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1. 发明授权

US08388618B2 Control of mucus membrane bleeding with cold plasma 有权
标题翻译：用冷血浆控制粘膜出血
公开(公告)号：US08388618B2
公开(公告)日：2013-03-05
申请号：US12175756
申请日：2008-07-18
申请人： Gregory Fridman , Alexander Fridman , Alexander F. Gutsol , Gennady Friedman , David Staack , Richard J. Hamilton
发明人： Gregory Fridman , Alexander Fridman , Alexander F. Gutsol , Gennady Friedman , David Staack , Richard J. Hamilton
IPC分类号： A61B18/18
CPC分类号： A61B18/042 , A61B2018/00982
摘要： The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is partially encapsulated by a dielectric. The non-thermal plasma is applied to the area of bleeding for treatment.
摘要翻译：本文描述了使用非热等离子体来治疗粘液膜出血。使用具有从电源接收交流电位的第一电极的装置产生非热等离子体。当放置在靠近组织的适当位置时，产生非热等离子体，第二电极是人体组织，血液等。为了减少产生电弧的可能性，可能导致组织损伤或疼痛，第一电极被电介质部分封装。将非热等离子体施加到出血处理区域。

2. 发明申请

US20120100524A1 TUBULAR FLOATING ELECTRODE DIELECTRIC BARRIER DISCHARGE FOR APPLICATIONS IN STERILIZATION AND TISSUE BONDING 审中-公开
标题翻译：用于灭菌和组织结合的管状浮动电极介质阻挡放电
公开(公告)号：US20120100524A1
公开(公告)日：2012-04-26
申请号：US13256301
申请日：2010-03-16
申请人： Gregory Fridman , Alexander Fridman , Alexander F. Gutsol , Gennady Friedman , David Staack
发明人： Gregory Fridman , Alexander Fridman , Alexander F. Gutsol , Gennady Friedman , David Staack
IPC分类号： A61B18/18 , A61L2/14 , B01J19/08
CPC分类号： A61L2/14 , A61L2/0011 , B01J19/087 , H05H1/2406 , H05H2001/245 , H05H2001/2456 , H05H2245/122
摘要： Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the gas. The RF electrode, disposed circumferentially proximate to the exterior of the dielectric conduit, generates non-thermal plasma from the ionized gas. The non-thermal plasma is discharged from the dielectric conduit and contacts a biological substrate. The non-thermal plasma discharge may be suitable for tissue bonding and sterilization applications.
摘要翻译：公开了一种用于接触生物底物的装置和方法。非热等离子体装置使用电介质导管，点火器电极和RF电极来传送非热等离子体放电。电介质导管使气体通过其流体连通，并且点火器电极使至少一部分气体电离。沿电介质导管的外部周向设置的RF电极从电离气体产生非热等离子体。非热等离子体从电介质导管排出并与生物基板接触。非热等离子体放电可适用于组织粘合和灭菌应用。

3. 发明申请

US20120156091A1 METHODS AND DEVICES FOR TREATING SURFACES WITH SURFACE PLASMA` 审中-公开
标题翻译：用表面等离子体处理表面的方法和装置
公开(公告)号：US20120156091A1
公开(公告)日：2012-06-21
申请号：US13256727
申请日：2010-03-16
申请人： Gregory Fridman , Alexander Fridman , Alexander F. Gutsol , Gennady Friedman
发明人： Gregory Fridman , Alexander Fridman , Alexander F. Gutsol , Gennady Friedman
IPC分类号： A61L2/03
CPC分类号： A61L2/03 , A61L2/14 , A61L2202/24
摘要： Methods and devices for treating surfaces of objects using a non-thermal plasma are disclosed herein. The non-thermal plasma is generated through the use of an apparatus configured to generate a non-thermal plasma on its surface. The apparatus is comprised of a substrate that contains one or more electrodes of different polarity. The electrodes are placed within a layer of the substrate acting as a dielectric layer. The apparatus may also have additional layers to contain the dielectric layer. When an appropriate potential, being either an alternating current or pulsed high voltage potential, is applied and removed from the one or more electrodes, the gas on at least one surface of the apparatus becomes ionized and forms a non-thermal plasma. The electrodes can be configured to be of various shapes and sizes to modify or tune the plasma.
摘要翻译：本文公开了使用非热等离子体处理物体表面的方法和装置。通过使用被配置为在其表面上产生非热等离子体的装置来产生非热等离子体。该装置由含有一个或多个不同极性的电极的基板组成。电极被放置在用作电介质层的衬底的层内。该装置还可以具有附加层以容纳电介质层。当从一个或多个电极施加或移除作为交流或脉冲高电压电位的适当电位时，装置的至少一个表面上的气体被离子化并形成非热等离子体。电极可以被配置为具有各种形状和尺寸以修改或调谐等离子体。

