专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5026699A Use of 5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-ones substituted in the 11-position for treating bradycardia and bradyarrhythmia in human and veterinary medicine 失效
标题翻译：在11位取代的5,11-二氢-6H-吡啶并[2,3-b] [1,4]苯并二氮杂-6-酮在人和兽医学中用于治疗心动过缓和缓慢性心律失常
公开(公告)号：US5026699A
公开(公告)日：1991-06-25
申请号：US367397
申请日：1989-06-15
申请人： Gerhard Mihm , Wolfgang Eberlein , Welfhard Engel , Gunter Trummlitz , Norbert Mayer , Henri Doods , Rudolf Hammer
发明人： Gerhard Mihm , Wolfgang Eberlein , Welfhard Engel , Gunter Trummlitz , Norbert Mayer , Henri Doods , Rudolf Hammer
IPC分类号： C07D471/04 , A61K31/55 , A61P1/00 , A61P9/04 , A61P9/06 , A61P11/00 , A61P13/02 , A61P15/00
CPC分类号： A61K31/55
摘要： 5,11-Dihydro-6H-pyrido[2,3-b][1,4]-benzo-diazepinones substituted in the 11-position corresponding to general formula I ##STR1## wherein R.sup.1 and R.sup.2 represent hydrogen atoms or alkyl groups having 1 to 3 carbon atoms, A.sup.1 is a straight-chained or branched alkylene group with 1 to 5 carbon atoms, A.sup.2 is a methylene group or, if R.sup.1 is hydrogen and R.sup.2 is methyl, A.sup.2 may also be an ethylene group, and the physiologically acceptable acid addition salts thereof are suitable for treating bradycardia and bradyarrhythmia and spasm in the colon, bladder and bronchi.
摘要翻译：在对应于通式I（I）的11位上取代的5,11-二氢-6H-吡啶并[2,3-b] [1,4] - 苯并二氮杂其中R 1和R 2表示氢原子或具有1至3个碳原子的烷基，A1是具有1至5个碳原子的直链或支链亚烷基，A2是亚甲基，或者如果R1是氢，R2是甲基，A2也可以是亚乙基，其生理上可接受的酸加成盐适用于治疗结肠，膀胱和支气管中的心动过缓和缓慢性心律失常和痉挛。

2. 发明授权

US5175158A Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds 失效
标题翻译：浓缩的双酚A，其制备方法及含有这些化合物的药物组合物
公开(公告)号：US5175158A
公开(公告)日：1992-12-29
申请号：US261950
申请日：1988-10-24
申请人： Wolfgang Eberlein , Wolfhard Engel , Gunter Trummlitz , Gerhard Mihm , Norbert Mayer , Henri Doods
发明人： Wolfgang Eberlein , Wolfhard Engel , Gunter Trummlitz , Gerhard Mihm , Norbert Mayer , Henri Doods
IPC分类号： A61K31/00 , A61P9/06 , A61P25/02 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/04 , C07D495/14
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04
摘要： New diazepinones of formula I ##STR1## wherein the substituents are defined herein, which compounds exhibit favorable effects on heart rate and in view of the absence of inhibitory effects on gastric acid secretion and salivation and the absence of mydriatic effects, are suitable as vagal pacemakers for the treatment of bradycardia and bradyarrhythmia in human and veterinary medicine.
摘要翻译：式I的新二氮杂酮（I）其中取代基在本文中定义，这些化合物对心率表现出有利的影响，并且鉴于对胃酸分泌和唾液分泌和不存在散瞳效应的抑制作用不存在是合适的作为迷走神经心脏起搏器，用于治疗人类和兽医学中的心动过缓和慢性心律失常。

