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1. 发明授权

US07375089B2 Rehydration composition 失效
标题翻译：补液组成
公开(公告)号：US07375089B2
公开(公告)日：2008-05-20
申请号：US10697428
申请日：2003-10-30
申请人： George Verlaan , Robert Johan Joseph Hageman , Rudolf Leonardus Lodewijk Smeets
发明人： George Verlaan , Robert Johan Joseph Hageman , Rudolf Leonardus Lodewijk Smeets
IPC分类号： A61K31/715 , A61K31/13
CPC分类号： A23L2/38 , A23L33/16 , A23V2002/00 , A61K45/06 , A23V2250/5114 , A23V2250/0644 , A23V2250/0632 , A23V2250/061 , A23V2250/606 , A23V2250/1614 , A23V2250/16
摘要： The invention relates to a fluid that can be used for preventing or treating hypohydration and the secondary consequences thereof. The fluid comprises one or more carbohydrates and minerals and is further characterized by a low osmolarity. The invention further relates to the use of such a fluid for medical, dietetic and other applications.
摘要翻译：本发明涉及可用于预防或治疗缺氧的流体及其二次后果。流体包含一种或多种碳水化合物和矿物质，其进一步特征在于低渗透压。本发明还涉及这种流体用于医疗，饮食和其它应用的用途。

2. 发明授权

US06420342B1 Nutritional preparation comprising ribose and medical use thereof 有权
标题翻译：营养制剂，包括核糖和医疗用途
公开(公告)号：US06420342B1
公开(公告)日：2002-07-16
申请号：US09566381
申请日：2000-05-08
申请人： Robert Johan Joseph Hageman , Rudolf Leonardus Lodewijk Smeets , George Verlaan
发明人： Robert Johan Joseph Hageman , Rudolf Leonardus Lodewijk Smeets , George Verlaan
IPC分类号： A61K3170
CPC分类号： A61K31/522 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/7004 , Y02A50/411 , A61K2300/00 , A23V2250/626 , A23V2250/70 , A23V2250/1642 , A23V2250/1588 , A23V2250/218 , A23V2250/1626 , A23V2250/5424 , A23V2250/5114 , A23V2250/704 , A23V2250/156 , A23V2250/032 , A23V2250/0632 , A23V2250/5072 , A23V2250/06 , A23V2250/1944 , A23V2250/026 , A23V2250/161 , A23V2250/712 , A23V2250/708 , A23V2250/314 , A23V2250/306 , A23V2250/062
摘要： Trauma, surgery, inflammation, subfertility, lactation problems, gut disorders, infant nutrition, cancer, arthritis and other joints problems, vascular problems and cardio- or cerebro vascular problems, ischaemia, aging, impaired immune function, burns, sepsis, malnutrition, problems with liver or kidneys, malaria, cystic fibrosis, migraine, neurological problems, respiratory infections, improvement of sports results, muscle soreness, drug intoxication and pain can be treated with a nutritional composition containing effective amounts of ribose and folic acid, optionally combined with other components such as niacin, histidine, glutamine, orotate, vitamin B6 and other components.
摘要翻译：创伤，手术，炎症，不孕症，哺乳期问题，肠道疾病，婴儿营养，癌症，关节炎和其他关节问题，血管问题和心脑血管问题，缺血，老化，免疫功能受损，烧伤，败血症，营养不良，问题可以用含有有效量的核糖和叶酸的营养组合物，任选地与其他组合使用，治疗肝脏或肾脏，疟疾，囊性纤维化，偏头痛，神经系统问题，呼吸道感染，运动结果改善，肌肉酸痛，药物中毒和疼痛组分如烟酸，组氨酸，谷氨酰胺，乳清酸，维生素B6等成分。

