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1. 发明授权

US6050972A Guidewire inflation system 失效
标题翻译：导丝通货膨胀系统
公开(公告)号：US6050972A
公开(公告)日：2000-04-18
申请号：US975723
申请日：1997-11-20
申请人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
发明人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
IPC分类号： A61M25/01 , A61F2/958 , A61M25/00 , A61M25/16 , A61M29/02 , A61M39/00 , A61M29/00
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/1018 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093 , A61M25/0026 , A61M25/10
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port. Also disclosed herein is an inflation adaptor for moving the sealer portion within the catheter to establish or close the fluid pathway between the inflation port and the inflatable balloon.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。本文还公开了一种充气适配器，用于移动导管内的密封部分，以建立或关闭充气端口和可膨胀气囊之间的流体通路。

2. 发明授权

US06325777B1 Low profile catheter valve and inflation adaptor 有权
标题翻译：薄型导管阀和充气适配器
公开(公告)号：US06325777B1
公开(公告)日：2001-12-04
申请号：US09410456
申请日：1999-10-01
申请人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
发明人： Gholam-Reza Zadno-Azizi , April A. Marano-Ford , Celso J. Bagaoisan , Jefferey C. Bleam , Isaac J. Kim , Jeffrey F. Field , Roy Leguidleguid , Mukund Patel , George Tsai
IPC分类号： A61M2900
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port. Also disclosed herein is an inflation adaptor for moving the sealer portion within the catheter to establish or close the fluid pathway between the inflation port and the inflatable balloon.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。本文还公开了一种充气适配器，用于移动导管内的密封部分，以建立或关闭充气端口和可膨胀气囊之间的流体通路。

3. 发明授权

US06355016B1 Catheter core wire 有权
标题翻译：导管芯线
公开(公告)号：US06355016B1
公开(公告)日：2002-03-12
申请号：US09253971
申请日：1999-02-22
申请人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
发明人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/09 , A61M25/09033 , A61M2025/09175 , A61M2025/1093 , C22F1/006
摘要： Disclosed herein is an improved core wire for use in a medical catheter. In one aspect, a tapering core wire is incorporated into the distal end of a catheter. The catheter has a tubular body. Both ends of an inflatable balloon are mounted to the tubular body. The core wire extends from the distal end of the tubular body. In one embodiment, substantially all of the taper of the core wire occurs in the extending portion of the core wire over a length of at least 15 mm but no more than 60 mm. In another aspect, a core wire with a shapeable tip and method of manufacturing the same are provided. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本文公开了一种用于医疗导管的改进的芯线。在一个方面，锥形芯线被并入导管的远端。导管具有管状体。可充气气囊的两端安装在管状体上。芯线从管状体的远端延伸。在一个实施例中，芯线的基本上所有的锥形在芯线的延伸部分中发生长度至少为15mm但不大于60mm。另一方面，提供了具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

4. 发明授权

US06786888B1 Low profile catheter for emboli protection 失效
标题翻译：低剖面导管用于栓塞保护
公开(公告)号：US06786888B1
公开(公告)日：2004-09-07
申请号：US09684186
申请日：2000-10-06
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： A low profile catheter valve comprises a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port.
摘要翻译：低剖面导管阀包括位于导管的充气腔内的可移动密封件部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。

5. 发明授权

US06500166B1 Method of emboli protection using a low profile catheter 失效
标题翻译：使用低剖面导管的栓塞保护方法
公开(公告)号：US06500166B1
公开(公告)日：2002-12-31
申请号：US09455878
申请日：1999-12-06
申请人： Gholam-Reza Zadno Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
发明人： Gholam-Reza Zadno Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
IPC分类号： A61M3100
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port.
摘要翻译：本文公开了一种低剖面导管阀，其包括位于导管的充气腔内的可移动的密封部分。密封器部分通过牢固地接触充气腔的一部分的整个周边而与充气腔形成流体密封的密封。密封器部分可以位于导管上的侧向通过充气端口的近侧，以在充气端口和导管远端上的可充气气囊之间建立不受限制的流体通路。根据需要，临床医生可以将密封部分移动到充气端口的远侧位置，从而防止任何流体经由充气口引入或从气囊中排出。

