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1. 发明申请

US20090275624A1 INHIBITORS OF CDC PHOSPHATASES 失效
标题翻译： CDC PHOSPHATASES的抑制剂
公开(公告)号：US20090275624A1
公开(公告)日：2009-11-05
申请号：US11722075
申请日：2005-12-16
申请人： Marie-Odile Galcera-Contour , Dennis Bigg , Grégoire Prevost , Alban Sidhu
发明人： Marie-Odile Galcera-Contour , Dennis Bigg , Grégoire Prevost , Alban Sidhu
IPC分类号： A61K31/428 , C07D417/12 , C07D413/12 , A61K31/423 , A61P35/00 , A61P25/00 , A61P37/00
CPC分类号： C07D417/14 , C07D263/56 , C07D277/64
摘要： A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
摘要翻译：本发明的主题是包含抑制cdc25磷酸酶特别是cdc25-C磷酸酶的2或3个苯并噻唑-4,7-二酮 - 或苯并恶唑-4,7-二酮型单元的新型化合物。这些化合物特别可用于治疗癌症。

2. 发明申请

US20090186930A1 NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE 有权
标题翻译：新咪唑唑衍生物，作为医药的制剂和用途
公开(公告)号：US20090186930A1
公开(公告)日：2009-07-23
申请号：US12298757
申请日：2007-04-26
申请人： Anne-Marie Liberatore , Dennis Bigg , Dominique Pons , Grégoire Prevost
发明人： Anne-Marie Liberatore , Dennis Bigg , Dominique Pons , Grégoire Prevost
IPC分类号： A61K31/4164 , C07D233/58 , A61P35/00
CPC分类号： C07D233/64
摘要： The invention concerns novel imidazole derivatives of general formula (I), wherein Z′ and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
摘要翻译：本发明涉及通式（I）的新型咪唑衍生物，其中Z'和Z代表不同的可变基团。所述产品具有抗肿瘤活性。本发明还涉及含有所述产品的药物组合物及其用于制备抗肿瘤药物的用途。

3. 发明授权

US07279467B2 Benzothiazole-and benzoxazole-4, 7-dione derivatives and their use as dcd25 phosphatase inhibitors 失效
标题翻译：苯并噻唑和苯并恶唑-4,7-二酮衍生物及其作为dcd25磷酸酶抑制剂的用途
公开(公告)号：US07279467B2
公开(公告)日：2007-10-09
申请号：US10500411
申请日：2002-12-24
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment
摘要翻译：本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物

4. 发明授权

US07132553B2 Product comprising an inhibitor of the transduction of heterotrimeric G protein signals combined with an anti-hypertensive agent for therapeutic use in the treatment of arterial hypertension 失效
标题翻译：包含异源三聚体G蛋白信号转导抑制剂与抗高血压剂联合用于治疗动脉高血压的产品
公开(公告)号：US07132553B2
公开(公告)日：2006-11-07
申请号：US11010727
申请日：2004-12-13
申请人： Grégoire Prevost , Marc Teillot
发明人： Grégoire Prevost , Marc Teillot
IPC分类号： A61K31/4985
CPC分类号： A61K45/06 , A61K31/495 , A61K31/40 , A61K31/275 , A61K2300/00
摘要： A composition comprising at least one G protein inhibitor of the formula wherein the substituents are defined as in the specification and the salts thereof and at least one other antihypertensive agent for the treatment of arterial hypertension.
摘要翻译：一种组合物，其包含至少一种下式的G蛋白抑制剂，其中取代基如说明书及其盐和至少一种用于治疗动脉高血压的其它抗高血压药所定义。

