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1. 发明授权

US5681817A Treatment of ovarian estrogen dependent conditions 失效
标题翻译：治疗卵巢雌激素依赖条件
公开(公告)号：US5681817A
公开(公告)日：1997-10-28
申请号：US191631
申请日：1994-02-04
申请人： Gary D. Hodgen , Robert F. Williams , Daniel Grow
发明人： Gary D. Hodgen , Robert F. Williams , Daniel Grow
IPC分类号： A61K38/22 , A61K38/00 , A61K38/04 , A61K38/09 , A61P5/06 , A61P5/36 , A61P13/02 , A61P15/00 , A61P35/00 , C07K14/575 , A61K35/48 , A61K38/24 , C07K14/59
CPC分类号： A61K38/09 , Y10S514/01
摘要： A method of treating an ovarian estrogen dependent condition such as endometriosis, uterine leiomyomata, PMS or DUB involving the administration of gonadotropin releasing hormone analog and the administration of antiprogestin, which will provide a therapeutic method for long term treatment without rapid loss of bone density, as occurs using GnRH analogs alone.
摘要翻译：一种治疗卵巢雌激素依赖性疾病如子宫内膜异位症，子宫平滑肌瘤，PMS或DUB的方法，其涉及给予促性腺激素释放激素类似物和施用抗孕激素，其将提供长期治疗的治疗方法，而不会快速丧失骨密度，如使用GnRH类似物一样。

2. 再颁专利

USRE39861E1 Methods of extended use oral contraception 有权
标题翻译：延长使用口服避孕方法
公开(公告)号：USRE39861E1
公开(公告)日：2007-09-25
申请号：US10893795
申请日：2004-07-19
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K31/56
摘要： A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively. The advantages include less menstrual bleeding, less patient anemia, less total exposure to medication, higher compliance rates and more lifestyle convenience for patients.
摘要翻译：女性避孕方法包括将雌激素和孕激素的组合连续施用60-110天，其中雌激素和孕激素的日剂量分别等于约5-35mcg的乙炔雌二醇和约0.025至10mg的醋酸炔诺酮。其优点包括月经量少，患者贫血少，药物总暴露较少，依从性较高，患者生活便利性更高。

3. 发明授权

US5691314A Adjunctive therapy 失效
标题翻译：辅助治疗
公开(公告)号：US5691314A
公开(公告)日：1997-11-25
申请号：US617048
申请日：1996-03-18
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K38/09
CPC分类号： A61K38/09 , Y10S514/80
摘要： A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.
摘要翻译：在施用有效量的促性腺激素释放激素类似物或其他卵巢类固醇抑制剂生产或作用之后，诸如肿瘤，肥厚组织或囊肿的生长被活检或更完全切除。

4. 发明授权

US5552394A Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy 失效
标题翻译：低剂量口服避孕药具有较少的突破性出血和持续疗效
公开(公告)号：US5552394A
公开(公告)日：1996-09-03
申请号：US279300
申请日：1994-07-22
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K31/565 , A61K31/56
CPC分类号： A61K31/565 , A61K31/567 , Y10S514/843
摘要： A method of female contraception which is characterized by a reduced incidence of breakthrough bleeding after the first cycle involves monophasicly administering a combination of estrogen and progestin for 23-25 consecutive days of a 28 day cycle in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively and in which the weight ratio of estrogen to progestin is at least 1:45 calculated as ethinyl estradiol to norethindrone acetate.
摘要翻译：一种女性避孕方法，其特征在于在第一次循环后出现突破性出血的发生率降低，包括雌激素和孕激素的组合在28天的28天周期中单次施用雌激素和孕激素的组合，其中雌激素和孕激素的日剂量是相等的至约5-35mcg的乙炔雌二醇和约0.025至10mg的醋酸炔诺酮，其中雌激素与孕激素的重量比为乙炔雌二醇至乙酸炔诺酮计算为至少1:45。

