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1. 发明申请

US20060122240A1 Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof 审中-公开
标题翻译：苯并三唑及其代谢相关疾病的预防或治疗方法
公开(公告)号：US20060122240A1
公开(公告)日：2006-06-08
申请号：US10533799
申请日：2003-11-04
申请人： Graeme Semple , Philip Skinner , Martin Cherrier , Peter Webb , Susan Tamura
发明人： Graeme Semple , Philip Skinner , Martin Cherrier , Peter Webb , Susan Tamura
IPC分类号： C07D249/16 , A61K31/4192
CPC分类号： C07D405/06 , A61K31/4192 , C07D249/18
摘要： The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
摘要翻译：本发明涉及一些表现出有用的药物性质的式（I）的苯并三唑羧酸或酯衍生物，其药学上可接受的盐和溶剂化物，例如被称为hRUP38的GPCR的激动剂。本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病（包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，类型 2型糖尿病，综合征X等。此外，本发明还提供本发明化合物与其它活性剂如属于葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

2. 发明申请

US20110228404A1 Fiber-Coupled Collimator for Generating Multiple Collimated Optical Beams Having Different Wavelengths 有权
标题翻译：用于产生具有不同波长的多个准直光束的光纤耦合准直器
公开(公告)号：US20110228404A1
公开(公告)日：2011-09-22
申请号：US12729187
申请日：2010-03-22
申请人： Peter Webb , David Lande
发明人： Peter Webb , David Lande
IPC分类号： G02B27/30
CPC分类号： G02B27/30 , G02B6/327
摘要： An apparatus for providing multiple collimated light beams from optical fibers and the method for producing such beams. The apparatus includes first and second optical fibers that carry light of first and second wavelengths, respectively, a fixture that maintains the fibers in a fixed relationship to one another, and a collimating lens. Light from each of the first and second optical fibers diverges from a face of the fixture. The collimating lens produces first and second collimated light beams that are displaced relative to one another from the light leaving the face. The face of the fixture is positioned to correct for chromatic aberration in the lens.
摘要翻译：一种用于从光纤提供多个准直光束的装置以及用于产生这种光束的方法。该装置包括分别承载第一和第二波长的光的第一和第二光纤，将光纤保持彼此固定关系的固定装置和准直透镜。来自第一和第二光纤中的每一个的光从夹具的表面发散。准直透镜产生第一和第二准直光束，其相对于彼此离开离开面部的光而相对移动。固定装置的表面被定位以校正透镜中的色差。

3. 发明申请

US20060116827A1 Systems and methods for producing chemical array layouts 审中-公开
公开(公告)号：US20060116827A1
公开(公告)日：2006-06-01
申请号：US11000681
申请日：2004-11-30
申请人： Peter Webb , Charles Nelson , Amitabh Shukla , Marylinn Munson
发明人： Peter Webb , Charles Nelson , Amitabh Shukla , Marylinn Munson
IPC分类号： G06F19/00 , G06Q10/00 , G06Q50/00
CPC分类号： G06Q50/22 , G16B25/00 , G16B50/00
摘要： Systems and methods for using the same to obtain a chemical array layout are provided. Also provided are computer program products for executing the subject methods.

4. 发明申请

US20050106754A1 Fabricating biopolymer arrays 失效
标题翻译：制造生物聚合物阵列
公开(公告)号：US20050106754A1
公开(公告)日：2005-05-19
申请号：US10932886
申请日：2004-09-01
申请人： Michael Caren , Carol Schembri , Peter Webb
发明人： Michael Caren , Carol Schembri , Peter Webb
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/2575
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.
摘要翻译：一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。头部具有储存室和至少一个可将液滴分配到基底上的射流。喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。射流还包括喷射器，其在被激活时使得液滴从孔口喷出。该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室面对并邻近孔口。头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

