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1. 发明授权

US08143027B2 Method of making a plasminogen activator polypeptide with clot-specific streptokinase activity 有权
标题翻译：制备具有凝块特异性链激酶活性的纤溶酶原激活物多肽的方法
公开(公告)号：US08143027B2
公开(公告)日：2012-03-27
申请号：US11781927
申请日：2007-07-23
申请人： Girish Sahni , Rajesh Kumar , Chiati Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chiati Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： C12P21/00 , C07K1/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译：本发明提供编码具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质的多核苷酸，包括增强的纤维蛋白选择性。这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。还公开了制备蛋白质的方法。

2. 发明申请

US20080171362A1 Polynucleotides Encoding Proteins with Clot-Specific Streptokinase Activity 有权
标题翻译：编码具有凝块特异性链激酶活性的蛋白质的多核苷酸
公开(公告)号：US20080171362A1
公开(公告)日：2008-07-17
申请号：US11781927
申请日：2007-07-23
申请人： Girish Sahni , Rajesh Kumar , Chiati Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chiati Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： C12P21/00 , C07H21/04 , C12N15/00 , C12N5/00 , C12N1/21 , C12N1/19 , C12N1/15
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译：本发明提供编码具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质的多核苷酸，包括增强的纤维蛋白选择性。这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。还公开了制备蛋白质的方法。

3. 发明申请

US20050260598A1 Novel clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said protein 有权
标题翻译：具有改变的纤溶酶原激活特征的新型凝块特异性链激酶蛋白和用于制备所述蛋白质的方法
公开(公告)号：US20050260598A1
公开(公告)日：2005-11-24
申请号：US10631558
申请日：2003-07-31
申请人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： A61K38/00 , C07H21/04 , C07K14/315 , C07K14/78 , C07K19/00 , C12N1/21 , C12N9/12 , C12N9/70 , C12N15/58 , C12Q1/68
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译：具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质，包括增强的纤维蛋白选择性。这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。还公开了制备蛋白质的方法。

4. 发明授权

US07250503B2 Nucleic acid molecules encoding clot-specific streptokinase fusion proteins possessing altered plasminogen activation characteristics 有权
标题翻译：编码凝块特异性链激酶融合蛋白的核酸分子具有改变的纤溶酶原激活特征
公开(公告)号：US07250503B2
公开(公告)日：2007-07-31
申请号：US10631558
申请日：2003-07-31
申请人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： C07H21/04 , C12N9/48 , C12P21/00 , C12P21/06
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译：本发明提供编码具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质的多核苷酸，包括增强的纤维蛋白选择性。这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。还公开了制备蛋白质的方法。

5. 发明授权

US07163817B2 Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for their preparation 有权
标题翻译：具有改变的纤溶酶原激活特征的凝块特异性链激酶蛋白及其制备方法
公开(公告)号：US07163817B2
公开(公告)日：2007-01-16
申请号：US09940235
申请日：2001-08-27
申请人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： C12N9/48 , C12P21/00 , C12P21/06
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： The invention disclosed herein provides clot specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译：本文公开的本发明提供具有改变的纤溶酶原特征的凝血特异性链激酶蛋白，包括增强的纤维蛋白选择性。这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。还公开了制备蛋白质的方法。

6. 发明申请

US20070287660A1 Novel clot-specific steptokinase proteins possessing altered plasminogen activation-characteristics and a process for the preparation of said proteins 审中-公开
标题翻译：具有改变的纤溶酶原激活特征的新型凝块特异性步进激酶蛋白和用于制备所述蛋白质的方法
公开(公告)号：US20070287660A1
公开(公告)日：2007-12-13
申请号：US11605480
申请日：2006-11-29
申请人： Girish Sahai , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahai , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： A61K38/00 , A61P9/00 , C07K14/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译：具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质，包括增强的纤维蛋白选择性。这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。还公开了制备蛋白质的方法。

7. 发明授权

US10685947B2 Distributed semiconductor die and package architecture 有权
公开(公告)号：US10685947B2
公开(公告)日：2020-06-16
申请号：US15869637
申请日：2018-01-12
申请人： Wilfred Gomes , Mark T. Bohr , Rajesh Kumar , Robert L. Sankman , Ravindranath V. Mahajan , Wesley D. Mc Cullough
发明人： Wilfred Gomes , Mark T. Bohr , Rajesh Kumar , Robert L. Sankman , Ravindranath V. Mahajan , Wesley D. Mc Cullough
IPC分类号： H01L23/48 , H01L25/18 , H01L25/00 , H01L23/00 , H01L23/538 , H01L23/522 , H01L25/16 , H01L25/065 , H01L23/498
摘要： The present disclosure is directed to systems and methods of conductively coupling a plurality of relatively physically small core dies to a relatively physically larger base die using an electrical mesh network that is formed in whole or in part in, on, across, or about all or a portion of the base die. Electrical mesh networks beneficially permit the positioning of the cores in close proximity to support circuitry carried by the base die. The minimal separation between the core circuitry and the support circuitry advantageously improves communication bandwidth while reducing power consumption. Each of the cores may include functionally dedicated circuitry such as processor core circuitry, field programmable logic, memory, or graphics processing circuitry. The use of core dies beneficially and advantageously permits the use of a wide variety of cores, each having a common or similar interface to the electrical mesh network.

