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1. 发明申请

US20050037436A1 Test systems and the use thereof for identifying and characterizing compounds 审中-公开
标题翻译：测试系统及其用于鉴定和表征化合物的用途
公开(公告)号：US20050037436A1
公开(公告)日：2005-02-17
申请号：US10363946
申请日：2001-08-24
申请人： Georg Samson-Himmelstjerna , Achim Harder , Frank Wunderlich , Hans-Peter Schmitt-Wrede , Beate Saeger
发明人： Georg Samson-Himmelstjerna , Achim Harder , Frank Wunderlich , Hans-Peter Schmitt-Wrede , Beate Saeger
IPC分类号： C07K14/435 , C07K14/705 , C07K14/72 , C12Q1/68 , E04H6/10 , G01N33/50 , G01N33/53 , G01N33/68 , G01N33/567
CPC分类号： G01N33/502 , C07K14/4354 , C07K14/705 , C07K14/723 , C07K2319/21 , C07K2319/41 , C07K2319/60 , C12Q1/6888 , G01N33/5008 , G01N33/5308 , G01N33/6872 , G01N2333/4353 , G01N2333/4719 , G01N2333/705
摘要： The invention relates to test systems which are based on transmembrane receptors from helminths and arthropods, and to the use thereof for identifying and characterizing substances which act on helminths, arthropods or which act on the calcium balance of organisms and/or cells. The invention furthermore relates to the use of a specific ligand in this test system and to the use thereof as anthelmintic or arthropodicidal active substance.
摘要翻译：本发明涉及基于来自蠕虫和节肢动物的跨膜受体的测试系统，以及其用于鉴定和表征作用于蠕虫，节肢动物或作用于生物体和/或细胞的钙平衡的物质的用途。本发明还涉及在该测试系统中特异性配体的用途及其作为驱肠虫或节肢动物杀活性活性物质的用途。

2. 发明申请

US20130172385A1 ANTHELMINTICS FOR PREVENTING PARASITIC INFECTIONS IN HUMANS AND ANIMALS 失效
标题翻译：用于预防人类和动物中的PARASITIC感染的方法
公开(公告)号：US20130172385A1
公开(公告)日：2013-07-04
申请号：US12117939
申请日：2008-05-09
申请人： Achim Harder , Georg von Samson-Himmlstjerna , Bernd-Wieland Kruger , Heinz Mehlhorn , Jurgen Schmidt
发明人： Achim Harder , Georg von Samson-Himmlstjerna , Bernd-Wieland Kruger , Heinz Mehlhorn , Jurgen Schmidt
IPC分类号： A01N47/18 , C07C271/34 , C07C271/16 , A01N47/12 , C07D211/22 , A01N47/16
CPC分类号： A01N47/18 , A01N47/12 , A01N47/16 , A61K31/27 , A61K31/445 , C07C271/16 , C07C271/34 , C07D211/22
摘要： The present invention relates to compositions comprising certain active compounds which are suitable as repellents, and to their use for preventing an infection of humans or of animals by the infectious states of parasitic flatworms (platyhelminths).
摘要翻译：本发明涉及包含适合作为驱避剂的某些活性化合物的组合物，以及它们用于通过寄生扁平虫（扁桃体）感染状态预防人或动物感染的用途。

3. 发明申请

US20050256173A1 Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I) 审中-公开
标题翻译：杂环氟烯基硫醚及其作为农药的用途（I）
公开(公告)号：US20050256173A1
公开(公告)日：2005-11-17
申请号：US11152541
申请日：2005-06-14
申请人： Udo Kraatz , Bernd Gallenkamp , Heiko Rieck , Albrecht Marhold , Peter Wolfrum , Wolfram Andersch , Christoph Erdelen , Peter Losel , Andreas Turberg , Olaf Hansen , Achim Harder
发明人： Udo Kraatz , Bernd Gallenkamp , Heiko Rieck , Albrecht Marhold , Peter Wolfrum , Wolfram Andersch , Christoph Erdelen , Peter Losel , Andreas Turberg , Olaf Hansen , Achim Harder
IPC分类号： A01N43/72 , A01N43/82 , A01N43/88 , C07D285/00 , C07D285/01 , C07D285/15 , C07D285/36 , A61K31/433
CPC分类号： C07D285/01 , A01N43/72 , A01N43/82 , A01N43/88 , C07D285/15 , C07D285/36
摘要： The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which x represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n represents 0, 1 or 2, Y represents unsubstituted or substituted methylene and p represents 1, 2 or 3, and to processes for their preparation and to their use as pesticides.
摘要翻译：本发明涉及式（I）的新型杂环氟烯基硫醚，其中x表示氢，卤素或烷基，m表示2至10的整数，n表示0,1或2，Y表示未取代或取代的亚甲基，p表示 1,2或3，以及其制备方法及其作为农药的用途。

