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1. 发明授权

US08117929B2 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor 有权
标题翻译：在使用激光传感器的采样过程中控制样品收集器与待分析表面之间的位置关系
公开(公告)号：US08117929B2
公开(公告)日：2012-02-21
申请号：US12217225
申请日：2008-07-02
申请人： Gary J. Van Berkel , Vilmos Kertesz
发明人： Gary J. Van Berkel , Vilmos Kertesz
IPC分类号： G01N35/10
CPC分类号： H01J49/0459
摘要： A system and method utilizes distance-measuring equipment including a laser sensor for controlling the collection instrument-to-surface distance during a sample collection process for use, for example, with mass spectrometric detection. The laser sensor is arranged in a fixed positional relationship with the collection instrument, and a signal is generated by way of the laser sensor which corresponds to the actual distance between the laser sensor and the surface. The actual distance between the laser sensor and the surface is compared to a target distance between the laser sensor and the surface when the collection instrument is arranged at a desired distance from the surface for sample collecting purposes, and adjustments are made, if necessary, so that the actual distance approaches the target distance.
摘要翻译：一种系统和方法利用距离测量设备，包括激光传感器，用于在样品采集过程中控制收集仪器到表面的距离，例如使用质谱检测。激光传感器与收集仪器以固定的位置关系布置，并且通过与激光传感器和表面之间的实际距离对应的激光传感器产生信号。将激光传感器和表面之间的实际距离与激光传感器和表面之间的目标距离进行比较，当采集仪器布置在离表面所需的距离处以进行样品收集时，如果需要，进行调整实际距离接近目标距离。

2. 发明申请

US20100224013A1 Method and system for formation and withdrawal of a sample from a surface to be analyzed 审中-公开
标题翻译：从待分析的表面形成和取出样品的方法和系统
公开(公告)号：US20100224013A1
公开(公告)日：2010-09-09
申请号：US12380980
申请日：2009-03-05
申请人： Gary J. Van Berkel , Vilmos Kertesz
发明人： Gary J. Van Berkel , Vilmos Kertesz
IPC分类号： G01N1/20
CPC分类号： H01J49/0431 , G01N35/1095 , G01N2001/1031 , H01J49/045 , H01J49/0463 , H01J49/167
摘要： A method and system for formation and withdrawal of a sample from a surface to be analyzed utilizes a collection instrument having a port through which a liquid solution is conducted onto the surface to be analyzed. The port is positioned adjacent the surface to be analyzed, and the liquid solution is conducted onto the surface through the port so that the liquid solution conducted onto the surface interacts with material comprising the surface. An amount of material is thereafter withdrawn from the surface. Pressure control can be utilized to manipulate the solution balance at the surface to thereby control the withdrawal of the amount of material from the surface. Furthermore, such pressure control can be coordinated with the movement of the surface relative to the port of the collection instrument within the X-Y plane.
摘要翻译：用于从待分析的表面形成和取出样品的方法和系统利用采集仪器，其具有将液体溶液通过该端口传导到要分析的表面上。端口定位在待分析表面附近，并且液体溶液通过端口传导到表面上，使得被引导到表面上的液体溶液与包含表面的材料相互作用。此后从表面取出一定量的材料。可以使用压力控制来操纵表面处的溶液平衡，从而控制从表面撤出的材料量。此外，这种压力控制可以与表面相对于收集仪器在X-Y平面内的端口的运动相配合。

