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1. 发明授权

US5449602A Template-directed photoligation 失效
标题翻译：模板定向照片
公开(公告)号：US5449602A
公开(公告)日：1995-09-12
申请号：US143586
申请日：1988-01-13
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： G01N33/50 , C07D311/14 , C07D311/16 , C07D311/18 , C07D493/04 , C07H21/04 , C12N15/09 , C12Q1/68 , C07H15/12 , C07H17/00 , C12N15/00
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827
摘要： Methods, apparatus and compositions are presented for ligating ligands together which bind to a common target. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive groups in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.
摘要翻译：提出了将配体结合到共同靶标上的方法，装置和组合物。一个实施方案包括具有光反应性官能团的多核苷酸探针。探针能够在靶向多核苷酸上假定基本连续的反应性位置，使得多个光反应基团并置。具有辐射能的光反应性官能团的活化形成探针反应产物，其中探针彼此结合。

2. 发明授权

US5219734A Template-directed photoligation 失效
标题翻译：模板指导的摄影
公开(公告)号：US5219734A
公开(公告)日：1993-06-15
申请号：US143586
申请日：1988-01-13
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： G01N33/50 , C07D311/14 , C07D311/16 , C07D311/18 , C07D493/04 , C07H21/04 , C12N15/09 , C12Q1/68
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827 , C12Q2533/107 , C12Q2531/143 , C12Q2531/113 , C12Q2537/119 , C12Q2523/313 , C12Q2523/101
摘要： Methods, apparatus and compositions are presented for ligating ligands together which bind to a common target. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive groups in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.

3. 发明授权

US06306587B1 Template-directed photoligation 失效
标题翻译：模板定向照片
公开(公告)号：US06306587B1
公开(公告)日：2001-10-23
申请号：US08967011
申请日：1997-11-10
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： A01N102
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827 , C12Q2533/107 , C12Q2531/143 , C12Q2531/113 , C12Q2537/119 , C12Q2523/313 , C12Q2523/101
摘要： Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive group in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.
摘要翻译：提出了将配体结合到共同受体上的方法，装置和组合物。一个实施方案包括具有光反应性官能团的多核苷酸探针。探针能够在放置光反应性基团并置的靶多核苷酸上假设基本上连续的反应位置。具有辐射能的光反应性官能团的活化形成探针反应产物，其中探针彼此结合。

4. 发明授权

US5686243A Template-directed ligation and amplification assay 失效
标题翻译：模板定向连接和扩增测定
公开(公告)号：US5686243A
公开(公告)日：1997-11-11
申请号：US436117
申请日：1995-05-08
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： G01N33/50 , C07D311/14 , C07D311/16 , C07D311/18 , C07D493/04 , C07H21/04 , C12N15/09 , C12Q1/68 , C07H21/02 , C12P19/34
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827
摘要： A method for the detection of a target polynucleotide sequence wherein the target polynucleotide sequence is used as a template to direct hybridization of first and second polynucleotide probes to contiguous portions of the target. The hybridized probes are then ligated, preferably by covalent linkage of photoreactive functional groups present on each of the probes, to produce a ligated reaction product. The ligated reaction product is then multiplied with a polymerase such as Q-beta replicase to produce an enzyme reaction product which is then detected. The presence of the enzyme reaction product is indicative of the presence of the target polynucleotide sequence.
摘要翻译：一种用于检测靶多核苷酸序列的方法，其中所述靶多核苷酸序列用作模板以将第一和第二多核苷酸探针与目标物的连续部分直接杂交。然后将杂交的探针连接，优选通过存在于每个探针上的光反应性官能团的共价连接以产生连接的反应产物。然后将连接的反应产物与聚合酶例如Q-β复制酶相乘以产生酶反应产物，然后检测其。酶反应产物的存在表明靶多核苷酸序列的存在。

5. 发明授权

US4804625A Assay procedures 失效
标题翻译：测定程序
公开(公告)号：US4804625A
公开(公告)日：1989-02-14
申请号：US656011
申请日：1984-09-27
申请人： Larry E. Morrison , Garfield P. Royer , Michael J. Heller
发明人： Larry E. Morrison , Garfield P. Royer , Michael J. Heller
IPC分类号： G01N33/536 , C12Q1/28 , C12Q1/37 , C12Q1/42 , G01N33/535 , G01N33/543 , G01N33/563
CPC分类号： G01N33/535 , Y10S435/81 , Y10S436/805
摘要： Binding assay methods involving determining the presence of analytes in samples through enzymatic formation of detectable substances in amounts related to the amount of analyte present in the sample and monitoring for the presence of the substances in distinct phases. Methods according to the invention include use of labelled materials which associate with the analyte to be determined or compete with the analyte for association with an added binder. The labelled materials employed include label portions which enzymatically form substances from substrates provided in or existing as a first phase, or, upon enzymatic treatment in a first phase, disassociate into substances capable of existing in or as a second distinct phase. Formation of the detectable substances is monitored by determining the transfer of the substance to a second distinct phase in contact with the first phase or by determining formation of a second distinct phase. The assays are useful in determining human IgG protein in blood samples and other constituents of blood or other biological samples without elaborate instrumentation, allowing for practice outside the clinical laboratory.
摘要翻译：结合测定方法包括通过以与样品中存在的分析物的量相关的量的酶形成可检测物质来测定样品中分析物的存在并监测不同阶段中物质的存在。根据本发明的方法包括使用与待测定的分析物相关联的标记材料或与分析物竞争与所添加的粘合剂缔合。所使用的标记材料包括标记部分，其从在第一阶段中提供或存在的底物酶促形成物质，或者在第一阶段的酶处理中，分解成能够存在于或作为第二不同相的物质。通过确定物质与第一相接触的第二不同相的转移或通过确定第二不同相的形成来监测可检测物质的形成。该测定法可用于测定血液样本中血液或其他生物样品中其他成分的人类IgG蛋白质，而无需精心设计，可在临床实验室外进行实践。