4. 发明授权

US06468966B1 Octacyclodepsipeptides having an endoparasiticidal action 失效
标题翻译：具有内寄生性杀伤作用的Octacyclodepsipeptide
公开(公告)号：US06468966B1
公开(公告)日：2002-10-22
申请号：US08246022
申请日：1994-05-19
申请人： Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
发明人： Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
IPC分类号： A61K3800
CPC分类号： C07D273/00 , A61K38/00 , C07K11/02
摘要： The present invention relates to compounds of the general formula (I) in which R1 and R12 represent the same or different radicals selected from the group of C2-9-alkyl, C1-8-halogen-alkyl, C3-6-cycloalkyl, aralkyl or aryl, R3 to R10 represent the same or different radicals selected from the group of hydrogen, C1-5-alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a —NR13R14 group in which R13 or R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C1-4-alkyl, R2 and R11 represent the same of different radicals selected from the group of C1-4-alkyl, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1和R 12表示相同或不同的选自C 2-9 - 烷基，C 1-8 - 卤素 - 烷基，C 3-6 - 环烷基，芳烷基或芳基，R 3至R 10表示选自氢，可任选被羟基，烷氧基，羧基，羧酰胺，咪唑基，吲哚基，胍基，硫代或硫代烷基取代的C 1-5 - 烷基的相同或不同的基团，并且表示芳基，烷基芳基或杂芳基甲基，其任选被卤素，羟基，烷基，烷氧基，硝基或-NR 13 R 14基团取代，其中R 13或R 14彼此独立地表示氢或烷基或与相邻的氮原子一起形成5,6或任选地被O，S或N中断并且任选被C 1-4 - 烷基取代的R 7和R 11代表与选自C 1-4 - 烷基及其立体异构体的不同基团相同的7-元环，进行准备a 并将其用作内寄生物杀虫剂。

5. 发明授权

US06355615B1 Desoxycyclodepsipeptides and their use for combatting endoparasites 失效
标题翻译：脱氧环肽和它们用于对抗内寄生虫的用途
公开(公告)号：US06355615B1
公开(公告)日：2002-03-12
申请号：US09424803
申请日：1999-11-29
申请人： Hubert Dyker , Jürgen Scherkenbeck , Achim Harder , Norbert Mencke , Georg von Samson-Himmelstjerna
发明人： Hubert Dyker , Jürgen Scherkenbeck , Achim Harder , Norbert Mencke , Georg von Samson-Himmelstjerna
IPC分类号： C07D27300
CPC分类号： C07D273/00 , C07D413/10 , C07D413/14
摘要： The invention relates to novel deoxycyclodepsipeptides which are prepared from cyclodepsipeptides having 24 ring members which are constructed from alternating &agr;-aminocarboxylic acids and &agr;-hydroxycarboxylic acids, by complete or partial chemoselective reduction of the carbonyl groups of the amide function to give methylene groups using suitable reduction processes, and to mixtures and derivatives thereof. The deoxycyclodepsipeptides according to the invention have anthelmintic activity.
摘要翻译：本发明涉及新的脱氧环肽，其由具有24个环成员的环缩缩肽制备，所述环成员由交替的α-氨基羧酸和α-羟基羧酸构成，通过完全或部分化学选择性还原酰胺官能团的羰基以使用合适的还原过程，以及其混合物和衍生物。根据本发明的脱氧环肽是具有驱虫活性的。