4. 发明申请

US20100145253A1 METHODS FOR NON-THERMAL APPLICATION OF GAS PLASMA TO LIVING TISSUE 有权
标题翻译：将气体等离子体非热应用于生活组织的方法
公开(公告)号：US20100145253A1
公开(公告)日：2010-06-10
申请号：US11911479
申请日：2006-04-25
申请人： Alexander F. Gutsol , Alexander Fridman , Gennady Friedman , Gregory Fridman , Manjula Balasubramanian
发明人： Alexander F. Gutsol , Alexander Fridman , Gennady Friedman , Gregory Fridman , Manjula Balasubramanian
IPC分类号： A61B18/18 , A61N1/00 , A61M31/00
CPC分类号： A61B18/042 , A61N1/40 , H05H1/2406 , H05H2001/2412 , H05H2240/20 , H05H2245/122
摘要： Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.
摘要翻译：公开了用高压放电等离子体对人体或动物组织进行非热处理的方法。所公开的方法采用电流通过等离子体和通过组织而不是用于加热组织的目的，而是将血浆保持在靠近待治疗组织的位置。还公开了一种限制通过等离子体和通过组织的电流的方法，以通过在电极和组织之间放置绝缘体或半导体来最小化组织加热，导致产生类似于电介质阻挡放电的高压放电。所公开的非热等离子体处理可用于促进血液凝结，消毒，消毒，组织再连接，以及治疗组织疾病而不引起明显的热组织损伤。

5. 发明授权

US08521274B2 Methods for non-thermal application of gas plasma to living tissue 有权
标题翻译：气体等离子体对生物体组织非热应用的方法
公开(公告)号：US08521274B2
公开(公告)日：2013-08-27
申请号：US11911479
申请日：2006-04-25
申请人： Alexander F. Gutsol , Alexander Fridman , Gennady Friedman , Gregory Fridman , Manjula Balasubramanian
发明人： Alexander F. Gutsol , Alexander Fridman , Gennady Friedman , Gregory Fridman , Manjula Balasubramanian
IPC分类号： A61N1/06
CPC分类号： A61B18/042 , A61N1/40 , H05H1/2406 , H05H2001/2412 , H05H2240/20 , H05H2245/122
摘要： Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.
摘要翻译：公开了用高压放电等离子体对人体或动物组织进行非热处理的方法。所公开的方法采用电流通过等离子体和通过组织而不是用于加热组织的目的，而是将血浆保持在靠近待治疗组织的位置。还公开了一种限制通过等离子体和通过组织的电流的方法，以通过在电极和组织之间放置绝缘体或半导体来最小化组织加热，导致产生类似于电介质阻挡放电的高压放电。所公开的非热等离子体处理可用于促进血液凝结，消毒，消毒，组织再连接，以及治疗组织疾病而不引起明显的热组织损伤。

6. 发明申请

US20090054896A1 CONTROL OF MUCUS MEMBRANE BLEEDING WITH COLD PLASMA 有权
标题翻译：用冷等离子体处理薄膜的控制
公开(公告)号：US20090054896A1
公开(公告)日：2009-02-26
申请号：US12175756
申请日：2008-07-18
申请人： Gregory Fridman , Alexander Fridman , Alexander Gutsol , Gennady Friedman , David Staack , Richard Joseph Hamilton
发明人： Gregory Fridman , Alexander Fridman , Alexander Gutsol , Gennady Friedman , David Staack , Richard Joseph Hamilton
IPC分类号： A61B18/18
CPC分类号： A61B18/042 , A61B2018/00982
摘要： The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is partially encapsulated by a dielectric. The non-thermal plasma is applied to the area of bleeding for treatment.
摘要翻译：本文描述了使用非热等离子体来治疗粘液膜出血。使用具有从电源接收交流电位的第一电极的装置产生非热等离子体。当放置在靠近组织的适当位置时，产生非热等离子体，第二电极是人体组织，血液等。为了减少产生电弧的可能性，可能导致组织损伤或疼痛，第一电极被电介质部分封装。将非热等离子体施加到出血处理区域。

