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1. 发明申请

US20060051493A1 Apparatus and methods for printing arrays 审中-公开
标题翻译：打印阵列的装置和方法
公开(公告)号：US20060051493A1
公开(公告)日：2006-03-09
申请号：US10630490
申请日：2003-07-29
申请人： Richard Tella , William Fisher , Michael Caren , Lawrence DaQuino , Peter Webb
发明人： Richard Tella , William Fisher , Michael Caren , Lawrence DaQuino , Peter Webb
IPC分类号： A61L33/00 , B05D3/00 , B05C11/00
CPC分类号： B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00722 , B01L9/52
摘要： Apparatus and methods are disclosed for printing a plurality of biopolymer features on the surfaces of substrates. An apparatus comprises a substrate mount for receiving a substrate, a dispensing device for dispensing reagents for synthesizing a biopolymer on a surface of the substrate, an optical system for positioning the substrate mount along a y-axis and an optical system for positioning the dispensing device along an x-axis. The apparatus may comprise a touch system for positioning the substrate and the dispensing device along a z-axis. One of the substrate mount or the dispensing device is adapted for translation along the y-axis and for rotation about a central axis that is parallel to a z-axis. The other of the above is adapted to move along the x-axis transversely to the direction of, and independently of, movement of the one adapted for translation along the y-axis. The optical systems cooperate to position the substrate mount and the dispensing device relative to one another. Also disclosed in conjunction with the apparatus and methods are washing stations and loading stations.
摘要翻译：公开了用于在基板的表面上印刷多个生物聚合物特征的装置和方法。一种装置包括用于接收基板的基板支架，用于分配用于在基板的表面上合成生物聚合物的试剂的分配装置，用于沿y轴定位基板支架的光学系统和用于定位分配装置的光学系统沿x轴。该装置可以包括用于沿z轴定位衬底和分配装置的触摸系统。衬底安装件或分配装置中的一个适于沿着y轴平移并围绕平行于z轴的中心轴线旋转。上述中的另一个适于沿着沿着y轴的适于平移的一个的移动的方向横向移动x轴。光学系统协作以相对于彼此定位衬底安装件和分配装置。还结合装置和方法公开的是洗涤站和装载站。

2. 发明申请

US20050106754A1 Fabricating biopolymer arrays 失效
标题翻译：制造生物聚合物阵列
公开(公告)号：US20050106754A1
公开(公告)日：2005-05-19
申请号：US10932886
申请日：2004-09-01
申请人： Michael Caren , Carol Schembri , Peter Webb
发明人： Michael Caren , Carol Schembri , Peter Webb
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/2575
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.
摘要翻译：一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。头部具有储存室和至少一个可将液滴分配到基底上的射流。喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。射流还包括喷射器，其在被激活时使得液滴从孔口喷出。该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室面对并邻近孔口。头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

3. 发明申请

US20050026154A1 Masking chemical arrays 审中-公开
标题翻译：掩蔽化学阵列
公开(公告)号：US20050026154A1
公开(公告)日：2005-02-03
申请号：US10633609
申请日：2003-07-31
申请人： Laurakay Bruhn , Douglas Amorese , Michael Caren , Leslie Leonard , Richard Pittaro , Carol Schembri , Peter Webb , Paul Wolber
发明人： Laurakay Bruhn , Douglas Amorese , Michael Caren , Leslie Leonard , Richard Pittaro , Carol Schembri , Peter Webb , Paul Wolber
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68 , C40B40/06 , G01N21/25 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/58 , G06F19/00
CPC分类号： B01L3/545 , B01J2219/00662 , B01J2219/00693 , B01J2219/00722 , B01L3/5088 , B01L2200/025 , B01L2300/024 , B01L2300/0819 , C40B40/06 , G01N21/253
摘要： A method of using a chemical array unit having a chemical array with probes at multiple feature locations. A request for test may be read, which test uses a sub-array of the array. A pattern of the sub-array may be retrieved from a memory using the test request, which memory carries a pattern for the sub-array which is retrievable with the different test request. Also, a method of reading a chemical array unit which has been exposed to a sample, and feature locations of which have been rendered incapable of providing signal data representative of binding of a sample component. Further methods, apparatus, and computer program products are provided.
摘要翻译：一种在多个特征位置使用具有化学阵列的化学阵列单元和探针的方法。可以读取测试请求，哪个测试使用数组的子阵列。可以使用测试请求从存储器检索子阵列的模式，该存储器携带用于使用不同测试请求可检索的子阵列的模式。此外，读取已经暴露于样品的化学阵列单元的方法，其特征位置已经不能提供表示样品组分的结合的信号数据。提供其他方法，装置和计算机程序产品。

