或1,4-二（叔丁氧基羰基-1-烷氧基）二氰基苯。

3. 发明授权

US4503148A Process for determining the pH value in the interior of a cell 失效
公开(公告)号：US4503148A
公开(公告)日：1985-03-05
申请号：US346094
申请日：1982-02-05
申请人： G/u/ nter Valet , Gerhard Ruhenstroth-Bauer , Erich W/u/ nsch , Luis Moroder
发明人： G/u/ nter Valet , Gerhard Ruhenstroth-Bauer , Erich W/u/ nsch , Luis Moroder
IPC分类号： G01N21/75 , C07C255/51 , C07C255/53 , C07C271/06 , C12Q1/00 , C12Q1/02 , C12Q1/37 , C12Q1/44 , G01N21/64 , G01N21/80 , G01N33/84 , C12Q1/38
CPC分类号： C07C255/00 , G01N33/84
摘要： A process for determining the pH value in the interior of a cell is described. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.

4. 发明授权

US5041533A Hinge peptide, a process for its manufacture, and its use for the manufacture of synthetic immunogens 失效
标题翻译：铰链肽，其制造方法及其在制造合成免疫原中的应用
公开(公告)号：US5041533A
公开(公告)日：1991-08-20
申请号：US175383
申请日：1988-03-30
申请人： Erich Wunsch , Luis Moroder
发明人： Erich Wunsch , Luis Moroder
IPC分类号： A61K38/00 , A61K39/00 , C07K1/02 , C07K1/113 , C07K7/06 , C07K14/595 , C07K16/06
CPC分类号： C07K16/065 , A61K39/00 , Y10S530/866
摘要： The invention relates to a hinge peptide of the general formula I that maye utilized for the manufacture of synthetic immunogens. The invention also comprises a process for the manufacture of this hinge peptide and a process for the manufacture of synthetic immunogens, where the hinge peptide is employed as a carrier protein.
摘要翻译：本发明涉及可用于制造合成免疫原的通式I的铰链肽。本发明还包括制备该铰链肽的方法和用于制造合成免疫原的方法，其中铰链肽用作载体蛋白。

5. 发明授权

US07208521B2 Selective inhibitors of the urokinase plasminogen activator 失效
标题翻译：尿激酶纤溶酶原激活物的选择性抑制剂
公开(公告)号：US07208521B2
公开(公告)日：2007-04-24
申请号：US11058699
申请日：2005-02-16
申请人： Viktor Magdolen , Luis Moroder , Stefan Sperl , Jörg Stürzebecher , Olaf Wilhelm
发明人： Viktor Magdolen , Luis Moroder , Stefan Sperl , Jörg Stürzebecher , Olaf Wilhelm
IPC分类号： A61K31/24 , B65D69/00
CPC分类号： C07D277/54 , A61K31/155 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/426 , A61K31/655 , C07C279/18 , C07C311/19
摘要： The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC3,4.21.31) of the aryl guanidine type.
摘要翻译：本发明涉及芳基胍类型的尿激酶纤溶酶原激活物（uPA，EC3,4.21.31）的新型选择性抑制剂。

6. 发明授权

US07049344B2 Highly selective inhibitors of the urokinase plasminogen activator 失效
标题翻译：尿激酶纤溶酶原激活物的高选择性抑制剂
公开(公告)号：US07049344B2
公开(公告)日：2006-05-23
申请号：US10992844
申请日：2004-11-22
申请人： Viktor Magdolen , Stefan Sperl , Joerg Stuerzebecher , Olaf Wilhelm , Nuria Arroyo De Prada , Luis Moroder , Robert Huber , Uwe Jacob , Wolfram Bode
发明人： Viktor Magdolen , Stefan Sperl , Joerg Stuerzebecher , Olaf Wilhelm , Nuria Arroyo De Prada , Luis Moroder , Robert Huber , Uwe Jacob , Wolfram Bode
IPC分类号： A61K31/165
CPC分类号： C07C279/18 , A61K31/155 , C07C2603/74
摘要： A method is described for inhibiting urokinase plasminogen activator in a human or animal patient. The method involves administering to the patient a urokinase plasminogen activator inhibiting effective amount of a compound of the formula (I):
摘要翻译：描述了一种抑制人或动物患者尿激酶纤溶酶原激活物的方法。该方法包括向患者施用抑制有效量的式（I）化合物的尿激酶纤溶酶原激活剂：

