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1. 发明申请

US20120220672A1 Presence of ERG Gene Rearrangements and Protein Over-expression in Low Grade PIN (LG-PIN) in Prostate Biopsies 审中-公开
标题翻译：前列腺活检中低级别PIN（LG-PIN）中ERG基因重排和蛋白质过表达的存在
公开(公告)号：US20120220672A1
公开(公告)日：2012-08-30
申请号：US13404675
申请日：2012-02-24
申请人： Gary Pestano , Ray Nagle , Ubaradka Sathyanarayana , Alexandra Dea Nagy , Connie Cortez , Karl Garsha , Ryan Dittamore
发明人： Gary Pestano , Ray Nagle , Ubaradka Sathyanarayana , Alexandra Dea Nagy , Connie Cortez , Karl Garsha , Ryan Dittamore
IPC分类号： G01N21/64 , A61P35/00 , A61K35/00 , C12Q1/68 , C40B30/04
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/156 , G01N33/57434 , G01N2333/4703
摘要： The present disclosure relates to methods for the early detection of ERG over-expression, gene rearrangements, and diagnosis and/or prognosis of prostate cancer using a combined ERG IHC-FISH assay.
摘要翻译：本公开涉及使用组合的ERG IHC-FISH测定法早期检测ERG过表达，基因重排以及前列腺癌的诊断和/或预后的方法。

2. 发明申请

US20130171642A1 AUTOMATED ANALYSIS OF CIRCULATING TUMOR CELLS 审中-公开
标题翻译：循环肿瘤细胞的自动分析
公开(公告)号：US20130171642A1
公开(公告)日：2013-07-04
申请号：US13729225
申请日：2012-12-28
申请人： Gary Pestano , Ryan Dittamore , Karl Garsha , Michael Otter , Chol Steven Yun , Alexandra Dea Nagy
发明人： Gary Pestano , Ryan Dittamore , Karl Garsha , Michael Otter , Chol Steven Yun , Alexandra Dea Nagy
IPC分类号： C12Q1/68
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/156 , G01N2800/52 , G01N2800/54 , G01N2800/56
摘要： The disclosure provides methods for automated characterization of circulating tumor cells (CTCs), for example using automated tissue strainers. In specific examples, such methods permit characterizing a prostate cancer sample by simultaneously or contemporaneously detecting ERG rearrangements and PTEN deletions in the same CTC. Also provided are kits that can be used with such methods.
摘要翻译：本公开提供了用于自动表征循环肿瘤细胞（CTC）的方法，例如使用自动组织过滤器。在具体实例中，这种方法允许通过同时或同时检测相同CTC中的ERG重排和PTEN缺失来表征前列腺癌样品。还提供了可以与这些方法一起使用的试剂盒。

3. 发明申请

US20120200694A1 MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 有权
标题翻译：多模式对比度和亮度对比度增强，用于增强组织病理学确定和组织中的多分析检测
公开(公告)号：US20120200694A1
公开(公告)日：2012-08-09
申请号：US13499959
申请日：2010-10-07
申请人： Karl Garsha , Gary Pestano , Michael Otter , Alexandra Dea Nagy , Ray B. Nagle , Phillip Miller , Jan Froehlich , William Day
发明人： Karl Garsha , Gary Pestano , Michael Otter , Alexandra Dea Nagy , Ray B. Nagle , Phillip Miller , Jan Froehlich , William Day
IPC分类号： G06K9/36 , H04N7/18
CPC分类号： G01N21/6456
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.
摘要翻译：可以使用多重模态对比来产生可以组合和渲染的图像，以产生类似于在透射白光照明下观察到的波长吸收染色产生的图像的图像。使用其他补充对比模式获得的图像可以使用基于用于显示相同解剖结构和组织化学的经典对比度方法的工程配色方案来呈现，从而提供与医学培训和经验相关的图像。将衍生自折射率和荧光DAPI复染图像的暗视野对比图像组合以产生与用于病理解释的常规H＆E染色获得的图像相似的图像。这种多模式图像数据可以流式传输用于组织学样本的实时导航，并且可以与遗传DNA探针（FISH），mRNA表达位点（mRNA-ISH）和定位于其上的免疫组织化学（IHC）探针的分子定位相结合相同的组织切片，用于评估和绘制用于成像质谱法制备的组织切片。