6. 发明授权

US06306872B1 6-substituted 1,2,4a,5a,8a,8b-hexahydro- and 1,2,3,4,4a,5a,8a,8b-octahydro-6H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyrid-8(7H)-one derivatives and their use in combatting endoparasites 有权
标题翻译： 6-取代的1,2,4a，5a，8a，8b-六氢 - 和1,2,3,4,4a，5a，8a，8b-八氢-6H-吡咯并[3'，4'：4,5] 呋喃并[3,2-b]吡啶-8（7H） - 酮衍生物及其用于对抗内寄生虫
公开(公告)号：US06306872B1
公开(公告)日：2001-10-23
申请号：US09423685
申请日：1999-11-10
申请人： Peter Jeschke , Achim Harder , Norbert Mencke , Georg von Samson-Himmelstjerna
发明人： Peter Jeschke , Achim Harder , Norbert Mencke , Georg von Samson-Himmelstjerna
IPC分类号： A61K31437
CPC分类号： C07D491/14
摘要： The present invention relates to 6-substituted 1,2,4a,5a,8a,8b-hexahydro- and 1,2,3,4,4a,5a,8a,8b-octahydro-6H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyrid-8(7H)-one derivatives of the general formula (I) and their salts in which the radicals R1, R2, R3, R4, B and A are each as defined in the description, to processes for their preparation and to their use for controlling endoparasites.
摘要翻译：本发明涉及6-取代的1,2,4a，5a，8a，8b-六氢 - 和1,2,3,4,4a，5a，8a，8b-八氢-6H-吡咯并[3'，4' ：4,5]呋喃并[3,2-b]吡啶-8（7H） - 酮衍生物及其盐，其基团R 1，R 2，R 3，R 4，B和A各自如描述，其准备过程及其用于控制内寄生虫的用途。

7. 发明授权

US6159932A Endoparasiticidal compositions 失效
标题翻译：寄生杀虫剂组合物
公开(公告)号：US6159932A
公开(公告)日：2000-12-12
申请号：US952356
申请日：1997-11-19
申请人： Norbert Mencke , Achim Harder , Peter Jeschke , Barbara Kolbl
发明人： Norbert Mencke , Achim Harder , Peter Jeschke , Barbara Kolbl
IPC分类号： C07D273/00 , A61K31/395 , A61K38/15 , A61P33/00 , C07D493/22 , A61K38/00 , A61K31/335 , A61K31/70
CPC分类号： A61K38/15 , A61K31/70 , A61K31/55 , A61K31/495 , A61K2300/00
摘要： The present invention relates to mixtures of avermectins, 22,23-dihydroavermectins B.sub.1 (ivermectins) and milbemycins from the class of the macrocyclic lactones in combination with cyclic depsipeptides, optionally in the presence of praziquantel or epsiprantel, for increasing the endoparasiticidal action in endoparasiticidal compositions.
摘要翻译： PCT No.PCT / EP96 / 02170 Sec。 371日期：1997年11月19日 102（e）日期1997年11月19日PCT提交1996年5月20日PCT公布。出版物WO96 / 38165 日期1996年12月5日本发明涉及阿维菌素，22,23-二氢阿维菌素B1（伊维菌素）和来自大环内酯类的米尔倍霉素与环状缩酚酸肽的混合物，任选地在吡喹酮或卡泊普坦的存在下，用于增加内寄生虫杀螨组合物中的内寄生性杀伤作用。

