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1. 发明授权

US06501990B1 Extendable and retractable lead having a snap-fit terminal connector 有权
标题翻译：具有卡扣式端子连接器的可伸缩的引线
公开(公告)号：US06501990B1
公开(公告)日：2002-12-31
申请号：US09472098
申请日：1999-12-23
申请人： Gregory L. Sundberg , David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
发明人： Gregory L. Sundberg , David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N1/056 , A61N1/0573 , A61N1/3752 , Y10T29/49204 , Y10T29/49208 , Y10T29/49217
摘要： A lead having an extendable and retractable fixation mechanism has a rotating terminal pin at the terminal end which rotates the fixation mechanism at the distal end. As the terminal pin is rotated, the fixation mechanism is extended or retracted from the distal end of the lead. A threaded collar allows for the fixation mechanism to smoothly extend and retract from the lead, and allows for a 1:1 turn ratio between the terminal pin and the fixation mechanism. A fluoroscopic ring disposed at the distal end of the lead provides information during the implantation process. The lead includes a terminal assembly having an outer terminal ring, a terminal pin, and an insulative sleeve disposed between the outer terminal ring and the terminal pin. The insulative sleeve is coupled with the outer terminal ring with a snap-fit connection.
摘要翻译：具有可伸缩的固定机构的引线具有在终端处的旋转端子销，其在远端旋转固定机构。当端子销旋转时，固定机构从引线的远端延伸或缩回。螺纹轴环允许固定机构从引线平滑地延伸和缩回，并且允许端子销和固定机构之间的1:1的匝数比。设置在引线远端的荧光镜环在植入过程中提供信息。引线包括具有外端子环，端子引脚和布置在外端子环和端子引脚之间的绝缘套管的端子组件。绝缘套管与外部端子环与卡扣配合连接。

2. 发明授权

US08209035B2 Extendable and retractable lead having a snap-fit terminal connector 有权
标题翻译：具有卡扣式端子连接器的可伸缩的引线
公开(公告)号：US08209035B2
公开(公告)日：2012-06-26
申请号：US12144316
申请日：2008-06-23
申请人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
发明人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/3752 , Y10S439/909
摘要： A lead having an extendable and retractable fixation mechanism has a rotating terminal pin at the terminal end which rotates the fixation mechanism at the distal end. As the terminal pin is rotated, the fixation mechanism is extended or retracted from the distal end of the lead. A threaded collar allows for the fixation mechanism to smoothly extend and retract from the lead, and allows for a 1:1 turn ratio between the terminal pin and the fixation mechanism. A fluoroscopic ring disposed at the distal end of the lead provides information during the implantation process.
摘要翻译：具有可伸缩的固定机构的引线具有在终端处的旋转端子销，其在远端旋转固定机构。当端子销旋转时，固定机构从引线的远端延伸或缩回。螺纹轴环允许固定机构从引线平滑地延伸和缩回，并且允许端子销和固定机构之间的1:1的匝数比。设置在引线远端的荧光镜环在植入过程中提供信息。

3. 发明申请

US20080262587A1 EXTENDABLE AND RETRACTABLE LEAD HAVING A SNAP-FIT TERMINAL CONNECTOR 有权
标题翻译：具有连接端子连接器的可扩展和可退回的引线
公开(公告)号：US20080262587A1
公开(公告)日：2008-10-23
申请号：US12144316
申请日：2008-06-23
申请人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
发明人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/3752 , Y10S439/909
摘要： A lead having an extendable and retractable fixation mechanism has a rotating terminal pin at the terminal end which rotates the fixation mechanism at the distal end. As the terminal pin is rotated, the fixation mechanism is extended or retracted from the distal end of the lead. A threaded collar allows for the fixation mechanism to smoothly extend and retract from the lead, and allows for a 1:1 turn ratio between the terminal pin and the fixation mechanism. A fluoroscopic ring disposed at the distal end of the lead provides information during the implantation process.
摘要翻译：具有可伸缩的固定机构的引线具有在终端处的旋转端子销，其在远端旋转固定机构。当端子销旋转时，固定机构从引线的远端延伸或缩回。螺纹轴环允许固定机构从引线平滑地延伸和缩回，并且允许端子销和固定机构之间的1:1的匝数比。设置在引线远端的荧光镜环在植入过程中提供信息。

4. 发明授权

US07392095B2 Extendable and retractable lead having a snap-fit terminal connector 有权
标题翻译：具有卡扣式端子连接器的可伸缩的引线
公开(公告)号：US07392095B2
公开(公告)日：2008-06-24
申请号：US11173664
申请日：2005-07-01
申请人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
发明人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/3752 , Y10S439/909
摘要： A lead having an extendable and retractable fixation mechanism has a rotating terminal pin at the terminal end which rotates the fixation mechanism at the distal end. As the terminal pin is rotated, the fixation mechanism is extended or retracted from the distal end of the lead. A threaded collar allows for the fixation mechanism to smoothly extend and retract from the lead, and allows for a 1:1 turn ratio between the terminal pin and the fixation mechanism. A fluoroscopic ring disposed at the distal end of the lead provides information during the implantation process.
摘要翻译：具有可伸缩的固定机构的引线具有在终端处的旋转端子销，其在远端旋转固定机构。当端子销旋转时，固定机构从引线的远端延伸或缩回。螺纹轴环允许固定机构从引线平滑地延伸和缩回，并且允许端子销和固定机构之间的1:1的匝数比。设置在引线远端的荧光镜环在植入过程中提供信息。