7. 发明申请

US20130330229A1 PLASMA SYSTEM FOR AIR STERILIZATION 审中-公开
标题翻译：用于空气灭菌的等离子体系统
公开(公告)号：US20130330229A1
公开(公告)日：2013-12-12
申请号：US13637466
申请日：2011-03-30
申请人： Gregory Fridman , Alexander Fridman , Yurii V. Mukhin , Alexander F. Gutsol , Nachiket Vaze
发明人： Gregory Fridman , Alexander Fridman , Yurii V. Mukhin , Alexander F. Gutsol , Nachiket Vaze
IPC分类号： A61L2/14
CPC分类号： A61L2/14 , A61L9/22
摘要： A method for decontaminating bioaerosol with high concentrations of bacterial, viral, spore and other airborne microorganisms or biologic contaminants in flight at high flow rates. A plasma screen created across the flow of air contaminated with airborne biologic agents renders contaminants non-culturable within milliseconds. The technology may cooperate with heating, ventilation, and air conditioning (HVAC) systems. It may be particularly beneficial in preventing bioterrorism and the spread of toxic or infectious agents, containing airborne pandemic threats such as avian flu, sterilizing spaces such as hospitals, pharmaceutical plants and manufacturing facilities, treating exhaust ventilation streams, minimizing biological environmental pollutants in industrial settings, improving general air quality, preventing sick building syndrome.
摘要翻译：用高浓度细菌，病毒，孢子和其他空气传播的微生物或高流量飞行中的生物污染物去除生物气溶胶的方法。在空气传播生物制剂污染的空气流中产生的等离子体屏幕使得污染物在几毫秒内不能培养。该技术可与加热，通风和空调（HVAC）系统配合使用。特别有利于防止生物恐怖主义和包含禽流感等空气传播大流行威胁，医院，制药厂和制造设施等消毒空间的毒性或感染因子的传播，处理排气通风流，尽量减少工业环境中的生物环境污染物提高一般空气质量，预防病态综合征。

8. 发明授权

US08968286B2 Nano discharges in liquids 有权
标题翻译：纳米液体中排出
公开(公告)号：US08968286B2
公开(公告)日：2015-03-03
申请号：US13055998
申请日：2009-08-19
申请人： David Staack , Alexander Gutsol , Alexander Fridman , Yury Gogotsi , Gennady Friedman
发明人： David Staack , Alexander Gutsol , Alexander Fridman , Yury Gogotsi , Gennady Friedman
IPC分类号： A61B18/00 , G01N27/68 , B82Y15/00 , G01N21/67
CPC分类号： A61B18/042 , A61B2018/00125 , B82Y15/00 , G01N21/67 , G01N27/68
摘要： The present invention is direct to a nano-probe corona tool and uses thereof. A nano-probe corona tool is disclosed having a tip with a diameter in the nano-scale, typically around 100 nm. The nano-probe corona tool is constructed of electrically conductive material. On the other end of the tool, a pulsed voltage source outputs a pulsed voltage to generated a pulsed electrical potential at the tip. The pulsed electrical potential at the tip causes a plasma discharge corona to occur. Uses of the corona discharge include, but are not limited to, optical emission spectroscopy, in the enhancement of deposition of coatings and nanoscale welding, e.g., nanotube or nanowires to a contact pad and welding two nanowires together, and in nanoscale surgery. For example, a nano-probe comprising CNTs may be inserted into cell membranes. The resulting corona discharge may be used to destroy tumors within the cell.
摘要翻译：本发明直接涉及纳米探针电晕工具及其应用。公开了纳米探针电晕工具，其具有直径在纳米级的尖端，通常为约100nm。纳米探针电晕工具由导电材料构成。在工具的另一端，脉冲电压源输出脉冲电压以在尖端产生脉冲电位。尖端处的脉冲电位导致发生等离子体放电电晕。电晕放电的使用包括但不限于光学发射光谱法，用于增强涂层的沉积和纳米尺度焊接，例如纳米管或纳米线到接触焊盘，并将两个纳米线焊接在一起，以及在纳米级手术中。例如，可以将包含CNT的纳米探针插入细胞膜。所产生的电晕放电可用于破坏细胞内的肿瘤。

