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1. 发明授权

US07811804B2 Nitrilases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：腈水解酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US07811804B2
公开(公告)日：2010-10-12
申请号：US12556528
申请日：2009-09-09
申请人： Grace DeSantis , Jay Short , Mark Burk , Kelvin Wong , Kelly Chatman , Bob Farwell
发明人： Grace DeSantis , Jay Short , Mark Burk , Kelvin Wong , Kelly Chatman , Bob Farwell
IPC分类号： C12N9/78 , C12P21/04 , C12N15/00 , C12N1/20 , C12Q1/00 , C07H21/04 , C12Q1/68
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

2. 发明授权

US08088613B2 Nitrilases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：腈水解酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08088613B2
公开(公告)日：2012-01-03
申请号：US12773317
申请日：2010-05-04
申请人： Mark Burk , Kelly Chatman , Grace Desantis , Bob Farwell , Jay M. Short , Kelvin Wong
发明人： Mark Burk , Kelly Chatman , Grace Desantis , Bob Farwell , Jay M. Short , Kelvin Wong
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , C07H21/04
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

3. 发明申请

US20100009426A1 Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
公开(公告)号：US20100009426A1
公开(公告)日：2010-01-14
申请号：US12556528
申请日：2009-09-09
申请人： Grace DeSantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Kelly Chatman , Robert Farwell
发明人： Grace DeSantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Kelly Chatman , Robert Farwell
IPC分类号： C12N9/78
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

4. 发明申请

US20120009637A1 Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them 失效
标题翻译： Nitrilases，Nucleic Acids编码他们和制造和使用它们的方法
公开(公告)号：US20120009637A1
公开(公告)日：2012-01-12
申请号：US13236862
申请日：2011-09-20
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
IPC分类号： C12P7/40 , C07H21/04 , C12N1/19 , C12N15/63 , C12N9/78 , C12N1/21
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

5. 发明申请

US20100216214A1 Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
标题翻译： Nitrilases，编码它们的核酸及其制备和使用方法
公开(公告)号：US20100216214A1
公开(公告)日：2010-08-26
申请号：US12773317
申请日：2010-05-04
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
IPC分类号： C12N9/78
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

6. 发明授权

US08318471B2 Nitrilases, nucleic acids encoding them and methods for making and using them 失效
公开(公告)号：US08318471B2
公开(公告)日：2012-11-27
申请号：US13236862
申请日：2011-09-20
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12P21/06 , C12Q1/00 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

7. 发明授权

US07608445B1 Nitrilases, nucleic acids encoding them and methods for making and using them 失效
标题翻译：腈水解酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US07608445B1
公开(公告)日：2009-10-27
申请号：US10514004
申请日：2003-05-15
申请人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
发明人： Grace Desantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Robert Farwell , Kelly Chatman
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12N9/78 , C12P7/42 , C12P13/04 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

8. 发明申请

US20050153407A1 Chemoenzymatic methods for the synthesis of statins and stain intermediates 失效
标题翻译：用于合成他汀类和染色中间体的化学酶学方法
公开(公告)号：US20050153407A1
公开(公告)日：2005-07-14
申请号：US10472157
申请日：2003-08-19
申请人： William Greenberg , Mark Burk , Alexander Varvak , Kelvin Wong
发明人： William Greenberg , Mark Burk , Alexander Varvak , Kelvin Wong
IPC分类号： A01H1/00 , A01K67/027 , C07H21/04 , C12N9/10 , C12N9/88 , C12N15/82 , C12P20060101 , C12P7/42 , C12P7/62 , C12P13/00 , C12P17/02 , C12P17/06 , C12P17/10 , C12P17/12
CPC分类号： C12P13/004 , C12N9/88 , C12P7/42 , C12P17/02 , C12P17/06 , C12P17/10 , C12P17/12
摘要： The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
摘要翻译：本发明提供了新的醛缩酶，编码它们的核酸以及制备和使用它们的方法，包括制备β，δ-二羟基庚酸侧链的化学酶法和包含这些侧链的组合物，例如[R-（R *，R *） ] -2-（4-氟苯基）-b，d-二羟基-5-（1-甲基乙基）-3-苯基-4-（苯基氨基） - 羰基] -1H-吡咯-1-庚酸（阿托伐他汀，LIPITOR TM）），罗苏伐他汀（CRESTOR TM），氟伐他汀（LESCOL TM）），相关化合物及其中间体。

9. 发明授权

US07996801B2 Methods and systems for on-the-fly chip verification 有权
标题翻译：用于实时芯片验证的方法和系统
公开(公告)号：US07996801B2
公开(公告)日：2011-08-09
申请号：US12188749
申请日：2008-08-08
申请人： Kelvin Wong
发明人： Kelvin Wong
IPC分类号： G06F17/50
CPC分类号： G06F17/5022
摘要： Methods and systems for on-the-fly chip verification method for tracking non-contiguous events. A method includes comparing a first search marker associated with a first check vector to a search key associated with an output vector of a design under test (DUT). The method also includes performing either: verifying a validity of the output vector when the first search marker equals the search key, or comparing a second search marker associated with a second check vector to the search key when the first search marker does not equal the search key.
摘要翻译：用于跟踪非连续事件的用于实时芯片验证方法的方法和系统。一种方法包括将与第一校验向量相关联的第一搜索标记与与待测设计（DUT）的输出向量相关联的搜索关键字进行比较。该方法还包括执行以下操作之一：当第一搜索标记等于搜索关键字时验证输出向量的有效性，或者当第一搜索标记不等于搜索时，将与第二检查向量相关联的第二搜索标记与搜索关键字进行比较键。

10. 发明授权

US07882900B2 Power tool with signal generator 有权
标题翻译：带信号发生器的电动工具
公开(公告)号：US07882900B2
公开(公告)日：2011-02-08
申请号：US12198712
申请日：2008-08-26
申请人： Gianni Borinato , Kelvin Wong , Shisong Zhang , Paolo Andriolo , Warren Brown , Hongfeng Zhong , Fangshi Liu , Chengzhong Chen
发明人： Gianni Borinato , Kelvin Wong , Shisong Zhang , Paolo Andriolo , Warren Brown , Hongfeng Zhong , Fangshi Liu , Chengzhong Chen
IPC分类号： B23B45/02
CPC分类号： B23B45/008 , B25B21/008 , B25F5/001 , Y10T74/19274
摘要： A power tool includes a housing, a motor, an output shaft, a gear transmission mechanism and a control system. The gear transmission mechanism is connected between the motor and the output shaft to transmit the rotary power of the motor to the output shaft. The power tool includes a signal generator and a control system electrically coupled to the signal generator and operatively engaged with the gear transmission mechanism such that when the signal generator is manually activated, an electric signal is generated and transmitted to the control system to cause the gear transmission mechanism to vary the gear reduction ratio.
摘要翻译：电动工具包括壳体，马达，输出轴，齿轮传动机构和控制系统。齿轮传动机构连接在电动机和输出轴之间，以将电机的旋转动力传递到输出轴。电动工具包括信号发生器和电耦合到信号发生器并与齿轮传动机构可操作地接合的控制系统，使得当手动启动信号发生器时，产生电信号并将其传送到控制系统以使齿轮传动机构改变齿轮减速比。

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