3. 发明授权

US5179090A Condensed diazepinones and medicaments containing these compounds 失效
标题翻译：浓缩二氮杂酮和含有这些化合物的药物
公开(公告)号：US5179090A
公开(公告)日：1993-01-12
申请号：US779203
申请日：1991-10-18
申请人： Klaus Rudolf , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gerhard Mihm , Henri Doods , Norbert Mayer
发明人： Klaus Rudolf , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gerhard Mihm , Henri Doods , Norbert Mayer
IPC分类号： C07D487/18 , C07D519/00
CPC分类号： C07D487/18 , C07D519/00
摘要： Condensed diazepinones of general formula I ##STR1## in which]B represents one of the divalent groups ##STR2## X is a .dbd.CH-- group or a nitrogen atom,R represents a lower alkyl radical, which may optionally be further substituted by a phenyl optionally carrying halogen, methyl or methoxy,R.sup.4 and R.sup.5 represent hydrogen, halogen or lower alkyl,R.sup.6 is hydrogen, chlorine or methyl,R.sup.7 and R.sup.8 denote lower alkyl, R.sup.8 also additionally denotes halogen, andm, n, o and p represent the numbers 0, 1, 2 or 3 with the following limitations: the sum of m+n and the sum of o+p each denote the numbers 1, 2 or 3, the sum of n+o and the sum of m+p each denote the numbers 1, 2, 3, 4 or 5, wherein, however, the sum of m+n+o+p must always be greater than 2, andA.sup.1, A.sup.2, A.sup.3 and A.sup.4 denote hydrogen, or, for the case where m, n, o and p each denote the number 1, A.sup.1 and A.sup.2 together or A.sup.3 and A.sup.4 together represent an ethylene bridge,are suitable for the treatment of cholinergically induced spasms and motility disorders of the gastrointestinal tract and in the region of the evacuating bile ducts, for the symptomatic treatment of cystitis and of spasms from urelithiasis, for the treatment of relative incontinence, for the symptomatic treatment of bronchial asthma and bronchitis, and for the treatment of ischaemic heart diseases. The compounds are characterized by good selectivity.
摘要翻译：（I）其中] + E，crc / B /表示二价基团之一的通式I的缩二氮杂酮类（I）其中一个二价基团（S）（T） V）X是= CH-基或氮原子，R表示低级烷基，其可以任选地被任选地带有卤素，甲基或甲氧基的苯基进一步取代，R4和R5代表氢，卤素或低级烷基，R6 是氢，氯或甲基，R7和R8表示低级烷基，R8还另外表示卤素，m，n，o和p表示数字0,1,2或3，具有以下限制：m + n和 o + p的和表示数字1,2或3，n + o和m + p之和各自表示数字1,2,3,4或5，其中，然而， m + n + o + p必须始终大于2，A1，A2，A3和A4表示氢，或者对于m，n，o和p分别表示数字1，A1和A2一起或A3 和A4一起代表乙烯桥，适合于处理o f胆碱能诱发胃肠道的痉挛和运动障碍以及排空胆管区域，用于膀胱炎和尿毒症痉挛的症状治疗，用于治疗相对失禁，用于支气管哮喘和支气管炎的症状治疗，并用于治疗缺血性心脏病。该化合物的特征在于良好的选择性。

4. 发明授权

US5002943A Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds 失效
标题翻译：浓缩二氮杂酮，其制备方法和含有这些化合物的药物组合物
公开(公告)号：US5002943A
公开(公告)日：1991-03-26
申请号：US366828
申请日：1989-06-15
申请人： Gerhard Mihm , Wolfgang Eberlein , Wolfhard Engel , Gunter Trummlitz , Norbert Mayer , Adrian de Jonge , Henri Doods
发明人： Gerhard Mihm , Wolfgang Eberlein , Wolfhard Engel , Gunter Trummlitz , Norbert Mayer , Adrian de Jonge , Henri Doods
IPC分类号： A61K31/00 , A61K31/55 , A61K31/551 , A61P1/00 , A61P9/04 , A61P9/06 , A61P11/00 , A61P13/02 , A61P15/00 , C07D243/14 , C07D403/12 , C07D471/04 , C07D471/14 , C07D495/04
CPC分类号： C07D403/12 , C07D471/04 , C07D471/14 , C07D495/04
摘要： Novel condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, A.sup.1, A.sup.2 and R.sup.1 -R.sup.10 are as defined herein. The condensed diazepinones are suitable as vagal pacemakers for the treatment of bradycardia and bradyarrhythmia and they have spasmolytic effects on peripheral organs, particularly the colon, bladder and bronchi.
摘要翻译：新的通式I的缩合二氮杂酮其中B表示二价基团之一，其中X，A1，A2和R1-R10如本文所定义。浓缩的二氮嗪酮适合作为迷走神经起搏器用于治疗心动过缓和缓慢性心律失常，并且对周围器官特别是结肠，膀胱和支气管具有解痉作用。