8. 发明授权

US5717063A Octacyclodepsipeptides having an endoparasiticidal action 失效
标题翻译：具有内寄生性杀伤作用的Octacyclodepsipeptide
公开(公告)号：US5717063A
公开(公告)日：1998-02-10
申请号：US456148
申请日：1995-05-31
申请人： Jurgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
发明人： Jurgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
IPC分类号： A01N43/72 , A61K31/395 , A61K38/00 , A61P33/00 , A61P33/10 , C07D273/00 , C07K1/113 , C07K11/02 , A61K38/15 , C07K11/00
CPC分类号： C07D273/00 , C07K11/02 , A61K38/00
摘要： The present invention relates to compounds of the general formula (I) ##STR1## in which R.sup.1 and R.sup.12 represent the same or different radicals selected from the group of C.sub.2-9 -alkyl, C.sub.1-8 -halogeno-alkyl, C.sub.3-6 -cycloalkyl, aralkyl or aryl, R.sup.3 to R.sup.10 represent the same or different radicals selected from the group of hydrogen, C.sub.1-5 -alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a --NR.sup.13 R.sup.14 group in which R.sup.13 or R.sup.14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C.sub.1-4 -alkyl, R.sup.2 and R.sup.11 represent the same of different radicals selected from the group of C.sub.1-4 -alkyl, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1和R 12表示相同或不同的选自C 2-9 - 烷基，C 1-8 - 卤代烷基，C 3 - -6-环烷基，芳烷基或芳基，R 3至R 10表示相同或不同的选自氢，可任选被羟基，烷氧基，羧基，羧酰胺，咪唑基，吲哚基，胍基，硫代或硫代烷基，并且表示任选被卤素，羟基，烷基，烷氧基，硝基或-NR 13 R 14基团取代的芳基，烷基芳基或杂芳基甲基，其中R 13或R 14彼此独立地表示氢或烷基或与相邻的氮原子形成5,6或7-元环，其任选地被O，S或N中断，并且其任选被C 1-4 - 烷基取代，R 2和R 11表示与选自C 1-4的不同基团相同的基团 - 烷基和它们的立体异构体继承人的准备和用作内寄生虫病药物。

9. 发明授权

US5585493A Use of substituted 1,2,4-oxadiazole derivatives for combating endoparasites, new substituted 1,2,4-oxadiazole derivatives, and processes for their preparation 失效
标题翻译：使用取代的1,2,4-恶二唑衍生物对抗内寄生虫，新的取代的1,2,4-恶二唑衍生物及其制备方法
公开(公告)号：US5585493A
公开(公告)日：1996-12-17
申请号：US288173
申请日：1994-08-10
申请人： Peter Jeschke , Werner Lindner , Achim Harder , Norbert Mencke , Axel Haberkorn
发明人： Peter Jeschke , Werner Lindner , Achim Harder , Norbert Mencke , Axel Haberkorn
IPC分类号： A61K31/41 , A01N43/82 , A01N43/836 , A61K31/4245 , A61P33/00 , A61P33/10 , C07D271/06
CPC分类号： C07D271/06 , A01N43/82
摘要： Substituted 1,2,4-oxadiazole derivatives of the formula (I) and their stereoisomers ##STR1## in which formula R.sup.1 represents hydrogen, C.sub.1-8 -alkyl which is optionally substituted by halogen, cycloalkyl, alkoxy, hydroxyl, aryl, alkylcarbonyl, alkoxycarbonyl and cycloalkyl,and their use as endoparasiticides.
摘要翻译：式（I）的取代的1,2,4-恶二唑衍生物及其立体异构体，其中式R 1表示氢，任选被卤素，环烷基，烷氧基，羟基，芳基取代的C 1-8 - 烷基，烷基羰基，烷氧基羰基和环烷基，以及它们作为内寄生物杀生物剂的用途。

10. 发明授权

US5525591A Endoparasiticidal compositions based on open-chain octadepsipeptides 失效
标题翻译：基于开链十八肽的内寄生性杀虫组合物
公开(公告)号：US5525591A
公开(公告)日：1996-06-11
申请号：US347628
申请日：1994-12-01
申请人： Jurgen Scherkenbeck , Peter Jeschke , Andrew Plant , Achim Harder , Norbert Mencke
发明人： Jurgen Scherkenbeck , Peter Jeschke , Andrew Plant , Achim Harder , Norbert Mencke
IPC分类号： A61K31/22 , A61P33/10 , C07K7/06 , A61K38/15 , C07K11/00
CPC分类号： A61K31/22
摘要： The present invention relates to the use of open-chain octadepsipeptides of the general formula (I) ##STR1## which are used for combating endoparsites in medicine and veterinary medicine.
摘要翻译：本发明涉及在医药兽医学中使用通式（I）的钠盐的开链八肽。

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