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1. 发明授权

US6056861A Process and device for generating resonance phenomena in particle suspensions 失效
标题翻译：用于在颗粒悬浮液中产生共振现象的方法和装置
公开(公告)号：US6056861A
公开(公告)日：2000-05-02
申请号：US77334
申请日：1998-07-27
申请人： Gunter Fuhr , Jan Gimsa , Torsten Muller , Thomas Schnelle
发明人： Gunter Fuhr , Jan Gimsa , Torsten Muller , Thomas Schnelle
IPC分类号： G01N33/483 , B03C5/00 , B03C5/02 , C12M1/00 , C12M1/42 , C12N13/00 , G01N15/00 , H02N13/00 , G01N27/26
CPC分类号： C12N13/00 , B03C5/028 , C12M33/00 , H02N13/00
摘要： A method and a device for position and/or type-selective control of the position and/or change of position of suspended particles in a multielectrode system by the effect of polarization forces that are induced in the particles by alternating electric fields in the multielectrode system, which particles comprise biological or synthetic objects with dimensions essentially corresponding to those of biological cells or cell organelles, viruses or macromolecules, base on the fact that the multielectrode system forms with the particle suspension an electrical network, in which means of resonance are provided for creating a resonant increase or damping of the field strength of the alternating electric fields at certain frequencies in at least one locally demarcated region of the multielectrode system.
摘要翻译： PCT No.PCT / EP96 / 05244 Sec。 371日期：1998年7月27日 102（e）1998年7月27日PCT PCT 1996年11月27日PCT公布。出版物WO97 / 20210 日期：1997年6月5日在多电极系统中通过交替电致使粒子诱导的极化力的作用，位置和/或型式选择性地控制悬浮颗粒的位置和/或位置变化的方法和装置所述多电极系统中的所述颗粒包含基本上对应于生物细胞或细胞器，病毒或大分子的尺寸的生物或合成物体，其基于所述多电极系统与所述粒子悬浮液形成电网，提供谐振以在多电极系统的至少一个局部分界区域中产生在某些频率处的交变电场的场强的共振增加或阻尼。

2. 发明授权

US07439075B2 Method and device for withdrawing suspended microparticles from a fluidic microsystem 失效
标题翻译：从流体微系统中取出悬浮微粒的方法和装置
公开(公告)号：US07439075B2
公开(公告)日：2008-10-21
申请号：US10203168
申请日：2001-02-08
申请人： Gunter Fuhr , Stephen Graham Shirley , Torsten Muller , Thomas Schnelle , Rolf Hagedorn
发明人： Gunter Fuhr , Stephen Graham Shirley , Torsten Muller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： G01N1/10 , G01N15/06 , G01N21/00 , G01N31/00 , G01N33/00 , G01N27/26 , B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , G01L9/18 , G01L1/20 , G01F1/64 , C02F1/469 , C02F1/40 , C02F11/00 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/00891 , B01L3/0241 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , G01N15/1404 , G01N27/44791 , G01N2015/1409 , Y10T436/2575
摘要： A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the microsystem, and the discharge flow is delivered through a conduction element (19). A microsystem with a flow output device for implementation of this method is also described.
摘要翻译：描述了从流体微系统（10）排出具有悬浮微粒的流体流的方法，由此流体流与至少一个输出流收敛以在微系统的排放通道（14）的端部处形成排出流，并且通过导电元件（19）输送排出流。还描述了具有用于实现该方法的流输出装置的微系统。