5. 发明授权

US5001122A Use of diazepinones for treating disorders of the microcirculation 失效
标题翻译：二氮嗪酮用于治疗微循环障碍的用途
公开(公告)号：US5001122A
公开(公告)日：1991-03-19
申请号：US353262
申请日：1989-05-17
申请人： Wolfgang Eberlein , Volker Trach , Wolfhard Engel , Gerhard Mihm , Norbert Mayer , Henri Doods , Richard Reichl
发明人： Wolfgang Eberlein , Volker Trach , Wolfhard Engel , Gerhard Mihm , Norbert Mayer , Henri Doods , Richard Reichl
IPC分类号： C07D243/38 , A61K31/00 , A61K31/55 , A61P9/00 , A61P9/08 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： A61K31/55 , Y10S514/921
摘要： A method for treating shock in a patient, which comprises administering to the patient a therapeutically effective amount of a diazepinone of the general formula: ##STR1## wherein A represents a 5,11-dihydro-6H-pyrido[2,3-b] [1,4] benzodiazepin-6-one group bound in the 11-position; a 5,10-dihydro-11H-dibenzo [b,e] [1,4] diazepin-11-one group bound in the 5-position; a 5,11-dihydro-10H-pyrido [3-2b] [1-4] benzodiazepin-10-one group bound in the 5-position; a 4,9-dihydro-10H-thieno [3,4-b] [1,5] benzodiazpin-10-one group bound in the 4-position, unsubstituted or substituted at the 1- or 3-position or both in the 1- and 3-position by an alkyl group having from 1 to 4 carbon atoms, or in the 3-positionby chlorine, fluorine or bromine; a 6-11-dihydro-5H-pyrido [2,3-b] [1,5] benzodiazepin-5-one group bound in the 11-position; or a 1-methyl-1,4,9,10-tetrahydropyrrolo-[3,2-b] [1,5] benzodiazepin-10-one group bound in the 4-position, unsubstituted or substituted at the 3-position by methyl or methyl or chlorine;R.sub.1 represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms;R.sub.2 represents an alkyl group having from 1 to 3 carbon atoms; andn and m each represent an integer from 1 to 3.
摘要翻译：一种治疗患者休克的方法，其包括向患者施用治疗有效量的通式如下的二氮杂酮：其中A代表5,11-二氢-6H-吡啶并[2,3-b] 结合在11位的[1,4]苯并二氮杂- 5位结合的5,10-二氢-11H-二苯并[b，e] [1,4]二氮杂-11-酮基; 5位结合的5,11-二氢-10H-吡啶并[3-2b] [1-4]苯并二氮杂-10-酮基; 在4-位上结合的未取代或取代的4,9-二氢-10H-噻吩并[3,4-b] [1,5]苯并二氮杂基-10-酮基或在通过具有1至4个碳原子的烷基或3-，3-位上的氯，氟或溴取代1-和3-位; 在11位结合的6-11-二氢-5H-吡啶并[2,3-b] [1,5]苯并二氮杂-5-基; 或在4-位上结合的1-甲基-1,4,9,10-四氢吡咯并[3,2-b] [1,5]苯并二氮杂-10-酮基，其未被取代或在3位被甲基或甲基或氯; R1表示氢原子或具有1至3个碳原子的烷基; R2表示具有1至3个碳原子的烷基; n和m各自表示1〜3的整数。

6. 发明授权

US5011836A Agents for the treatment of acute and chronic obstructive respiratory passage diseases 失效
标题翻译：用于治疗急性和慢性阻塞性呼吸道疾病的药剂
公开(公告)号：US5011836A
公开(公告)日：1991-04-30
申请号：US438827
申请日：1989-11-17
申请人： Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Klaus Rudolf , Henri Doods , Norbert Mayer
发明人： Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Klaus Rudolf , Henri Doods , Norbert Mayer
IPC分类号： C07D223/20 , A61K31/55 , A61P11/00 , C07D401/12
CPC分类号： A61K31/55 , Y10S514/826
摘要： A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]azepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-one, alone or in combination.
摘要翻译：一种治疗阻塞性呼吸道传播障碍的方法，其包括使用5,11-二氢-11 - [[（1-甲基-4-哌啶基） - 氨基]羰基] -6H-二苯并[b，e]氮杂- 一; 5,11-二氢-11 - [（1-甲基-4-哌嗪基）乙酰基] -6H-二苯并[b，e]氮杂-6-酮，5,11-二氢-11 - [（4-甲基-1- - 哌嗪基）乙酰基] -6H-二苯并[b，e]氮杂-6-酮，单独或组合使用。

