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1. 发明申请

US20070258954A1 Directed evolution of enzymes and antibodies 审中-公开
标题翻译：酶和抗体的定向进化
公开(公告)号：US20070258954A1
公开(公告)日：2007-11-08
申请号：US11317680
申请日：2005-12-22
申请人： Brent Iverson , George Georgiou , Gang Chen , Mark Olsen , Patrick Daugherty
发明人： Brent Iverson , George Georgiou , Gang Chen , Mark Olsen , Patrick Daugherty
IPC分类号： G01N33/554 , C07K16/00 , C12N1/00
CPC分类号： C07K14/245 , C07K16/00 , C07K16/16 , C07K16/44 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/035 , C12N9/16 , C12N9/86 , C12N15/1037 , C12N15/625 , C40B40/02
摘要： The invention relates to methods of selecting proteins, out of large libraries, having desirable characteristics. Exemplified are methods of expressing enzymes and antibodies on the surface of host cells and selecting for desired activities. These methods have the advantage of speed and ease of operation when compared with current methods. They also provide, without additional cloning, a source of significant quantities of the protein of interest.
摘要翻译：本发明涉及从具有所需特征的大型文库中选择蛋白质的方法。示例是在宿主细胞表面上表达酶和抗体并选择所需活性的方法。与当前的方法相比，这些方法具有速度快和易操作的优点。他们还提供了大量的目标蛋白质来源，无需额外的克隆。

2. 发明申请

US20070099267A1 COMBINATORIAL PROTEIN LIBRARY SCREENING BY PERIPLASMIC EXPRESSION 审中-公开
标题翻译：通过周边表达组合蛋白图书馆筛选
公开(公告)号：US20070099267A1
公开(公告)日：2007-05-03
申请号：US11466352
申请日：2006-08-22
申请人： Barrett Harvey , George Georgiou , Brent Iverson
发明人： Barrett Harvey , George Georgiou , Brent Iverson
IPC分类号： C12P21/06 , C07H21/04 , C12N15/74 , C07K14/245
CPC分类号： C12N15/1034 , C07K2319/034 , C12N15/1037 , C12N15/1086 , C40B40/02
摘要： The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides. In the technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in the periplasm of gram negative bacteria and mixed with a labeled ligand. In clones expressing recombinant polypeptides with affinity for the ligand, the concentration of the labeled ligand bound to the binding protein is increased and allows the cells to be isolated from the rest of the library. Where fluorescent labeling of the target ligand is used, cells may be isolated by fluorescence activated cell sorting (FACS). The approach is more rapid than prior art methods and avoids problems associated with the outer surface-expression of ligand fusion proteins employed with phage display.
摘要翻译：本发明通过提供用于分离能够结合小分子和肽的结合蛋白的快速方法来克服现有技术的缺陷。在该技术中，候选结合蛋白（例如抗体序列）的文库在革兰氏阴性细菌的周质中表达并与标记的配体混合。在表达对配体具有亲和性的重组多肽的克隆中，与结合蛋白结合的标记配体的浓度增加，并允许细胞与文库的其余部分分离。当使用靶配体的荧光标记时，可以通过荧光激活细胞分选（FACS）分离细胞。该方法比现有技术方法更快速，并且避免了与噬菌体展示一起使用的配体融合蛋白的外表面表达相关的问题。

3. 发明授权

US5567687A Texaphyrins and uses thereof 失效
标题翻译： Texaphyrins及其用途
公开(公告)号：US5567687A
公开(公告)日：1996-10-22
申请号：US310501
申请日：1994-09-21
申请人： Darren Magda , Jonathan L. Sessler , Brent Iverson , Petra L. Jansen , Meredith Wright , Tarak D. Mody , Gregory W. Hemmi
发明人： Darren Magda , Jonathan L. Sessler , Brent Iverson , Petra L. Jansen , Meredith Wright , Tarak D. Mody , Gregory W. Hemmi
IPC分类号： A61K41/00 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/04 , A61L2/00 , B01J31/02 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , C12N15/113
CPC分类号： C07D487/22 , A61K41/0042 , A61K41/0076 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/085 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1815 , C07H21/00 , C12N15/113 , B01J2531/025 , B01J2531/26 , B01J2531/27 , B01J2531/33 , B01J2531/37 , B01J2531/38 , B01J31/0201 , C12N2310/15 , C12N2310/321 , C12N2310/3511
摘要： A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.
摘要翻译：公开了具有含乙氧基的取代基的泰克萨菲瑞，光动力学治疗中使用泰克萨菲瑞的方法和脱氧核糖核酸的聚合物的切割。使用Lu（III）泰克萨菲瑞复合物证明体内治疗肿瘤和动脉粥样硬化。优选的使用方法是脱氧核糖核酸的聚合物的位点特异性切割，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到位点定向分子，优选寡核苷酸的泰克萨菲林。

