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1. 再颁专利

USRE39861E1 Methods of extended use oral contraception 有权
标题翻译：延长使用口服避孕方法
公开(公告)号：USRE39861E1
公开(公告)日：2007-09-25
申请号：US10893795
申请日：2004-07-19
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K31/56
摘要： A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively. The advantages include less menstrual bleeding, less patient anemia, less total exposure to medication, higher compliance rates and more lifestyle convenience for patients.
摘要翻译：女性避孕方法包括将雌激素和孕激素的组合连续施用60-110天，其中雌激素和孕激素的日剂量分别等于约5-35mcg的乙炔雌二醇和约0.025至10mg的醋酸炔诺酮。其优点包括月经量少，患者贫血少，药物总暴露较少，依从性较高，患者生活便利性更高。

2. 发明授权

US5691314A Adjunctive therapy 失效
标题翻译：辅助治疗
公开(公告)号：US5691314A
公开(公告)日：1997-11-25
申请号：US617048
申请日：1996-03-18
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K38/09
CPC分类号： A61K38/09 , Y10S514/80
摘要： A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.
摘要翻译：在施用有效量的促性腺激素释放激素类似物或其他卵巢类固醇抑制剂生产或作用之后，诸如肿瘤，肥厚组织或囊肿的生长被活检或更完全切除。

3. 发明授权

US5552394A Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy 失效
标题翻译：低剂量口服避孕药具有较少的突破性出血和持续疗效
公开(公告)号：US5552394A
公开(公告)日：1996-09-03
申请号：US279300
申请日：1994-07-22
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K31/565 , A61K31/56
CPC分类号： A61K31/565 , A61K31/567 , Y10S514/843
摘要： A method of female contraception which is characterized by a reduced incidence of breakthrough bleeding after the first cycle involves monophasicly administering a combination of estrogen and progestin for 23-25 consecutive days of a 28 day cycle in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively and in which the weight ratio of estrogen to progestin is at least 1:45 calculated as ethinyl estradiol to norethindrone acetate.
摘要翻译：一种女性避孕方法，其特征在于在第一次循环后出现突破性出血的发生率降低，包括雌激素和孕激素的组合在28天的28天周期中单次施用雌激素和孕激素的组合，其中雌激素和孕激素的日剂量是相等的至约5-35mcg的乙炔雌二醇和约0.025至10mg的醋酸炔诺酮，其中雌激素与孕激素的重量比为乙炔雌二醇至乙酸炔诺酮计算为至少1:45。

4. 发明授权

US4413985A Hydrocephalic antenatal vent for intrauterine treatment (HAVIT) 失效
标题翻译：用于宫内治疗的脑积水产前通气（HAVIT）
公开(公告)号：US4413985A
公开(公告)日：1983-11-08
申请号：US325730
申请日：1981-11-30
申请人： Edward Wellner , Maria Michejda , Gary D. Hodgen
发明人： Edward Wellner , Maria Michejda , Gary D. Hodgen
IPC分类号： A61M1/00 , A61M27/00
CPC分类号： A61M39/0247 , A61M27/006 , A61M2039/025 , A61M2039/0261 , A61M2039/027 , A61M2039/0276 , A61M2210/02 , A61M2210/145
摘要： A hydrocephalic drainage valve consisting of a hollow shank with a pointed conical tip. The shank has an intake port adjacent the conical tip. A ball check valve in the shank is urged by a coiled spring toward closing relationship with the port. A hollow set screw is adjustably mounted in the shank to vary the biasing force on the valve ball. In one form, for manual implantation, a sleeve is slidably mounted on the shank, has a centrally apertured enlarged head and has implantation enlarged threads near the head. The head has aligned opposite radial grooves which are engageable by a manual insertion tool. In other forms, for pneumatic insertion, the shank has an enlarged head, employed as a driving piston in a pneumatic insertion tube. A washer member with implantation barbs is slidably mounted on the shank and is arranged to be locked to the shank subjacent the head responsive to the pneumatic driving action, with its barbs embedded in the fetal skin around the implantation puncture, thus holding the shank in operating position with the intake port exposed in the cranial vault.
摘要翻译：一种脑积水引流阀，由具有尖锐锥形尖端的中空柄组成。柄具有邻近锥形尖端的进气口。螺栓中的球止回阀被螺旋弹簧推向与端口的关系。中空的固定螺钉可调节地安装在柄中以改变阀球上的偏压力。在一种形式中，为了手动植入，套筒可滑动地安装在柄上，具有中心孔径扩大的头部并且在头部附近具有植入放大的线。头部具有可由手动插入工具接合的相对的径向凹槽。在其他形式中，为了气动插入，柄部具有扩大的头部，用作气动插入管中的驱动活塞。具有植入倒钩的垫圈构件可滑动地安装在柄上并且被布置成响应于气动驱动动作而被锁定到位于头部下方的柄部，其倒钩嵌入植入穿刺中的胎儿皮肤中，从而将柄保持在操作中位置与入口端口暴露在颅骨库。