7. 发明授权

US06489327B1 Tryptase inhibitors 失效
标题翻译：胰蛋白酶抑制剂
公开(公告)号：US06489327B1
公开(公告)日：2002-12-03
申请号：US09601317
申请日：2000-10-20
申请人： Thomas Bär , Thomas Martin , Josef Stadlwieser , Wolf-Rüdiger Ulrich , Andreas Dominik , Ulrich Thibaut , Daniela Bundschuh , Rolf Beume , Karl-Josef Goebel , Wolfram Bode , Luis Moroder , Pedro Jose Barbosa Pereira , Andreas Bergner , Robert Huber , Christian Sommerhoff , Norbert Schaschke
发明人： Thomas Bär , Thomas Martin , Josef Stadlwieser , Wolf-Rüdiger Ulrich , Andreas Dominik , Ulrich Thibaut , Daniela Bundschuh , Rolf Beume , Karl-Josef Goebel , Wolfram Bode , Luis Moroder , Pedro Jose Barbosa Pereira , Andreas Bergner , Robert Huber , Christian Sommerhoff , Norbert Schaschke
IPC分类号： A61K31495
CPC分类号： C07D213/81 , C07C279/16 , C07D211/58 , C07D213/82 , C07D295/185 , C07D295/215 , C07D401/14
摘要： The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.
摘要翻译：本发明涉及用于药物工业用于生产药物的人类类胰蛋白酶的新型抑制剂。

8. 发明申请

US20080014141A1 Substance Binding Human Igg Fc Receptor Iib (Fcyriib) 有权
标题翻译：物质结合人Igg Fc受体Iib（Fcyriib）
公开(公告)号：US20080014141A1
公开(公告)日：2008-01-17
申请号：US10580813
申请日：2004-11-26
申请人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
发明人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
IPC分类号： A61K39/395 , A61K38/00 , A61K49/00 , A61P37/00 , C07K14/00 , C12N15/63 , C12N5/10 , C07K16/00 , C07H21/04 , A61P19/02 , A61K39/00
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcγRIIb or FcγIIa.
摘要翻译：本发明涉及携带构象鉴别表位（CDEs）的新型免疫原和用于产生特异性识别与非常密切相关的同系物的蛋白质的抗体的免疫方法。特别地，本发明涉及对FcgammaRIIb或FcgammaIIa特异的抗体。

9. 发明申请

US20050215642A1 Selective inhibitors of the urokinase plasminogen activator 失效
标题翻译：尿激酶纤溶酶原激活物的选择性抑制剂
公开(公告)号：US20050215642A1
公开(公告)日：2005-09-29
申请号：US11058699
申请日：2005-02-16
申请人： Viktor Magdolen , Luis Moroder , Stefan Sperl , Jorg Sturzebecher , Olaf Wilhelm
发明人： Viktor Magdolen , Luis Moroder , Stefan Sperl , Jorg Sturzebecher , Olaf Wilhelm
IPC分类号： A61K31/155 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/426 , A61K31/655 , A61P35/00 , C07C279/18 , C07C311/19 , C07D277/54 , A61K31/195
CPC分类号： C07D277/54 , A61K31/155 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/426 , A61K31/655 , C07C279/18 , C07C311/19
摘要： The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC3,4.21.31) of the aryl guanidine type.
摘要翻译：本发明涉及芳基胍类型的尿激酶纤溶酶原激活物（uPA，EC3,4.21.31）的新型选择性抑制剂。

10. 发明申请

US20120269837A1 SUBSTANCE BINDING HUMAN IgG Fc RECEPTOR IIb (FcgammaRIIb) 审中-公开
标题翻译：物质结合人IgG Fc受体IIb（FcgammaRIIb）
公开(公告)号：US20120269837A1
公开(公告)日：2012-10-25
申请号：US13492237
申请日：2012-06-08
申请人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
发明人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
IPC分类号： C07K7/64 , C07K5/12 , C07K16/28 , A61P37/04 , C12N15/11 , C12N15/13 , C12N15/63 , C12N1/00 , C07K2/00 , A61K39/00
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： This invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcγRIIb and FcγRIIa.
摘要翻译：本发明涉及携带构象鉴别表位（CDEs）的新型免疫原和用于产生特异性识别具有非常密切相关同系物的蛋白质的抗体的免疫方法。特别地，本发明涉及对FcγRIIb和FcγRIIa特异性的抗体。

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