专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070161085A1 Methods of Producing Influenza Vaccine Compositions 审中-公开
标题翻译：生产流感疫苗组合物的方法
公开(公告)号：US20070161085A1
公开(公告)日：2007-07-12
申请号：US11668587
申请日：2007-01-30
申请人： George Trager , George Kemble , Richard Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred Pan , Eric Tsao , Chiaoyin Wang , Luisa Yee , Palani Balu
发明人： George Trager , George Kemble , Richard Schwartz , Harshvardhan Mehta , Vu Truong-Le , Zhongying Chen , Alfred Pan , Eric Tsao , Chiaoyin Wang , Luisa Yee , Palani Balu
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： A61K39/145 , A61K35/76 , A61K39/12 , A61K47/02 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/525 , A61K2039/5254 , B01D61/145 , B01D61/147 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
摘要翻译：提供了适合作为流感疫苗优化流感病毒生产的方法和组合物。

2. 发明申请

US20060110406A1 Refrigerator-temperature stable influenza vaccine compositions 审中-公开
标题翻译：冰箱温度稳定型流感疫苗组合物
公开(公告)号：US20060110406A1
公开(公告)日：2006-05-25
申请号：US11242018
申请日：2005-10-04
申请人： George Kemble , George Trager , Richard Schwartz
发明人： George Kemble , George Trager , Richard Schwartz
IPC分类号： A61K39/145 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

3. 发明申请

US20120282294A1 REFRIGERATOR-TEMPERATURE STABLE INFLUENZA VACCINE COMPOSITIONS 有权
标题翻译：制冷剂温度稳定的流感疫苗组合物
公开(公告)号：US20120282294A1
公开(公告)日：2012-11-08
申请号：US13552625
申请日：2012-07-18
申请人： George Kemble , George Trager , Richard Schwartz
发明人： George Kemble , George Trager , Richard Schwartz
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

4. 发明授权

US08247207B2 Refrigerator-temperature stable influenza vaccine compositions 有权
标题翻译：冰箱温度稳定型流感疫苗组合物
公开(公告)号：US08247207B2
公开(公告)日：2012-08-21
申请号：US12487343
申请日：2009-06-18
申请人： George Kemble , George Trager , Richard Schwartz
发明人： George Kemble , George Trager , Richard Schwartz
IPC分类号： C12N7/02 , A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

5. 发明授权

US08652822B2 Refrigerator-temperature stable influenza vaccine compositions 有权
标题翻译：冰箱温度稳定型流感疫苗组合物
公开(公告)号：US08652822B2
公开(公告)日：2014-02-18
申请号：US13552625
申请日：2012-07-18
申请人： George Kemble , George Robert Trager , Richard Schwartz
发明人： George Kemble , George Robert Trager , Richard Schwartz
IPC分类号： A61K39/145 , C12N7/02
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
摘要翻译：提供了用于优化和生产冰箱温度稳定病毒如流感的组合物的方法和组合物。提供了包含冷藏温度稳定的病毒组合物的制剂和免疫原性组合物。

6. 发明授权

US08846032B2 MDCK cell lines supporting viral growth to high titers and bioreactor process using the same 有权
标题翻译：支持病毒生长至高滴度的MDCK细胞系和使用其的生物反应器过程
公开(公告)号：US08846032B2
公开(公告)日：2014-09-30
申请号：US13595897
申请日：2012-08-27
申请人： Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Maranga , Mridul Ghosh , Ajit Subramanian , Simon Sheng-Tsiung Hsu
发明人： Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Maranga , Mridul Ghosh , Ajit Subramanian , Simon Sheng-Tsiung Hsu
IPC分类号： A61K39/145 , A01N65/00 , A61K39/00 , C12N5/02 , C07K17/00 , C12N7/00
CPC分类号： C12N7/00 , C12N2760/16151 , C12N2760/16152 , C12N2760/16251 , C12N2760/16252
摘要： The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
摘要翻译：本发明涉及可以在细胞培养中将病毒（例如流感病毒）生长至比先前可能更高滴度的新型MDCK细胞。 MDCK细胞可适应于无血清培养基。本发明还涉及包含MDCK细胞的细胞培养组合物和用于培养MDCK细胞的培养方法。本发明还涉及使用本发明的MDCK细胞在细胞培养中生产流感病毒的方法。

7. 发明授权

US08748174B2 Non-tumorigenic MDCK cell line for propagating viruses 有权
标题翻译：用于传播病毒的非致瘤性MDCK细胞系
公开(公告)号：US08748174B2
公开(公告)日：2014-06-10
申请号：US13355252
申请日：2012-01-20
申请人： Richard Schwartz , John Michael Berry , Ajit Subramanian , Xiao Shi
发明人： Richard Schwartz , John Michael Berry , Ajit Subramanian , Xiao Shi
IPC分类号： C12N5/00 , C12N7/08 , C12N5/02
CPC分类号： C12N7/00 , C12N5/0037 , C12N5/0043 , C12N2500/36 , C12N2500/76 , C12N2500/90 , C12N2501/11 , C12N2501/395 , C12N2510/02 , C12N2760/16151 , C12N2760/16161 , C12N2760/16251 , C12N2760/16261
摘要： The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
摘要翻译：本发明提供可在血清存在或不存在的情况下生长的新型MDCK衍生的粘附性非致瘤细胞系。本发明的细胞系可用于生产疫苗材料（例如病毒）。更具体地说，本发明的细胞系通常用于生产流感病毒，尤其是流感病毒。本发明还提供了用于适应和培养MDCK细胞的方法和培养基制剂，使得它们保持非致瘤性。此外，本发明提供了在本发明的新型细胞系中生产疫苗材料（例如流感病毒）的方法。

