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1. 发明授权

US5539132A Cerulenin compounds for fatty acid synthesis inhibition 失效
标题翻译：木瓜烯化合物用于脂肪酸合成抑制
公开(公告)号：US5539132A
公开(公告)日：1996-07-23
申请号：US188409
申请日：1994-01-24
申请人： Garfield P. Royer , Craig A. Townsend
发明人： Garfield P. Royer , Craig A. Townsend
IPC分类号： A61K31/20 , A61K31/335 , A61K31/34 , A61K31/365 , A61K31/40 , C07C45/29 , C07C45/51 , C07C47/232 , C07C47/277 , C07D207/44 , C07D207/452 , C07D233/54 , C07D303/48 , C07D493/04 , C07D303/38 , C07D303/46
CPC分类号： C07D207/452 , A61K31/20 , A61K31/335 , A61K31/34 , A61K31/365 , A61K31/40 , C07C45/292 , C07C45/513 , C07C47/232 , C07C47/277 , C07D303/48 , C07D493/04
摘要： Novel compounds for use in inhibiting fatty acid synthesis are disclosed. The compounds can be used for the treatment of tumors or microbial infections.
摘要翻译：公开了用于抑制脂肪酸合成的新型化合物。该化合物可用于治疗肿瘤或微生物感染。

2. 发明授权

US5219734A Template-directed photoligation 失效
标题翻译：模板指导的摄影
公开(公告)号：US5219734A
公开(公告)日：1993-06-15
申请号：US143586
申请日：1988-01-13
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： G01N33/50 , C07D311/14 , C07D311/16 , C07D311/18 , C07D493/04 , C07H21/04 , C12N15/09 , C12Q1/68
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827 , C12Q2533/107 , C12Q2531/143 , C12Q2531/113 , C12Q2537/119 , C12Q2523/313 , C12Q2523/101
摘要： Methods, apparatus and compositions are presented for ligating ligands together which bind to a common target. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive groups in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.

3. 发明授权

US4326009A Polymeric particulate carrier 失效
标题翻译：聚合颗粒载体
公开(公告)号：US4326009A
公开(公告)日：1982-04-20
申请号：US169264
申请日：1980-07-15
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K9/50 , C08J3/12 , C08J9/26 , C12N11/08 , B32B5/16
CPC分类号： C12N11/08 , A61K9/5052 , C08J3/12 , C08J9/26 , C08J2379/08 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： A polymeric carrier is disclosed having a particle size such that the largest dimension thereof is less than about 8 mm and the smallest dimension is at least about 0.1 mm. The carrier comprises a plurality of polymeric segments containing chemically modifiable groups on the surface. The segments are united into a coherent, stable porous matrix by means of cross-links between segments. The matrix defines at least one cavity of predetermined size, and the particle size of the carrier, the porosity of the matrix and the presence of the cavity combine to provide desirable liquid compatibility and diffusional characteristics.
摘要翻译：公开了一种聚合物载体，其具有使得其最大尺寸小于约8mm且最小尺寸为至少约0.1mm的粒度。载体包括在表面上含有化学修饰基团的多个聚合物链段。通过段之间的交联将这些段结合成一个相干稳定的多孔基质。基质定义至少一个具有预定尺寸的空腔，并且载体的粒径，基体的孔隙率和空腔的存在结合起来以提供所需的液体相容性和扩散特性。

4. 发明授权

US08435565B2 Bioresorbable polymer matrices and methods of making and using the same 有权
标题翻译：生物可再吸收聚合物基质及其制备和使用方法
公开(公告)号：US08435565B2
公开(公告)日：2013-05-07
申请号：US13228267
申请日：2011-09-08
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K9/14
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/12 , A61K9/7007 , A61K47/10 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/438 , A61L2300/602 , A61L2300/64 , C08L5/02
摘要： A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. The composition may be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture which includes the reactants and a bioactive agent. A kit which includes a double syringe respectively containing the first and second aliquot portions of the reaction mixture may be provided so that the same may be mixed just prior to use.
摘要翻译：用于递送生物活性剂的生物腐蚀性组合物是包含氧化葡聚糖溶液的反应混合物和含有二酰肼，生物活性剂和任选的pH调节剂的固体混合物的反应产物，其量足以实现反应混合物的pH值在6以下。组合物可以包括用于从组合物中控制释放生物活性剂的脱模剂。组合物可以通过提供包含反应物和生物活性剂的反应混合物的第一等分试样部分施用于需要其的身体部位。可以提供包括分别含有反应混合物的第一和第二等分试样部分的双重注射器的试剂盒，使得其可以在使用前混合。

