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1. 发明申请

US20130210780A1 Nutritional Composition for the Stimulation of Muscle Protein Synthesis 审中-公开
公开(公告)号：US20130210780A1
公开(公告)日：2013-08-15
申请号：US13808630
申请日：2011-07-06
申请人： Marion-Eve Adeline Jourdan , Yvette Charlotte Luiking , George Verlaan , Sovianne Ter Borg
发明人： Marion-Eve Adeline Jourdan , Yvette Charlotte Luiking , George Verlaan , Sovianne Ter Borg
IPC分类号： A61K31/59 , A23L1/29 , A61K31/198
CPC分类号： A61K31/593 , A23L33/155 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2200/316 , A23V2250/0614 , A23V2250/0628 , A23V2250/306 , A23V2250/71 , A61K31/198 , A61K31/59 , A61K31/592 , A61K2300/00 , A23V2200/302 , A23V2250/54252
摘要： The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal.

2. 发明授权

US08846759B2 Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis 有权
标题翻译：低热量高蛋白营养组合物用于刺激肌肉蛋白质合成
公开(公告)号：US08846759B2
公开(公告)日：2014-09-30
申请号：US13518281
申请日：2010-12-23
申请人： Yvette Charlotte Luiking , George Verlaan , Marion Jourdan
发明人： Yvette Charlotte Luiking , George Verlaan , Marion Jourdan
IPC分类号： A61K35/20 , A23L1/304 , A23L1/305 , A23L1/29 , A61K31/70 , A61K35/74 , A61K38/17 , A23L1/302 , A23L1/308
CPC分类号： A23L1/296 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/19 , A23L33/21 , A23L33/40 , A61K31/70 , A61K35/74 , A61K38/1709
摘要： The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, which involves muscle decline, as well as to specific low-caloric high-protein nutritional compositions for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least about 12 g of proteinaceous matter which comprises at least about 80 weight % of whey protein, relative to the total proteinaceous matter, and which comprises at least about 11 weight % of leucine, relative to the total proteinaceous matter, of which at least about 20 weight % is in a free form, relative to the total leucine, (ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition which involves muscle decline in a mammal, especially an elderly mammal, wherein the nutritional composition is administered as 1 to 2 servings daily, each serving comprising between 80 and 200 kcal.
摘要翻译：本发明涉及低热量高蛋白营养组合物用于预防或治疗涉及肌肉下降的哺乳动物的疾病或病症的用途，以及特定的低热量高蛋白营养物质刺激哺乳动物肌肉蛋白质合成的组合物。特别地，本发明涉及包含每100千卡的营养组合物的用途：（i）至少约12克相对于总蛋白质物质至少约80重量％的乳清蛋白质的蛋白质物质，以及哪些相对于总蛋白质物质，其至少约11重量％的亮氨酸相对于总亮氨酸为至少约20重量％，其中至少约20重量％为游离形式，（ii）脂肪源和可消化碳水化合物源用于预防或治疗哺乳动物，特别是老年哺乳动物中涉及肌肉衰退的疾病或病症，其中营养组合物每天以1-2份服用，每份服用包含80至200千卡。

3. 发明申请

US20130203658A1 Low-Caloric High-Protein Nutritional Composition for the Stimulation of Muscle Protein Synthesis 有权
标题翻译：低热量高蛋白营养组合物刺激肌肉蛋白质合成
公开(公告)号：US20130203658A1
公开(公告)日：2013-08-08
申请号：US13518281
申请日：2010-12-23
申请人： Yvette Charlotte Luiking , George Verlaan , Marion Jourdan
发明人： Yvette Charlotte Luiking , George Verlaan , Marion Jourdan
IPC分类号： A23L1/29 , A61K31/70 , A61K38/17
CPC分类号： A23L1/296 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/19 , A23L33/21 , A23L33/40 , A61K31/70 , A61K35/74 , A61K38/1709
摘要： The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, which involves muscle decline, as well as to specific low-caloric high-protein nutritional compositions for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least about 12 g of proteinaceous matter which comprises at least about 80 weight % of whey protein, relative to the total proteinaceous matter, and which comprises at least about 11 weight % of leucine, relative to the total proteinaceous matter, of which at least about 20 weight % is in a free form, relative to the total leucine, (ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition which involves muscle decline in a mammal, especially an elderly mammal, wherein the nutritional composition is administered as 1 to 2 servings daily, each serving comprising between 80 and 200 kcal.
摘要翻译：本发明涉及低热量高蛋白营养组合物用于预防或治疗涉及肌肉下降的哺乳动物的疾病或病症的用途，以及特定的低热量高蛋白营养物质刺激哺乳动物肌肉蛋白质合成的组合物。特别地，本发明涉及包含每100千卡的营养组合物的用途：（i）至少约12克相对于总蛋白质物质至少约80重量％的乳清蛋白质的蛋白质物质，以及哪些相对于总蛋白质物质，其至少约11重量％的亮氨酸相对于总亮氨酸为至少约20重量％，其中至少约20重量％为游离形式，（ii）脂肪源和可消化碳水化合物源用于预防或治疗哺乳动物，特别是老年哺乳动物中涉及肌肉衰退的疾病或病症，其中营养组合物每天以1-2份服用，每份服用包含80至200千卡。

4. 发明申请

US20090291877A1 TREATMENTS USING CITRULLINE 审中-公开
标题翻译：治疗使用CITRULLINE
公开(公告)号：US20090291877A1
公开(公告)日：2009-11-26
申请号：US12293283
申请日：2007-04-02
申请人： Nicolaas Emile Deutz , Norman Alan Greenberg , Kala Marie Kaspar , Candis Kvamme , Yvette Charlotte Luiking
发明人： Nicolaas Emile Deutz , Norman Alan Greenberg , Kala Marie Kaspar , Candis Kvamme , Yvette Charlotte Luiking
IPC分类号： A61K31/195 , A61K38/00 , A61K31/20 , A61K31/70 , A61P17/02 , A61P37/00
CPC分类号： A61K31/198 , A23L33/175 , A61K45/06 , A61K2300/00
摘要： The invention provides a method and formulation for the treatment or maintenance of conditions that would be benefited from increasing or maintaining Arginine levels in the blood, and having improved taste characteristics over current Arginine supplementations. Further, this maintenance of Arginine levels in the blood will be beneficial in acute and chronic diseases with an impaired arginine to citrulline production rate. Further the invention provides a method for treating at least one of satiety and dyspepsia in an individual. In one embodiment, the method includes administering to an individual an effective amount of L-citrulline.
摘要翻译：本发明提供了一种用于治疗或维持将有益于增加或维持血液中精氨酸水平并且与当前精氨酸补充剂相比具有改善的味觉特性的病症的方法和制剂。此外，精氨酸水平维持在血液中将有益于急性和慢性疾病，精氨酸受损与瓜氨酸生产率有关。此外，本发明提供了治疗个体中饱和感和消化不良中的至少一种的方法。在一个实施方案中，该方法包括向个体施用有效量的L-瓜氨酸。

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