9. 发明申请

US20120296265A1 APPARATUS FOR ATMOSPHERIC PRESSURE PIN-TO-HOLE SPARK DISCHARGE AND USES THEREOF 有权
标题翻译：大气压针孔到火花放电的装置及其用途
公开(公告)号：US20120296265A1
公开(公告)日：2012-11-22
申请号：US13256556
申请日：2010-03-16
申请人： Danil V. Dobrynin , Alexander Fridman , Young I. Cho , Gregory Fridman , Gennady Friedman
发明人： Danil V. Dobrynin , Alexander Fridman , Young I. Cho , Gregory Fridman , Gennady Friedman
IPC分类号： A61M37/00
CPC分类号： A61N1/44 , A61N1/0468 , A61N1/0472
摘要： Disclosed herein are atmospheric pressure pin-to-hole pulsed spark discharge devices and methods for creating plasma. The devices include a conduit for fluidically communicating a gas, a plasma, or both, therethrough, portion of the conduit capable of being connected to a gas supply, and a second portion of the conduit capable of emitting a plasma; a positive electrode comprising a sharp tip; and a ground plate electrode. Disclosed are methods for treating a skin ulcer using non-thermal plasma include flowing a gas through a cold spark discharge zone simultaneously with the creation of a pulsed spark discharge to give rise to a non-thermal plasma emitted from a conduit, the non-thermal plasma comprising NO; and contacting a skin ulcer with said non-thermal plasma for sufficient time and intensity to give rise to treatment of the skin ulcer.
摘要翻译：本文公开了大气压针对孔脉冲火花放电装置和用于产生等离子体的方法。这些装置包括用于使气体，等离子体或两者流体连通的管道，其能够连接到气体源的导管部分和能够发射等离子体的导管的第二部分; 包括锋利尖端的正电极; 和接地板电极。公开了使用非热等离子体治疗皮肤溃疡的方法，包括在产生脉冲火花放电的同时使气体流过冷火花放电区，以产生从导管发射的非热等离子体，非热等离子体包含NO; 并使皮肤溃疡与所述非热等离子体接触足够的时间和强度以引起皮肤溃疡的治疗。

10. 发明授权

US08992518B2 Methods and devices for the treatment and prevention of malignancy in enteric diseases using non-thermal plasma 有权
标题翻译：使用非热等离子体治疗和预防肠道疾病恶性肿瘤的方法和装置
公开(公告)号：US08992518B2
公开(公告)日：2015-03-31
申请号：US13256313
申请日：2010-03-16
申请人： Gregory Fridman , Danil V. Dobrynin , Alexander Fridman , Gennady Friedman , Kalyan Chakravarthy , Sreekant Murthy
发明人： Gregory Fridman , Danil V. Dobrynin , Alexander Fridman , Gennady Friedman , Kalyan Chakravarthy , Sreekant Murthy
IPC分类号： A61B18/18 , A61N1/40 , H05H1/24
CPC分类号： A61N1/40 , H05H1/24 , H05H1/2406 , H05H2001/2412 , H05H2001/245 , H05H2240/20 , H05H2245/122
摘要： Non-thermal plasma is a partly ionized gas, which can be generated by a high-voltage electric field at a low pressure. Disclosed herein are apparatuses and methods for treating an enteric disease in vivo using non-thermal plasma. The disclosed apparatuses have a first conduit comprising a lumen and a tip; a first electrode disposed within the lumen of the first conduit; a second electrode comprised of a metal conduit disposed within the first conduit; an insulator disposed within the lumen of the first conduit, the insulator configured to electrically insulate the first electrode from the second electrode; and a gas channel disposed between the outer surface of the metal conduit and the inner surface of the first conduit, the gas channel being capable of feeding a gas from a gas source to the tip, wherein when the potential is applied, the gas is ionized to produce the non-thermal plasma.
摘要翻译：非热等离子体是部分电离的气体，其可以通过低压下的高压电场产生。本文公开了使用非热等离子体在体内治疗肠道疾病的装置和方法。所公开的装置具有包括内腔和尖端的第一导管; 设置在所述第一导管的内腔内的第一电极; 第二电极，包括设置在第一导管内的金属导管; 设置在所述第一导管的内腔内的绝缘体，所述绝缘体被配置为使所述第一电极与所述第二电极电绝缘; 以及设置在金属导管的外表面和第一导管的内表面之间的气体通道，气体通道能够将气体从气体源供给到尖端，其中当施加电位时，气体被电离以产生非热等离子体。

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