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1. 发明申请

WO2017193065A1 SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION INCLUDING TESTING THEREOF 审中-公开
标题翻译：具有使用透析流体制剂的腹膜透析的系统和方法，包括对其进行测试
公开(公告)号：WO2017193065A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031396
申请日：2017-05-05
申请人： GAMBRO LUNDIA AB , WELLINGS, Anders
发明人： WELLINGS, Anders , WIESLANDER, Anders , JANSSON, Olof
IPC分类号： A61M1/16 , A61M1/28
摘要： A peritoneal dialysis system includes a disposable set, source(s) of concentrate(s), a water purifier, a sensor, and a control unit. The disposable set includes a water port, an inlet port, a drain port, a water line in fluid communication with the water port, a drain line in fluid communication with the drain port, and a container to hold a dialysis fluid prepared by mixing water and the concentrate(s). The source(s) of concentrate(s) are in fluid communication with the inlet port, and the water purifier is configured to purify water and feed the water towards the water port so the sensor can detect a fluid property. The control unit is configured to deliver dialysis fluid mixed in the disposable set to the drain line and water purified by the water purifier along the water line, into the disposable set, and out the drain line to push dialysis fluid to the sensor.
摘要翻译：腹膜透析系统包括一次性装置，浓缩物的来源，净水器，传感器和控制单元。一次性装置包括水端口，入口端口，排水端口，与水端口流体连通的水管线，与排水端口流体连通的排水管线以及容纳透析流体的容器，所述透析流体通过混合水和浓缩物。一种或多种浓缩物源与入口端口流体连通，并且净水器被配置为净化水并将水供给到水端口，从而传感器可以检测流体性质。控制单元被配置为将在一次性装置中混合的透析流体输送到排水管线，并且由水净化器沿着水管线净化的水进入一次性装置，并且排出排水管线以将透析流体推送到传感器。 p>

2. 发明公开

EP3452137A1 SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION INCLUDING TESTING THEREOF 有权转让
公开(公告)号：EP3452137A1
公开(公告)日：2019-03-13
申请号：EP17723905.0
申请日：2017-05-05
申请人： Gambro Lundia AB , Wellings, Anders
发明人： WELLINGS, Anders , WIESLANDER, Anders , JANSSON, Olof
IPC分类号： A61M1/16 , A61M1/28

3. 发明申请

WO2014177656A1 AN ANTICOAGULATION FLUID COMPRISING CITRATE AND PHOSPHATE 审中-公开
标题翻译：包含柠檬酸和磷酸盐的抗凝液
公开(公告)号：WO2014177656A1
公开(公告)日：2014-11-06
申请号：PCT/EP2014/058912
申请日：2014-04-30
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61K31/194 , A61K31/7004 , A61K33/10 , A61K33/14 , A61K33/42 , A61P7/08 , A61K9/08
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/08 , A61K31/194 , A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/10 , A61K33/14 , A61M1/1654 , A61K2300/00
摘要： The present invention concerns an anticoagulation fluid comprising 10- 40 m M citrate and 0.1-4 m M phosphate. The anticoagulation fluid is to be used for regional citrate anticoagulation in an extracorporeal blood circuit. The anticoagulation fluid may be combined with at least one treatment fluid in the dialysis treatment, and it may be included in a system for regional citrate anticoagulation in an extracorporeal blood circuit.
摘要翻译：本发明涉及包含10-40M柠檬酸盐和0.1-4mM磷酸盐的抗凝血液。抗凝液体用于体外血液循环中的局部柠檬酸抗凝。在透析治疗中，抗凝血液可以与至少一种治疗液合并，并且可以包括在用于体外血液循环中的局部柠檬酸盐抗凝的系统中。

4. 发明申请

WO2013131906A1 DIALYSIS COMPOSITION COMPRISING CITRATE, CALCIUM AND MAGNESIUM 审中-公开
标题翻译：包含柠檬酸盐，钙和镁的透析组合物
公开(公告)号：WO2013131906A1
公开(公告)日：2013-09-12
申请号：PCT/EP2013/054386
申请日：2013-03-05
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Anders , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61K31/194 , A61K33/06 , A61K33/14 , A61P7/08
CPC分类号： A61K9/08 , A61K31/194 , A61K33/06 , A61K33/14 , A61M1/1654 , A61K2300/00
摘要： The present invention concerns dialysis compositions comprising 0.5 to 3 mM citrate, 1 to 5 mM total calcium, and 0 to 1.5 mM total magnesium.
摘要翻译：本发明涉及包含0.5至3mM柠檬酸盐，1至5mM总钙和0至1.5mM总镁的透析组合物。

