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1. 发明授权

US07298144B2 Homodyne reconstruction of water and fat images based on iterative decomposition of MRI signals 有权
标题翻译：基于MRI信号的迭代分解的水和脂肪图像的零差重建
公开(公告)号：US07298144B2
公开(公告)日：2007-11-20
申请号：US11253825
申请日：2005-10-18
申请人： Scott B. Reeder , Brian A. Hargreaves , Jean H. Brittain
发明人： Scott B. Reeder , Brian A. Hargreaves , Jean H. Brittain
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5608
摘要： Homodyne image reconstruction is combined with an iterative decomposition of water and fat from MR signals obtained from a partial k-space signal acquisition in order to maximize the resolution of calculated water and fat images. The method includes asymmetrical acquisition of under-sampled MRI data, obtaining low resolution images, and then estimating a magnetic field map and phase maps of water and fat image signals from the low resolution images. The acquired data is again filtered and Fourier transformed to obtain an estimate of combined fat and water signals using the estimated magnetic field map and phase maps. Water and fat images are then estimated from which phases of the water and fat images are determined. The real parts of the water and fat images are then used in calculating water and fat images using a homodyne process.
摘要翻译：将零差图像重建与从部分k空间信号采集获得的MR信号的水和脂肪的迭代分解相结合，以便最大化计算出的水和脂肪图像的分辨率。该方法包括对采样不全的MRI数据进行不对称采集，获得低分辨率图像，然后从低分辨率图像中估计出水分和脂肪图像信号的磁场图和相位图。所获取的数据再次被滤波和傅里叶变换，以使用估计的磁场图和相位图来获得组合的脂肪和水信号的估计。然后估计水和脂肪图像，从而确定水和脂肪图像的哪个阶段。然后将水和脂肪图像的真实部分用于使用零差过程计算水和脂肪图像。

2. 发明授权

US08803523B2 Flexible ordering for multiple slice MRI 有权
标题翻译：多层MRI的灵活排序
公开(公告)号：US08803523B2
公开(公告)日：2014-08-12
申请号：US13366086
申请日：2012-02-03
申请人： Brian A. Hargreaves
发明人： Brian A. Hargreaves
IPC分类号： G01V3/00
CPC分类号： G01R33/4835 , G01R33/4818 , G01R33/561
摘要： A method of ordering slices for interleaved MRI is provided that includes selecting a number of interleaved slice locations (NS) each having a plurality of excitations (NE,S), where S is the slice number between 1 and NS and NE,S may differ for different slice numbers, selecting an excitation duration (TS) of each the excitation in each the slice, selecting a repetition time (TR) between successive excitations of the same slice, TR has a duration of Ni×TS, Ni is the number of interleaved slices per TR period, and arranging the order for the slices such that the total scan time (T) is minimized such that TR is the product of Ni and Ts, where Ni can be arbitrarily chosen between 1 and NT/NE,max where NT is the total number of excitations for all the slices and where NE,max is the maximum number of the excitations for one slice.
摘要翻译：提供了一种对交织MRI进行排序的方法，包括选择每个具有多个激励（NE，S）的交织片位置数（NS），其中S是1与NS和NE之间的片数，S可能不同对于不同的切片数，选择每个切片中每个激励的激励持续时间（TS），选择相同切片的连续激发之间的重复时间（TR），TR具有Ni×TS的持续时间，Ni是每个TR周期交错切片，并且对切片的顺序进行排列，使得总扫描时间（T）最小化，使得TR是Ni和Ts的乘积，其中Ni可以在1和NT / NE之间任意选择max，其中 NT是所有切片的总激励次数，其中NE，max是一个切片的最大激励次数。