8. 发明授权

US08336541B2 Endotracheal intubation device 有权
标题翻译：气管内插管装置
公开(公告)号：US08336541B2
公开(公告)日：2012-12-25
申请号：US12592406
申请日：2009-11-24
申请人： John Schwartz , Richard Schwartz , Christopher L. Hogg
发明人： John Schwartz , Richard Schwartz , Christopher L. Hogg
IPC分类号： A61M11/00
CPC分类号： A61M16/0488 , A61B1/267 , A61M16/0418 , A61M16/0434
摘要： An endotracheal intubation device 10 is disclosed. The endotracheal intubation device 10 includes a stylet 100, an elongate rod 300 mounted within the stylet 100 and adapted to deform/curve the stylet 100 as well as an endotracheal tube 400 mounted thereto by contacting an inner wall of the endotracheal tube 400 via a slot 130 through which the rod 300 bows outwardly, and a handle 200 mounted to the stylet 100 and adapted to actuate the elongate rod 300 to deform/curve the stylet 100. The endotracheal intubation device 10 can be used on a patient by a medical professional to access the patient's trachea by inserting the endotracheal tube 400 into the patient. Upon insertion, the handle 200 is actuated to deform the stylet 100.
摘要翻译：公开了一种气管内插管装置10。气管内插管装置10包括探针装置100，安装在探针100内的细长杆300，并且适于使探针管100变形/弯曲，以及通过气管插管400的内壁经由插槽 130，杆300通过其向外弯曲;以及手柄200，其安装到探针100上并且适于致动细长杆300以使管心针100变形/弯曲。气管插管装置10可由医疗专业人员在患者身上使用通过将气管插管400插入患者来进入病人的气管。在插入时，手柄200被致动以使探针100变形。

9. 发明申请

US20120115206A1 NON-TUMORIGENIC MDCK CELL LINE FOR PROPAGATING VIRUSES 有权
标题翻译：用于传播病毒的非特异性MDCK细胞系
公开(公告)号：US20120115206A1
公开(公告)日：2012-05-10
申请号：US13355252
申请日：2012-01-20
申请人： Richard Schwartz , John Michael Berry , Ajit Subramanian , Xiao Shi
发明人： Richard Schwartz , John Michael Berry , Ajit Subramanian , Xiao Shi
IPC分类号： C12N7/04 , C12N7/02
CPC分类号： C12N7/00 , C12N5/0037 , C12N5/0043 , C12N2500/36 , C12N2500/76 , C12N2500/90 , C12N2501/11 , C12N2501/395 , C12N2510/02 , C12N2760/16151 , C12N2760/16161 , C12N2760/16251 , C12N2760/16261
摘要： The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
摘要翻译：本发明提供可在血清存在或不存在的情况下生长的新型MDCK衍生的粘附性非致瘤细胞系。本发明的细胞系可用于生产疫苗材料（例如病毒）。更具体地说，本发明的细胞系通常用于生产流感病毒，尤其是流感病毒。本发明还提供了用于适应和培养MDCK细胞的方法和培养基制剂，使得它们保持非致瘤性。此外，本发明提供了在本发明的新型细胞系中生产疫苗材料（例如流感病毒）的方法。

10. 发明申请

US20110196204A1 Shape-conforming intubation device 审中-公开
标题翻译：形状符合插管装置
公开(公告)号：US20110196204A1
公开(公告)日：2011-08-11
申请号：US12931746
申请日：2011-02-09
申请人： Harsha Setty , Richard Schwartz , John Schwartz
发明人： Harsha Setty , Richard Schwartz , John Schwartz
IPC分类号： A61M16/04 , A61B1/04 , A61B1/06
CPC分类号： A61M16/04 , A61B1/00052 , A61B1/00154 , A61B1/0052 , A61B1/0056 , A61B1/0058 , A61B1/018 , A61B1/267 , A61M16/0418 , A61M16/0431 , A61M16/0488 , A61M2205/502
摘要： The disclosure generally relates to an endotracheal intubation device 100 including a channel element 120 that defines a first channel 122 and additional retaining structure that defines a second channel 140. The device 100 is reversibly movable between a first relaxed position A (e.g., a generally extended or straight position) and a second curved position B (e.g., an articulated, generally non-linear position) with an articulating means 160. An endotracheal tube 200 can be inserted into the second channel 140, and the intubation device 100 then can be used to intubate a patient P according to a disclosed intubation method.
摘要翻译：本公开内容通常涉及气管插管装置100，其包括限定第一通道122的通道元件120和限定第二通道140的附加保持结构。装置100可在第一松弛位置A（例如，大体上延伸或直线位置）和第二弯曲位置B（例如，铰接的，大致非线性位置）具有关节运动装置160.气管插管200可插入第二通道140中，然后可以使用插管装置100 根据所公开的插管方法插管患者P。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式