5. 发明授权

US5699806A Ultrasound system with nonuniform rotation corrector 失效
标题翻译：超声系统与不均匀旋转校正器
公开(公告)号：US5699806A
公开(公告)日：1997-12-23
申请号：US724203
申请日：1996-10-01
申请人： Peter Webb , Edward Verdonk
发明人： Peter Webb , Edward Verdonk
IPC分类号： A61B8/12 , G01S7/52 , G01S15/89
CPC分类号： A61B8/12 , A61B8/587 , G01S15/894 , G01S7/52049
摘要： An ultrasound apparatus for imaging tissues from interior of a cavity in the body of a patient is disclosed. The apparatus includes a probe for entering the body to the cavity. The probe has a distal end for entering the body and a proximal end to extend outside the body. At the distal end of the probe is a transducer associated with a rotatable mechanism for transmitting sequential ultrasonic pulses as the rotatable mechanism rotates, forming an angular pattern of transmitted pulses. Ultrasonic energy reflected and scattered from the patient's body tissues is received by an transducer so that each pulse generates a received signal (RF-line). The apparatus has a mechanism for identifying the angular separation between the RF-lines by analyzing the RF-lines caused by reflection and scattering by the body tissues alone. In this way, any distortion caused by the difference between the transmitted angular pattern and the intended angular pattern, if present, can be determined and corrected.
摘要翻译：公开了一种用于从患者体内的空腔内部对组织进行成像的超声波装置。该装置包括用于将身体进入空腔的探针。探针具有用于进入身体的远端和近端延伸到身体外部。在探头的远端处是与可旋转机构相关联的换能器，用于在可旋转机构旋转时传送顺序超声波脉冲，形成发射脉冲的角度图案。通过换能器接收从患者身体组织反射和散射的超声能量，使得每个脉冲产生接收信号（RF线）。该装置具有通过分析由单独的身体组织的反射和散射引起的RF线来识别RF线之间的角度间隔的机构。以这种方式，可以确定和校正由传输的角度图案与预期角度图案之间的差异（如果存在）引起的任何失真。

6. 发明申请

US20080027655A1 Systems and methods for probe selection 审中-公开
标题翻译：用于探针选择的系统和方法
公开(公告)号：US20080027655A1
公开(公告)日：2008-01-31
申请号：US11495331
申请日：2006-07-28
申请人： Charles F. Nelson , Jing Gao , Peter Webb , Amitabh Shukla
发明人： Charles F. Nelson , Jing Gao , Peter Webb , Amitabh Shukla
IPC分类号： G06F19/00
CPC分类号： G16B30/00 , G16B25/00
摘要： Systems and methods for using the same to select probes specific for a target nucleic acid are provided. Also provided are computer program products for executing the subject methods.
摘要翻译：提供了使用其选择对靶核酸特异的探针的系统和方法。还提供了用于执行主题方法的计算机程序产品。

7. 发明申请

US20070100563A1 Probe selection methods, computer program products, systems and arrays 审中-公开
标题翻译：探头选择方法，计算机程序产品，系统和阵列
公开(公告)号：US20070100563A1
公开(公告)日：2007-05-03
申请号：US11377325
申请日：2006-03-15
申请人： Peter Webb
发明人： Peter Webb
IPC分类号： G06F19/00
CPC分类号： G16B25/00
摘要： Probe selection methods, computer program products, systems and arrays are provided. The probes can be used, for example, in genome scanning applications such as array CGH and/or location analysis.
摘要翻译：提供探头选择方法，计算机程序产品，系统和阵列。探针可用于例如基因组扫描应用，例如阵列CGH和/或位置分析。

8. 发明申请

US20060115822A1 Systems and methods for probe design 审中-公开
标题翻译：探针设计的系统和方法
公开(公告)号：US20060115822A1
公开(公告)日：2006-06-01
申请号：US11001672
申请日：2004-11-30
申请人： Peter Webb , Charles Nelson , Amitabh Shukla , Marylinn Munson
发明人： Peter Webb , Charles Nelson , Amitabh Shukla , Marylinn Munson
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06Q50/22 , B01J2219/00378 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , G16B25/00 , G16B50/00
摘要： Systems and methods for using the same to obtain one or more probe sequences, e.g., for use on an array, are provided. Also provided are computer program products for executing the subject methods.
摘要翻译：提供了使用其来获得一个或多个探针序列的系统和方法，例如用于阵列上。还提供了用于执行主题方法的计算机程序产品。