3. 发明申请

US20130200892A1 Flexible Ordering for Multiple Slice MRI 有权
标题翻译：灵活订购多片MRI
公开(公告)号：US20130200892A1
公开(公告)日：2013-08-08
申请号：US13366086
申请日：2012-02-03
申请人： Brian A. Hargreaves
发明人： Brian A. Hargreaves
IPC分类号： G01R33/48
CPC分类号： G01R33/4835 , G01R33/4818 , G01R33/561
摘要： A method of ordering slices for interleaved MRI is provided that includes selecting a number of interleaved slice locations (NS) each having a plurality of excitations (NE,S), where S is the slice number between 1 and NS and NE,S may differ for different slice numbers, selecting an excitation duration (TS) of each the excitation in each the slice, selecting a repetition time (TR) between successive excitations of the same slice, TR has a duration of Ni×TS, Ni is the number of interleaved slices per TR period, and arranging the order for the slices such that the total scan time (T) is minimized such that TR is the product of Ni and Ts, where Ni can be arbitrarily chosen between 1 and NT/NE,max where NT is the total number of excitations for all the slices and where NE,max is the maximum number of the excitations for one slice.
摘要翻译：提供了一种对交错MRI进行排序的方法，包括选择每个具有多个激励（NE，S）的交织片位置数（NS），其中S是1与NS和NE之间的片数，S可能不同对于不同的切片数，选择每个切片中每个激励的激励持续时间（TS），选择相同切片的连续激发之间的重复时间（TR），TR具有Ni×TS的持续时间，Ni是每个TR周期交错切片，并且对切片的顺序进行布置，使得总扫描时间（T）最小化，使得TR是Ni和Ts的乘积，其中Ni可以在1和NT / NE之间任意选择max，其中 NT是所有切片的总激励次数，其中NE，max是一个切片的最大激励次数。

4. 发明授权

US07187170B1 Multiple acquisition phase-sensitive SSFP for species separating in MRI 有权
标题翻译：用于物种分离MRI的多次采集相敏SSFP
公开(公告)号：US07187170B1
公开(公告)日：2007-03-06
申请号：US11225920
申请日：2005-09-13
申请人： Brian A. Hargreaves , Neal K. Bangerter
发明人： Brian A. Hargreaves , Neal K. Bangerter
IPC分类号： G01V3/00
CPC分类号： G01R33/5614 , G01R33/4828 , G01R33/5613
摘要： MRI signals from two species such as fat and water are separated by repeatedly applying a steady state free precession (SSFP) sequence to an object with the phase of each RF excitation pulse in a sequence being increased by 2πn/N radians on each repetition, where acquisition number n ranges from 1 to N. Alternatively, center frequency for each scan is incremented compared with the first scan center frequency. Images are reconstructed from the acquired signals and summed. Slowing varying phase due to sources other than chemical shift can be removed. Species signals are separated based on phase (sign) of the summed image signals.
摘要翻译：通过重复地将一个稳态自由进动（SSFP）序列施加到一个物体上来分离来自两种物质如脂肪和水的MRI信号，其中每个RF激发脉冲的相位在每个重复上增加2pin / N弧度，其中采集数n的范围从1到N.或者，每个扫描的中心频率与第一扫描中心频率相比增加。从获取的信号重建图像并求和。可以除去由于化学位移以外的来源引起的变化相变。物种信号根据相加图像信号的相位（符号）分开。

5. 发明授权

US07151370B1 Quadratic species separation using balanced SSFP MRI 有权
标题翻译：使用平衡SSFP MRI进行二次物种分离
公开(公告)号：US07151370B1
公开(公告)日：2006-12-19
申请号：US11321770
申请日：2005-12-28
申请人： Brian A. Hargreaves
发明人： Brian A. Hargreaves
IPC分类号： G01V3/00
CPC分类号： G01R33/5613 , G01R33/4828
摘要： MRI signals from two species such as water and fat are separated by using two SSFP acquisitions (S1, S2) with the two species signals having two different phase differences (e.g., 180°, 90°) and binomial quadratic expansion in which the species are determined based on magnitude and sign of S1 and the magnitude of S2.
摘要翻译：两种物质如水和脂肪的MRI信号通过使用两种SSFP获取（S 1，S 2，2）分离，两种物种信号具有两个不同的相位差（例如，180°，90°）和二项式二次扩展，其中根据S＆lt; 1＆gt;的大小和符号确定物种和S 2> 2的大小。

