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1. 发明申请

US20070093700A1 Computational optical biopsy 审中-公开
标题翻译：计算光学活检
公开(公告)号：US20070093700A1
公开(公告)日：2007-04-26
申请号：US11444282
申请日：2006-05-31
申请人： Ge Wang , Yi Li , Ming Jiang , Wenxiang Cong , Xin Quian
发明人： Ge Wang , Yi Li , Ming Jiang , Wenxiang Cong , Xin Quian
IPC分类号： A61B5/00
CPC分类号： A61B5/0059
摘要： Methods, systems and apparatuses for reconstructing a light source distribution or estimating a light source feature within a subject include an optical data receiving mechanism that is positionable at least at one location within the subject and is configured to acquire signal data from a light source located within a subject. A computational device is configured to receive signal data acquired by the optical data receiving mechanism and to reconstruct the light source distribution or to estimate a light source feature from at least a portion of the received data.
摘要翻译：用于重建光源分布或估计对象内的光源特征的方法，系统和装置包括光学数据接收机构，该光学数据接收机构至少可位于对象内的一个位置，并被配置为从位于所述对象内的光源获取信号数据课程。计算设备被配置为接收由光学数据接收机构获取的信号数据，并重建光源分布或者从至少一部分接收到的数据估计光源特征。

2. 发明授权

US08676302B2 Systems and methods for multi-spectral bioluminescence tomography 有权
标题翻译：多光谱生物发光断层扫描的系统和方法
公开(公告)号：US08676302B2
公开(公告)日：2014-03-18
申请号：US11619495
申请日：2007-01-03
申请人： Ge Wang , Alexander X. Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
发明人： Ge Wang , Alexander X. Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0077 , A61B6/03 , A61B6/4488 , A61B6/482 , A61B6/508 , A61B6/5247 , A61B2503/40
摘要： Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
摘要翻译：已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。使用生物学技术，靶细胞可以用记录器进行标记，记者在覆盖红外范围的广谱中产生特征光子。扩散光的一部分可以到达对象/标本（例如，小动物）的身体表面，使用光学装置分离成若干光谱带，并由敏感摄像机收集。本文公开了用于多光谱生物发光断层摄影（MBLT）的系统和方法，其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态，以及实现和提高MBLT的质量。

3. 发明申请

US20070244395A1 SYSTEMS AND METHODS FOR MULTI-SPECTRAL BIOLUMINESCENCE TOMOGRAPHY 有权
标题翻译：多光谱生物荧光光谱的系统与方法
公开(公告)号：US20070244395A1
公开(公告)日：2007-10-18
申请号：US11619495
申请日：2007-01-03
申请人： Ge Wang , Alexander Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
发明人： Ge Wang , Alexander Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0077 , A61B6/03 , A61B6/4488 , A61B6/482 , A61B6/508 , A61B6/5247 , A61B2503/40
摘要： Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
摘要翻译：已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。使用生物学技术，靶细胞可以用记录器进行标记，记者在覆盖红外范围的广谱中产生特征光子。扩散光的一部分可以到达对象/标本（例如，小动物）的身体表面，使用光学装置分离成若干光谱带，并由敏感摄像机收集。本文公开了用于多光谱生物发光断层摄影（MBLT）的系统和方法，其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态，以及实现和提高MBLT的质量。

4. 发明申请

US20230026961A1 LOW-DIMENSIONAL MANIFOLD CONSTRAINED DISENTANGLEMENT NETWORK FOR METAL ARTIFACT REDUCTION 有权
公开(公告)号：US20230026961A1
公开(公告)日：2023-01-26
申请号：US17859186
申请日：2022-07-07
申请人： Ge Wang , Chuang Niu , Wenxiang Cong
发明人： Ge Wang , Chuang Niu , Wenxiang Cong
IPC分类号： G06T11/00 , G06T5/00 , G06N3/04
摘要： In one embodiment, there is provided an apparatus for low-dimensional manifold constrained disentanglement for metal artifact reduction (MAR) in computed tomography (CT) images. The apparatus includes a patch set construction module, a manifold dimensionality module, and a training module. The patch set construction module is configured to construct a patch set based, at least in part on training data. The manifold dimensionality module is configured to determine a dimensionality of a manifold. The training module is configured to optimize a combination loss function comprising a network loss function and the manifold dimensionality. The optimizing the combination loss function includes optimizing at least one network parameter.

