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1. 发明授权

US07064545B2 Method and apparatus of background suppression in MR imaging using spin locking 有权
标题翻译：使用自旋锁定的MR成像中背景抑制的方法和装置
公开(公告)号：US07064545B2
公开(公告)日：2006-06-20
申请号：US10711169
申请日：2004-08-30
申请人： Gregory G. Zaharchuk , Jean H. Brittain
发明人： Gregory G. Zaharchuk , Jean H. Brittain
IPC分类号： G01V3/00
CPC分类号： G01R33/563
摘要： The present invention is directed to a method and system of tissue or background suppression for the acquisition of image data from blood flow or tissue perfusion. Background suppression with minimal effects upon inflowing spins is achieved through a series of spin locking low level RF pulses that cause adiabatic demagnetization of tissue with a relaxation time T1-rho that is intermediate between T1 and T2 relaxation times. In this regard, the effective transverse magnetization of static tissue resulting from the application of a series of low level RF pulses is reduced and, with the spin locking, longitudinal magnetization regrowth is minimized. As such, inflowing spins to an imaging volume may be directly imaged with significant background tissue suppression. The present invention is particularly applicable to time-of-flight MRA and MR perfusion imaging.
摘要翻译：本发明涉及用于从血流或组织灌注获取图像数据的组织或背景抑制的方法和系统。通过一系列自旋锁定低水平射频脉冲来实现对流入旋转影响最小的背景抑制，其使得在T1和T2弛豫时间之间的弛豫时间T1-rho导致组织绝热退磁。在这方面，由于施加一系列低电平RF脉冲导致的静电组织的有效横向磁化强度降低，并且随着自旋锁定，纵向磁化强度再生长被最小化。这样，流入成像体积的流动可以直接用显着的背景组织抑制成像。本发明特别适用于飞行时间MRA和MR灌注成像。

2. 发明申请

US20080275329A1 Diffusion weighted preparatory sequence for magnetic resonance imaging pulse sequence 有权
标题翻译：磁共振成像脉冲序列扩散加权准备序列
公开(公告)号：US20080275329A1
公开(公告)日：2008-11-06
申请号：US11800374
申请日：2007-05-04
申请人： Scott B. Reeder , Reed Busse , Jean H. Brittain
发明人： Scott B. Reeder , Reed Busse , Jean H. Brittain
IPC分类号： A61B5/055
CPC分类号： G01R33/56341
摘要： A preparatory pulse sequence is applied prior to an imaging pulse sequence during a diffusion-weighted MRI scan. The preparatory pulse sequence diffusion weights the longitudinal magnetization using a gradient waveform that is first moment nulled to reduce image artifacts caused by patient motion.
摘要翻译：在扩散加权MRI扫描期间，在成像脉冲序列之前应用预备脉冲序列。准备脉冲序列扩散使用一个梯度波形对纵向磁化进行加权，该波形首先被归零，以减少由患者运动引起的图像伪影。

3. 发明授权

US07486073B2 Sliding window reconstruction and phase/field map updating for dynamic chemical shift imaging 有权
标题翻译：动态化学位移成像的滑动窗口重建和相位/场地图更新
公开(公告)号：US07486073B2
公开(公告)日：2009-02-03
申请号：US11738347
申请日：2007-04-20
申请人： Huanzhou Yu , Charles A. McKenzie , Jean H. Brittain , Norbert J. Pelc , Scott B. Reeder
发明人： Huanzhou Yu , Charles A. McKenzie , Jean H. Brittain , Norbert J. Pelc , Scott B. Reeder
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01R33/4828
摘要： A method for generating dynamic magnetic resonance images is provided. A cyclical magnetic resonance imaging excitation is applied for a plurality of cycles at a cycle rate. A plurality of magnetic resonance image echoes is acquired for each cycle. A plurality of frames of images is generated from the acquired plurality of magnetic resonance echoes at a frame rate that is at least twice the cycle rate, wherein each frame of the plurality of frames is generated from a plurality of echoes and wherein some of the plurality of frames are generated from magnetic resonance image echoes of adjacent cycles.
摘要翻译：提供了一种用于产生动态磁共振图像的方法。周期磁共振成像激励以循环速率施加多个周期。对于每个周期获取多个磁共振图像回波。从所获取的多个磁共振回波以至少为循环速率的两倍的帧速率产生多个图像帧，其中，多个帧中的每个帧由多个回波生成，并且其中多个帧中的一些的帧由相邻周期的磁共振图像回波产生。