5. 发明授权

US06915169B2 Extendable and retractable lead having a snap-fit terminal connector 有权
公开(公告)号：US06915169B2
公开(公告)日：2005-07-05
申请号：US10264494
申请日：2002-10-04
申请人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
发明人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/3752 , Y10S439/909
摘要： A lead having an extendable and retractable fixation mechanism has a rotating terminal pin at the terminal end which rotates the fixation mechanism at the distal end. As the terminal pin is rotated, the fixation mechanism is extended or retracted from the distal end of the lead. A threaded collar allows for the fixation mechanism to smoothly extend and retract from the lead, and allows for a 1:1 turn ratio between the terminal pin and the fixation mechanism. A fluoroscopic ring disposed at the distal end of the lead provides information during the implantation process.

6. 发明授权

US06463334B1 Extendable and retractable lead 有权
标题翻译：具有卡扣式端子连接器的可伸缩的引线
公开(公告)号：US06463334B1
公开(公告)日：2002-10-08
申请号：US09359580
申请日：1999-07-22
申请人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
发明人： David M. Flynn , Michael Brenzel , Jason Skubitz , Larry L. Hum , Carol Werlein , Christopher Paul Knapp , Gregory R. Ley , Jason Alan Shiroff , Brian David Soltis
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/3752 , Y10S439/909
摘要： A lead having an extendable and retractable fixation mechanism has a rotating terminal pin at the terminal end which rotates the fixation mechanism at the distal end. As the terminal pin is rotated, the fixation mechanism is extended or retracted from the distal end of the lead. A threaded collar allows for the fixation mechanism to smoothly extend and retract from the lead, and allows for a 1:1 turn ratio between the terminal pin and the fixation mechanism. A fluoroscopic ring disposed at the distal end of the lead provides information during the implantation process.
摘要翻译：具有可伸缩的固定机构的引线具有在终端处的旋转端子销，其在远端旋转固定机构。当端子销旋转时，固定机构从引线的远端延伸或缩回。螺纹轴环允许固定机构从引线平滑地延伸和缩回，并且允许端子销和固定机构之间的1:1的匝数比。设置在引线远端的荧光镜环在植入过程中提供信息。

7. 发明授权

US06361780B1 Microporous drug delivery system 有权
标题翻译：微孔药物输送系统
公开(公告)号：US06361780B1
公开(公告)日：2002-03-26
申请号：US09190902
申请日：1998-11-12
申请人： Gregory R. Ley , Christopher Paul Knapp
发明人： Gregory R. Ley , Christopher Paul Knapp
IPC分类号： A61K900
CPC分类号： A61M31/002 , A61F2250/0067 , A61M31/00 , A61M2025/0057
摘要： A drug delivery device is described comprising a porous biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion in an aqueous solution. This may also be described as a drug delivery device comprising a porous annulus comprising a biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion in an aqueous solution, the annulus having a top outer surface with an outside diameter, an inner surface with an inside diameter, and a side surface, at least one of the side surface and the top outer surface having openings of the pores exposed on that surface. The device may comprise pores having an average size of the greatest dimensions within the pores of between about 10−6 and 10−1 mm. The device may have a medical device or component of a medical device pass through an opening in the annulus. Examples of such medical devices may include, but not be limited to medical devices or components of medical devices selected from the group consisting of catheters, tubes, and electrical leads. A catheter or electrical lead may have at least a portion of its length surrounded by the porous drug delivery device. A more specific description of an aspect of the present invention would include a catheter or cardiac lead having a collar comprising a porous, solid material surrounding at least a length of the catheter or cardiac lead, the collar comprising a porous material selected from the group consisting of inorganic oxides, metals, polymers, and composite materials, the porous material having pores with an average greatest dimension of between about 10−6 and 10−1 mm, and the collar having a largest dimension of less than 5 mm.
摘要翻译：描述了药物递送装置，其包含在其孔内具有至少一种治疗药物的多孔生物相容性固体，所述治疗药物可通过浸入水溶液中而从孔中除去。这也可以被描述为包括多孔环的药物递送装置，所述多孔环包含在其孔内具有至少一种治疗药物的生物相容性固体，所述治疗药物可通过浸入水溶液而从孔中除去，所述环具有顶部外表面具有外径，具有内径的内表面和侧表面，所述侧表面和所述顶外表面中的至少一个具有暴露在所述表面上的孔的开口。所述装置可以包括具有平均尺寸孔内的最大尺寸在约10-6和10-1mm之间。该装置可以具有通过环形空间中的开口的医疗装置的医疗装置或部件。这样的医疗装置的示例可以包括但不限于从由导管，管和电引线组成的组中选择的医疗装置或医疗装置的部件。导管或电引线可以具有由多孔药物输送装置包围的其长度的至少一部分。本发明的一个方面的更具体的描述将包括导管或心脏引线，其具有包括围绕所述导管或心脏引线的至少一段长度，所述套环包括选自无机氧化物，金属，聚合物和复合材料的多孔材料，所述多孔材料具有平均最大尺寸在约10-6之间的孔和10-1mm，并且所述套环具有小于5mm的最大尺寸。

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