8. 发明授权

US09719011B2 Proppant 有权
公开(公告)号：US09719011B2
公开(公告)日：2017-08-01
申请号：US13126905
申请日：2009-10-29
申请人： Christopher M. Tanguay , John Erickson , Victoria Manea , Jyh-Chiarng Huarng , Rajesh Kumar , Fikri Emrah Alemdaroglu
发明人： Christopher M. Tanguay , John Erickson , Victoria Manea , Jyh-Chiarng Huarng , Rajesh Kumar , Fikri Emrah Alemdaroglu
IPC分类号： E21B43/26 , B05D7/00 , C09K8/92 , C09K8/80 , C09K8/62
CPC分类号： C09K8/805 , C09K8/62
摘要： A proppant comprises a particle and a polycarbodiimide coating disposed on the particle. The polycarbodiimide coating comprises the reaction product of a polymeric isocyanate and a monomeric isocyanate, in the presence of a catalyst. A method of forming the proppant comprises the steps of providing the particle, providing the polymeric isocyanate, providing the monomeric isocyanate, providing the catalyst, reacting the polymeric isocyanate and the monomeric isocyanate in the presence of the catalyst to form the polycarbodiimide coating, and coating the particle with the polycarbodiimide coating.

9. 发明授权

US09535865B2 Interconnection of multiple chips in a package 有权
标题翻译：封装中多个芯片的互连
公开(公告)号：US09535865B2
公开(公告)日：2017-01-03
申请号：US13996107
申请日：2011-12-22
申请人： Thomas P. Thomas , Randy B. Osborne , Rajesh Kumar
发明人： Thomas P. Thomas , Randy B. Osborne , Rajesh Kumar
IPC分类号： G06F13/00 , G06F13/364 , G06F13/14 , G06F13/40 , G06F13/42 , G06F3/0488 , G06F13/16
CPC分类号： G06F13/364 , G06F3/0488 , G06F13/14 , G06F13/16 , G06F13/4068 , G06F13/4273 , Y02D10/14 , Y02D10/151
摘要： An interface. A first set of single-ended transmitter circuits reside on a first die having a master device. A first set of single-ended receiver circuits reside on a second die. The receiver circuits have no termination and no equalization. The second die has a slave device responsive to the master device of the first die. Conductive lines connect the first set of transmitter circuits and the first set of receiver circuits. The lengths of the conductive lines are matched.
摘要翻译：一个接口第一组单端发射器电路驻留在具有主器件的第一管芯上。第一组单端接收器电路驻留在第二管芯上。接收器电路没有终端，没有均衡。第二管芯具有响应于第一管芯的主器件的从器件。导电线连接第一组发射器电路和第一组接收器电路。导线的长度相匹配。

10. 发明申请

US20160328768A1 TOWING / VENDOR CONNECTION APPARATUS AND METHOD OF USE THEREOF 审中-公开
标题翻译：推送器/供应商连接装置及其使用方法
公开(公告)号：US20160328768A1
公开(公告)日：2016-11-10
申请号：US14706919
申请日：2015-05-07
申请人： Rajesh Kumar , Todd DeMasseo
发明人： Rajesh Kumar , Todd DeMasseo
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0619
摘要： The invention comprises a connection system, implemented as an apparatus and method of use thereof, for linking vehicle towing related information with a service and/or a product provided by a company. The connection system optionally timely provides information about a towed vehicle and/or towing event to a service system where the towing related information is optionally: obtained through a standardized uplink utilized by a set of towing companies; used to develop a towing/services relationship calibration; provided to a probabilistic prediction system; directly related to an incident; related to non-incident vehicle status; related to a specific actor, location, incident, vehicle type, and/or vehicle sub-system; and/or is provided to the service system, such as a retailor or a vendor.
摘要翻译：本发明包括实现为其装置及其使用方法的连接系统，用于将车辆牵引相关信息与由公司提供的服务和/或产品相关联。连接系统可选地及时地将牵引车辆和/或牵引事件的信息提供给服务系统，其中牵引相关信息可选地通过一组牵引公司使用的标准上行链路获得; 用于开发牵引/服务关系校准; 提供给概率预测系统; 直接与事件有关; 涉及非事故车辆状况; 与具体演员，位置，事件，车辆类型和/或车辆子系统相关; 和/或被提供给服务系统，例如零售商或供应商。

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