5. 发明授权

US08039021B2 Bioresorbable polymer matrices and methods of making and using the same 有权
标题翻译：生物可再吸收聚合物基质及其制备和使用方法
公开(公告)号：US08039021B2
公开(公告)日：2011-10-18
申请号：US11983454
申请日：2007-11-09
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K35/32
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/12 , A61K9/7007 , A61K47/10 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/438 , A61L2300/602 , A61L2300/64 , C08L5/02
摘要： A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for controlled release of the bioactive agent from the composition. A bioactive agent may therefore be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture comprising an oxidized dextran solution, and a second aliquot portion of a reaction mixture comprising a mixture of solids comprised of a dihydrazide, a bioactive agent, and a solid acid which is present in an amount sufficient to achieve a pH of the reaction mixture of 6 or less, mixing the first and second aliquot portions to form the reaction mixture thereof, and thereafter installing the reaction mixture at the body site and allowing a solidified bioerodible drug delivery composition to be formed thereby in situ.
摘要翻译：用于递送生物活性剂的生物腐蚀性组合物是包含氧化葡聚糖溶液的反应混合物和含有二酰肼，生物活性剂和任选的pH调节剂的固体混合物的反应产物，其量足以实现反应混合物的pH值在6以下。组合物可以包括用于从组合物中控制释放生物活性剂的脱模剂。因此，生物活性剂可以通过提供包含氧化的葡聚糖溶液的反应混合物的第一等分试样部分和反应混合物的第二等分试样部分施用于需要其的身体部位，所述反应混合物的第二等分试样部分包含由二酰肼，生物活性剂和固体酸，其以足以实现6或更小的反应混合物的pH的量存在，将第一和第二等分试样部分混合以形成其反应混合物，然后将反应混合物置于从而原位形成凝固的生物可蚀解药物递送组合物。

6. 发明申请

US20100203136A1 METHOD FOR DELIVERING A HUMAN CHORIONIC GONADOTROPIN (Hcg) VACCINE FOR LONG-ACTING ANTIBODY PROTECTION 审中-公开
标题翻译：用于长时间运行抗体保护的人类氯氰菊酯（Hcg）疫苗的方法
公开(公告)号：US20100203136A1
公开(公告)日：2010-08-12
申请号：US12299721
申请日：2007-05-02
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K9/00 , A61K39/00 , A61K39/385 , A61P35/00
CPC分类号： A61K39/0006 , A61K9/0019 , A61K9/107 , A61K47/646 , A61K2039/55505 , A61K2039/5555 , A61K2039/55566 , A61K2039/55583 , A61K2039/585 , A61K2039/6037
摘要： This invention comprises a method of immunization in which human chorionic gonadotropin (hCG) vaccine antigens are incorporated into an inorganic salt/biopolymer complex using a simple manufacturing process. The resulting solid matrix is administered to human subjects in the form of microparticles. The method comprises suspending microparticles in an emulsion of a natural oil and water containing an adjuvant compound acceptable for human use and injecting a pharmaceutical dose of the suspension intramuscularly. The vaccine antigens are conjugates of peptide fragments of the beta subunit of hCG with a carrier protein, diphtheria toxoid. Vaccine antigens delivered in this formulation are effective for eliciting antibodies in recipients for the treatment of cancer or hormone-related diseases.
摘要翻译：本发明包括使用简单的制造方法将人绒毛膜促性腺激素（hCG）疫苗抗原掺入无机盐/生物聚合物复合物中的免疫方法。将所得固体基质以微粒的形式施用于人受试者。该方法包括将微粒悬浮在天然油和含有人类可接受的佐剂的水的乳液中，并肌内注射药物剂量的悬浮液。疫苗抗原是hCG的β亚基的肽片段与载体蛋白质白喉类毒素的缀合物。在该制剂中递送的疫苗抗原在用于治疗癌症或激素相关疾病的受体中引发抗体是有效的。

7. 发明授权

US06630486B1 Inorganic-polymer complexes for the controlled release of compounds including medicinals 失效
标题翻译：用于控释药物的无机聚合物复合物，包括药物
公开(公告)号：US06630486B1
公开(公告)日：2003-10-07
申请号：US09509016
申请日：2000-03-21
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K922
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/1652 , A61K47/02 , A61K47/36 , A61K47/56 , A61K47/58 , Y10S514/937 , Y10S514/944 , Y10S514/947 , Y10S514/951
摘要： This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.
摘要翻译：本发明一般涉及无机 - 聚合物配合物的生产和使用，用于控制药物包括药物的释放。有利地，所用的无机物是硫酸钙。