3. 发明授权

US07276207B2 Microsystem for the dielectric and optical manipulation of particles 失效
标题翻译：微系统用于电介质和光学操纵的粒子
公开(公告)号：US07276207B2
公开(公告)日：2007-10-02
申请号：US10432793
申请日：2001-11-28
申请人： Torsten Muller , Thomas Schnelle , Gunter Fuhr
发明人： Torsten Muller , Thomas Schnelle , Gunter Fuhr
IPC分类号： B01L3/00 , G01N27/447 , G01N27/453
CPC分类号： G01N15/1056 , B03C5/026 , B03C5/028 , H05H3/04
摘要： Described is a fluidic microsystem with at least one compartment for the receiving and/or the through-flow of a liquid and having an electrode arrangement with a multiplicity of electrodes, between which a coaction zone is established, whereby the compartment possesses at least one wall, through which electromagnetic radiation can be linked into the said coaction zone in accord with a predetermined incident direction, and on at least one electrode a cooling apparatus is provided, and on which at least one respective electrode at least one reflector layer is provided, and wherein the respective electrode is at least partially shielded in reference to the incident beam direction, and having at least one heat conducting layer by means of which the respective electrode stands in thermal communication with a wall of the compartment, and/or includes an active cooling element, which is placed in thermal contact with the respective electrode.
摘要翻译：描述了一种流体微系统，其具有至少一个用于液体的接收和/或通过流动的隔室，并且具有多个电极的电极装置，在其间建立了一个共同作用区域，从而隔室具有至少一个壁，电磁辐射可以根据预定的入射方向连接到所述配位区中，并且在至少一个电极上设置有冷却装置，并且在其上设置至少一个相应的电极至少一个反射器层，以及其中相应的电极相对于入射光束方向被至少部分地屏蔽，并且具有至少一个导热层，通过该导热层，相应的电极与隔室的壁热连通，和/或包括主动冷却元件，其被放置成与相应的电极热接触。

4. 发明申请

US20070221501A1 Method and Device for Collecting Suspended Particles 失效
标题翻译：收集悬浮颗粒的方法和装置
公开(公告)号：US20070221501A1
公开(公告)日：2007-09-27
申请号：US11568895
申请日：2005-05-06
申请人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
发明人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
IPC分类号： B01D57/02
CPC分类号： B03C5/026
摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.
摘要翻译：给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中，，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流（30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环）。还描述了用于收集颗粒的相应装置。

5. 发明授权

US07399395B2 Method and device for generating microconvections 失效
标题翻译：用于产生微对流的方法和装置
公开(公告)号：US07399395B2
公开(公告)日：2008-07-15
申请号：US10416054
申请日：2001-11-09
申请人： Thomas Schnelle , Torsten Muller
发明人： Thomas Schnelle , Torsten Muller
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01F3/08 , B01F5/0403 , B01F13/0001 , B01F13/0006 , B01F13/001 , B01F13/0077 , B01F2003/125 , B01L3/50273 , B01L2300/0867 , B01L2400/0415 , B01L2400/0442 , B03C5/028
摘要： The invention relates to a method for generating a convective liquid motion in a fluidic microsystem. According to this method, a liquid in a microsystem is simultaneously exposed to an electrical field and a thermal gradient. The electrical field is generated by means of an electrode arrangement which is subjected to a time-variant voltage. In this way, a time variant electrical field is formed in the liquid volume. The thermal gradient is produced by means of at least one radiation absorber located in the compartment which is exposed to at least one external radiation field.
摘要翻译：本发明涉及在流体微系统中产生对流液体运动的方法。根据该方法，微系统中的液体同时暴露于电场和热梯度。电场通过经历时变电压的电极装置产生。以这种方式，在液体体积中形成时变电场。热梯度是通过位于室内的至少一个辐射吸收器产生的，其暴露于至少一个外部辐射场。