5. 发明申请

US20220375142A1 FEW-VIEW CT IMAGE RECONSTRUCTION SYSTEM 有权
公开(公告)号：US20220375142A1
公开(公告)日：2022-11-24
申请号：US17642725
申请日：2020-09-14
申请人： Huidong Xie , Ge Wang , Hongming Shan , Wenxiang Cong
发明人： Huidong Xie , Ge Wang , Hongming Shan , Wenxiang Cong
IPC分类号： G06T11/00
摘要： A system for few-view computed tomography (CT) image reconstruction is described. The system includes a preprocessing module, a first generator network, and a discriminator network. The preprocessing module is configured to apply a ramp filter to an input sinogram to yield a filtered sinogram. The first generator network is configured to receive the filtered sinogram, to learn a filtered back-projection operation and to provide a first reconstructed image as output. The first reconstructed image corresponds to the input sinogram. The discriminator network is configured to determine whether a received image corresponds to the first reconstructed image or a corresponding ground truth image. The generator network and the discriminator network correspond to a Wasserstein generative adversarial network (WGAN). The WGAN is optimized using an objective function based, at least in part, on a Wasserstein distance and based, at least in part, on a gradient penalty.

6. 发明申请

US20160113602A1 DYNAMIC BOWTIE FILTER FOR CONE-BEAM/MULTI-SLICE CT 审中-公开
标题翻译：锥形/多层CT的动态波纹过滤器
公开(公告)号：US20160113602A1
公开(公告)日：2016-04-28
申请号：US14924495
申请日：2015-10-27
申请人： Ge Wang , Fenglin Liu , Wenxiang Cong , Qingsong Yang
发明人： Ge Wang , Fenglin Liu , Wenxiang Cong , Qingsong Yang
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/4035 , A61B6/032 , A61B6/482 , A61B6/544 , A61B6/583
摘要： Dynamic bowties, imaging systems including a bowtie, and methods of imaging including such bowties or systems are provided. A bowtie can be a three-dimensional (3-D) dynamic bowtie and can include a highly-attenuating bowtie (HB) and a weakly-attenuating bowtie (WB). The HB can be filled with a liquid, and the WB can be immersed in the liquid of the HB.
摘要翻译：提供动态弯曲，包括弓形的成像系统，以及包括这种弯曲或系统的成像方法。 Bowtie可以是一个三维（3-D）动态的蝴蝶结，可以包括高度衰减的蝴蝶结（HB）和弱衰减的蝴蝶结（WB）。 HB可以充满液体，WB可以浸入HB的液体中。

7. 发明授权

US11806175B2 Few-view CT image reconstruction system 有权
公开(公告)号：US11806175B2
公开(公告)日：2023-11-07
申请号：US17642725
申请日：2020-09-14
申请人： Huidong Xie , Ge Wang , Hongming Shan , Wenxiang Cong
发明人： Huidong Xie , Ge Wang , Hongming Shan , Wenxiang Cong
IPC分类号： A61B6/03 , G06T11/00 , A61B6/00
CPC分类号： A61B6/032 , A61B6/5205 , G06T11/005 , G06T11/006 , G06T2211/421 , G06T2211/436
摘要： A system for few-view computed tomography (CT) image reconstruction is described. The system includes a preprocessing module, a first generator network, and a discriminator network. The preprocessing module is configured to apply a ramp filter to an input sinogram to yield a filtered sinogram. The first generator network is configured to receive the filtered sinogram, to learn a filtered back-projection operation and to provide a first reconstructed image as output. The first reconstructed image corresponds to the input sinogram. The discriminator network is configured to determine whether a received image corresponds to the first reconstructed image or a corresponding ground truth image. The generator network and the discriminator network correspond to a Wasserstein generative adversarial network (WGAN). The WGAN is optimized using an objective function based, at least in part, on a Wasserstein distance and based, at least in part, on a gradient penalty.

8. 发明申请

US20160135769A1 X-RAY PHASE-CONTRAST IMAGING 有权
标题翻译： X射线相位成像
公开(公告)号：US20160135769A1
公开(公告)日：2016-05-19
申请号：US14943157
申请日：2015-11-17
申请人： Ge Wang , Yan Xi , Wenxiang Cong
发明人： Ge Wang , Yan Xi , Wenxiang Cong
IPC分类号： A61B6/00 , G06T11/00 , G06T7/00
CPC分类号： A61B6/484 , A61B6/032 , A61B6/4035 , A61B6/4233 , A61B6/4291 , A61B6/5205 , G06T11/005 , G21K1/025 , G21K2207/005
摘要： Systems and methods for X-ray phase-contrast imaging (PCI) are provided. A quasi-periodic phase grating can be positioned between an object being imaged and a detector. An analyzer grating can be disposed between the phase grating and the detector. Second-order approximation models for X-ray phase retrieval using paraxial Fresnel-Kirchhoff diffraction theory are also provided. An iterative method can be used to reconstruct a phase-contrast image or a dark-field image.
摘要翻译：提供了X射线相位对比成像（PCI）的系统和方法。准周期相位光栅可以位于被成像对象和检测器之间。分析器光栅可以设置在相位光栅和检测器之间。还提供了使用近轴菲涅尔 - 基尔霍夫衍射理论的X射线相位检索的二阶近似模型。可以使用迭代方法来重建相位对比度图像或暗视场图像。