8. 发明授权

US06391336B1 Inorganic-polymer complexes for the controlled release of compounds including medicinals 失效
标题翻译：用于控释药物的无机聚合物复合物，包括药物
公开(公告)号：US06391336B1
公开(公告)日：2002-05-21
申请号：US08935300
申请日：1997-09-22
申请人： Garfield P. Royer
发明人： Garfield P. Royer
IPC分类号： A61K922
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/1652 , A61K47/02 , A61K47/36 , A61K47/56 , A61K47/58 , Y10S514/937 , Y10S514/944 , Y10S514/947 , Y10S514/951
摘要： This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. The inorganic compound used is advantageously calcium sulfate-hemihydrate. The invention includes a composition for the controlled release of an active agent comprising: a) a hydrated or crystallized inorganic compound, and b) a matrix polymer which slows the release of the active agent, wherein the composition is a solid matrix due to the hydration or crystallization of the inorganic compound. Further included is a composition for the controlled release of an active agent comprising: a) a hydrated or crystallized inorganic compound, and b) a complexing agent which forms a salt or conjugate with the active agent, wherein the composition is a solid matrix due to the hydration or crystallization of the inorganic compound.
摘要翻译：本发明一般涉及无机 - 聚合物配合物的生产和使用，用于控制药物包括药物的释放。所用的无机化合物有利地是硫酸钙 - 半水合物。本发明包括用于控制释放活性剂的组合物，其包含：a）水合或结晶的无机化合物，和b）减缓活性剂释放的基质聚合物，其中由于水合而使组合物为固体基质或无机化合物的结晶。进一步包括用于控制释放活性剂的组合物，包括：a）水合或结晶的无机化合物，和b）与活性剂形成盐或缀合物的络合剂，其中由于无机化合物的水合或结晶。

9. 发明授权

US5686243A Template-directed ligation and amplification assay 失效
标题翻译：模板定向连接和扩增测定
公开(公告)号：US5686243A
公开(公告)日：1997-11-11
申请号：US436117
申请日：1995-05-08
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： G01N33/50 , C07D311/14 , C07D311/16 , C07D311/18 , C07D493/04 , C07H21/04 , C12N15/09 , C12Q1/68 , C07H21/02 , C12P19/34
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827
摘要： A method for the detection of a target polynucleotide sequence wherein the target polynucleotide sequence is used as a template to direct hybridization of first and second polynucleotide probes to contiguous portions of the target. The hybridized probes are then ligated, preferably by covalent linkage of photoreactive functional groups present on each of the probes, to produce a ligated reaction product. The ligated reaction product is then multiplied with a polymerase such as Q-beta replicase to produce an enzyme reaction product which is then detected. The presence of the enzyme reaction product is indicative of the presence of the target polynucleotide sequence.
摘要翻译：一种用于检测靶多核苷酸序列的方法，其中所述靶多核苷酸序列用作模板以将第一和第二多核苷酸探针与目标物的连续部分直接杂交。然后将杂交的探针连接，优选通过存在于每个探针上的光反应性官能团的共价连接以产生连接的反应产物。然后将连接的反应产物与聚合酶例如Q-β复制酶相乘以产生酶反应产物，然后检测其。酶反应产物的存在表明靶多核苷酸序列的存在。

10. 发明授权

US4804625A Assay procedures 失效
标题翻译：测定程序
公开(公告)号：US4804625A
公开(公告)日：1989-02-14
申请号：US656011
申请日：1984-09-27
申请人： Larry E. Morrison , Garfield P. Royer , Michael J. Heller
发明人： Larry E. Morrison , Garfield P. Royer , Michael J. Heller
IPC分类号： G01N33/536 , C12Q1/28 , C12Q1/37 , C12Q1/42 , G01N33/535 , G01N33/543 , G01N33/563
CPC分类号： G01N33/535 , Y10S435/81 , Y10S436/805
摘要： Binding assay methods involving determining the presence of analytes in samples through enzymatic formation of detectable substances in amounts related to the amount of analyte present in the sample and monitoring for the presence of the substances in distinct phases. Methods according to the invention include use of labelled materials which associate with the analyte to be determined or compete with the analyte for association with an added binder. The labelled materials employed include label portions which enzymatically form substances from substrates provided in or existing as a first phase, or, upon enzymatic treatment in a first phase, disassociate into substances capable of existing in or as a second distinct phase. Formation of the detectable substances is monitored by determining the transfer of the substance to a second distinct phase in contact with the first phase or by determining formation of a second distinct phase. The assays are useful in determining human IgG protein in blood samples and other constituents of blood or other biological samples without elaborate instrumentation, allowing for practice outside the clinical laboratory.
摘要翻译：结合测定方法包括通过以与样品中存在的分析物的量相关的量的酶形成可检测物质来测定样品中分析物的存在并监测不同阶段中物质的存在。根据本发明的方法包括使用与待测定的分析物相关联的标记材料或与分析物竞争与所添加的粘合剂缔合。所使用的标记材料包括标记部分，其从在第一阶段中提供或存在的底物酶促形成物质，或者在第一阶段的酶处理中，分解成能够存在于或作为第二不同相的物质。通过确定物质与第一相接触的第二不同相的转移或通过确定第二不同相的形成来监测可检测物质的形成。该测定法可用于测定血液样本中血液或其他生物样品中其他成分的人类IgG蛋白质，而无需精心设计，可在临床实验室外进行实践。

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