3. 发明申请

US20100000338A1 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor 有权
标题翻译：在使用激光传感器的采样过程中控制样品收集器与待分析表面之间的位置关系
公开(公告)号：US20100000338A1
公开(公告)日：2010-01-07
申请号：US12217225
申请日：2008-07-02
申请人： Gary J. Van Berkel , Vilmos Kertesz
发明人： Gary J. Van Berkel , Vilmos Kertesz
IPC分类号： G01N1/02
CPC分类号： H01J49/0459
摘要： A system and method utilizes distance-measuring equipment including a laser sensor for controlling the collection instrument-to-surface distance during a sample collection process for use, for example, with mass spectrometric detection. The laser sensor is arranged in a fixed positional relationship with the collection instrument, and a signal is generated by way of the laser sensor which corresponds to the actual distance between the laser sensor and the surface. The actual distance between the laser sensor and the surface is compared to a target distance between the laser sensor and the surface when the collection instrument is arranged at a desired distance from the surface for sample collecting purposes, and adjustments are made, if necessary, so that the actual distance approaches the target distance.
摘要翻译：一种系统和方法利用距离测量设备，包括激光传感器，用于在样品采集过程中控制收集仪器到表面的距离，例如使用质谱检测。激光传感器与收集仪器以固定的位置关系布置，并且通过与激光传感器和表面之间的实际距离对应的激光传感器产生信号。将激光传感器和表面之间的实际距离与激光传感器和表面之间的目标距离进行比较，当采集仪器布置在离表面所需的距离处以进行样品收集时，如果需要，进行调整实际距离接近目标距离。

4. 发明授权

US08637813B2 System and method for laser assisted sample transfer to solution for chemical analysis 有权
标题翻译：用于激光辅助样品转移到化学分析溶液的系统和方法
公开(公告)号：US08637813B2
公开(公告)日：2014-01-28
申请号：US12896018
申请日：2010-10-01
申请人： Gary J. Van Berkel , Vilmos Kertesz
发明人： Gary J. Van Berkel , Vilmos Kertesz
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/0463
摘要： A system and method for laser desorption of an analyte from a specimen and capturing of the analyte in a suspended solvent to form a testing solution are described. The method can include providing a specimen supported by a desorption region of a specimen stage and desorbing an analyte from a target site of the specimen with a laser beam centered at a radiation wavelength (λ). The desorption region is transparent to the radiation wavelength (λ) and the sampling probe and a laser source emitting the laser beam are on opposite sides of a primary surface of the specimen stage. The system can also be arranged where the laser source and the sampling probe are on the same side of a primary surface of the specimen stage. The testing solution can then be analyzed using an analytical instrument or undergo further processing.
摘要翻译：描述了用于从样品中分析物的激光解吸和在悬浮溶剂中捕获分析物以形成测试溶液的系统和方法。该方法可以包括提供由样品台的解吸区域支撑的样品，并用以辐射波长（λ）为中心的激光束从样品的靶位点解吸分析物。解吸区对于辐射波长（λ）是透明的，并且采样探针和发射激光束的激光源位于样品台的主表面的相对侧上。该系统还可以布置在激光源和采样探针位于样品台的主表面的同一侧上。然后可以使用分析仪器分析测试溶液或进行进一步处理。

5. 发明授权

US08519330B2 Systems and methods for laser assisted sample transfer to solution for chemical analysis 有权
公开(公告)号：US08519330B2
公开(公告)日：2013-08-27
申请号：US13152836
申请日：2011-06-03
申请人： Gary J. Van Berkel , Vilmos Kertesz , Olga S. Ovchinnikova
发明人： Gary J. Van Berkel , Vilmos Kertesz , Olga S. Ovchinnikova
IPC分类号： G01N1/22
CPC分类号： G01N1/04 , G01N1/22 , G01N1/38 , G01N2001/045 , G01N2001/383 , G01Q30/02 , H01J49/0463 , H01J49/165
摘要： Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.