4. 发明授权

US06897655B2 Moving table MRI with frequency-encoding in the z-direction 有权
标题翻译：在z方向进行频率编码的移动表MRI
公开(公告)号：US06897655B2
公开(公告)日：2005-05-24
申请号：US10235454
申请日：2002-09-04
申请人： Jean H. Brittain , John M. Pauly
发明人： Jean H. Brittain , John M. Pauly
IPC分类号： G01R33/28 , G01R33/54 , G01R33/563 , G01V3/00 , A61B5/05
CPC分类号： G01R33/28 , G01R33/54 , G01R33/56375 , G01R33/56383
摘要： A system and method are disclosed using continuous table motion while acquiring data to reconstruct MR images across a large FOV without significant slab-boundary artifacts that reduces acquisition time. At each table position, full z-encoding data are acquired for a subset of the transverse k-space data. The table is moved through a number of positions over the desired FOV and MR data are acquired over the plurality of table positions. Since full z-data are acquired for each slab, the data can be Fourier transformed in z, interpolated, sorted, and aligned to match anatomic z locations. The fully sampled and aligned data is then Fourier transformed in remaining dimension(s) to reconstruct the final image that is free of slab-boundary artifacts.
摘要翻译：公开了使用连续表格运动的系统和方法，同时获取数据以重建跨越大FOV的MR图像，而没有减少获取时间的显着的平板边界伪像。在每个表位置，对于横向k空间数据的子集获取完整的z编码数据。该表移动通过所需FOV的多个位置，并且在多个表位置上获取MR数据。由于为每个平板获取完整的z数据，所以数据可以在z中进行傅立叶变换，内插，排序和对齐以匹配解剖z位置。完全采样和对齐的数据然后在剩余维度中进行傅里叶变换，以重建没有平板边界伪像的最终图像。

5. 发明授权

US06570383B1 Method and apparatus for a pulse sequence for magnetic resonance imaging in an inhomogeneous magnetic field 失效
标题翻译：用于在非均匀磁场中磁共振成像的脉冲序列的方法和装置
公开(公告)号：US06570383B1
公开(公告)日：2003-05-27
申请号：US09748928
申请日：2000-12-27
申请人： Graeme C. McKinnon , Jean H. Brittain
发明人： Graeme C. McKinnon , Jean H. Brittain
IPC分类号： G01V300
CPC分类号： G01R33/445 , G01R33/48 , G01R33/5617
摘要： A method and system for imaging using an inhomogeneous static magnetic field is disclosed herein. The imaging includes providing the inhomogeneous static magnetic field to an object of interest located within an imaging volume. The imaging further includes providing a pulse sequence including a readout gradient pulse and a slice selection gradient pulse, both gradient pulses comprising a part of the inhomogeneous static magnetic field. The pulse sequence is configured to acquire a plurality of lines of k-space data per excitation.
摘要翻译：本文公开了使用非均匀静磁场成像的方法和系统。该成像包括将不均匀的静磁场提供给位于成像体积内的感兴趣对象。该成像还包括提供包括读出梯度脉冲和切片选择梯度脉冲的脉冲序列，两个梯度脉冲包括一部分非均匀静态磁场。脉冲序列被配置为每次激励获取多行k空间数据。

6. 发明授权

US07804299B2 Diffusion weighted preparatory sequence for magnetic resonance imaging pulse sequence 有权
标题翻译：磁共振成像脉冲序列扩散加权准备序列
公开(公告)号：US07804299B2
公开(公告)日：2010-09-28
申请号：US11800374
申请日：2007-05-04
申请人： Scott B. Reeder , Reed Busse , Jean H. Brittain
发明人： Scott B. Reeder , Reed Busse , Jean H. Brittain
IPC分类号： G01V3/00
CPC分类号： G01R33/56341
摘要： A preparatory pulse sequence is applied prior to an imaging pulse sequence during a diffusion-weighted MRI scan. The preparatory pulse sequence diffusion weights the longitudinal magnetization using a gradient waveform that is first moment nulled to reduce image artifacts caused by patient motion.
摘要翻译：在扩散加权MRI扫描期间，在成像脉冲序列之前应用预备脉冲序列。准备脉冲序列扩散使用一个梯度波形对纵向磁化进行加权，该波形首先被归零，以减少由患者运动引起的图像伪影。