4. 发明授权

US09310302B2 Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue 有权
标题翻译：多模态对比和明场上下文渲染，用于增强组织中的病理学确定和多分析物检测
公开(公告)号：US09310302B2
公开(公告)日：2016-04-12
申请号：US13499959
申请日：2010-10-07
申请人： Karl Garsha , Gary Pestano , Michael Otter , Alexandra Dea Nagy , Ray B. Nagle , Phillip Miller , Jan Froehlich , William Day
发明人： Karl Garsha , Gary Pestano , Michael Otter , Alexandra Dea Nagy , Ray B. Nagle , Phillip Miller , Jan Froehlich , William Day
IPC分类号： G06K9/36 , G01N21/64
CPC分类号： G01N21/6456
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.
摘要翻译：可以使用多重模态对比来产生可以组合和渲染的图像，以产生类似于在透射白光照明下观察到的波长吸收染色产生的图像的图像。使用其他补充对比模式获得的图像可以使用基于用于显示相同解剖结构和组织化学的经典对比度方法的工程配色方案来呈现，从而提供与医学培训和经验相关的图像。将衍生自折射率和荧光DAPI复染图像的暗视野对比图像组合以产生与用于病理解释的常规H＆E染色获得的图像相似的图像。这种多模式图像数据可以流式传输用于组织学样本的实时导航，并且可以与遗传DNA探针（FISH），mRNA表达位点（mRNA-ISH）和定位于其上的免疫组织化学（IHC）探针的分子定位相结合相同的组织切片，用于评估和绘制用于成像质谱法制备的组织切片。

5. 发明授权

US09435812B2 Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration 有权
标题翻译： ETS相关基因（ERG）和磷酸酶和张力蛋白同源物（PTEN）的表达与前列腺癌囊膜浸润相关
公开(公告)号：US09435812B2
公开(公告)日：2016-09-06
申请号：US13596266
申请日：2012-08-28
申请人： Gary Pestano , Ray B. Nagle , Connie Cortez , Kristie A. Vanpatten , Amit M. Algotar
发明人： Gary Pestano , Ray B. Nagle , Connie Cortez , Kristie A. Vanpatten , Amit M. Algotar
IPC分类号： G01N33/53 , G01N33/68 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N33/5748 , G01N33/6893 , G01N2333/47
摘要： The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be correlated with prostate cancer capsular penetration and more aggressive forms of prostate cancer. Such methods are useful for the prognosis of prostate cancer capsular penetration and for making treatment decisions in patients with prostate cancer that has penetrated the capsule. Also provided are kits that can be used with such methods.
摘要翻译：本公开提供了通过检测ERG，PTEN或两者的表达来表征前列腺癌样品的方法，其中相对于正常对照在本文中显示为与前列腺癌荚膜穿透和更具侵略性形式的前列腺癌相关的变化。这种方法对于前列腺癌囊膜穿透的预后以及用于在已经穿透胶囊的前列腺癌患者中作出治疗决定是有用的。还提供了可以与这些方法一起使用的试剂盒。

6. 发明申请

US20130196866A1 EXPRESSION OF ETS RELATED GENE (ERG) AND PHOSPHATASE AND TENSIN HOMOLOG (PTEN) CORRELATES WITH PROSTATE CANCER CAPSULAR PENETRATION 有权
标题翻译：表达ETS相关基因（ERG）和磷酸化酶和TENSIN HOMOLOG（PTEN）与前列腺癌囊肿的相关性
公开(公告)号：US20130196866A1
公开(公告)日：2013-08-01
申请号：US13596266
申请日：2012-08-28
申请人： Gary Pestano , Ray B. Nagle , Connie Cortez , Kristie A. Vanpatten , Amit M. Algotar
发明人： Gary Pestano , Ray B. Nagle , Connie Cortez , Kristie A. Vanpatten , Amit M. Algotar
IPC分类号： G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N33/5748 , G01N33/6893 , G01N2333/47
摘要： The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be correlated with prostate cancer capsular penetration and more aggressive forms of prostate cancer. Such methods are useful for the prognosis of prostate cancer capsular penetration and for making treatment decisions in patients with prostate cancer that has penetrated the capsule. Also provided are kits that can be used with such methods.
摘要翻译：本公开提供了通过检测ERG，PTEN或两者的表达来表征前列腺癌样品的方法，其中相对于正常对照在本文中显示为与前列腺癌荚膜穿透和更具侵略性形式的前列腺癌相关的变化。这种方法对于前列腺癌囊膜穿透的预后以及用于在已经穿透胶囊的前列腺癌患者中作出治疗决定是有用的。还提供了可以与这些方法一起使用的试剂盒。