6. 发明申请

US20070119714A1 Methods and devices for analysing a deformable object 审中-公开
标题翻译：用于分析可变形物体的方法和装置
公开(公告)号：US20070119714A1
公开(公告)日：2007-05-31
申请号：US10595771
申请日：2004-11-10
申请人： Thomas Schnelle , Torsten Muller , Andre Homke
发明人： Thomas Schnelle , Torsten Muller , Andre Homke
IPC分类号： B03C5/02
CPC分类号： G01N15/1056 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2400/0415 , B01L2400/0424 , G01N15/1456 , G01N15/1459 , G01N2015/105 , G01N2015/1495 , G01N2015/1497
摘要： Methods are described for analyzing at least one deformable object (O) in a suspension fluid, including the following steps: generation of an electric positioning field and positioning of the object (O) in a potential minimum of the positioning field, generation of an electric deformation field in such a way that a deformation force is exerted on the object (O), and detection of at least one property selected from the group including the dielectric, geometric and optical properties of the object (O), wherein the positioning field is generated in a compartment (12) of a fluidic microsystem (10) and the positioning of the object (O) takes place in a contactless manner in a freely suspended state. Measuring apparatuses for carrying out this method are also described.
摘要翻译：描述了用于分析悬浮液中的至少一个可变形物体（O）的方法，包括以下步骤：产生电定位区域和将物体（O）定位在定位区域的潜在最小值中，产生电变形场，使得变形力施加在物体（O）上，以及检测从包括物体（O）的电介质，几何和光学性质的组中选择的至少一种性质，其中定位场是产生在流体微系统（10）的隔室（12）中，并且物体（O）的定位以无接触的方式在自由悬挂状态下进行。还描述了用于执行该方法的测量装置。

7. 发明申请

US20060152708A1 Multiparametric detection in a fluidic microsystem 审中-公开
标题翻译：流体微系统中的多参数检测
公开(公告)号：US20060152708A1
公开(公告)日：2006-07-13
申请号：US10544423
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.
摘要翻译：公开了一种用于测量移动通过流体微系统的颗粒的性质的方法，所述颗粒悬浮在液体中。根据本发明的方法，首先在第一测试台（11）测量特定颗粒的第一参数。然后在与第一测试站（11）在空间上分离的第二测试站（12）以与第一测量的间隔的间隔测量颗粒的第二参数，并且以相关方式联合评估第一和第二参数，第一和第二参数是测试颗粒的不同性质的特征。评估包括第一和第二参数与预定预期值的比较。根据比较的结果，对测试的颗粒进行另一测量或操作。还公开了被设计用于实施本发明方法的流体微系统。

8. 发明申请

US20060126921A1 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy 有权
标题翻译：用于提供高分辨率显微镜的悬浮微物体三维成像的方法和装置
公开(公告)号：US20060126921A1
公开(公告)日：2006-06-15
申请号：US10532147
申请日：2003-10-24
申请人： Spencer Shorte , Torsten Muller , Thomas Schnelle
发明人： Spencer Shorte , Torsten Muller , Thomas Schnelle
IPC分类号： G06K9/00
CPC分类号： G02B21/22 , G01N2015/144 , G01N2015/1445 , G01N2015/1452 , G02B21/367
摘要： A method for high-resolution image recording of at least one object with a microscope, includes the steps of: (a) positioning the object in a receptacle being arranged in the optical axis of the microscope, (b) generating at least two first data sets per object which represent intermediate images of the object with at least two different orientations relative to the optical axis of the microscope, wherein the different orientations of the object are provided by moving the object relative to the receptacle, and (c) evaluating the data sets for obtaining quantitative three dimensional information.
摘要翻译：一种用显微镜对至少一个物体进行高分辨率图像记录的方法，包括以下步骤：（a）将物体放置在布置在显微镜的光轴上的容器中，（b）产生至少两个第一数据通过相对于显微镜的光轴具有至少两个不同取向来表示对象的每个对象的集合，其中通过相对于插座移动对象来提供对象的不同取向，以及（c）评估数据用于获得定量三维信息。