6. 发明授权

US06219571B1 Magnetic resonance imaging using driven equilibrium fourier transform 有权
标题翻译：磁共振成像采用驱动平衡傅里叶变换
公开(公告)号：US06219571B1
公开(公告)日：2001-04-17
申请号：US09280223
申请日：1999-03-29
申请人： Brian A. Hargreaves , Dwight G. Nishimura
发明人： Brian A. Hargreaves , Dwight G. Nishimura
IPC分类号： A61B5055
CPC分类号： G01R33/5613 , A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/7257
摘要： A new technique for imaging a material with a high T2/T1 ratio such as articular cartilage uses driven equilibrium Fourier transform (DEFT), a method of enhancing signal strength without waiting for full T1 recovery. Compared to other methods, DEFT imaging provides a good combination of bright cartilage and high contrast between cartilage and surrounding tissue. Both theoretical predictions and images show that DEFT is a valuable method for imaging articular cartilage when compared to spoiled gradient recalled acquisition in the steady-state (SPGR) or fast spin echo (FSE). T2-decay, T1 recovery, echo time, magnetization density, proton density, and equilibrium density per proton are related by a derived equation.
摘要翻译：用于成像具有较高T2 / T1比例的材料（例如关节软骨）的新技术使用驱动平衡傅立叶变换（DEFT），这是增强信号强度而不等待完全T1恢复的方法。与其他方法相比，DEFT成像提供软骨和周围组织之间明亮的软骨和高对比度的良好组合。理论预测和图像显示，与稳态（SPGR）或快速自旋回波（FSE）中的损坏梯度回归采集相比，DEFT是成像关节软骨的有价值的方法。 T2衰减，T1恢复，回波时间，磁化密度，质子密度和每个质子的平衡密度都由一个派生方程相关。

7. 发明申请

US20090306496A1 AUTOMATIC SEGMENTATION OF ARTICULAR CARTILAGE FROM MRI 有权
标题翻译：磁共振成像自动分类
公开(公告)号：US20090306496A1
公开(公告)日：2009-12-10
申请号：US12133293
申请日：2008-06-04
申请人： Seungbum Koo , Brian A. Hargreaves , Garry E. Gold
发明人： Seungbum Koo , Brian A. Hargreaves , Garry E. Gold
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/7267
摘要： A method for musculoskeletal tissue segmentation used in magnetic resonance imaging (MRI) is provided. MRI image data is collected using at least two different contrast mechanisms. Voxel values from data from each contrast mechanism are used as elements of a feature vector. The feature vector is compared with classification boundaries to classify musculoskeletal tissue type of the voxel. The previous two steps are repeated for a plurality of voxels. An image is generated from the classified musculoskeletal tissue types for the plurality of voxels to provide a musculoskeletal segmentation image.
摘要翻译：提供了一种用于磁共振成像（MRI）的肌肉骨骼组织分割方法。使用至少两种不同的对比度机制来收集MRI图像数据。来自每个对比度机制的数据的体素值被用作特征向量的元素。将特征向量与分类边界进行比较，以对体素的肌肉骨骼组织类型进行分类。对于多个体素重复前述两个步骤。从用于多个体素的分类的肌肉骨骼组织类型产生图像以提供肌肉骨骼分割图像。