4. 发明申请

US20070238105A1 High resolution chromosomal mapping 有权
标题翻译：高分辨率染色体定位
公开(公告)号：US20070238105A1
公开(公告)日：2007-10-11
申请号：US11400481
申请日：2006-04-07
申请人： Michael Barrett , Michael Caren
发明人： Michael Barrett , Michael Caren
IPC分类号： C12Q1/68 , C12P19/34 , C12M3/00
CPC分类号： C12Q1/6841
摘要： The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. For instance, the oligonucleotides may be at least substantially complementary to the chromosome, e.g., substantially complementary to a specific location of the chromosome.
摘要翻译：本发明一般涉及空间和结构基因组分析组合物，其可以用于染色体的定位和染色体重排的结构分析，包括整个染色体以及染色体感兴趣的具体部分或区域。在一些实施例中，可以区分基因组的多个部分，例如使用不同于第一检测实体的第一检测实体和第二检测实体。检测实体可以相对于寡核苷酸被固定，寡核苷酸可被选择以结合染色体内的不同位置。例如，寡核苷酸可以至少基本上与染色体互补，例如与染色体的特定位置基本互补。

5. 发明申请

US20050116986A1 Method and apparatus to clean an inkjet reagent deposition device 失效
标题翻译：清洁喷墨试剂沉积装置的方法和装置
公开(公告)号：US20050116986A1
公开(公告)日：2005-06-02
申请号：US10952234
申请日：2004-09-27
申请人： Michael Caren , Carol Schembri
发明人： Michael Caren , Carol Schembri
IPC分类号： B01J19/00 , B41J2/165 , C40B40/06 , C40B60/14
CPC分类号： B41J2/1707 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B41J2/16552 , C40B40/06 , C40B60/14
摘要： A method is described for removing residue from a fluid deposited on the interior surface of an inkjet printhead after the printhead has contained or dispensed the fluid at least once. The method makes use of a reverse flushing technique optionally used in combination with sonication. A cleaning station for flushing an inkjet printhead with a wash fluid, rinse fluid, and/or inert gas is provided as well.
摘要翻译：描述了一种用于在打印头已经包含或分配流体至少一次之后从沉积在喷墨打印头的内表面上的流体去除残留物的方法。该方法利用可选地与超声波结合使用的反冲洗技术。还提供了用于冲洗具有洗涤流体，冲洗流体和/或惰性气体的喷墨打印头的清洁站。

6. 发明申请

US20050084866A1 Methods and apparatus for sample mixing 审中-公开
标题翻译：样品混合的方法和装置
公开(公告)号：US20050084866A1
公开(公告)日：2005-04-21
申请号：US10687277
申请日：2003-10-15
申请人： Michael Caren , Carol Schembri
发明人： Michael Caren , Carol Schembri
IPC分类号： B01F11/00 , B01F13/00 , B01L3/00 , G01N1/10 , C12Q1/68
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/50273 , B01L2300/0636 , B01L2300/0825 , B01L2400/0481 , Y10T436/2575
摘要： Apparatus and methods for mixing fluids are disclosed. An apparatus comprises a housing or channel having an interior with capillary dimensions and a pressure activated mechanism in fluid communication with the interior. The pressure activated mechanism is activatable to cause motion of fluid in the interior of the housing thereby mixing the fluid in the interior. An apparatus may comprise an activating mechanism for activating the pressure activated mechanism. Typically, at least a portion of the interior of the housing comprises a linear array of features for conducting chemical reactions. Optionally, an apparatus comprises a fluid dispensing device.
摘要翻译：公开了用于混合流体的装置和方法。一种装置包括具有毛细管尺寸内部和与内部流体连通的压力启动机构的壳体或通道。压力激活机构可激活以引起壳体内部的流体的运动，从而将流体混合在内部。设备可以包括用于启动压力启动机构的启动机构。通常，壳体内部的至少一部分包括用于进行化学反应的线性阵列的特征。可选地，装置包括流体分配装置。

7. 发明申请

US20050064436A1 Methods and compositions for identifying patient samples 审中-公开
标题翻译：用于鉴定患者样品的方法和组合物
公开(公告)号：US20050064436A1
公开(公告)日：2005-03-24
申请号：US10670862
申请日：2003-09-24
申请人： Michael Barrett , Michael Caren
发明人： Michael Barrett , Michael Caren
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883
摘要： Methods and compositions for identifying patient samples are provided. In practicing the subject methods, an SNP profile is determined for a nucleic acid sample, where the determined SNP profile is then employed to identify the source of the sample, e.g., the subject or patient from which the sample was obtained. Also provided are methods of assaying subjects for a condition, e.g., a disease condition, where the assays included an SNP profile based sample source identification step. In addition, compositions and kits for use in practicing the subject methods are provided. The subject methods and compositions find use in a variety of different applications, and are particularly suited for use in clinical assay applications.
摘要翻译：提供了用于鉴定患者样品的方法和组合物。在实施本发明方法时，确定核酸样品的SNP谱，其中确定的SNP谱用于鉴定样品的来源，例如获得样品的受试者或患者。还提供了测定受试者的病症，例如疾病状况的方法，其中测定包括基于SNP分布的样品源鉴定步骤。另外，提供了用于实践本发明方法的组合物和试剂盒。本发明的方法和组合物可用于各种不同的应用，并且特别适用于临床测定应用。