3. 发明授权

US06548483B2 Nutritional preparation comprising ribose and medical use thereof 有权
公开(公告)号：US06548483B2
公开(公告)日：2003-04-15
申请号：US10178736
申请日：2002-06-25
申请人： Robert Johan Joseph Hageman , Rudolf Leonardus Lodewijk Smeets , George Verlaan
发明人： Robert Johan Joseph Hageman , Rudolf Leonardus Lodewijk Smeets , George Verlaan
IPC分类号： A61K3170
CPC分类号： A61K31/522 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/7004 , Y02A50/411 , A61K2300/00 , A23V2250/626 , A23V2250/70 , A23V2250/1642 , A23V2250/1588 , A23V2250/218 , A23V2250/1626 , A23V2250/5424 , A23V2250/5114 , A23V2250/704 , A23V2250/156 , A23V2250/032 , A23V2250/0632 , A23V2250/5072 , A23V2250/06 , A23V2250/1944 , A23V2250/026 , A23V2250/161 , A23V2250/712 , A23V2250/708 , A23V2250/314 , A23V2250/306 , A23V2250/062
摘要： Trauma, surgery, inflammation, subfertility, pregnancy, lactation problems, gut disorders, infant nutrition, cancer, arthritis and other joint problems, vascular problems and cardio-or cerebro-vascular problems, ischaemia, aging, impaired immune function, burns, sepsis, malnutrition, problems with liver, pancreas or kidneys, malaria, cystic fibrosis, migraine, neurological problems, respiratory infections, improvement of sports results, muscle soreness, drug intoxication and pain can be treated with a nutritional composition containing effective amounts of ribose and folic acid, optionally combined with other components such as niacin, histidine, glutamine, orotate, vitamin B6 and other components.

4. 发明申请

US20080161398A1 STIMULATION OF IN VIVO PRODUCTION OF PROTEINS 审中-公开
标题翻译：刺激生殖蛋白的生物学
公开(公告)号：US20080161398A1
公开(公告)日：2008-07-03
申请号：US11872804
申请日：2007-10-16
申请人： George Verlaan , Rudolf Leonardus Lodewijk Smeets , Robert Reese Wolfe
发明人： George Verlaan , Rudolf Leonardus Lodewijk Smeets , Robert Reese Wolfe
IPC分类号： A61K31/198 , A61P3/00
CPC分类号： A61K45/06 , A23L33/175 , A23V2002/00 , A61K31/198 , A61K2300/00 , A23V2250/0628 , A23V2250/542
摘要： The invention relates to a formulation in the form of a pharmaceutical composition, a food product, a feed product or a dietary supplement, comprising leucine and protein in specific amounts. Consumption of a formulation according to the invention has a very positive effect on the generation of muscle tissue and is therefore particularly useful for organisms wherein an anabolic response is desired.
摘要翻译：本发明涉及包含特定量的亮氨酸和蛋白质的药物组合物，食品，饲料产品或膳食补充剂形式的制剂。根据本发明的制剂的消耗对肌肉组织的产生具有非常积极的作用，因此特别适用于需要合成代谢反应的生物体。

5. 发明授权

US07288570B2 Stimulation of in vivo production of proteins 有权
标题翻译：刺激蛋白质的体内产生
公开(公告)号：US07288570B2
公开(公告)日：2007-10-30
申请号：US10325711
申请日：2002-12-20
申请人： George Verlaan , Rudolf Leonardus Lodewijk Smeets , Robert Reese Wolfe
发明人： George Verlaan , Rudolf Leonardus Lodewijk Smeets , Robert Reese Wolfe
IPC分类号： A01N37/12
CPC分类号： A61K45/06 , A23L33/175 , A23V2002/00 , A61K31/198 , A61K2300/00 , A23V2250/0628 , A23V2250/542
摘要： The invention relates to a formulation in the form of a pharmaceutical composition, a food product, a feed product or a dietary supplement, comprising leucine and protein in specific amounts. Consumption of a formulation according to the invention has a very positive effect on the generation of muscle tissue and is therefore particularly useful for organisms wherein an anabolic response is desired.
摘要翻译：本发明涉及包含特定量的亮氨酸和蛋白质的药物组合物，食品，饲料产品或膳食补充剂形式的制剂。根据本发明的制剂的消耗对肌肉组织的产生具有非常积极的作用，因此特别适用于需要合成代谢反应的生物体。

