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1. 发明申请

US20070161085A1 Methods of Producing Influenza Vaccine Compositions 审中-公开
标题翻译：生产流感疫苗组合物的方法
公开(公告)号：US20070161085A1
公开(公告)日：2007-07-12
申请号：US11668587
申请日：2007-01-30
申请人： George Trager , George Kemble , Richard Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred Pan , Eric Tsao , Chiaoyin Wang , Luisa Yee , Palani Balu
发明人： George Trager , George Kemble , Richard Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred Pan , Eric Tsao , Chiaoyin Wang , Luisa Yee , Palani Balu
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： A61K39/145 , A61K35/76 , A61K39/12 , A61K47/02 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/525 , A61K2039/5254 , B01D61/145 , B01D61/147 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
摘要翻译：提供了适合作为流感疫苗优化流感病毒生产的方法和组合物。

2. 发明申请

US20060110406A1 Refrigerator-temperature stable influenza vaccine compositions 审中-公开
标题翻译：冰箱温度稳定型流感疫苗组合物
公开(公告)号：US20060110406A1
公开(公告)日：2006-05-25
申请号：US11242018
申请日：2005-10-04
申请人： George Kemble , George Trager , Richard Schwartz
发明人： George Kemble , George Trager , Richard Schwartz
IPC分类号： A61K39/145 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

3. 发明申请

US20120282294A1 REFRIGERATOR-TEMPERATURE STABLE INFLUENZA VACCINE COMPOSITIONS 有权
标题翻译：制冷剂温度稳定的流感疫苗组合物
公开(公告)号：US20120282294A1
公开(公告)日：2012-11-08
申请号：US13552625
申请日：2012-07-18
申请人： George Kemble , George Trager , Richard Schwartz
发明人： George Kemble , George Trager , Richard Schwartz
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

4. 发明授权

US08247207B2 Refrigerator-temperature stable influenza vaccine compositions 有权
标题翻译：冰箱温度稳定型流感疫苗组合物
公开(公告)号：US08247207B2
公开(公告)日：2012-08-21
申请号：US12487343
申请日：2009-06-18
申请人： George Kemble , George Trager , Richard Schwartz
发明人： George Kemble , George Trager , Richard Schwartz
IPC分类号： C12N7/02 , A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

5. 发明授权

US06669958B1 Gel delivery vehicles for anticellular proliferative agents 失效
标题翻译：凝胶输送车辆用于抗细胞增生剂
公开(公告)号：US06669958B1
公开(公告)日：2003-12-30
申请号：US09505303
申请日：2000-02-16
申请人： George Trager , Richard E. Jones
发明人： George Trager , Richard E. Jones
IPC分类号： A61K910
CPC分类号： A61K9/0019 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/38
摘要： Methods and compositions are provided for the treatment of a host suffering from a cellular proliferative diease. In the subject methods, antiproliferative agents are administered in a substantially non-aqueous gel delivery vehicle comprising at least one polar organic solvent in combination with one or more thickening agents. The subject methods and compositions provide for the enhanced efficacy of regionally or locally administered antiproliferative proliferative agents.
摘要翻译：提供了用于治疗患有细胞增殖性坏死酶的宿主的方法和组合物。在本发明方法中，抗增殖剂在基本上非水性凝胶输送载体中施用，其包含至少一种极性有机溶剂与一种或多种增稠剂的组合。本发明的方法和组合物提供了区域或局部施用的抗增殖性增殖剂的增强功效。

6. 发明申请

US20080228162A1 SINGLE-USE AMPOULE 审中-公开
标题翻译：单次使用
公开(公告)号：US20080228162A1
公开(公告)日：2008-09-18
申请号：US11864361
申请日：2007-09-28
申请人： George Trager , Lance Wong
发明人： George Trager , Lance Wong
IPC分类号： A61J1/06
CPC分类号： A61J1/067
摘要： A single-use, blow-molded container for medical or pharmaceutical media is presented. The container comprises a flexible storage portion connected to one end a dispensing portion and a cap connected to the other end of the dispensing portion, wherein the cap is separated from the dispensing portion to create an outlet opening so that the medical media can be expelled from the flexible storage portion. One improvement comprises at least one barrier member disposed on the dispensing portion, wherein the barrier member is sized and dimensioned to limit the insertion of the dispensing member into a patient's nostril. Another improvement comprises an orifice controlling the pattern and direction of the medical media as it exits the ampoule container and wherein the orifice is spaced apart from the outlet opening.
摘要翻译：介绍了一种用于医疗或药物介质的一次性吹塑容器。容器包括柔性存储部分，其连接到一端，分配部分和连接到分配部分的另一端的帽，其中帽与分配部分分离以产生出口开口，使得医疗介质可以被排出柔性储存部分。一个改进包括设置在分配部分上的至少一个阻挡构件，其中阻挡构件的尺寸和尺寸被限制以限制将分配构件插入患者鼻孔中。另一改进包括在离开安瓿容器时控制医疗介质的图案和方向的孔，并且其中孔与出口开口间隔开。

7. 发明授权

US06630168B1 Gel delivery vehicles for anticellular proliferative agents 失效
标题翻译：凝胶输送车辆用于抗细胞增生剂
公开(公告)号：US06630168B1
公开(公告)日：2003-10-07
申请号：US08803128
申请日：1997-02-20
申请人： Richard E. Jones , Keith Washco , Kathleen V. Roskos , Richard Maskiewicz , George Trager
发明人： Richard E. Jones , Keith Washco , Kathleen V. Roskos , Richard Maskiewicz , George Trager
IPC分类号： A61K910
CPC分类号： A61K9/0019 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/38
摘要： Methods and compositions are provided for the treatment of a host suffering from a cellular proliferative disease. In the subject methods, antiproliferative agents are administered in a substantially non-aqueous gel delivery vehicle comprising at least one polar organic solvent in combination with one or more thickening agents. The subject methods and compositions provide for the enhanced efficacy of regionally or locally administered antiproliferative proliferative agents.
摘要翻译：提供了用于治疗患有细胞增殖性疾病的宿主的方法和组合物。在本发明方法中，抗增殖剂在基本上非水性凝胶输送载体中施用，其包含至少一种极性有机溶剂与一种或多种增稠剂的组合。本发明的方法和组合物提供了区域或局部施用的抗增殖性增殖剂的增强功效。

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