4. 发明授权

US5559207A Texaphyrin metal complex mediated ester hydrolysis 失效
标题翻译： Texaphyrin金属络合物介导酯水解
公开(公告)号：US5559207A
公开(公告)日：1996-09-24
申请号：US227370
申请日：1994-04-14
申请人： Jonathan L. Sessler , Daniel A. Smith , Richard A. Miller , Kevin L. Ross , Meredith Wright , William C. Dow , Vladimir A. Kr al , Brent Iverson , Darren Magda
发明人： Jonathan L. Sessler , Daniel A. Smith , Richard A. Miller , Kevin L. Ross , Meredith Wright , William C. Dow , Vladimir A. Kr al , Brent Iverson , Darren Magda
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/04 , A61L2/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07B61/00 , C07D487/22 , C07F9/06 , C07F9/6558 , C07F9/6561 , C07H21/00 , C07K2/00 , C07F5/00 , C07H3/00 , C07K16/00
CPC分类号： A61K47/48069 , A61K41/0038 , A61K41/0076 , A61K49/0021 , A61K49/0036 , A61K49/085 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.
摘要翻译：磷酸酯水解的方法，包括将磷酸酯水溶液与泰克萨菲金属络合物的溶液孵育。金属是具有催化活性的金属阳离子，用于在水溶液中酯键水解，特别是镧系元素金属阳离子，优选Eu（III）或Dy（III）。优选的底物是RNA，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到定点分子，优选寡核苷酸的泰克萨菲林。

5. 发明申请

US20060177198A1 Media player configured to receive playback filters from alternative storage mediums 失效
标题翻译：媒体播放器配置为从替代存储介质接收播放过滤器
公开(公告)号：US20060177198A1
公开(公告)日：2006-08-10
申请号：US11327103
申请日：2006-01-05
申请人： Matthew Jarman , Brent Iverson
发明人： Matthew Jarman , Brent Iverson
IPC分类号： H04N5/91
CPC分类号： H04N21/45452 , H04L65/4084 , H04L2012/2849 , H04N5/765 , H04N5/781 , H04N5/85 , H04N5/907 , H04N9/8042 , H04N9/87 , H04N21/435
摘要： A media player configured with a first removable memory reader, such as a DVD drive, and a second removable memory reader, such as a flash memory reader, adapted to communicate with a removable memory containing filter data. The media player is configured to allow filtered playback of a multimedia presentation, such as a movie. Filtered playback causes certain portions of the multimedia presentation to be skipped, muted, blurred, cropped, or otherwise modified to eliminate or reduce potentially objectionable scenes, language, or other content. The second memory reader provides a convenient medium for the loading of filter information, whether data files, executable program code, or the like, to local memory of the media player to employ during filtered playback. Alternatively, the filters may be accessed from the removable storage media during playback rather than loading to local memory.
摘要翻译：配置有诸如DVD驱动器的第一可移动存储器读取器和诸如闪存读取器的第二可移动存储器读取器的媒体播放器，其适于与包含滤波器数据的可移动存储器通信。媒体播放器被配置为允许多媒体呈现（例如电影）的过滤回放。被过滤的播放导致多媒体呈现的某些部分被跳过，静音，模糊，裁剪或以其它方式进行修改，以消除或减少可能令人反感的场景，语言或其他内容。第二存储器读取器提供用于将过滤器信息（无论是数据文件，可执行程序代码等）加载到媒体播放器的本地存储器以在滤波回放期间采用的方便的介质。或者，可以在播放期间从可移动存储介质访问过滤器，而不是加载到本地存储器。