6. 发明授权

US08497473B2 Electrospray ion source with reduced analyte electrochemistry 有权
标题翻译：具有降低分析物电化学的电喷雾离子源
公开(公告)号：US08497473B2
公开(公告)日：2013-07-30
申请号：US13207783
申请日：2011-08-11
申请人： Vilmos Kertesz , Gary J. Van Berkel
发明人： Vilmos Kertesz , Gary J. Van Berkel
IPC分类号： H01J49/10
CPC分类号： H01J49/167
摘要： An electrospray ion (ESI) source and method capable of ionizing an analyte molecule without oxidizing or reducing the analyte of interest. The ESI source can include an emitter having a liquid conduit, a working electrode having a liquid contacting surface, a spray tip, a secondary working electrode, and a charge storage coating covering partially or fully the liquid contacting surface of the working electrode. The liquid conduit, the working electrode and the secondary working electrode can be in liquid communication. The electrospray ion source can also include a counter electrode proximate to, but separated from, said spray tip. The electrospray ion source can also include a power system for applying a voltage difference between the working electrodes and a counter-electrode. The power system can deliver pulsed voltage changes to the working electrodes during operation of said electrospray ion source to minimize the surface potential of the charge storage coating.
摘要翻译：能够电离分析物分子而不氧化或还原感兴趣的分析物的电喷雾离子（ESI）源和方法。 ESI源可以包括具有液体导管的发射器，具有液体接触表面的工作电极，喷射尖端，次级工作电极和覆盖工作电极的液体接触表面的电荷储存涂层。液体导管，工作电极和辅助工作电极可以液体连通。电喷雾离子源还可以包括邻近但与所述喷雾尖端分开的对电极。电喷雾离子源还可以包括用于在工作电极和对电极之间施加电压差的电力系统。在所述电喷雾离子源的操作期间，电力系统可以向工作电极提供脉冲电压变化，以使电荷存储涂层的表面电位最小化。

7. 发明申请

US20110269166A1 SEALING SURFACE SAMPLING PROBE APPLIED TO BLOOD SPOTS AND TISSUES 审中-公开
标题翻译：密封表面采样探针适用于血液和组织
公开(公告)号：US20110269166A1
公开(公告)日：2011-11-03
申请号：US12771736
申请日：2010-04-30
申请人： Gary J. Van Berkel , Vilmos Kertesz
发明人： Gary J. Van Berkel , Vilmos Kertesz
IPC分类号： C12Q1/02 , C12N5/078 , C12M1/34
CPC分类号： G01N33/49 , A61B10/0233 , G01N1/2813 , G01N33/5088 , G01N2001/2873
摘要： A sample assembly includes a stack of a sample and a hydrophobic elastic layer located on the back side surface thereof or a filter layer. The sample may include a biological material or a chemical, and can include an absorptive material. The filter layer includes an absorptive material in which a sample material is embedded. A sealing surface sampling probe including a knife edge lands on an area of interest in the sample or the filter layer. The hydrophobic elastic layer or the substrate in conjunction with the knife edge provides a complete sealing of a confined portion of the sample or the filter layer to prevent inclusion of any other material from outside the confined volume and to enhance the precision and sensitivity of the analysis.
摘要翻译：样品组件包括样品的堆叠和位于其背侧表面上的疏水性弹性层或过滤层。样品可以包括生物材料或化学品，并且可以包括吸收材料。过滤层包括嵌入样品材料的吸收材料。包括刀刃的密封表面采样探针落在样品或过滤层中的感兴趣区域上。疏水性弹性层或与刀刃结合的基底提供了样品或过滤层的封闭部分的完全密封，以防止从限制体积外部包含任何其他材料，并提高分析的精度和灵敏度。

8. 发明申请

US20100072357A1 ELECTROSPRAY ION SOURCE WITH REDUCED ANALYTE ELECTROCHEMISTRY 有权
标题翻译：具有减少分析电化学的电离离子源
公开(公告)号：US20100072357A1
公开(公告)日：2010-03-25
申请号：US12237892
申请日：2008-09-25
申请人： VILMOS KERTESZ , Gary J. Van Berkel
发明人： VILMOS KERTESZ , Gary J. Van Berkel
IPC分类号： B01D59/44
CPC分类号： H01J49/167
摘要： An electrospray ion (ESI) source and method capable of ionizing an analyte molecule without oxidizing or reducing the analyte of interest. The ESI source can include an emitter having a liquid conduit, a working electrode having a liquid contacting surface, a spray tip, a secondary working electrode, and a charge storage coating covering partially or fully the liquid contacting surface of the working electrode. The liquid conduit, the working electrode and the secondary working electrode can be in liquid communication. The electrospray ion source can also include a counter electrode proximate to, but separated from, said spray tip. The electrospray ion source can also include a power system for applying a voltage difference between the working electrodes and a counter-electrode. The power system can deliver pulsed voltage changes to the working electrodes during operation of said electrospray ion source to minimize the surface potential of the charge storage coating.
摘要翻译：能够电离分析物分子而不氧化或还原感兴趣的分析物的电喷雾离子（ESI）源和方法。 ESI源可以包括具有液体导管的发射器，具有液体接触表面的工作电极，喷射尖端，次级工作电极和覆盖工作电极的液体接触表面的电荷储存涂层。液体导管，工作电极和辅助工作电极可以液体连通。电喷雾离子源还可以包括邻近但与所述喷雾尖端分开的对电极。电喷雾离子源还可以包括用于在工作电极和对电极之间施加电压差的电力系统。在所述电喷雾离子源的操作期间，电力系统可以向工作电极提供脉冲电压变化，以使电荷存储涂层的表面电位最小化。