6. 发明申请

US20130210780A1 Nutritional Composition for the Stimulation of Muscle Protein Synthesis 审中-公开
公开(公告)号：US20130210780A1
公开(公告)日：2013-08-15
申请号：US13808630
申请日：2011-07-06
申请人： Marion-Eve Adeline Jourdan , Yvette Charlotte Luiking , George Verlaan , Sovianne Ter Borg
发明人： Marion-Eve Adeline Jourdan , Yvette Charlotte Luiking , George Verlaan , Sovianne Ter Borg
IPC分类号： A61K31/59 , A23L1/29 , A61K31/198
CPC分类号： A61K31/593 , A23L33/155 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2200/316 , A23V2250/0614 , A23V2250/0628 , A23V2250/306 , A23V2250/71 , A61K31/198 , A61K31/59 , A61K31/592 , A61K2300/00 , A23V2200/302 , A23V2250/54252
摘要： The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal.

7. 发明授权

US07214386B2 Method for the treatment and prevention of overweight in mammals 有权
标题翻译：治疗和预防哺乳动物超重的方法
公开(公告)号：US07214386B2
公开(公告)日：2007-05-08
申请号：US10384750
申请日：2003-03-11
申请人： Rene John Raggers , George Verlaan
发明人： Rene John Raggers , George Verlaan
IPC分类号： A61K9/20
CPC分类号： A61K36/185 , A61K36/23 , A61K36/77 , A61K36/82 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to a method for the prevention and/or treatment of overweight in mammals. More particularly the invention is concerned with such a method comprising the enteral administration to a mammal of a preparation comprising an effective amount of a combination of dill or an isolate thereof and one or more components capable of stimulating in vivo lipolysis. Suitable examples of components capable of stimulating in vivo lipolysis include methylxanthines, adrenergic amines, Paullinia cupana or an isolate thereof, Zingziber officinale or an isolate thereof, Camellia sinensis or an isolate thereof, Ilex paraguayiensis or an isolate thereof.Another aspect of the invention relates to a solid or semi-solid unit dosage, preferably selected from the group consisting of tablets, pills, microparticles, microspheres, suppositories, capsules, caplets and the like, that is suitable for enteral unitary administration to human subjects and other mammals comprising: a. dill or an isolate thereof in an amount equivalent to between 5 mg and 20 g dill and b. a component capable of stimulating in vivo lipolysis.
摘要翻译：本发明涉及一种用于预防和/或治疗哺乳动物超重的方法。更具体地，本发明涉及这样的方法，其包括向哺乳动物施用有效量的莳萝或其分离物的组合的一种或多种能够刺激体内脂肪分解的成分的哺乳动物的肠内施用。能够刺激体内脂肪分解的组分的合适实例包括甲基黄嘌呤，肾上腺素能胺，保加利亚或其分离物，姜黄或其分离物，山茶或其分离物，白僵菌或其分离物。本发明的另一方面涉及一种固体或半固体单位剂量，优选选自由片剂，丸剂，微粒，微球，栓剂，胶囊，囊片等组成的组，其适用于人受试者的肠内单一给药和其他哺乳动物，包括：a。莳萝或其分离物的量相当于5mg和20g莳萝之间，b。能够刺激体内脂肪分解的成分。