6. 发明授权

US06325778B1 Low profile catheter valve and inflation adaptor 失效
公开(公告)号：US06325778B1
公开(公告)日：2001-12-04
申请号：US09410797
申请日：1999-10-01
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/10185 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/104 , A61M2025/0018 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/1093
摘要： Disclosed herein is a low profile catheter valve comprising a movable sealer portion positioned within the inflation lumen of a catheter. The sealer portion forms a fluid tight seal with the inflation lumen by firmly contacting the entire circumference of a section of the inflation lumen. The sealer portion may be positioned proximally of a side-access inflation port on the catheter, to establish an unrestricted fluid pathway between the inflation port and an inflatable balloon on the distal end of the catheter. As desired, the clinician may move the sealer portion to a position distal of the inflation port, thereby preventing any fluid from being introduced into or withdrawn from the balloon via the inflation port. Also disclosed herein is an inflation adaptor for moving the sealer portion within the catheter to establish or close the fluid pathway between the inflation port and the inflatable balloon.

7. 发明授权

US5833644A Method for emboli containment 失效
标题翻译：栓塞方法
公开(公告)号：US5833644A
公开(公告)日：1998-11-10
申请号：US812875
申请日：1997-03-06
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Ketan P. Muni , Jefferey C. Bleam
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Ketan P. Muni , Jefferey C. Bleam
IPC分类号： A61B17/22 , A61F2/958 , A61M1/00 , A61M25/00 , A61M29/02 , B29C55/04 , A61M31/00
CPC分类号： A61B17/22 , A61M25/0009 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/1011 , A61M25/1018 , A61M25/104 , B29C55/04 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M2025/0018 , A61M2025/0081 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1031 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , A61M25/0026 , A61M25/0068 , A61M25/007 , A61M25/10 , A61M25/1027
摘要： A multi-catheter emboli containment system is disclosed in which a treatment chamber within a blood vessel is formed by at least two occlusion balloons on opposite sides of a stenotic lesion, thereby preventing emboli migration during the treatment procedure. Irrigation and aspiration are provided to remove emboli and debris from the chamber. The irrigation and aspiration can be provided through separate catheters, or, the catheters used to create the chamber, together with the catheter used to provide therapy to the stenosis can be used. The catheters are all sized so as to be concentric, slidably disposed with respect to one another, and able to be delivered into blood vessels less than 25 mm in diameter or even smaller.
摘要翻译：公开了一种多导管栓塞容纳系统，其中通过在狭窄病变的相对侧上的至少两个闭塞球形成血管内的治疗室，从而防止在治疗过程中的栓塞迁移。提供灌溉和抽吸以从腔室中除去栓子和碎屑。可以通过单独的导管提供灌洗和抽吸，或者可以使用用于产生腔室的导管以及用于为狭窄治疗提供的导管。导管的尺寸均匀，可相对于彼此同心，可滑动地设置，并且能够被输送到直径小于25mm或更小的血管。

8. 发明授权

US06500147B2 Flexible catheter 有权
标题翻译：柔性导管
公开(公告)号：US06500147B2
公开(公告)日：2002-12-31
申请号：US09253591
申请日：1999-02-22
申请人： Samuel L. Omaleki , Isaac J. Kim , Jefferey C. Bleam , Juan T. Domingo , Andres D. Tomas , Celso J. Bagaoisan
发明人： Samuel L. Omaleki , Isaac J. Kim , Jefferey C. Bleam , Juan T. Domingo , Andres D. Tomas , Celso J. Bagaoisan
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/0054 , A61M25/09 , A61M25/09033 , A61M2025/0098 , A61M2025/09008 , A61M2025/09183 , A61M2025/1079 , A61M2025/1093
摘要： A balloon catheter having improved flexibility in and about its distal end is provided. The flexibility of the catheter is determined in part by improving the properties of a wire or catheter located within the area where the balloon is mounted. In one aspect of the present invention, connecting wires extend through the balloon from the distal end of a catheter body to the proximal end of a core wire. The core wire extends distally away from the connecting wires and the catheter body. In another aspect of the present invention, a core wire is provided having a proximal end extending within the balloon into the catheter tubular body but is not mounted therein. This allows the proximal end of the core wire to “float” within the tubular body, such that when the catheter is advanced through the vasculature of a patient, the core wire may move longitudinally within the tubular body. In another aspect of the present invention, the balloon is mounted over a tubular body which is configured to give the catheter longitudinal flexibility.
摘要翻译：提供了具有在其远端中及其远端具有改进的柔性的球囊导管。导管的灵活性部分地通过改进位于安装气球的区域内的线或导管的性质来确定。在本发明的一个方面，连接线从导管主体的远端延伸穿过球囊到芯线的近端。芯线远离连接线和导管主体延伸。在本发明的另一方面，提供了一种芯线，其具有在气囊内延伸到导管管状体中但未安装在其中的近端。这允许芯线的近端在管状体内“漂浮”，使得当导管前进通过患者的脉管系统时，芯线可以在管状体内纵向移动。在本发明的另一方面，气囊被安装在管状体上，该管状体被配置成给予导管的纵向柔性。