9. 发明授权

US06952013B2 Electrochemistry with porous flow cell 有权
标题翻译：多孔流化床电化学
公开(公告)号：US06952013B2
公开(公告)日：2005-10-04
申请号：US10849098
申请日：2004-05-19
申请人： Michael C. Granger , Gary J. Van Berkel
发明人： Michael C. Granger , Gary J. Van Berkel
IPC分类号： B01D59/44 , B05B20060101 , H01J49/04 , H01J49/10
CPC分类号： H01J49/165 , H01J49/0436
摘要： Disclosed are systems and methods that include a flow-cell that includes porous conductive material(s) that provides a working electrode(s), an inlet connected to the flow-cell to deliver a solution continuing an analyte(s), an outlet connected to the flow-cell to allow the solution to exit the flow-cell, a counter electrode positioned proximate to the outlet, and a voltage source(s) coupled to the working electrode(s) and the counter electrode. The methods can include delivering a solution containing an analyte(s) through an inlet to a flow-cell that includes porous conductive material(s) that provides a working electrode(s), connecting the flow-cell to an outlet for allowing the solution to exit the flow-cell, placing a counter-electrode proximate the outlet, and supplying a voltage from a voltage source(s) to the working electrode(s) and/or the counter-electrode.
摘要翻译：公开了包括流动池的系统和方法，流动池包括提供工作电极的多孔导电材料，连接到流动池以输送连续分析物的溶液的入口，连接的出口流动池以允许溶液离开流动池，靠近出口定位的对电极和耦合到工作电极和对电极的电压源。所述方法可以包括将含有分析物的溶液通过入口输送到流动池，该流动池包括提供工作电极的多孔导电材料，将流动池连接到出口以允许溶液离开流通池，将反电极放置在靠近出口处，并将电压从电压源提供给工作电极和/或对电极。

10. 发明授权

US09153425B2 Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis 有权
标题翻译：样品的高空间分辨率化学分析装置和高空间分辨率化学分析方法
公开(公告)号：US09153425B2
公开(公告)日：2015-10-06
申请号：US12873412
申请日：2010-09-01
申请人： Gary J. Van Berkel
发明人： Gary J. Van Berkel
IPC分类号： H01J49/04
CPC分类号： H01J49/0431
摘要： A system and method for analyzing a chemical composition of a specimen are described. The system can include at least one pin; a sampling device configured to contact a liquid with a specimen on the at least one pin to form a testing solution; and a stepper mechanism configured to move the at least one pin and the sampling device relative to one another. The system can also include an analytical instrument for determining a chemical composition of the specimen from the testing solution. In particular, the systems and methods described herein enable chemical analysis of specimens, such as tissue, to be evaluated in a manner that the spatial-resolution is limited by the size of the pins used to obtain tissue samples, not the size of the sampling device used to solubilize the samples coupled to the pins.
摘要翻译：描述用于分析试样的化学成分的系统和方法。该系统可以包括至少一个销; 采样装置，被配置为使液体与所述至少一个销上的样品接触以形成测试溶液; 以及步进机构，其构造成使所述至少一个销和所述取样装置相对于彼此移动。该系统还可以包括用于从测试溶液中测定样品的化学成分的分析仪器。特别地，本文描述的系统和方法使得可以以空间分辨率受到用于获得组织样本的针的尺寸限制的方式来评估样品（例如组织）的化学分析，而不是采样的尺寸用于溶解耦合到引脚的样品的装置。

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