5. 发明授权

US06887869B2 Mikanolide derivatives, their preparation and therapeutic uses 失效
标题翻译：米考洛德衍生物，其制备和治疗用途
公开(公告)号：US06887869B2
公开(公告)日：2005-05-03
申请号：US10250383
申请日：2002-01-11
申请人： Olivier Lavergne , Christophe Lanco , Grégoire Prevost , Beng Poon Teng
发明人： Olivier Lavergne , Christophe Lanco , Grégoire Prevost , Beng Poon Teng
IPC分类号： A61K31/34 , A61K31/343 , A61P9/10 , A61P13/08 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07D493/18 , C07D493/08 , C07D493/22
CPC分类号： C07D493/18
摘要： The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I)2, wherein: R1 represents H, SR4 or NR4R5; R2 represents SR6 or NR6R7; R3 represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18 or O(CO)NHR18, each of the radicals R4, R6, R15, R16 and R17 representing independently (in particular) an alkyl radical, the radicals R5 and R7 representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R14 and R18 representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1 does not represent a hydrogen atom
摘要翻译：本发明涉及新颖的米卡尼定衍生物，其制备方法及其治疗用途，特别是抗癌和抗病毒剂。化合物对应于对应于通式（I）的通式（1）1和2其中：R 1 表示H，SR 4或NR 4 R 5; R 2表示SR 6或NR 6 R 7; R 3表示OH，O（CO）R 14，OSiR 15 R 16 R 17， O（CO）OR 18或O（CO）NHR 18，基团R 4，R 3， R 6，R 15，R 16和R 17独立地表示（特别是）烷基，基团R _{时，R 1不表示氢原子}

6. 发明授权

US06846822B2 Product comprising a heterotrimeric G protein signal transduction inhibitor associated with anti-hypertensive agent for therapeutic use in the treatment of arterial hypertension 失效
标题翻译：包含与治疗用于治疗动脉高血压的抗高血压剂相关的异源三聚体G蛋白信号转导抑制剂的产品
公开(公告)号：US06846822B2
公开(公告)日：2005-01-25
申请号：US10169656
申请日：2001-01-05
申请人： Grégoire Prevost , Marc Teillot
发明人： Grégoire Prevost , Marc Teillot
IPC分类号： C07D487/04 , A61K31/277 , A61K31/401 , A61K31/495 , A61K31/4985 , A61K45/06 , A61P9/12 , A61P43/00
CPC分类号： A61K45/06 , A61K31/495 , A61K31/40 , A61K31/275 , A61K2300/00
摘要： The invention concerns a product comprising at least an inhibitor of heterotrimeric G protein signal transduction, associated with at least another anti-hypertensive agent, in particular calcium channel blockers and conversion enzyme inhibitors, for simultaneous, separate or prolonged therapeutic use, in the treatment of hypertension.
摘要翻译：本发明涉及至少包含异三聚体G蛋白信号转导抑制剂的产品，其与至少另一种抗高血压剂特别是钙通道阻滞剂和转化酶抑制剂相关联，用于同时，分别或延长治疗用途，用于治疗高血压。

7. 发明授权

US06544995B1 Use of cysteine derivatives for preparing a medicine for treating pathologies resulting from the formation of heterotrimeric G protein 失效
标题翻译：半胱氨酸衍生物用于制备用于治疗异源三聚体G蛋白形成所致病态的药物
公开(公告)号：US06544995B1
公开(公告)日：2003-04-08
申请号：US09743208
申请日：2001-01-04
申请人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
发明人： Grégoire Prevost , Marie-Odile Lonchampt , Thomas Gordon
IPC分类号： C07D48704
CPC分类号： C07D487/04 , A61K31/223 , A61K31/498 , A61K31/4985 , C12N9/88 , Y02A50/471
摘要： The invention relates to the use of cysteine derivatives for preparing a medicament intended to treat diseases which result from the formation of the heterotrimeric G protein. These diseases include in particular diseases linked to the following biological functions or disorders: smell, taste, perception of the light, neurotransmission, neurodegeneration, endocrine and exocrine gland functions, autocrine and paracrine regulation, arterial tension, embroygenesis, benign cell proliferation, oncogenesis, viral infection, immunological functions, diabetes, obesity, and benign and malign proliferative diseases. Said cysteine derivatives include in particular: bis-1,1′-[7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazine disulphide (I), and bis-1,1′-7-(2-amino-1-oxo-3-thiopropyl-(2-(1-naphtyl)-8-(2-methylpropyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazin-7-yl)disulphide (II).
摘要翻译：本发明涉及半胱氨酸衍生物用于制备旨在治疗由异三聚体G蛋白形成引起的疾病的药物的用途。这些疾病特别包括与以下生物功能或疾病有关的疾病：气味，味觉，感觉，神经传递，神经变性，内分泌和外分泌腺功能，自分泌和旁分泌调节，动脉张力，发生，良性细胞增殖，肿瘤形成，病毒感染，免疫功能，糖尿病，肥胖症和良性和恶性增殖性疾病。所述半胱氨酸衍生物特别包括：双-1,1' - [7-（2-氨基-1-氧代-3-硫丙基）-8- （环己基甲基）-2-（2-甲氧基苯基）-5,6,7,8-四氢咪唑并[1.2a]吡嗪二硫化物（I）和双 - 1,1'-7-（2-氨基-1-氧代-3 （2-（1-萘基）-8-（2-甲基丙基）-5,6,7,8-四氢咪唑并[1.2a]吡嗪-7-基）二硫化物（II）。

