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    • 1. 发明申请
    • METHODS FOR PURIFYING ANTIBODIES USING CERAMIC HYDROXYAPATITE
    • 使用陶瓷羟基磷灰石来治疗抗体的方法
    • US20100234577A1
    • 2010-09-16
    • US12304782
    • 2007-06-13
    • Gregory J. MazzolaThomas M. Smith
    • Gregory J. MazzolaThomas M. Smith
    • C07K1/22C07K16/00
    • C07K1/20C07K1/18C07K16/065
    • This invention relates to the purification of monoclonal antibodies from mammalian cell culture fluid utilizing sequential, orthogonal chromatography and filtration techniques resulting in material of high purity and quality that is suitable for human administration. The method involves capturing an IgG product using immobilized protein A affinity chromatography, followed by at least one ion exchange technique prior to adsorbing the IgG to hydroxyapatite and selectively eluting the product in a single isocratic step to achieve purification from impurities and simultaneously reducing multiple types of impurities including but not limited to IgG aggregates, residual protein A, non-IgG proteins, host cell proteins, viral particles, and DNA
    • 本发明涉及使用顺序,正交色谱和过滤技术从哺乳动物细胞培养液中纯化单克隆抗体,产生适于人类施用的高纯度和高质量的材料。 该方法包括使用固定化蛋白A亲和色谱法捕获IgG产物,接着在将IgG吸附到羟基磷灰石之前进行至少一种离子交换技术,并在单个等度梯度步骤中选择性洗脱产物,以实现纯化从杂质中同时降低多种类型 杂质包括但不限于IgG聚集体,残留蛋白A,非IgG蛋白,宿主细胞蛋白,病毒颗粒和DNA
    • 6. 发明授权
    • Induction splicing of photographic film strips
    • 摄影胶片条的感应拼接
    • US06887328B1
    • 2005-05-03
    • US10716158
    • 2003-11-18
    • Thomas M. SmithBrian H. JohnstonNarasimharao DontulaLuba Kordovski
    • Thomas M. SmithBrian H. JohnstonNarasimharao DontulaLuba Kordovski
    • G03D15/04B65H69/06
    • G03D15/043Y10T428/19
    • A method is described for splicing together overlapping ends of first and second lengths of photographic film strips of common film strip width, comprising positioning a bonding element between an overlapping end of the first length of photographic film and a corresponding overlapped end of the second length of photographic film, and heating the bonding element to effect an adhesive bond between such film ends, wherein the bonding element comprises an induction heating receptive support and thermoplastic adhesive layers on each side of the support, and wherein the heating of the bonding element is performed by induction heating. The present invention allows for the preparation of photographic film splices, consisting of either homogeneous or dissimilar film bases, using a bonding element and induction heating to provide smooth yet strong splices. In particular, the invention enables successful splicing of acetate support (e.g., cellulose triacetate (CTA)) based films and polyester support (e.g., polyethylene terephthalate (PET)) based films either to themselves or each other. The invention provides a method of forming composite rolls of motion picture film containing different film bases as well as eliminating the need for emulsion skiving, and the use of toxic, flammable film cements when splicing CTA films.
    • 描述了一种用于将共同胶片带宽度的第一和第二长度的照相胶片条的重叠端拼接在一起的方法,包括将结合元件定位在第一长度的照相胶片的重叠端和第二长度的相应重叠端之间 照相胶片,并且加热粘合元件以实现这种胶片端部之间的粘结,其中粘合元件包括感应加热接受支撑体和在支撑体的每一侧上的热塑性粘合剂层,并且其中粘合元件的加热由 感应加热。 本发明允许使用粘合元件和感应加热来制备由均相或异种膜基底组成的照相胶片接合件,以提供平滑而强烈的接合。 特别地,本发明能够成功地将乙酸酯载体(例如,三乙酸纤维素(CTA))基膜和聚酯载体(例如聚对苯二甲酸乙二醇酯(PET))基膜接合到其自身或彼此上。 本发明提供了一种形成含有不同膜基的电影胶片复合辊的方法,并且不需要乳液切割,以及在接合CTA膜时使用有毒的易燃膜水泥。
    • 9. 发明授权
    • Abrasion-resistant protective laminates
    • 耐磨保护层压板
    • US5085907A
    • 1992-02-04
    • US577839
    • 1990-09-04
    • Thomas M. Smith
    • Thomas M. Smith
    • B32B7/02G03C11/08
    • B32B7/02G03C11/08Y10T428/1452Y10T428/2809Y10T428/2848
    • Multi-layer sheet materials useful as protective laminates for application to substrates, such as photographic elements, which require the protection of an abrasion-resistant material, are comprised of a strippable carrier, an abrasion-resistant layer which overlies the carrier, a structural interlayer which overlies the abrasion-resistant layer, and an adhesive layer which overlies the structural interlayer. The structural interlayer is very thin in relation to the thickness of the carrier, and is permanently bonded to one surface of the abrasion-resistant layer, whereas the carrier is releasably bonded to the other surface of the abrasion-resistant layer so as to permit it to be stripped away after it has served its purpose. A process for manufacturing the multi-layer sheet material comprises the steps of advancing the carrier in web form through a coating station at which it is coated with a layer of liquid composition that is curable to a solid form; laminating the structural interlayer to the coated surface of the carrier; curing the liquid layer in situ to a solid form to thereby form an abrasion-resistant layer; and applying an adhesive layer over the surface of the structural interlayer.
    • 可用作保护层压材料的多层片材材料,用于应用于需要保护耐磨材料的基材(例如照相元件),包括可剥离载体,覆盖载体的耐磨层,结构中间层 其覆盖在耐磨层上,粘合剂层覆盖在结构中间层上。 结构中间层相对于载体的厚度非常薄,并且永久地结合到耐磨层的一个表面,而载体可释放地结合到耐磨层的另一个表面,以便允许其 在其服务目的之后被剥离。 制造多层片材的方法包括以下步骤:将幅材载体通过涂覆站推进,在该涂布工位上涂覆有可固化成固体形式的液体组合物层; 将结构中间层层压到载体的涂覆表面上; 将液体原位固化成固体形式,从而形成耐磨层; 以及在结构中间层的表面上施加粘合剂层。
    • 10. 发明授权
    • Aqueous solution for forming a fire-retardant protective coating
    • 用于形成阻燃保护涂层的水溶液
    • US5049187A
    • 1991-09-17
    • US498782
    • 1990-03-26
    • Thomas M. Smith
    • Thomas M. Smith
    • C09D5/18C09K21/04
    • C09D5/18C09K21/04
    • An aqueous solution useful as a coating composition to form a fire-retardant protective overcoat on a surface requiring such protection, such as one or both surfaces of a photographic element, comprises (1) a water-soluble film-forming cross-linkable copolymer of methyl vinyl ether and maleic anhydride, (2) a water-soluble polyhydric alcohol which serves to cross-link the copolymer when a coating of the composition is applied over the surface to be protected and dried, and (3) a water-soluble ammonium polyphosphate which reacts with the polyhydric alcohol to form a fire-retardant composition when the protective overcoat is exposed to the heat of a fire.
    • 可用作涂料组合物以在需要这种保护的表面(例如照相材料的一个或两个表面)上形成阻燃保护外涂层的水溶液包括(1)水溶性成膜可交联共聚物 甲基乙烯基醚和马来酸酐,(2)当将组合物的涂层施加到待保护和干燥的表面上时,用作交联共聚物的水溶性多元醇,和(3)水溶性铵 当保护性外涂层暴露于火的热量时,多磷酸酯与多元醇反应形成阻燃组合物。