9. 发明授权

US06569148B2 Methods for emboli containment 失效
公开(公告)号：US06569148B2
公开(公告)日：2003-05-27
申请号：US09769775
申请日：2001-01-25
申请人： Celso J. Bagaoisan , Jefferey C. Bleam , Ketan P. Muni , Gholam RezaZadno Azizi
发明人： Celso J. Bagaoisan , Jefferey C. Bleam , Ketan P. Muni , Gholam RezaZadno Azizi
IPC分类号： A61M3100
CPC分类号： A61M25/10184 , A61B17/22 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M25/0009 , A61M25/0026 , A61M25/0029 , A61M25/005 , A61M25/0053 , A61M25/0054 , A61M25/0068 , A61M25/007 , A61M25/0075 , A61M25/008 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/1027 , A61M25/104 , A61M2025/0018 , A61M2025/0037 , A61M2025/0081 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1031 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , B29C55/04
摘要： A multi-catheter emboli containment system is disclosed which is adapted to provide at least one pair of optimized paths for irrigation and aspiration fluid flow. Through careful design of the cross-sectional area of these paths, the present system is able to be compactly utilized in even the smaller size blood vessels. The catheter system itself is provided with occlusive devices to form an emboli containment chamber in which irrigation and aspiration occur. The catheter system of the present invention provides an improved emboli containment and removal system which can be utilized in a wide range of vessel diameters. The system is easy to use and can quickly and efficiently evacuate the containment chamber.

10. 发明授权

US07510568B2 Valved connector assembly and sterility barriers for heat exchange catheters and other closed looped catheters 有权
标题翻译：用于热交换导管和其他闭环导管的阀门连接器组件和无菌屏障
公开(公告)号：US07510568B2
公开(公告)日：2009-03-31
申请号：US11061803
申请日：2005-02-17
申请人： Jefferey C. Bleam , George Tsai
发明人： Jefferey C. Bleam , George Tsai
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61B90/40 , A61F2007/126 , A61M5/1723 , A61M5/445 , A61M25/1002 , A61M2025/1072 , A61M2205/36
摘要： A connector assembly for catheters having closed loop flow circuits, such as some balloon catheters and heat exchange catheters. The connector assembly comprises first and second connector bodies that may be connected and disconnected from one another. When the connector bodies are disconnected, a syringe or negative pressure source may be attached to withdraw residual fluid from the catheter's closed loop circuit and to deflate any expandable portion of the closed loop circuit (e.g., balloon or expandable heat exchanger). A one way flow valve prevents make up air or other fluid from entering the catheter while the negative pressure is being applied. Also disclosed are sterility barrier assemblies for all types of catheters. Such sterility barrier assemblies are operative to prevent contamination of the portion of a catheter that remains outside of a patient's body so that the catheter may subsequently be further advanced into the patient's body without introducing microbes or other contaminants into the patient's body.
摘要翻译：用于具有闭环流动回路的导管的连接器组件，例如一些气囊导管和热交换导管。连接器组件包括可以彼此连接和断开的第一和第二连接器本体。当连接器主体断开时，可以连接注射器或负压源以从导管的闭环回路中抽出残余流体并使闭合回路的任何可膨胀部分（例如球囊或可膨胀热交换器）放气。单向流量阀防止在施加负压时补充空气或其它流体进入导管。还公开了用于所有类型的导管的无菌屏障组件。这种无菌屏障组件可操作以防止留在患者身体外部的导管部分的污染，使得导管随后可以进一步前进到患者体内，而不会将微生物或其它污染物引入患者体内。

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