9. 发明申请

US20060051493A1 Apparatus and methods for printing arrays 审中-公开
标题翻译：打印阵列的装置和方法
公开(公告)号：US20060051493A1
公开(公告)日：2006-03-09
申请号：US10630490
申请日：2003-07-29
申请人： Richard Tella , William Fisher , Michael Caren , Lawrence DaQuino , Peter Webb
发明人： Richard Tella , William Fisher , Michael Caren , Lawrence DaQuino , Peter Webb
IPC分类号： A61L33/00 , B05D3/00 , B05C11/00
CPC分类号： B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00722 , B01L9/52
摘要： Apparatus and methods are disclosed for printing a plurality of biopolymer features on the surfaces of substrates. An apparatus comprises a substrate mount for receiving a substrate, a dispensing device for dispensing reagents for synthesizing a biopolymer on a surface of the substrate, an optical system for positioning the substrate mount along a y-axis and an optical system for positioning the dispensing device along an x-axis. The apparatus may comprise a touch system for positioning the substrate and the dispensing device along a z-axis. One of the substrate mount or the dispensing device is adapted for translation along the y-axis and for rotation about a central axis that is parallel to a z-axis. The other of the above is adapted to move along the x-axis transversely to the direction of, and independently of, movement of the one adapted for translation along the y-axis. The optical systems cooperate to position the substrate mount and the dispensing device relative to one another. Also disclosed in conjunction with the apparatus and methods are washing stations and loading stations.
摘要翻译：公开了用于在基板的表面上印刷多个生物聚合物特征的装置和方法。一种装置包括用于接收基板的基板支架，用于分配用于在基板的表面上合成生物聚合物的试剂的分配装置，用于沿y轴定位基板支架的光学系统和用于定位分配装置的光学系统沿x轴。该装置可以包括用于沿z轴定位衬底和分配装置的触摸系统。衬底安装件或分配装置中的一个适于沿着y轴平移并围绕平行于z轴的中心轴线旋转。上述中的另一个适于沿着沿着y轴的适于平移的一个的移动的方向横向移动x轴。光学系统协作以相对于彼此定位衬底安装件和分配装置。还结合装置和方法公开的是洗涤站和装载站。

10. 发明申请

US20060036373A1 Method and system for cropping an image of a multi-pack of microarrays 审中-公开
标题翻译：用于裁剪多包微阵列图像的方法和系统
公开(公告)号：US20060036373A1
公开(公告)日：2006-02-16
申请号：US10915849
申请日：2004-08-11
申请人： Srinka Ghosh , Peter Webb
发明人： Srinka Ghosh , Peter Webb
IPC分类号： G06F19/00 , G06K9/00 , G01N33/48 , G01N33/50
CPC分类号： G06K9/00 , G06T7/12 , G06T7/70 , G06T2207/20056 , G06T2207/20068 , G06T2207/30072
摘要： A method and system for cropping a digital image of multiple individual microarrays. Various embodiments of the present invention include, a digital image of multiple individual microarrays projected along a first coordinate axis by summing columns of pixel intensity values. A transformation maps the projected pixel intensity values to a transform in a frequency domain. A filter function is constructed from a power spectrum of the transform and multiplied by the transform to obtain a filtered transform. The filtered transform is mapped back to the spatial domain to give the filtered, spatial-domain image. The filtered, spatial-domain image is used to determine the coordinates of boundaries separating the individual microarrays along the first coordinate axis. The multi-pack of microarrays is rotated, and the method may be repeated for a second coordinate axis that is perpendicular to the first coordinate axis. The boundaries are used to identify the boundaries separating individual microarrays.
摘要翻译：用于裁剪多个单个微阵列的数字图像的方法和系统。本发明的各种实施例包括通过对像素强度值的列求和来沿着第一坐标轴投影的多个单独的微阵列的数字图像。 A变换将投影像素强度值映射到频域中的变换。滤波函数由变换的功率谱构成，并与变换相乘以获得滤波变换。滤波后的变换映射回空间域，以给出过滤的空间域图像。滤波后的空间域图像用于确定沿着第一坐标轴分开各个微阵列的边界的坐标。旋转多组微阵列，并且对于垂直于第一坐标轴的第二坐标轴可以重复该方法。边界用于识别分离各个微阵列的边界。

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