6. 发明授权

US5783214A Bio-erodible matrix for the controlled release of medicinals 失效
标题翻译：用于控释药物的生物侵蚀性基质
公开(公告)号：US5783214A
公开(公告)日：1998-07-21
申请号：US258672
申请日：1994-06-13
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： C12Q1/37 , A61K9/16 , A61K9/20 , A61K9/70 , A61K47/48 , A61K9/14 , A61F13/02 , A61K9/50 , A61K37/22
CPC分类号： A61K9/1658 , A61K9/1652 , A61K9/1664 , A61K9/205 , A61K9/2063 , A61K9/2068 , A61K9/7007
摘要： A bioerodible matrix for the controlled release of medicinals including protein therapeutics is disclosed. A method for controlled drug release is also disclosed.
摘要翻译：公开了用于控制药物释放的生物浸渍基质，包括蛋白质治疗剂。还公开了一种控制药物释放的方法。

7. 发明授权

US3930950A Method of immobilizing an enzyme 失效
标题翻译：确定酶的方法
公开(公告)号：US3930950A
公开(公告)日：1976-01-06
申请号：US459300
申请日：1974-04-09
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： C12N11/00 , C07G7/02
CPC分类号： C12N11/00
摘要： A method of immobilizing an enzyme is presented which comprises (1) providing an active support member which is capable of reacting with an enzyme to thereby cause the enzyme to become chemically bonded thereto and (2) contacting the active support member with an enzyme-substrate complex which has been formed by mixing together an enzyme and a specific substrate while minimizing the transformation of the substrate to product, whereby the enzyme component of the enzyme-substrate complex becomes chemically bonded to the support member. Subsequently, the substrate is removed from the enzyme-substrate complex by conventional means, such as water washing, thereby leaving the active enzyme chemically bonded to the support member.

8. 发明授权

US5539132A Cerulenin compounds for fatty acid synthesis inhibition 失效
标题翻译：木瓜烯化合物用于脂肪酸合成抑制
公开(公告)号：US5539132A
公开(公告)日：1996-07-23
申请号：US188409
申请日：1994-01-24
申请人： Garfield P. Royer , Craig A. Townsend
发明人： Garfield P. Royer , Craig A. Townsend
IPC分类号： A61K31/20 , A61K31/335 , A61K31/34 , A61K31/365 , A61K31/40 , C07C45/29 , C07C45/51 , C07C47/232 , C07C47/277 , C07D207/44 , C07D207/452 , C07D233/54 , C07D303/48 , C07D493/04 , C07D303/38 , C07D303/46
CPC分类号： C07D207/452 , A61K31/20 , A61K31/335 , A61K31/34 , A61K31/365 , A61K31/40 , C07C45/292 , C07C45/513 , C07C47/232 , C07C47/277 , C07D303/48 , C07D493/04
摘要： Novel compounds for use in inhibiting fatty acid synthesis are disclosed. The compounds can be used for the treatment of tumors or microbial infections.
摘要翻译：公开了用于抑制脂肪酸合成的新型化合物。该化合物可用于治疗肿瘤或微生物感染。

9. 发明授权

US4326009A Polymeric particulate carrier 失效
标题翻译：聚合颗粒载体
公开(公告)号：US4326009A
公开(公告)日：1982-04-20
申请号：US169264
申请日：1980-07-15
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K9/50 , C08J3/12 , C08J9/26 , C12N11/08 , B32B5/16
CPC分类号： C12N11/08 , A61K9/5052 , C08J3/12 , C08J9/26 , C08J2379/08 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： A polymeric carrier is disclosed having a particle size such that the largest dimension thereof is less than about 8 mm and the smallest dimension is at least about 0.1 mm. The carrier comprises a plurality of polymeric segments containing chemically modifiable groups on the surface. The segments are united into a coherent, stable porous matrix by means of cross-links between segments. The matrix defines at least one cavity of predetermined size, and the particle size of the carrier, the porosity of the matrix and the presence of the cavity combine to provide desirable liquid compatibility and diffusional characteristics.
摘要翻译：公开了一种聚合物载体，其具有使得其最大尺寸小于约8mm且最小尺寸为至少约0.1mm的粒度。载体包括在表面上含有化学修饰基团的多个聚合物链段。通过段之间的交联将这些段结合成一个相干稳定的多孔基质。基质定义至少一个具有预定尺寸的空腔，并且载体的粒径，基体的孔隙率和空腔的存在结合起来以提供所需的液体相容性和扩散特性。

10. 发明授权

US06497901B1 Resorbable matrices for delivery of bioactive compounds 有权
标题翻译：用于递送生物活性化合物的可再吸收基质
公开(公告)号：US06497901B1
公开(公告)日：2002-12-24
申请号：US09703710
申请日：2000-11-02
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K922
CPC分类号： A61K9/0024 , A61K33/06 , A61L27/025 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/406 , A61L2300/43 , A61L2300/438 , A61L2300/602 , A61K2300/00
摘要： This invention relates generally to the production and use of inorganic-conditioning agent complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate and the conditioning agent is calcium stearate.
摘要翻译：本发明一般涉及无机调理剂配合物的生产和使用，用于控释药物，包括药物。有利地，所用的无机物是硫酸钙，调理剂是硬脂酸钙。

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