5. 发明授权

US4413985A Hydrocephalic antenatal vent for intrauterine treatment (HAVIT) 失效
标题翻译：用于宫内治疗的脑积水产前通气（HAVIT）
公开(公告)号：US4413985A
公开(公告)日：1983-11-08
申请号：US325730
申请日：1981-11-30
申请人： Edward Wellner , Maria Michejda , Gary D. Hodgen
发明人： Edward Wellner , Maria Michejda , Gary D. Hodgen
IPC分类号： A61M1/00 , A61M27/00
CPC分类号： A61M39/0247 , A61M27/006 , A61M2039/025 , A61M2039/0261 , A61M2039/027 , A61M2039/0276 , A61M2210/02 , A61M2210/145
摘要： A hydrocephalic drainage valve consisting of a hollow shank with a pointed conical tip. The shank has an intake port adjacent the conical tip. A ball check valve in the shank is urged by a coiled spring toward closing relationship with the port. A hollow set screw is adjustably mounted in the shank to vary the biasing force on the valve ball. In one form, for manual implantation, a sleeve is slidably mounted on the shank, has a centrally apertured enlarged head and has implantation enlarged threads near the head. The head has aligned opposite radial grooves which are engageable by a manual insertion tool. In other forms, for pneumatic insertion, the shank has an enlarged head, employed as a driving piston in a pneumatic insertion tube. A washer member with implantation barbs is slidably mounted on the shank and is arranged to be locked to the shank subjacent the head responsive to the pneumatic driving action, with its barbs embedded in the fetal skin around the implantation puncture, thus holding the shank in operating position with the intake port exposed in the cranial vault.
摘要翻译：一种脑积水引流阀，由具有尖锐锥形尖端的中空柄组成。柄具有邻近锥形尖端的进气口。螺栓中的球止回阀被螺旋弹簧推向与端口的关系。中空的固定螺钉可调节地安装在柄中以改变阀球上的偏压力。在一种形式中，为了手动植入，套筒可滑动地安装在柄上，具有中心孔径扩大的头部并且在头部附近具有植入放大的线。头部具有可由手动插入工具接合的相对的径向凹槽。在其他形式中，为了气动插入，柄部具有扩大的头部，用作气动插入管中的驱动活塞。具有植入倒钩的垫圈构件可滑动地安装在柄上并且被布置成响应于气动驱动动作而被锁定到位于头部下方的柄部，其倒钩嵌入植入穿刺中的胎儿皮肤中，从而将柄保持在操作中位置与入口端口暴露在颅骨库。

6. 发明授权

US07538099B1 Antiprogestin method and kit for reducing side effects associated with low dosage HRT, oral contraception and regulating menses 失效
标题翻译：抗孕激素方法和试剂盒，用于减少与低剂量HRT，口服避孕和调节月经有关的副作用
公开(公告)号：US07538099B1
公开(公告)日：2009-05-26
申请号：US08462703
申请日：1995-06-05
申请人： Gary D. Hodgen , Kristof Chwalisz
发明人： Gary D. Hodgen , Kristof Chwalisz
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K2300/00
摘要： Menses regulation and, when desired, contraception is achieved at low doses of estrogen and progestin, which otherwise would create episodes of breakthrough bleeding and/or withdrawal amenorrhea, by periodically inducing menses with an antiprogestin.
摘要翻译：月经调节，并且在需要时，在低剂量的雌激素和孕激素下实现避孕，否则会通过定期诱导月经与抗孕激素的作用而产生突破性出血和/或戒断闭经的发作。