9. 发明申请

US20100310037A1 Multi-Parameter X-Ray Computed Tomography 有权
标题翻译：多参数X射线计算机断层扫描
公开(公告)号：US20100310037A1
公开(公告)日：2010-12-09
申请号：US12794160
申请日：2010-06-04
申请人： Ge WANG , Wenxiang Cong
发明人： Ge WANG , Wenxiang Cong
IPC分类号： G01N23/201 , A61B6/03
CPC分类号： A61B6/06 , A61B6/032 , A61B6/4291 , A61B6/583
摘要： The present invention relates to the field of x-ray imaging. More particularly, embodiments of the invention relate to methods, systems, and apparatus for imaging, which can be used in a wide range of applications, including medical imaging, security screening, and industrial non-destructive testing to name a few. Specifically provided as embodiments of the invention are systems for x-ray imaging comprising: a) a first collimator-and-detector assembly having a first operable configuration to provide at least one first dataset comprising primary x-ray signals as a majority component of its data capable of being presented as a first image of an object subjected to x-ray imaging; b) a second collimator-and-detector assembly having a second operable configuration or wherein the first collimator-and-detector assembly is adjustable to a second configuration to provide at least one second dataset comprising primary and dark-field x-ray signals as a majority component of its data capable of being presented as a second image of the object; and c) a computer operably coupled with the collimator-and-detector assemblies comprising a computer readable medium embedded with processing means for combining the first dataset and the second dataset to extract the dark-field x-ray signals and produce a target image having higher contrast quality than the images based on the first or second dataset alone. Such systems can be configured to comprise at least two collimator-and-detector assemblies or configurations differing with respect to collimator height, collimator aperture, imaging geometry, or distance between an object subjected to the imaging and the collimator-and-detector assembly.
摘要翻译：本发明涉及X射线成像领域。更具体地，本发明的实施例涉及用于成像的方法，系统和装置，其可以用于广泛的应用，包括医学成像，安全性筛选和工业非破坏性测试等等。作为本发明的实施例具体提供的是用于x射线成像的系统，包括：a）第一准直仪和检测器组件，其具有第一可操作配置，以提供至少一个第一数据集，所述第一数据集包括主X射线信号作为其主要成分能够被呈现为经受X射线成像的物体的第一图像的数据; b）具有第二可操作构型的第二准直器和检测器组件，或者其中第一准直器和检测器组件可调整到第二配置以提供包括主场和暗场x射线信号的至少一个第二数据集，作为其数据的多数分量能够被呈现为对象的第二图像; 以及c）与所述准直仪和检测器组件可操作地耦合的计算机，包括嵌入有处理装置的计算机可读介质，所述处理装置用于组合所述第一数据集和所述第二数据集以提取所述暗场x射线信号并产生具有较高对比质量比基于第一或第二数据集的图像单独。这样的系统可以被配置为包括关于准直器高度，准直器孔径，成像几何形状或经受成像的物体与准直器和检测器组件之间的距离不同的至少两个准直器和检测器组件或构造。

10. 发明授权

US09600910B2 Attenuation map reconstruction from TOF PET data 有权
公开(公告)号：US09600910B2
公开(公告)日：2017-03-21
申请号：US14592691
申请日：2015-01-08
申请人： Ge Wang , Wenxiang Cong , Qingsong Yang
发明人： Ge Wang , Wenxiang Cong , Qingsong Yang
IPC分类号： G06K9/00 , G06T11/00 , G01T1/164
CPC分类号： G06T11/003 , G01T1/1647 , G06T11/005
摘要： Advantageous methods, systems, and computer-readable media are provided. An attenuation map for an image can be reconstructed with no known sub-region of the attenuation map prior to performing the method. Gradient data of an attenuation sinogram can be estimated, and an algorithm can be performed to reconstruct the attenuation map from the estimated gradient data of the attenuation sinogram.

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