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1. 发明授权

US08629245B2 Immunoglobulin Fc libraries 有权
标题翻译：免疫球蛋白Fc文库
公开(公告)号：US08629245B2
公开(公告)日：2014-01-14
申请号：US12112971
申请日：2008-04-30
申请人： George Georgiou , Sang Taek Jung
发明人： George Georgiou , Sang Taek Jung
IPC分类号： C12Q1/68 , G01N33/569 , C07K16/00 , C07H21/04
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/32 , C07K2317/52 , C07K2317/72 , C07K2319/035 , C07K2319/30
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.
摘要翻译：用于筛选和分离糖基化抗体Fc结构域多肽的方法和组合物。例如，在某些方面，描述了用于鉴定结合Fc受体或优先结合特定Fc受体的糖基化Fc结构域的方法。此外，本发明提供以高亲和力结合Fc受体的糖基化Fc结构域。还提供了用于基于原核的相互作用筛选的增强的方法和介质。

2. 发明授权

US08679493B2 Immunoglobulin Fc polypeptides 有权
标题翻译：免疫球蛋白Fc多肽
公开(公告)号：US08679493B2
公开(公告)日：2014-03-25
申请号：US12827386
申请日：2010-06-30
申请人： George Georgiou , Sang Taek Jung , Sai Reddy
发明人： George Georgiou , Sang Taek Jung , Sai Reddy
IPC分类号： A61K39/395 , C12P21/08 , C12N1/21 , C12N5/02 , C12N5/10
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fe domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供多肽具有糖基化的Fe结构域，其选择性地结合FcγRI在糖基化Fc结构域的2倍以内的水平，但是与其它Fc受体结合显着降低。此外，提供了使用具有修饰的糖苷基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

3. 发明申请

US20100330076A1 IMMUNOGLOBULIN FC POLYPEPTIDES 有权
标题翻译：多柔比星FC多糖
公开(公告)号：US20100330076A1
公开(公告)日：2010-12-30
申请号：US12827386
申请日：2010-06-30
申请人： George Georgiou , Sang Taek Jung , Sai Reddy
发明人： George Georgiou , Sang Taek Jung , Sai Reddy
IPC分类号： A61K39/395 , C07K16/42 , C07H21/04 , C12N5/10 , C12P21/00 , C12N5/071 , G01N33/53 , A61P37/04
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fe domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供多肽具有糖基化的Fe结构域，其选择性地结合FcγRI在糖基化Fc结构域的2倍以内的水平，但是与其它Fc受体结合显着降低。此外，提供了使用具有修饰的糖苷基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

4. 发明申请

US20120208238A1 ENGINEERED IMMUNOGLOBULIN FC POLYPEPTIDES 有权
标题翻译：工程化免疫球蛋白FC多糖
公开(公告)号：US20120208238A1
公开(公告)日：2012-08-16
申请号：US13367063
申请日：2012-02-06
申请人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
发明人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
IPC分类号： C12P21/02 , C12N5/0784 , C12N15/13 , C12N5/10 , C07K16/40 , C12N15/63 , C12N1/21
CPC分类号： C07K16/283 , C07K16/32 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRIIa, but that is significantly reduced for binding to the highly homologous FcγRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供了多肽选择性结合FcγRIIa的糖基化Fc结构域，但是与结合高度同源的FcγRIIb受体相比显着降低。此外，提供了使用具有修饰的糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

5. 发明申请

US20090136936A1 IMMUNOGLOBULIN FC LIBRARIES 有权
标题翻译：免疫球蛋白图书馆
公开(公告)号：US20090136936A1
公开(公告)日：2009-05-28
申请号：US12112971
申请日：2008-04-30
申请人： George Georgiou , Sang Taek Jung
发明人： George Georgiou , Sang Taek Jung
IPC分类号： C12Q1/68 , G01N33/569 , C07K16/00 , C07H21/04
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/32 , C07K2317/52 , C07K2317/72 , C07K2319/035 , C07K2319/30
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.
摘要翻译：用于筛选和分离糖基化抗体Fc结构域多肽的方法和组合物。例如，在某些方面，描述了用于鉴定结合Fc受体或优先结合特定Fc受体的糖基化Fc结构域的方法。此外，本发明提供以高亲和力结合Fc受体的糖基化Fc结构域。还提供了用于基于原核的相互作用筛选的增强的方法和介质。

6. 发明授权

US08952132B2 Engineered immunoglobulin FC polypeptides 有权
标题翻译：工程化的免疫球蛋白FC多肽
公开(公告)号：US08952132B2
公开(公告)日：2015-02-10
申请号：US13367063
申请日：2012-02-06
申请人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
发明人： George Georgiou , Sang Taek Jung , William Kelton , Tae Hyun Kang
IPC分类号： C07K17/00 , C07K16/00 , C07K1/00 , C07K16/28 , C12P21/08
CPC分类号： C07K16/283 , C07K16/32 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2319/30
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRIIa, but that is significantly reduced for binding to the highly homologous FcγRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供了多肽选择性结合FcγRIIa的糖基化Fc结构域，但是与结合高度同源的FcγRIIb受体相比显着降低。此外，提供了使用具有修饰的糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