7. 发明授权

US5658884A Establishment of tonic ovarian estrogen secretion for extended therapeutic regimens 失效
标题翻译：建立补充卵巢雌激素分泌用于延长治疗方案
公开(公告)号：US5658884A
公开(公告)日：1997-08-19
申请号：US467860
申请日：1995-06-06
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K38/09 , C07K7/00
CPC分类号： A61K38/09
摘要： A regimen for the therapeutic management of a gonadal-steroid dependent condition in a mammal constitutes reducing the estrogen supply thereof by means of administration of a GnRH antagonist in an amount effective to inhibit proliferation of endometrial tissue without substantially stopping the production of endogenous estrogen. A method of determining whether the reduced estrogen supply in an individual is such that the concentration of estradiol has been suppressed to an optimized level appropriate to the therapeutic management of the gonadal-steroid dependent condition such as endometriosis in that individual by the administration of a GnRH antagonist at a given dosage level involves titering the dosage, e.g., by conducting a progesterone challenge test and optimal regimen doses of a GnRH antagonist.
摘要翻译：用于治疗哺乳动物性腺类固醇依赖状况的方案包括通过以有效抑制子宫内膜组织增殖的量施用GnRH拮抗剂来减少其雌激素供应，而基本上不停止内源性雌激素的产生。确定个体中雌激素供应减少的方法是否已经将雌二醇的浓度抑制至适合于性腺类固醇依赖状况的治疗性治疗的最佳水平，例如通过给予GnRH在该个体中的子宫内膜异位症拮抗剂在给定剂量水平涉及滴定剂量，例如通过进行孕激素试验和GnRH拮抗剂的最佳方案剂量。

8. 发明授权

US5468736A Hormone replacement therapy 失效
标题翻译：激素替代疗法
公开(公告)号：US5468736A
公开(公告)日：1995-11-21
申请号：US23692
申请日：1993-02-25
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K45/00 , A61K9/20 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/57 , A61P5/24 , A61P15/00 , A61P19/08 , A61P43/00
CPC分类号： A61K31/565 , A61K31/57 , Y10S514/01
摘要： A method of hormone replacement therapy involves the administration of estrogen together with an amount of antiprogestin which inhibits estrogen-induced endometrial proliferation in a woman.
摘要翻译：激素替代疗法的一种方法包括施用雌激素以及一定量的抗孕激素，其抑制女性中雌激素诱导的子宫内膜增生。

9. 发明授权

US4740364A Predicting predisposition to osteoporosis 失效
标题翻译：预测骨质疏松症的倾向
公开(公告)号：US4740364A
公开(公告)日：1988-04-26
申请号：US780739
申请日：1985-09-27
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： G01N33/70 , G01N33/48
CPC分类号： G01N33/70 , Y10T436/147777
摘要： A method of providing a diagnostic indicia which is predictive of the risk of a non-osteoporotic human being contracting osteoporosis as a consequence of being in a long-term hormonally agonadal state, which comprises the steps of determining the average ratio of calcium to creatinine in the urine or in the blood of that person, during a period when the person is ingesting only foodstuff sources of calcium and vitamin D, while in a hormonally gonadal state, and also while in a hormonally agonadal state; determining the magnitude of the difference in the ratio obtained in the latter state compared to the former state, a large difference being predictive of a high risk of that person contracting osteoporosis.
摘要翻译：一种提供诊断标记的方法，该诊断标记预示出由于处于长期激素激动状态而导致非骨质疏松的人承受骨质疏松症的风险，其包括以下步骤：确定钙与肌酐的平均比例在该人在激素性腺状态期间以及在激素激素状态期间，该人仅摄取钙和维生素D的食物来源的时期内的尿液或血液中的血液; 确定在后一种状态下与前一状态相比获得的差异的大小，大的差异是预测该人承受骨质疏松症的高风险。

10. 再颁专利

USRE40119E1 Adjunctive therapy 有权
标题翻译：辅助治疗
公开(公告)号：USRE40119E1
公开(公告)日：2008-02-26
申请号：US11016680
申请日：2004-12-20
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K38/09
CPC分类号： A61K38/09 , Y10S514/80
摘要： A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.
摘要翻译：在施用有效量的促性腺激素释放激素类似物或其它卵巢类固醇抑制剂生产或作用之后，诸如肿瘤，肥大组织或囊肿的生长被活检或更完全切除。

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