7. 发明授权

US07298144B2 Homodyne reconstruction of water and fat images based on iterative decomposition of MRI signals 有权
标题翻译：基于MRI信号的迭代分解的水和脂肪图像的零差重建
公开(公告)号：US07298144B2
公开(公告)日：2007-11-20
申请号：US11253825
申请日：2005-10-18
申请人： Scott B. Reeder , Brian A. Hargreaves , Jean H. Brittain
发明人： Scott B. Reeder , Brian A. Hargreaves , Jean H. Brittain
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5608
摘要： Homodyne image reconstruction is combined with an iterative decomposition of water and fat from MR signals obtained from a partial k-space signal acquisition in order to maximize the resolution of calculated water and fat images. The method includes asymmetrical acquisition of under-sampled MRI data, obtaining low resolution images, and then estimating a magnetic field map and phase maps of water and fat image signals from the low resolution images. The acquired data is again filtered and Fourier transformed to obtain an estimate of combined fat and water signals using the estimated magnetic field map and phase maps. Water and fat images are then estimated from which phases of the water and fat images are determined. The real parts of the water and fat images are then used in calculating water and fat images using a homodyne process.
摘要翻译：将零差图像重建与从部分k空间信号采集获得的MR信号的水和脂肪的迭代分解相结合，以便最大化计算出的水和脂肪图像的分辨率。该方法包括对采样不全的MRI数据进行不对称采集，获得低分辨率图像，然后从低分辨率图像中估计出水分和脂肪图像信号的磁场图和相位图。所获取的数据再次被滤波和傅里叶变换，以使用估计的磁场图和相位图来获得组合的脂肪和水信号的估计。然后估计水和脂肪图像，从而确定水和脂肪图像的哪个阶段。然后将水和脂肪图像的真实部分用于使用零差过程计算水和脂肪图像。

8. 发明授权

US07251520B2 Method and apparatus of slice selective magnetization preparation for moving table MRI 有权
标题翻译：用于移动台MRI的切片选择性磁化准备的方法和装置
公开(公告)号：US07251520B2
公开(公告)日：2007-07-31
申请号：US10604285
申请日：2003-07-08
申请人： Ajit Shankaranarayanan , Jean H. Brittain
发明人： Ajit Shankaranarayanan , Jean H. Brittain
IPC分类号： A61B5/055 , G01V3/00 , G01V3/15
CPC分类号： A61B5/055 , G01R33/56375
摘要： The present invention is directed to slice selective magnetization preparation for moving table MRI. The present invention includes a method of magnetization preparation that takes into account patient movement or translation during the imaging process. The present invention adjusts or modifies the frequency at which magnetization preparation pulses are applied to offset the preparation pulse in space. This allows preparation pulses to be interleaved with imaging and enables magnetization preparation without sacrificing other imaging variables or parameters defined for the particular MR study. As such, contrast within a reconstructed image is improved.
摘要翻译：本发明涉及用于移动台MRI的切片选择性磁化准备。本发明包括在成像过程中考虑患者移动或平移的磁化准备方法。本发明调整或修改施加磁化准备脉冲以偏移空间中的准备脉冲的频率。这允许准备脉冲与成像交错并且使得磁化准备不会牺牲为特定MR研究定义的其它成像变量或参数。因此，改善了重建图像内的对比度。

9. 发明授权

US07693569B1 Method and system of determining motion in a region-of-interest directly and independently of k-space trajectory 有权
标题翻译：直接和独立于k空间轨迹确定感兴趣区域中的运动的方法和系统
公开(公告)号：US07693569B1
公开(公告)日：2010-04-06
申请号：US10711892
申请日：2004-10-12
申请人： Jean H. Brittain , Anja C. S. Brau
发明人： Jean H. Brittain , Anja C. S. Brau
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/7207 , A61B5/721 , G01R33/482 , G01R33/5613 , G01R33/56375 , G01R33/56383 , G01R33/56509 , G01R33/5673 , G01R33/5676 , G06T7/20 , G06T2207/10088 , G06T2207/30004
摘要： A system and method for determining motion in a region-of-interest directly from MR data acquired from the region-of-interest and independently of k-space trajectory are disclosed.
摘要翻译：公开了一种用于直接从从感兴趣区域获取并且独立于k空间轨迹的MR数据确定感兴趣区域中的运动的系统和方法。

10. 发明授权

US07592810B2 MRI methods for combining separate species and quantifying a species 有权
标题翻译：用于组合分离物种和量化物种的MRI方法
公开(公告)号：US07592810B2
公开(公告)日：2009-09-22
申请号：US11738339
申请日：2007-04-20
申请人： Scott B. Reeder , Charles A. McKenzie , Jean H. Brittain
发明人： Scott B. Reeder , Charles A. McKenzie , Jean H. Brittain
IPC分类号： G01V3/00
CPC分类号： G01R33/4828
摘要： A method for generating a magnetic resonance images is provided. A first species signal for a first species is generated from magnetic resonance data. A second signal is generated from the magnetic resonance data. The first species signal is combined with the second signal to provide a recombined image. The recombined image may be displayed.
摘要翻译：提供了一种用于产生磁共振图像的方法。从磁共振数据产生第一物种的第一物种信号。从磁共振数据产生第二信号。第一物种信号与第二信号组合以提供重组图像。可以显示重新组合的图像。

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