8. 发明申请

US20080171720A1 Nutritional Supplement For Hiv Patients 审中-公开
标题翻译： Hiv患者营养补充剂
公开(公告)号：US20080171720A1
公开(公告)日：2008-07-17
申请号：US11912088
申请日：2006-04-19
申请人： Johan Garssen , Eric Alexander Franciscus Van Tol , Johannes Wilhelmus Christina Sijben , George Verlaan
发明人： Johan Garssen , Eric Alexander Franciscus Van Tol , Johannes Wilhelmus Christina Sijben , George Verlaan
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A23L33/12 , A23L33/175 , A23L33/18 , A23L33/185 , A23L33/21 , A23L33/40 , A23V2002/00 , A23V2250/54242 , A23V2250/5424 , A23V2250/1882 , A23V2250/0616 , A23V2250/28 , A23V2250/5062 , A23V2250/0634 , A23V2250/606 , A23V2250/6406
摘要： The present invention relates to a nutritional product for HIV patients. More specifically the invention relates to a nutritional composition that provides carefully selected nutritional ingredients including oligosaccharides and cysteine and/or a source of cysteine specifically supporting HIV patients with nutritionally related symptoms. This invention also relates to the manufacture of a nutritional supplement for use in HIV patients.
摘要翻译：本发明涉及HIV患者的营养产品。更具体地，本发明涉及营养组合物，其提供精心选择的营养成分，包括寡糖和半胱氨酸和/或特异性支持具有营养相关症状的HIV患者的半胱氨酸来源。本发明还涉及用于HIV患者的营养补充剂的制造。

9. 发明申请

US20080146579A1 TREATMENT OF PATIENTS WITH CHRONIC PULMONARY DISEASES AND NUTRITIONAL COMPOSITIONS THEREFORE 审中-公开
标题翻译：慢性慢性疾病患者和营养组合物的治疗
公开(公告)号：US20080146579A1
公开(公告)日：2008-06-19
申请号：US11611562
申请日：2006-12-15
申请人： Erwin Peke MEIJER , George Verlaan , Maarteen Anne Hoijer
发明人： Erwin Peke MEIJER , George Verlaan , Maarteen Anne Hoijer
IPC分类号： A61K31/519 , A23L1/302 , C07D307/20 , C07D475/02 , A61K31/341
CPC分类号： A61K31/341 , A23L5/00 , A23L9/00 , A23L29/30 , A23L33/10 , A23L33/12 , A23L33/125 , A23L33/15 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/198 , A61K31/519 , A61K31/7004 , A61K2300/00 , A23V2200/314 , A23V2250/626 , A23V2250/0634 , A23V2250/7056 , A23V2250/1882 , A23V2250/54246 , A23V2250/7044 , A23V2250/211 , A23V2250/187 , A23V2250/1868 , A23V2250/636 , A23V2250/708 , A23V2250/712 , A23V2200/326 , A23V2250/0616 , A23V2250/302 , A23V2250/1874 , A23V2250/704
摘要： The invention pertains to a method and compositions for treatment or prevention of chronic pulmonary dysfunction in a patient.
摘要翻译：本发明涉及用于治疗或预防患者的慢性肺功能障碍的方法和组合物。

10. 发明申请

US20080146514A1 Method and compositions for improving pulmonary hypertension 有权
标题翻译：改善肺动脉高压的方法和组合物
公开(公告)号：US20080146514A1
公开(公告)日：2008-06-19
申请号：US11640082
申请日：2006-12-15
申请人： George Verlaan , John A. St. Cyr
发明人： George Verlaan , John A. St. Cyr
IPC分类号： A61K31/7004 , A61P9/12
CPC分类号： A61K31/519 , A61K31/7004 , A61K2300/00
摘要： This invention discloses a method and compositions for treatment or prevention of pulmonary hypertension in a mammal. Representative mammals include humans and horses. The invention further relates to supplements especially beneficial in preventing or stopping the progression of pulmonary hypertension. The supplements include ribose and folate. Additional nutrients include omega-3 fatty acids and gamma linoleic acid.
摘要翻译：本发明公开了一种用于治疗或预防哺乳动物肺动脉高压的方法和组合物。代表性的哺乳动物包括人和马。本发明还涉及特别有利于预防或阻止肺动脉高压进展的补充剂。补充剂包括核糖和叶酸。额外的营养物质包括ω-3脂肪酸和γ-亚油酸。

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