7. 发明授权

US08679479B2 Methods for purifying pegylated arginase 有权
标题翻译：聚乙二醇化精氨酸酶的纯化方法
公开(公告)号：US08679479B2
公开(公告)日：2014-03-25
申请号：US13380776
申请日：2010-06-28
申请人： George Georgiou , Everett Stone
发明人： George Georgiou , Everett Stone
IPC分类号： A61K38/46
CPC分类号： C12N9/78 , C12Y305/03001
摘要： Methods and composition for generation of arginase variants with high serum persistence are provided. For example, in certain aspects methods for purifying pegylated arginase are described. Furthermore, the invention provides stabilized arginase multimers or pharmaceutical composition thereof.
摘要翻译：提供了用于产生具有高血清持久性的精氨酸酶变体的方法和组合物。例如，在某些方面描述了用于纯化聚乙二醇化精氨酸酶的方法。此外，本发明提供稳定的精氨酸酶多聚体或其药物组合物。

8. 发明申请

US20110200576A1 ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEREOF 有权
标题翻译：具有甲硫氨酸 - 乳酸酶的工程化酶及其药理学准备
公开(公告)号：US20110200576A1
公开(公告)日：2011-08-18
申请号：US13020268
申请日：2011-02-03
申请人： George Georgiou , Everett Stone
发明人： George Georgiou , Everett Stone
IPC分类号： A61K38/51 , C12N9/88 , C12N9/96 , C12N15/60 , C12N15/63 , C12N1/21 , A61K48/00 , C12N5/09 , C12Q1/02 , A61P35/00
CPC分类号： C12Q1/527 , A61K38/00 , C12N9/88 , C12N9/96 , C12Q1/10 , G01N2333/988
摘要： Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
摘要翻译：描述了与具有甲硫氨酸-γ-裂解酶活性的新蛋白质的工程相关的方法和组成。例如，在某些方面，可以公开包含一个或多个氨基酸取代并能降解甲硫氨酸的修饰的胱硫醚-γ-裂解酶（CGL）。此外，本发明的某些方面提供使用所公开的蛋白质或核酸用于用甲硫氨酸消耗治疗癌症的组合物和方法。

9. 发明申请

US20090220952A1 Compositions And Methods For Analyzing Protein Interactions 有权
标题翻译：用于分析蛋白质相互作用的组合物和方法
公开(公告)号：US20090220952A1
公开(公告)日：2009-09-03
申请号：US12064292
申请日：2006-08-22
申请人： Matthew DeLisa , George Georgiou , Dujduan Waraho
发明人： Matthew DeLisa , George Georgiou , Dujduan Waraho
IPC分类号： C12Q1/68 , G01N33/569 , C12N1/21
CPC分类号： C12N15/1055 , C40B30/04 , G01N33/5032
摘要： The present invention relates to compositions and methods for analyzing and modulating (e.g., enhancing or inhibiting) protein-protein interactions. In particular, compositions and methods of the present invention find use in identifying, reconstituting and characterizing protein-protein interactions, identifying binding subunits, and drug screening. The methods and compositions of the invention may also be used to identify agents that may agonize or antagonize a protein-protein interaction (e.g., using test compounds).
摘要翻译：本发明涉及用于分析和调节（例如，增强或抑制）蛋白质 - 蛋白质相互作用的组合物和方法。特别地，本发明的组合物和方法用于鉴定，重组和表征蛋白质 - 蛋白质相互作用，鉴定结合亚基和药物筛选。本发明的方法和组合物还可用于鉴定可能激动或拮抗蛋白质 - 蛋白质相互作用的试剂（例如，使用测试化合物）。

10. 发明申请

US20050106647A1 ANTIBODIES WITH INCREASED AFFINITIES FOR ANTHRAX ANTIGENS 有权
标题翻译：抗体对ANTHRAX抗原具有增加的作用
公开(公告)号：US20050106647A1
公开(公告)日：2005-05-19
申请号：US10620049
申请日：2003-07-15
申请人： Barrett Harvey , George Georgiou , Brent Iverson
发明人： Barrett Harvey , George Georgiou , Brent Iverson
IPC分类号： A61K39/00 , A61K39/07 , A61K39/395 , A61K39/40 , C07H21/04 , C07K7/00 , C07K16/00 , C07K16/12 , C12N20060101 , C12N1/21 , C12N15/10 , C12N15/13 , C12N15/70 , C12Q1/02 , C12Q1/04 , G01N33/554 , G01N33/569 , G01N33/68
CPC分类号： C07K16/005 , C07K2317/622 , C07K2317/92 , C12N15/1034 , C12Q1/025 , G01N33/6845
摘要： The invention overcomes the deficiencies of the prior art by providing antibody compositions having improved affinities for Bacillus anthracis antigens. The compositions have important thereapeutic and diagnostic applications, including treatment or detection of infection by Bacillus anthracis.
摘要翻译：本发明通过提供具有改善的炭疽芽孢杆菌抗原亲和力的抗体组合来克服现有技术的缺陷。该组合物具有重要的治疗和诊断应用，包括炭疽杆菌感染的治疗或检测。

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