8. 发明授权

US5641772A Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation 失效
标题翻译：浓缩二氮杂酮，其制备方法和含有这些化合物的药物，用于治疗中枢神经系统疾病和促进脑血液循环
公开(公告)号：US5641772A
公开(公告)日：1997-06-24
申请号：US421108
申请日：1995-04-13
申请人： Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
发明人： Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
IPC分类号： A61K31/55 , A61K31/5513 , A61K31/5517 , A61P9/00 , A61P9/06 , A61P25/00 , A61P25/28 , C07D243/12 , C07D243/38 , C07D401/06 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/04 , C07D495/14 , C07D243/10
CPC分类号： C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04
摘要： New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them.These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.
摘要翻译：（I）其中B表示二价基团之一的新的浓缩二氮杂酮通式I（I）其中B表示二价基团之一，其中X， m，n和R 1至R 7如本文所定义，以及其与无机或有机酸的盐及其制备方法。这些化合物可用于改善或归一化动脉硬化诱导的脑血流紊乱，用于治疗中枢神经系统疾病，特别是阿尔茨海默病和帕金森病，以及用于治疗心动过缓和缓慢心律失常的迷走神经心脏起搏器，以及用于改善记忆性能。

9. 发明授权

US5610155A Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation 失效
公开(公告)号：US5610155A
公开(公告)日：1997-03-11
申请号：US457061
申请日：1995-06-01
申请人： Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
发明人： Wolfgang Eberlein , Gerhard Mihm , Wolfhard Engel , Klaus Rudolf , Henri Doods , Harald Ziegler , Michael Entzeroth
IPC分类号： C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55 , C07D243/10
CPC分类号： C07D401/06 , C07D471/04 , C07D487/04 , C07D495/04
摘要： New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them.These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.

10. 发明授权

US5807875A Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：氨基酸衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5807875A
公开(公告)日：1998-09-15
申请号：US763504
申请日：1996-12-11
申请人： Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Henri Doods , Heike Andrea Wieland , Klaus-Dieter Willim , Jurgen Krause , Horst Dollinger , Franz Esser , Gerd Schnorrenberg , Michael Entzeroth , Wolfgang Wienen
发明人： Klaus Rudolf , Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Henri Doods , Heike Andrea Wieland , Klaus-Dieter Willim , Jurgen Krause , Horst Dollinger , Franz Esser , Gerd Schnorrenberg , Michael Entzeroth , Wolfgang Wienen
IPC分类号： A61K31/155 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/454 , A61K31/47 , A61K38/00 , A61P9/12 , A61P43/00 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/10 , C07C279/12 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/15 , C07C311/19 , C07C311/39 , C07C311/42 , C07D209/14 , C07D209/16 , C07D209/42 , C07D209/44 , C07D211/28 , C07D213/38 , C07D213/55 , C07D215/12 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/54 , C07D233/64 , C07D233/66 , C07D233/72 , C07D233/88 , C07D235/06 , C07D235/08 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D271/06 , C07D271/07 , C07D295/15 , C07D333/20 , C07D333/36 , C07D401/12 , C07D471/04 , C07K5/072 , C07C273/00 , C07C275/00
CPC分类号： C07D233/64 , C07C237/22 , C07C237/42 , C07C255/60 , C07C257/12 , C07C257/14 , C07C257/18 , C07C259/10 , C07C259/18 , C07C261/04 , C07C275/40 , C07C279/14 , C07C279/18 , C07C279/36 , C07C307/02 , C07C307/10 , C07C311/08 , C07C311/19 , C07C311/39 , C07C311/42 , C07D209/16 , C07D209/42 , C07D209/44 , C07D213/38 , C07D215/38 , C07D223/20 , C07D233/24 , C07D233/48 , C07D233/72 , C07D233/88 , C07D235/06 , C07D249/12 , C07D249/14 , C07D271/07 , C07D295/15 , C07D333/20 , C07D471/04 , C07K5/06095 , A61K38/00 , C07C2101/08 , C07C2101/14 , C07C2103/18 , C07C2103/74
摘要： Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R,S)-N.sup.2 -(diphenylacetyl)-N-�(4-hydroxyphenyl)methyl!-N.sup.5 -(1H-imidazol-2-yl)-ornithinamide.
摘要翻译：氨基酸衍生物，适用于治疗肥胖症。以下化合物是以下类别的示例：（R，S）-N 2 - （二苯基乙酰基）-N - [（4-羟基苯基）甲基] -N 5 - （1H-咪唑-2-基） - 甲硅烷基酰胺。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式