8. 发明授权

US08432166B2 Balanced steady-state free-precession transient imaging using variable flip angles for a predefined signal profile 有权
标题翻译：平衡稳态自由进动瞬态成像使用可变翻转角度预定义的信号轮廓
公开(公告)号：US08432166B2
公开(公告)日：2013-04-30
申请号：US12660676
申请日：2010-03-01
申请人： Pauline W. Worters , Brian A. Hargreaves
发明人： Pauline W. Worters , Brian A. Hargreaves
IPC分类号： G01V3/00
CPC分类号： G01R33/5614 , G01R33/5635
摘要： A magnetic resonance imaging system or method is provided including a balanced steady-state free-precession transient imaging (transient bSSFP) device capable of increasing the overall signal during transient bSSFP acquisition by fully or better utilization of the magnetization through variable RF flip angles. The transient bSSFP device is capable of generating a series of echoes with a desired transverse magnetization profile MT. It is further capable of generating RF pulses each having a distinct RF flip angle for each of the echoes in the series of echoes. The transient bSSFP device is coupled to a computer capable of calculating the distinct RF flip angle for the nth echo in the series of echoes. The computer calculation utilizes a program encoding an analytical inversion of the Bloch equation. Once the RF flip angle is calculated, it is used by the transient bSSFP device in the generation of the nth echo.
摘要翻译：提供了一种磁共振成像系统或方法，其包括平衡的稳态自由进动瞬态成像（瞬态bSSFP）装置，其能够通过可变RF翻转角完全或更好地利用磁化来增加瞬态bSSFP捕获期间的总体信号。瞬态bSSFP器件能够产生具有期望的横向磁化分布MT的一系列回波。它还能够产生RF脉冲，每个RF脉冲具有针对一系列回波中的每个回波的不同的RF翻转角。瞬态bSSFP器件耦合到能够计算该系列回波中第n个回波的不同RF翻转角的计算机。计算机计算利用编码Bloch方程的分析反演的程序。一旦计算了RF翻转角，则在产生第n个回波时，它被瞬态bSSFP器件使用。

9. 发明申请

US20120112743A1 T2-weighted and diffusion-weighted imaging using fast acquisition with double echo (FADE) 有权
标题翻译：采用双回波快速采集（FADE）的T2加权和弥散加权成像
公开(公告)号：US20120112743A1
公开(公告)日：2012-05-10
申请号：US12927213
申请日：2010-11-10
申请人： Kristin L. Granlund , Ernesto Staroswiecki , Brian A. Hargreaves
发明人： Kristin L. Granlund , Ernesto Staroswiecki , Brian A. Hargreaves
IPC分类号： G01R33/48
CPC分类号： G01R33/5614 , G01R33/5602 , G01R33/56341
摘要： A method of acquiring T2-weighted and diffusion-weighted images is provided. The method includes acquiring a first image and a second image in a single magnetic resonance imaging (MRI) scan, where the first image and the second image have different echo times (TE). The single MRI scan includes a series of repeated RF excitation pulses, where the echo signal for the first image and the echo signal for the second image are acquired between a pair of RF excitation pulses. A spoiler gradient is disposed to provide a first diffusion weighting to the first image and a second diffusion weighting to the second image, where the first image and the second image have different T2 weightings and different diffusion weightings.
摘要翻译：提供了一种获取T2加权和扩散加权图像的方法。该方法包括在单次磁共振成像（MRI）扫描中获取第一图像和第二图像，其中第一图像和第二图像具有不同的回波时间（TE）。单个MRI扫描包括一系列重复的RF激励脉冲，其中在一对RF激励脉冲之间获取用于第一图像的回波信号和用于第二图像的回波信号。设置扰流板梯度以对第一图像提供第一扩散加权，并对第二图像进行第二扩散加权，其中第一图像和第二图像具有不同的T2加权和不同的扩散权重。

10. 发明授权

US07332908B2 SSFP MRI with increased signal bandwidth 有权
标题翻译： SSFP MRI具有增加的信号带宽
公开(公告)号：US07332908B2
公开(公告)日：2008-02-19
申请号：US11381601
申请日：2006-05-04
申请人： Krishna S. Nayak , Brian A. Hargreaves
发明人： Krishna S. Nayak , Brian A. Hargreaves
IPC分类号： G01V3/00
CPC分类号： G01R33/5613 , G01R33/5602 , G01R33/5607 , G01R33/5614 , G01R33/56333 , G01R33/56563 , G01R33/5676
摘要： Disclosed is a wideband SSFP, wherein a standard balanced SSFP MRI sequence is played with repetition times of alternating lengths, TR and TRs, where TRs
摘要翻译：公开了一种宽带SSFP，其中标准平衡SSFP MRI序列以交替长度的重复时间TR和TR 播放，其中TR TR。结果显着改善了信号带宽和可用采集间隔长度之间的折衷。这是特别重要的，因为它可以平衡SSFP与高场成像的组合，用于许多应用，如心脏，肌肉骨骼和腹部成像。

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