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1. 发明授权

US07034024B1 Product inhibiting transduction of G heterotrimeric protein signals combined with another anti-cancer agent for therapeutic use in cancer treatment 失效
标题翻译：产物抑制G异源三聚蛋白信号转导与另一种用于癌症治疗的抗癌剂的治疗用途
公开(公告)号：US07034024B1
公开(公告)日：2006-04-25
申请号：US10129569
申请日：2000-11-08
申请人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon , Barry Morgan
发明人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon , Barry Morgan
IPC分类号： A61K31/495
CPC分类号： A61K45/06 , A61K31/495 , A61K31/4985 , A61K31/55 , A61K31/70 , A61K31/47 , A61K31/335 , A61K2300/00
摘要： The invention concerns a product inhibiting transduction of G heterotrimeric protein signals combined with another anti-cancer agent, in particular farnesyltransferase inhibitors, taxol or gemcitabin, for simultaneous, separate or prolonged therapeutic use in cancer treatment.
摘要翻译：本发明涉及抑制与另一种抗癌剂，特别是法呢基转移酶抑制剂，紫杉醇或吉西他滨组合的G异源三聚蛋白信号转导的产物，用于癌症治疗中的同时，分别或延长的治疗用途。

2. 发明授权

US06544995B1 Use of cysteine derivatives for preparing a medicine for treating pathologies resulting from the formation of heterotrimeric G protein 失效
标题翻译：半胱氨酸衍生物用于制备用于治疗异源三聚体G蛋白形成所致病态的药物
公开(公告)号：US06544995B1
公开(公告)日：2003-04-08
申请号：US09743208
申请日：2001-01-04
申请人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
发明人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
IPC分类号： C07D48704
CPC分类号： C07D487/04 , A61K31/223 , A61K31/498 , A61K31/4985 , C12N9/88 , Y02A50/471
摘要： The invention relates to the use of cysteine derivatives for preparing a medicament intended to treat diseases which result from the formation of the heterotrimeric G protein. These diseases include in particular diseases linked to the following biological functions or disorders: smell, taste, perception of the light, neurotransmission, neurodegeneration, endocrine and exocrine gland functions, autocrine and paracrine regulation, arterial tension, embroygenesis, benign cell proliferation, oncogenesis, viral infection, immunological functions, diabetes, obesity, and benign and malign proliferative diseases. Said cysteine derivatives include in particular: bis-1,1′-[7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazine disulphide (I), and bis-1,1′-7-(2-amino-1-oxo-3-thiopropyl-(2-(1-naphtyl)-8-(2-methylpropyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazin-7-yl)disulphide (II).
摘要翻译：本发明涉及半胱氨酸衍生物用于制备旨在治疗由异三聚体G蛋白形成引起的疾病的药物的用途。这些疾病特别包括与以下生物功能或疾病有关的疾病：气味，味觉，感觉，神经传递，神经变性，内分泌和外分泌腺功能，自分泌和旁分泌调节，动脉张力，发生，良性细胞增殖，肿瘤形成，病毒感染，免疫功能，糖尿病，肥胖症和良性和恶性增殖性疾病。所述半胱氨酸衍生物特别包括：双-1,1' - [7-（2-氨基-1-氧代-3-硫丙基）-8- （环己基甲基）-2-（2-甲氧基苯基）-5,6,7,8-四氢咪唑并[1.2a]吡嗪二硫化物（I）和双 - 1,1'-7-（2-氨基-1-氧代-3 （2-（1-萘基）-8-（2-甲基丙基）-5,6,7,8-四氢咪唑并[1.2a]吡嗪-7-基）二硫化物（II）。

3. 发明授权

US07034025B2 Use of cysteine derivatives for the preparation of a medicament intended to treat pathologies which result from the formation of the heterotrimeric G protein 失效
标题翻译：半胱氨酸衍生物用于制备旨在治疗异源三聚体G蛋白形成所致病态的药物
公开(公告)号：US07034025B2
公开(公告)日：2006-04-25
申请号：US10356862
申请日：2003-02-03
申请人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
发明人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
IPC分类号： A61P1/12
CPC分类号： C07D487/04 , A61K31/223 , A61K31/498 , A61K31/4985 , C12N9/88 , Y02A50/471
摘要： A method of treating cholera or travel diarrhea in a patient in need thereof by an effective amount of a compound of the formula wherein the substrates are defined in the specification or its non-toxic, pharmaceutically acceptable salts.
摘要翻译：一种通过有效量的下式化合物治疗有需要的患者的霍乱或旅行腹泻的方法，其中底物在说明书或其无毒的药学上可接受的盐中定义。