7. 发明授权

US08244021B2 Quantitative, multispectral image analysis of tissue specimens stained with quantum dots 有权
标题翻译：用量子点染色的组织标本的定量，多光谱图像分析
公开(公告)号：US08244021B2
公开(公告)日：2012-08-14
申请号：US11999914
申请日：2007-12-06
申请人： G. Scott Lett , Ned C. Haubein , Gary Pestano
发明人： G. Scott Lett , Ned C. Haubein , Gary Pestano
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/6458 , G01N2021/6421 , G01N2021/6423 , G01N2021/6439 , G06F3/04842 , G06F3/04847
摘要： A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C1 . . . CN at each pixel from the set of images and reference spectral data for the N fluorophores. The coefficients C1 . . . CN are related to the concentration of each of the individual fluorophores at each pixel location. Morphological processing instructions find biological structures, e.g., cells, cellular components, genes, etc., in the images of the specimen. Quantitative analysis is performed on the identified biological structures. A display module displays the quantitative analysis results to the user, along with images of the specimen. The images can include images constructed from one or more of the coefficients C1 . . . CN. The quantitative analysis display includes histograms of the biological structures, scatter plots of fluorophore concentrations, statistical data, spectral data and still others.
摘要翻译：生物样品如组织切片用一个或多个量子点和可能的其它荧光团（总共荧光团数N）染色。耦合到显微镜的照相机在N个荧光团的发射光谱带内以多个不同的波长产生样本的图像。分析模块计算系数C1。。。 CN在来自该组图像的每个像素和N个荧光团的参考光谱数据。系数C1。。。 CN与每个像素位置处的各个荧光团的浓度有关。形态学处理指令在样本的图像中发现生物结构，例如细胞，细胞组分，基因等。对所鉴定的生物结构进行定量分析。显示模块与用户的图像一起显示定量分析结果。图像可以包括由一个或多个系数C1构成的图像。。。 CN。定量分析显示包括生物结构的直方图，荧光团浓度的分散图，统计数据，光谱数据等。

8. 发明申请

US20070207489A1 Reagents and methods for cancer prognosis and pathological staging 审中-公开
标题翻译：癌症预后和病理分期的试剂和方法
公开(公告)号：US20070207489A1
公开(公告)日：2007-09-06
申请号：US11707691
申请日：2007-02-16
申请人： Gary Pestano , Linda Samadzadeh
发明人： Gary Pestano , Linda Samadzadeh
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： This invention provides reagents and methods for assessing tumor progression using tissue or tumor cell-containing samples from an individual. The invention also provides reagents and methods for assessing response to chemotherapy.
摘要翻译：本发明提供使用来自个体的组织或含肿瘤细胞的样品来评估肿瘤进展的试剂和方法。本发明还提供了用于评估对化疗反应的试剂和方法。

9. 发明申请

US20100209928A1 Grading, Staging and prognosing Cancer using Osteopontin-C 有权
标题翻译：使用骨桥蛋白C分级，分期和预后
公开(公告)号：US20100209928A1
公开(公告)日：2010-08-19
申请号：US12682310
申请日：2008-10-16
申请人： Mana Mirza , Elizabeth Shaughnessy , Georg F. Weber , John K. Hurley , Kristie A. Vanpatten , Gary Pestano
发明人： Mana Mirza , Elizabeth Shaughnessy , Georg F. Weber , John K. Hurley , Kristie A. Vanpatten , Gary Pestano
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53
CPC分类号： C12Q1/6886 , A61K47/6855 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade, stage, or aggressiveness of a cancer, appropriate therapeutic regiments can be selected and administered to the patient with the cancer. The method includes detecting osteopontin-c (OPN-c), wherein the presence of high amounts of OPN-c in the cancer sample indicates that the subject has a more aggressive form of cancer (e.g., grade 3).
摘要翻译：本公开提供了可用于确定乳腺或其他癌症（例如原位导管癌（DCIS））的等级或阶段的方法和试剂盒。通过确定癌症的分级，阶段或侵略性，可以选择适当的治疗团并将其施用于患有癌症的患者。该方法包括检测骨桥蛋白c（OPN-c），其中癌症样品中大量OPN-c的存在表明受试者具有更具侵袭性的癌症形式（例如3级）。

10. 发明申请

US20100196902A1 PROSTATE CANCER BIOMARKERS 审中-公开
标题翻译：前列腺癌生物标志物
公开(公告)号：US20100196902A1
公开(公告)日：2010-08-05
申请号：US12677324
申请日：2008-09-15
申请人： Gary Pestano , Ubaradka G. Satilayanarayana , Janice Riley , Ray B. Nagle
发明人： Gary Pestano , Ubaradka G. Satilayanarayana , Janice Riley , Ray B. Nagle
IPC分类号： C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/16 , G01N33/57434 , G01N2800/60
摘要： Disclosed are biomarkers, at least, useful for the diagnosis and/or prognosis of cancer and for making treatment decisions in cancer, for example prostate cancer.
摘要翻译：公开了生物标志物，至少可用于癌症的诊断和/或预后以及在癌症中作出治疗决定，例如前列腺癌。

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