8. 发明授权

US08624037B2 Imidazolidine-2,4-dione derivatives and use thereof as a medicament 有权
标题翻译：咪唑烷-2,4-二酮衍生物及其作为药物的用途
公开(公告)号：US08624037B2
公开(公告)日：2014-01-07
申请号：US13264972
申请日：2010-04-16
申请人： Dennis Bigg , Serge Auvin , Christophe Lanco , Grégoire Prevost
发明人： Dennis Bigg , Serge Auvin , Christophe Lanco , Grégoire Prevost
IPC分类号： A61K31/4166 , C07D403/06 , C07D403/12
CPC分类号： C07D403/12 , C07D403/06
摘要： The subject matter of the present application is novel imidazolidine-2,4-dione derivatives. These products have an antiproliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.
摘要翻译：本申请的主题是新的咪唑烷-2,4-二酮衍生物。这些产品具有抗增殖活性。它们特别有利于治疗与异常细胞增殖相关的病理状况和疾病，例如癌症。本发明还涉及含有所述产品的药物组合物及其用于制备药物的用途。

9. 发明授权

US08188133B2 Imidazole derivatives, preparation and user thereof as medicine 有权
标题翻译：咪唑衍生物，作为药物的制备和使用
公开(公告)号：US08188133B2
公开(公告)日：2012-05-29
申请号：US12298757
申请日：2007-04-26
申请人： Anne-Marie Liberatore , Dennis Bigg , Dominique Pons , Grégoire Prevost
发明人： Anne-Marie Liberatore , Dennis Bigg , Dominique Pons , Grégoire Prevost
IPC分类号： A61K31/33 , C07D233/58
CPC分类号： C07D233/64
摘要： The invention concerns novel imidazole derivatives of general formula (I), wherein Z′ and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
摘要翻译：本发明涉及通式（I）的新型咪唑衍生物，其中Z'和Z代表不同的可变基团。所述产品具有抗肿瘤活性。本发明还涉及含有所述产品的药物组合物及其用于制备抗肿瘤药物的用途。

10. 发明申请

US20100317658A1 4,7-Dioxobenzothiazole-2-Carboxamide Derivatives, Their Preparation And Their Therapeutic Uses 审中-公开
标题翻译： 4,7-二氧代苯并噻唑-2-甲酰胺衍生物及其制备及其治疗用途
公开(公告)号：US20100317658A1
公开(公告)日：2010-12-16
申请号：US12849573
申请日：2010-08-03
申请人： Marie-Odile Galcera-Contour , Grégoire Prevost , Alban Sidhu
发明人： Marie-Odile Galcera-Contour , Grégoire Prevost , Alban Sidhu
IPC分类号： A61K31/428 , A61K31/5377 , A61K31/496 , A61K31/4725 , A61P35/00
CPC分类号： C07D277/68 , C07D417/12
摘要： A subject of the present invention is 4,7-dioxobenzothiazole-2-carboxamide derivatives, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
摘要翻译：本发明的主题是抑制cdc25磷酸酶，特别是cdc25-C磷酸酶的4,7-二氧代苯并噻唑-2-甲酰胺衍生物。这些化合物特别可用于治疗癌症。

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