8. 发明申请

US20050112588A1 Methods and apparatus for analyzing arrays 审中-公开
标题翻译：分析阵列的方法和装置
公开(公告)号：US20050112588A1
公开(公告)日：2005-05-26
申请号：US10722228
申请日：2003-11-25
申请人： Michael Caren , Douglas Amorese
发明人： Michael Caren , Douglas Amorese
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/629
摘要： Devices, apparatus and methods for conducting hybridization reactions are disclosed. An embodiment of a device comprises two chambers in fluid communication. Each of the chambers has an interior wherein one of the chambers has at least one interior dimension that is larger (larger chamber) than at least one interior dimension of the other of the chambers (smaller chamber). Each of the interiors comprises an array of features.
摘要翻译：公开了用于进行杂交反应的装置，装置和方法。装置的一个实施例包括流体连通的两个腔室。每个室具有内部，其中一个室具有比另一个室（较小室）的至少一个内部尺寸更大（更大的室）的至少一个内部尺寸。每个内部都包括一组特征。

9. 发明申请

US20050089903A1 Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids 审中-公开
标题翻译：使用样品流体的热喷墨沉积进行基于阵列的杂交测定的方法
公开(公告)号：US20050089903A1
公开(公告)日：2005-04-28
申请号：US10933122
申请日：2004-09-01
申请人： Michael Caren , Kevin Luebke
发明人： Michael Caren , Kevin Luebke
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B60/14 , C12Q1/68 , G01N33/53
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Methods are provided for depositing a quantity of fluid onto the surface of an array. In the subject methods, a thermal inkjet head loaded with the fluid is positioned in opposing relationship to, e.g. over, the array surface. Actuation of the thermal ink-jet results in the expulsion of a quantity of fluid onto the array surface. The subject methods find particular use in array-based binding assays in which an array of binding agents is employed for the detection of an analyte(s), particularly array-based hybridization assays.
摘要翻译：提供了将数量的流体沉积到阵列的表面上的方法。在本发明的方法中，装载有流体的热喷墨头以例如相对的方式定位。在阵列表面。热喷墨的致动导致将一定量的流体排出到阵列表面上。主题方法在基于阵列的结合测定中特别有用，其中使用结合剂阵列来检测分析物，特别是基于阵列的杂交测定法。

10. 发明申请

US20050083781A1 Methods and apparatus for mixing of liquids 失效
标题翻译：混合液体的方法和装置
公开(公告)号：US20050083781A1
公开(公告)日：2005-04-21
申请号：US10687276
申请日：2003-10-15
申请人： Michael Caren , Carol Schembri
发明人： Michael Caren , Carol Schembri
IPC分类号： B01F5/06 , B01F13/00 , B01F15/02 , B01L3/00 , C40B60/14 , G01N35/00 , G01N35/04 , B01F9/10
CPC分类号： B01F15/0201 , B01F5/061 , B01F13/0059 , B01F15/0233 , B01F2005/0621 , B01F2005/0636 , B01F2215/0431 , B01J2219/00326 , B01J2219/0052 , B01J2219/00657 , B01J2219/00702 , B01L3/50273 , B01L2200/10 , B01L2300/0636 , B01L2300/0806 , B01L2300/0867 , B01L2400/0409 , B01L2400/0688 , B01L2400/086 , C40B60/14 , G01N2035/00237 , G01N2035/0449 , Y10S366/01 , Y10S366/03
摘要： An apparatus for mixing fluids comprises a housing having at least a portion of its interior, for example, a channel, with capillary dimensions and at least one structural member in the interior adjacent an end of the channel. The dimensions of and placement of the structural member are sufficient such that intermittent application of centrifugal force to the interior of the housing causes movement of the fluid therein. The housing may comprise a mixing chamber or area that is in fluid communication with the interior. The apparatus may comprise a mechanism adapted to generate centrifugal force within the housing to cause movement of fluid in the interior of the housing without exit of fluid therefrom.
摘要翻译：用于混合流体的装置包括壳体，其具有其内部的至少一部分，例如具有毛细管尺寸的通道，并且在内部中的至少一个结构构件邻近通道的端部。结构构件的尺寸和放置是足够的，使得将离心力间歇地施加到壳体内部导致其中的流体的移动。壳体可以包括与内部流体连通的混合室或区域。该装置可以包括适于在壳体内产生离心力的机构，以引起流体在壳体内部的移动而不从其流出流体。

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