6. 发明申请

US20050267294A1 Antibodies with increased affinities for anthrax antigens 有权
公开(公告)号：US20050267294A1
公开(公告)日：2005-12-01
申请号：US11179244
申请日：2005-07-12
申请人： Barrett Harvey , George Georgiou , Brent Iverson
发明人： Barrett Harvey , George Georgiou , Brent Iverson
IPC分类号： A61K39/00 , A61K39/07 , A61K39/395 , A61K39/40 , C07H21/04 , C07K7/00 , C07K16/00 , C07K16/12 , C12N20060101 , C12N1/21 , C12N15/10 , C12N15/13 , C12N15/70 , C12Q1/02 , C12Q1/04 , G01N33/554 , G01N33/569 , G01N33/68
CPC分类号： C07K16/005 , C07K2317/622 , C07K2317/92 , C12N15/1034 , C12Q1/025 , G01N33/6845
摘要： The invention overcomes the deficiencies of the prior art by providing antibody compositions having improved affinities for Bacillus anthracis antigens. The compositions have important thereapeutic and diagnostic applications, including treatment or detection of infection by Bacillus anthracis.

7. 发明申请

US20050260736A1 Selection of bacterial inner-membrane anchor polypeptides 有权
标题翻译：细菌内膜锚定多肽的选择
公开(公告)号：US20050260736A1
公开(公告)日：2005-11-24
申请号：US11084717
申请日：2005-03-18
申请人： George Georgiou , Ki Jun Jeong , Barrett Harvey , Brent Iverson
发明人： George Georgiou , Ki Jun Jeong , Barrett Harvey , Brent Iverson
IPC分类号： C12N1/21 , C12N15/10 , C12N15/74 , C40B40/02
CPC分类号： C40B40/02 , C07K2319/04 , C12N15/1037 , C12N15/1086
摘要： The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating polypeptides capable of anchoring heterologous polypeptides to a bacterial inner membrane. In the technique, libraries of candidate anchor polypeptides are expressed as fusions with a heterologous polypeptide that is capable of being detected when bound to the inner membrane. In bacteria expressing a functional anchor sequence, the heterologous polypeptide becomes bound to outer face of the inner membrane. Bacteria with the functional anchor sequence can be identified by removing the outer membrane to remove non-anchored heterologous polypeptide followed by detection of anchored heterologous polypeptide. Such bacteria may be detected in numerous ways, including use of direct fluorescence or secondary antibodies that are fluorescently labeled, allowing use of efficient techniques such as fluorescence activated cell sorting (FACS).
摘要翻译：本发明克服了现有技术的缺陷，提供了一种用于分离能够将异源多肽固定在细菌内膜上的多肽的快速方法。在该技术中，候选锚多肽的文库表达为与异源多肽的融合，当与内膜结合时能够被检测。在表达功能性锚定序列的细菌中，异源多肽与内膜的外表面结合。具有功能性锚定序列的细菌可以通过除去外膜以除去非锚定的异源多肽，然后检测锚定的异源多肽来鉴定。可以以许多方式检测这些细菌，包括使用荧光标记的直接荧光或二次抗体，允许使用有效技术，例如荧光激活细胞分选（FACS）。

8. 发明申请

US20070186235A1 SYNCHRONIZING FILTER METADATA WITH A MULTIMEDIA PRESENTATION 有权
标题翻译：与多媒体演示同步过滤元数据
公开(公告)号：US20070186235A1
公开(公告)日：2007-08-09
申请号：US11669138
申请日：2007-01-30
申请人： Matthew Jarman , Christopher Venn , Brent Iverson
发明人： Matthew Jarman , Christopher Venn , Brent Iverson
IPC分类号： H04N7/16 , G06F17/00
CPC分类号： H04L65/60 , H04L67/1095 , H04N7/163 , H04N7/17318 , H04N21/242 , H04N21/25891 , H04N21/4532 , H04N21/4542 , H04N21/47202 , H04N21/84 , H04N21/8456
摘要： A method, system and apparatus for applying and synchronizing filter information with a multimedia presentation, such as a movie provided in a video-on-demand context, to suppress objectionable content. In one example, filter information, which includes an indicia of a portion of the multimedia presentation including objectionable content and a type of suppression action, is provided on either a set-top-box or a video-on-demand server. A user selects a particular video-on-demand presentation, and the selection is transmitted to the set-top-box. Filtering may take place at the set-top-box side such that the complete video-on-demand movie is transmitted to the set-top box and then content suppression, such as skipping, muting, cropping, and blurring, takes place at the set-top-box. Alternatively, some or all suppression may take place at the server such that some or all of the objectionable content is not transmitted to the set-top-box. Additionally, whether in a video-on-demand, DVD, or other environment it may be necessary to synchronize filter with the multimedia content so that the proper objectionable content is suppressed.
摘要翻译：一种用于应用和同步滤波器信息与诸如在视频点播上下文中提供的电影的多媒体呈现的方法，系统和装置，以抑制不良内容。在一个示例中，在机顶盒或视频点播服务器上提供包括包括不良内容的多媒体呈现的一部分的标记和抑制动作的类型的过滤器信息。用户选择特定的视频点播呈现，并且选择被发送到机顶盒。过滤可能发生在机顶盒一侧，使得完整的视频点播电影传输到机顶盒，然后内容抑制（如跳过，静音，裁剪和模糊）发生在机顶盒。或者，可能在服务器处发生一些或全部抑制，使得部分或全部不良内容不被发送到机顶盒。此外，无论是在视频点播，DVD还是其他环境中，可能需要将过滤器与多媒体内容同步，以便抑制正确令人反感的内容。

