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1. 发明授权

US06355014B1 Low profile catheter valve 失效
标题翻译：薄型导管阀
公开(公告)号：US06355014B1
公开(公告)日：2002-03-12
申请号：US09039110
申请日：1998-03-13
申请人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jeffrey C. Bleam , Isaac J. Kim , Jeffrey F. Field
发明人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jeffrey C. Bleam , Isaac J. Kim , Jeffrey F. Field
IPC分类号： A61M2900
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。

2. 发明授权

US6050972A Guidewire inflation system 失效
标题翻译：导丝通货膨胀系统
公开(公告)号：US6050972A
公开(公告)日：2000-04-18
申请号：US975723
申请日：1997-11-20
申请人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
发明人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
IPC分类号： A61M25/01 , A61F2/958 , A61M25/00 , A61M25/16 , A61M29/02 , A61M39/00 , A61M29/00
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/1018 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093 , A61M25/0026 , A61M25/10
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port. Also disclosed herein is an inflation adaptor for moving the sealer portion within the catheter to establish or close the fluid pathway between the inflation port and the inflatable balloon.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。本文还公开了一种充气适配器，用于移动导管内的密封部分，以建立或关闭充气端口和可膨胀气囊之间的流体通路。

3. 发明授权

US06325777B1 Low profile catheter valve and inflation adaptor 有权
标题翻译：薄型导管阀和充气适配器
公开(公告)号：US06325777B1
公开(公告)日：2001-12-04
申请号：US09410456
申请日：1999-10-01
申请人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
发明人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
IPC分类号： A61M2900
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port. Also disclosed herein is an inflation adaptor for moving the sealer portion within the catheter to establish or close the fluid pathway between the inflation port and the inflatable balloon.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。本文还公开了一种充气适配器，用于移动导管内的密封部分，以建立或关闭充气端口和可膨胀气囊之间的流体通路。

4. 发明授权

US5893867A Stent positioning apparatus and method 失效
标题翻译：支架定位装置及方法
公开(公告)号：US5893867A
公开(公告)日：1999-04-13
申请号：US744632
申请日：1996-11-06
申请人： Celso J. Bagaoisan , Gholam-Reza Zadno-Azizi , Jeffrey F. Field
发明人： Celso J. Bagaoisan , Gholam-Reza Zadno-Azizi , Jeffrey F. Field
IPC分类号： A61F2/06 , A61F2/84 , A61M29/00
CPC分类号： A61F2/958 , A61F2002/9522
摘要： A stent positioning apparatus and method are provided for the attachment of a stent to a balloon to be used in the treatment of stenosis, such as coronary angioplasty. In one preferred embodiment, a first generally cylindrical member has a radially deformable wall defining a channel within which the stent and balloon assembly are inserted. A second generally cylindrical member has an opening sufficient to receive the first member with the assembly therein. The second member is then slid longitudinally over the deformable wall of the first member causing nonuniform depressions to be formed in the inner diameter of the stent, thus crimping the stent onto the balloon. Thus, the stent is attached to the balloon without damage and without risk of the stent falling off the balloon prematurely.
摘要翻译：提供一种用于将支架附接到球囊以用于治疗狭窄的冠状动脉血管成形术的支架定位装置和方法。在一个优选实施例中，第一大致圆柱形的构件具有限定通道的可径向变形的壁，支架和球囊组件在该通道内插入。第二大体为圆柱形的构件具有足以容纳其中具有组件的第一构件的开口。然后将第二构件纵向滑动在第一构件的可变形壁上，导致在支架的内径中形成不均匀的凹陷，从而将支架卷曲到气球上。因此，支架被附接到球囊而没有损伤，并且没有支架过早地脱离球囊的风险。

5. 发明授权

US06375629B1 Core wire with shapeable tip 有权
标题翻译：具有可塑尖端的芯线
公开(公告)号：US06375629B1
公开(公告)日：2002-04-23
申请号：US09690588
申请日：2000-10-17
申请人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
发明人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
IPC分类号： A61B500
CPC分类号： C22F1/006 , A61M25/09 , A61M2025/09175 , A61M2025/1093
摘要： The present invention provides an improved core wire for use in a medical catheter. In one aspect, the invention provides a core wire with a shapeable tip and method of manufacturing the same. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本发明提供一种用于医疗导管的改进的芯线。一方面，本发明提供一种具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