5. 再颁专利

USRE40119E1 Adjunctive therapy 有权
标题翻译：辅助治疗
公开(公告)号：USRE40119E1
公开(公告)日：2008-02-26
申请号：US11016680
申请日：2004-12-20
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K38/09
CPC分类号： A61K38/09 , Y10S514/80
摘要： A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.
摘要翻译：在施用有效量的促性腺激素释放激素类似物或其它卵巢类固醇抑制剂生产或作用之后，诸如肿瘤，肥大组织或囊肿的生长被活检或更完全切除。

6. 发明授权

US07256185B1 Control of selective estrogen receptor modulators 失效
标题翻译：选择性雌激素受体调节剂的控制
公开(公告)号：US07256185B1
公开(公告)日：2007-08-14
申请号：US09313628
申请日：1999-05-18
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K31/56 , A61K31/135
CPC分类号： A61K31/565 , A61K31/38 , A61K31/135 , A61K2300/00
摘要： The treatment of an estrogen sensitive condition by the administration of a selective estrogen receptor modulator is improved by additionally administering a progestationally active compound to the recipient. The additional agent can express both progestational and androgenic activity or an androgenically active material can be employed, if desired. Additionally, clomiphene in an array of isomeric ratios (EN:ZU) can be used alone for prevention of osteoporosis, maintenance of a healthful blood lipid profile, and prevention of breast tumors, or to sustain amenorrhea.
摘要翻译：通过向受体另外施用促孕活性化合物来改善通过施用选择性雌激素受体调节剂治疗雌激素敏感性病症。另外的药剂可以表达孕激素和雄激素活性，如果需要，可以使用雄激素活性物质。此外，异构体比例（EN：ZU）阵列中的克罗米酚可以单独用于预防骨质疏松症，维持健康的血脂特征，以及预防乳腺肿瘤或维持闭经。

7. 发明授权

US06258802B1 Corticoid therapy 失效
标题翻译：皮质激素治疗
公开(公告)号：US06258802B1
公开(公告)日：2001-07-10
申请号：US09413421
申请日：1999-10-06
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K3156
CPC分类号： A61K31/57 , A61K31/38 , A61K31/135 , A61K2300/00
摘要： Treatments in which a progestational corticoid active compound is administered are improved by additionally administering a selective estrogen receptor modulator.
摘要翻译：通过另外施用选择性雌激素受体调节剂来改善施用孕激素类皮质激素活性化合物的治疗。

8. 发明授权

US5898032A Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy 失效
标题翻译：超低剂量的口服避孕药具有较少的月经出血和持续的疗效
公开(公告)号：US5898032A
公开(公告)日：1999-04-27
申请号：US880419
申请日：1997-06-23
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K31/565 , A61K31/57 , A61K31/56
CPC分类号： A61K31/565 , A61K31/567 , Y10S514/843
摘要： A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively. The advantages include less menstrual bleeding, less patient anemia, less total exposure to medication, higher compliance rates and more lifestyle convenience for patients.
摘要翻译：女性避孕方法包括将雌激素和孕激素的组合连续施用60-110天，其中雌激素和孕激素的日剂量分别等于约5-35mcg的乙炔雌二醇和约0.025至10mg的醋酸炔诺酮。其优点包括月经量少，患者贫血少，药物总暴露较少，依从性较高，患者生活便利性更高。

9. 发明授权

US5824286A Mammography method 失效
标题翻译：乳房X线摄影法
公开(公告)号：US5824286A
公开(公告)日：1998-10-20
申请号：US464048
申请日：1995-06-05
申请人： Gary D. Hodgen
发明人： Gary D. Hodgen
IPC分类号： A61K49/04 , A61K31/00 , A61K49/00
CPC分类号： A61K49/04
摘要： The diagnostic interpretation of mammographic films is enhanced by administering to the women undergoing the procedure an effective amount of a gonadotropin releasing hormone antagonist or other inhibitor of ovarian steroid production or action on the breast thereof and effecting the mammogram before the effect of the antagonist or other inhibitor has dissipated.
摘要翻译：乳腺X线照相胶片的诊断解释通过对经历该程序的女性施用有效量的促性腺激素释放激素拮抗剂或其他卵巢类固醇抑制剂或其对乳房的作用并在拮抗剂或其它物质的影响之前进行乳房X线照片抑制剂消散。

10. 发明授权

US07538099B1 Antiprogestin method and kit for reducing side effects associated with low dosage HRT, oral contraception and regulating menses 失效
标题翻译：抗孕激素方法和试剂盒，用于减少与低剂量HRT，口服避孕和调节月经有关的副作用
公开(公告)号：US07538099B1
公开(公告)日：2009-05-26
申请号：US08462703
申请日：1995-06-05
申请人： Gary D. Hodgen , Kristof Chwalisz
发明人： Gary D. Hodgen , Kristof Chwalisz
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K2300/00
摘要： Menses regulation and, when desired, contraception is achieved at low doses of estrogen and progestin, which otherwise would create episodes of breakthrough bleeding and/or withdrawal amenorrhea, by periodically inducing menses with an antiprogestin.
摘要翻译：月经调节，并且在需要时，在低剂量的雌激素和孕激素下实现避孕，否则会通过定期诱导月经与抗孕激素的作用而产生突破性出血和/或戒断闭经的发作。

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