4. 发明申请

US20090270341A1 PRODUCT COMPRISING A TRANSDUCTION INHIBITOR OF HETEROTRIMERIC G PROTEIN SIGNALS COMBINED WITH ANOTHER ANTI-CANCER AGENT FOR THERAPEUTIC USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：包含用于治疗癌症的治疗用其他抗癌药组合的异位G蛋白信号转导抑制剂的产品
公开(公告)号：US20090270341A1
公开(公告)日：2009-10-29
申请号：US12496896
申请日：2009-07-02
申请人： Gregoire PREVOST , Marie-Odile Lonchampt , Thomas Gordon , Barry Morgan
发明人： Gregoire PREVOST , Marie-Odile Lonchampt , Thomas Gordon , Barry Morgan
IPC分类号： A61K31/7068 , A61K31/497 , A61P35/00 , A61K31/5513
CPC分类号： A61K45/06 , A61K31/495 , A61K31/4985 , A61K31/55 , A61K31/70 , A61K31/47 , A61K31/335 , A61K2300/00
摘要： A composition for treating cancer comprising an anti-tumorally effective amount of a product comprising at least one transduction inhibitor of heterotrimeric G protein signals and at least one other anti-cancer agent selected from the group consisting of prenyltransferase inhibitors, taxol and its analogues, gemcitabine and camptothecin and its analogues, administered simultaneously, separately or spread over a period of time and a pharmaceutical carrier.
摘要翻译：一种用于治疗癌症的组合物，其包含抗肿瘤有效量的产物，其包含异源三聚体G蛋白信号的至少一种转导抑制剂和选自异戊烯基转移酶抑制剂，紫杉醇及其类似物的至少一种其他抗癌剂，吉西他滨和喜树碱及其类似物，同时分开施用或分散施用一段时间，以及药物载体。

5. 发明申请

US20060074078A1 Product comprising a transduction inhibitor of heterotrimeric G protein signals combined with another anti-cancer agent for therapeutic use in the treatment of cancer 审中-公开
标题翻译：产品包含异源三聚体G蛋白信号转导抑制剂与另一种用于治疗癌症的抗癌剂
公开(公告)号：US20060074078A1
公开(公告)日：2006-04-06
申请号：US11272304
申请日：2005-11-10
申请人： Gregoire Prevost , Marie-Odile Lonchampt , Thomas Gordon , Barry Morgan
发明人： Gregoire Prevost , Marie-Odile Lonchampt , Thomas Gordon , Barry Morgan
IPC分类号： A61K31/7072 , A61K31/5513 , A61K31/4704 , A61K31/498 , A61K31/426 , A61K31/421 , A61K31/4172 , A61K31/337
CPC分类号： A61K45/06 , A61K31/495 , A61K31/4985 , A61K31/55 , A61K31/70 , A61K31/47 , A61K31/335 , A61K2300/00
摘要： A composition for treating cancer comprising an anti-tumorally effective amount of a product comprising at least one transduction inhibitor of heterotrimeric G protein signals and at least one other anti-cancer agent selected from the group consisting of prenyltransferase inhibitors, taxol and its analogues, gemcitabine and camptothecin and its analogues, administered simultaneously, separately or spread over a period of time and a pharmaceutical carrier.
摘要翻译：一种用于治疗癌症的组合物，其包含抗肿瘤有效量的产物，其包含异源三聚体G蛋白信号的至少一种转导抑制剂和选自异戊烯基转移酶抑制剂，紫杉醇及其类似物的至少一种其他抗癌剂，吉西他滨和喜树碱及其类似物，同时分开施用或分散施用一段时间，以及药物载体。

6. 发明申请

US20060035899A1 Use of cysteine derivatives for the preparation of a medicament intended to treat pathologies which result from the formation of the heterotrimeric G protein 审中-公开
标题翻译：半胱氨酸衍生物用于制备旨在治疗异源三聚体G蛋白形成所致病态的药物
公开(公告)号：US20060035899A1
公开(公告)日：2006-02-16
申请号：US11222601
申请日：2005-09-09
申请人： Gregoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
发明人： Gregoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
IPC分类号： A61K31/498
CPC分类号： C07D487/04 , A61K31/223 , A61K31/498 , A61K31/4985 , C12N9/88 , Y02A50/471
摘要： The invention relates to the use of cysteine derivatives for preparing a medicament intended to treat diseases which result from the formation of the heterotrimeric G protein. These diseases include in particular diseases linked to the following biological functions or disorders: smell, taste, perception of the light, neurotransmission, neurodegeneration, endocrine and exocrine gland functions, autocrine and paracrine regulation, arterial tension, embryogenesis, benign cell proliferation, oncogenesis, viral infection, immunological functions, diabetes, obesity, and benign :and malign proliferative diseases. Said cysteine derivatives include in particular: bis-1,1′-[7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazine disulphide (I), and bis-1,1′-7-(2-amino-1-oxo-3-thiopropyl-(2-(1-naphtyl)-8-(2-methylpropyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazin-7-yl) disulphide (II).
摘要翻译：本发明涉及半胱氨酸衍生物用于制备旨在治疗由异三聚体G蛋白形成引起的疾病的药物的用途。这些疾病特别包括与以下生物功能或障碍有关的疾病：气味，味觉，感觉，神经传递，神经变性，内分泌和外分泌腺功能，自分泌和旁分泌调节，动脉张力，胚胎发生，良性细胞增殖，肿瘤形成，病毒感染，免疫功能，糖尿病，肥胖和良性：恶性增殖性疾病。所述半胱氨酸衍生物特别包括：双-1,1' - [7-（2-氨基-1-氧代-3-硫丙基）-8-（环己基甲基）-2-（2-甲氧基苯基）-5,6,7 ，8-四氢咪唑并[1,2a]吡嗪二硫化物（I）和双-1,1'-7-（2-氨基-1-氧代-3-硫丙基 - （2-（1-萘基）-8-（2 - 甲基丙基）-5,6,7,8-四氢咪唑并[1.2a]吡嗪-7-基）二硫化物（II）。

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