6. 发明授权

US06355016B1 Catheter core wire 有权
标题翻译：导管芯线
公开(公告)号：US06355016B1
公开(公告)日：2002-03-12
申请号：US09253971
申请日：1999-02-22
申请人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
发明人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/09 , A61M25/09033 , A61M2025/09175 , A61M2025/1093 , C22F1/006
摘要： Disclosed herein is an improved core wire for use in a medical catheter. In one aspect, a tapering core wire is incorporated into the distal end of a catheter. The catheter has a tubular body. Both ends of an inflatable balloon are mounted to the tubular body. The core wire extends from the distal end of the tubular body. In one embodiment, substantially all of the taper of the core wire occurs in the extending portion of the core wire over a length of at least 15 mm but no more than 60 mm. In another aspect, a core wire with a shapeable tip and method of manufacturing the same are provided. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本文公开了一种用于医疗导管的改进的芯线。在一个方面，锥形芯线被并入导管的远端。导管具有管状体。可充气气囊的两端安装在管状体上。芯线从管状体的远端延伸。在一个实施例中，芯线的基本上所有的锥形在芯线的延伸部分中发生长度至少为15mm但不大于60mm。另一方面，提供了具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

7. 发明授权

US06190332B1 Core wire with shapeable tip 失效
标题翻译：具有可塑尖端的芯线
公开(公告)号：US06190332B1
公开(公告)日：2001-02-20
申请号：US09026357
申请日：1998-02-19
申请人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
发明人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
IPC分类号： A61B500
CPC分类号： C22F1/006 , A61M25/09 , A61M2025/09175 , A61M2025/1093
摘要： The present invention provides an improved core wire for use in a medical catheter. In one aspect, the invention provides a core wire with a shapeable tip and method of manufacturing the same. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本发明提供一种用于医疗导管的改进的芯线。一方面，本发明提供一种具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

8. 发明授权

US06605074B2 Method for containing and removing occlusions in the carotid arteries 失效
公开(公告)号：US06605074B2
公开(公告)日：2003-08-12
申请号：US10246077
申请日：2002-09-16
申请人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaoisan , Hung V. Ha
发明人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaoisan , Hung V. Ha
IPC分类号： A61M3100
CPC分类号： A61M25/008 , A61B17/22 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M25/0071 , A61M25/1011 , A61M2025/0081 , A61M2025/0183 , A61M2025/1052 , A61M2210/0693
摘要： A method for the treatment of a stenosis or an occlusion in a blood vessel is disclosed in which a main catheter is first delivered to a site proximal to the occlusion. The main catheter may include an occlusive device at its distal end. An inner catheter or elongate member (e.g., a guidewire) having an occlusive device at its distal end is delivered to the site of the occlusion, and the occlusive device is activated at a site distal to the occlusion. A therapy catheter is then introduced to treat the occlusion. Next, a catheter is delivered just proximal to the occlusive device, and this catheter is used to aspirate and/or irrigate the area removing particles and debris. The aspiration and irrigation steps are preferably repeated until the particles and debris are removed. Perfusion may be performed by using a perfusion-filter distal of the lesion to be treated or a hypotube which extends beyond the occlusive device attached to the guidewire. The present invention provides for a minimally invasive procedure which can be performed quickly and efficiently, with reduced risks to the patient.

9. 发明授权

US06786888B1 Low profile catheter for emboli protection 失效
标题翻译：低剖面导管用于栓塞保护
公开(公告)号：US06786888B1
公开(公告)日：2004-09-07
申请号：US09684186
申请日：2000-10-06
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： A low profile catheter valve comprises a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port.
摘要翻译：低剖面导管阀包括位于导管的充气腔内的可移动密封件部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。

10. 发明授权

US06500166B1 Method of emboli protection using a low profile catheter 失效
标题翻译：使用低剖面导管的栓塞保护方法
公开(公告)号：US06500166B1
公开(公告)日：2002-12-31
申请号：US09455878
申请日：1999-12-06
申请人： Gholam-Reza Zadno Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
发明人： Gholam-Reza Zadno Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
IPC分类号： A61M3100
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。

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