9. 发明申请

US20060101487A1 Method and user interface for downloading audio and video content filters to a media player 有权
公开(公告)号：US20060101487A1
公开(公告)日：2006-05-11
申请号：US11256419
申请日：2005-10-20
申请人： Matthew Jarman , Brent Iverson
发明人： Matthew Jarman , Brent Iverson
IPC分类号： H04N5/445 , H04N7/025 , H04N7/18 , H04N7/10
CPC分类号： H04N21/45455 , G06Q30/0601 , G11B27/031 , G11B27/105 , G11B27/32 , H04L65/60 , H04L67/1095 , H04L67/42 , H04N5/765 , H04N5/85 , H04N7/17318 , H04N21/44029 , H04N21/4508 , H04N21/4532 , H04N21/454 , H04N21/4542 , H04N21/472 , H04N21/47815 , H04N21/84 , H04N21/8456 , H04N21/8541
摘要： A client server arrangement for downloading media content filters from a server device to a client device. The media content filters define portions of a separate audio visual presentation containing potentially objectionable subject matter. Depending on user selections, identified portions of the audio/visual presentation may be skipped and/or muted during play. In one particular implementation, the client device, e.g., a DVD player, is configured to initiate a connection with a server device. Upon successful connection, the server device transmits one or more media content filters to the client device. The client device may be configured to determine whether a particular media content filter is available, to facilitate deletion of some existing media content filters in order to secure adequate memory space, and to ensure that the media player has an active account, before initiating a connection with the server device. The server device may be configured to determine whether the media player is associated with an active user account, whether a requested filter is available, and whether adequate memory space is available at the media player, before transmitting media content filters to the client device.

10. 发明申请

US20050106647A1 ANTIBODIES WITH INCREASED AFFINITIES FOR ANTHRAX ANTIGENS 有权
标题翻译：抗体对ANTHRAX抗原具有增加的作用
公开(公告)号：US20050106647A1
公开(公告)日：2005-05-19
申请号：US10620049
申请日：2003-07-15
申请人： Barrett Harvey , George Georgiou , Brent Iverson
发明人： Barrett Harvey , George Georgiou , Brent Iverson
IPC分类号： A61K39/00 , A61K39/07 , A61K39/395 , A61K39/40 , C07H21/04 , C07K7/00 , C07K16/00 , C07K16/12 , C12N20060101 , C12N1/21 , C12N15/10 , C12N15/13 , C12N15/70 , C12Q1/02 , C12Q1/04 , G01N33/554 , G01N33/569 , G01N33/68
CPC分类号： C07K16/005 , C07K2317/622 , C07K2317/92 , C12N15/1034 , C12Q1/025 , G01N33/6845
摘要： The invention overcomes the deficiencies of the prior art by providing antibody compositions having improved affinities for Bacillus anthracis antigens. The compositions have important thereapeutic and diagnostic applications, including treatment or detection of infection by Bacillus anthracis.
摘要翻译：本发明通过提供具有改善的炭疽芽孢杆菌抗原亲和力的抗体组合来克服现有技术的缺陷。该组合物具有重要的治疗和诊断应用，包括炭疽杆菌感染的治疗或检测。

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