9. 发明申请

US20060024802A1 Fluidic microsystem comprising field-forming passivation layers provided on microelectrodes 有权
标题翻译：流体微系统包括在微电极上提供的场形成钝化层
公开(公告)号：US20060024802A1
公开(公告)日：2006-02-02
申请号：US10536674
申请日：2003-11-26
申请人： Torsten Muller , Thomas Schnelle
发明人： Torsten Muller , Thomas Schnelle
IPC分类号： C12N13/00 , C12M1/34
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0645 , B01L2300/16 , B01L2400/0415 , B03C5/026
摘要： Described is a fluidic microsystem (100) comprising at least one channel (10) through which a particle suspension can flow; and first and second electrode devices (40, 60) which are arranged on first and second channel walls (21, 31) for generating electrical alternating-voltage fields in the channel (10); wherein the first electrode device (40) for field shaping in the channel comprises at least one first structure element (41, 51); and the second electrode device (60) comprises an area-like electrode layer (61) with a closed second electrode surface which comprises a second passivation layer (70); wherein the effective electrode surface of the first structure element (41, 51), of which element (41, 51) there is at least one, is smaller than the second electrode surface; and the second passivation layer (70) is a closed layer which completely covers the second electrode layer (61).
摘要翻译：描述了流体微系统（100），其包括至少一个通道（10），颗粒悬浮液可以通过该通道流动; 以及布置在第一和第二通道壁（21,31）上的用于在通道（10）中产生电气交变电压场的第一和第二电极装置（40,60）。其中用于所述通道中的场成形的所述第一电极装置（40）包括至少一个第一结构元件（41,51）; 并且第二电极装置（60）包括具有闭合的第二电极表面的区域状电极层（61），其包括第二钝化层（70）; 其中，所述元件（41,51）中至少有一个的所述第一结构元件（41,51）的有效电极表面小于所述第二电极表面; 并且所述第二钝化层（70）是完全覆盖所述第二电极层（61）的封闭层。

10. 发明申请

US20080296157A1 Method and Device for Handling Sedimenting Particles 审中-公开
标题翻译：处理沉淀颗粒的方法和装置
公开(公告)号：US20080296157A1
公开(公告)日：2008-12-04
申请号：US12088009
申请日：2006-09-27
申请人： Gunter Bauer , Torsten Muller , Thomas Schnelle
发明人： Gunter Bauer , Torsten Muller , Thomas Schnelle
IPC分类号： B01D35/06 , B03C5/02 , B03C1/30 , B03C1/02
CPC分类号： B03C1/288 , B01L3/021 , B01L3/0275 , B01L2200/0631 , B01L2200/0668 , B01L2300/0645 , B01L2400/0415 , B01L2400/043 , B03C5/026 , B03C2201/26 , G01N35/0098
摘要： The invention relates to a method for handling particles (1, 2) that are suspended in a carrier liquid (3). The method includes the following steps: the carrier liquid (3) is received with the particles (1, 2) in a liquid siphoning device (10) including at least one siphoning opening (11), electrical and/or magnetic separating fields are generated in the liquid siphoning device (10), a sedimentation movement of the particles (1, 2) is created in the liquid, each particle having a sedimentation speed that depends on the action of the separating fields on the particle (1, 2) and the particles (1, 2) forming a plurality of particle fractions (5, 6) according to the sedimentation speeds thereof, and the particle fractions (5, 6) are separately extracted from the liquid siphoning device (10). The invention also relates to a handling device (100) for handling suspended particles (1, 2).
摘要翻译：本发明涉及一种处理悬浮在载体液体（3）中的颗粒（1,2）的方法。该方法包括以下步骤：载体液体（3）在包括至少一个虹吸孔（11）的液体虹吸装置（10）中与颗粒（1,2）一起接收，产生电和/或磁分离场在液体虹吸装置（10）中，在液体中产生颗粒（1,2）的沉降运动，每个颗粒的沉降速度取决于颗粒（1,2）上的分离场的作用和从液体虹吸装置（10）分别提取根据其沉降速度形成多个颗粒部分（5,6）和颗粒部分（5,6）的颗粒（1,2）。本发明还涉及一种用于处理悬浮颗粒（1,2）的处理装置（100）。

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