5. 发明申请

WO2007046757A1 EXTRACORPOREAL BLOOD CLEANING 审中-公开
标题翻译：超声波清洗
公开(公告)号：WO2007046757A1
公开(公告)日：2007-04-26
申请号：PCT/SE2006/050349
申请日：2006-09-25
申请人： GAMBRO LUNDIA AB , STERNBY, Jan , WIESLANDER, Anders , KJELLSTRAND, Per , LINDÉN, Torbjörn
发明人： STERNBY, Jan , WIESLANDER, Anders , KJELLSTRAND, Per , LINDÉN, Torbjörn
IPC分类号： A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3472 , A61M1/3479 , A61M1/3482 , A61M1/3486 , A61M1/3686 , A61M1/3687 , A61M1/369 , A61M2205/055 , A61M2205/058
摘要： An apparatus (100) for extracorporeal blood cleaning includes a separation unit (110), at least two processing branches (120; 130) and a mixing unit (140). The separation unit (110) receives 5 incoming blood (B A ) and divides off a first fraction (f C ) from this blood. The first fraction (f C ) contains predominantly blood cells. The separation unit (110) also divides off at least one second fraction (f P ) , which contains predominantly blood plasma. A first processing branch (120) processes the first fraction (f C ) accor- 10 d i n g to a first cleaning process, in which cell-bound substances are removed from the blood cells. As a result, a first cleaned fraction (f C c ) containing washed blood cells is produced. A second processing branch (130) processes the second fraction (f P ) according to a second cleaning process in which toxins bound on proteins within the plasma and/or toxins dissolved in 15 the plasma are removed, and a second cleaned fraction (f P c ) is produced. The second cleaning process is different from the first cleaning process. Thereby each process can be tailored for the requirements of the respective fraction (f C , f P ) . The mixing unit 20 (140) receives the first and second cleaned fractions (f C c , f P c ) , combines these fractions (f C c , f P c ) , and outputs cleaned whole blood (B V ).
摘要翻译：用于体外血液清洁的装置（100）包括分离单元（110），至少两个处理分支（120; 130）和混合单元（140）。分离单元（110）接收5个进入的血液（B A），并从该血液中分离出第一部分（f _{C）。第一级分（f C C）主要含有血细胞。分离单元（110）还分离出主要含有血浆的至少一个第二级分（f SUB P）。第一处理分支（120）将第一分数（f C C C）进行处理，其中细胞结合物质从血细胞中移除。结果，第一清洗部分（f C）}

6. 发明申请

WO2005123149A1 A LOCK SOLUTION FOR MEDICAL DEVICES 审中-公开
标题翻译：医疗设备的解决方案
公开(公告)号：WO2005123149A1
公开(公告)日：2005-12-29
申请号：PCT/SE2005/000912
申请日：2005-06-15
申请人： GAMBRO LUNDIA AB , WIESLANDER, Anders , SCHNELL, Andrea , DEPPISCH, Reinhold , BECK, Werner , DIETRICH, Ruth , TRICK, Claudia
发明人： WIESLANDER, Anders , SCHNELL, Andrea , DEPPISCH, Reinhold , BECK, Werner , DIETRICH, Ruth , TRICK, Claudia
IPC分类号： A61L2/18
CPC分类号： A61K31/70 , A61L29/16 , A61L2300/23 , A61L2300/404 , A61L2300/42
摘要： The invention relates to a lock solution for medical devices comprising carbohydrates and/or glucose degradation products as antimicrobial agent(s).
摘要翻译：本发明涉及用于医疗装置的锁定解决方案，其包括作为抗微生物剂的碳水化合物和/或葡萄糖降解产物。

7. 发明申请

WO2017191302A1 DIALYSIS CONCENTRATE 审中-公开
标题翻译：透析浓缩液
公开(公告)号：WO2017191302A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/060771
申请日：2017-05-05
申请人： GAMBRO LUNDIA AB
发明人： WIESLANDER, Anders , CARLSSON, Ola , SANDIN, Karin , ENARSSON, Simon , HANCOCK, Viktoria
IPC分类号： A61M1/16 , A61M1/28
CPC分类号： A61K31/19 , A61K31/7004 , A61K33/06 , A61K33/14 , A61K47/02 , A61M1/1654 , A61M1/287 , A61K2300/00
摘要： The invention provides a first concentrate comprising lactate and calcium ions, said first concentrate having increased stability against precipitation at temperatures around +4 °C, said first concentrate being useful for preparing a ready-to-use dialysis fluid by mixing said first concentrate with water and optionally a second concentrate comprising glucose, wherein that the lactate concentration L conc (expressed in moles per litre, M) of the concentrate fulfills the conditions: a) L conc > 0.8 M; and b) L conc ready ) M; and wherein Ca ready is the calcium concentration of the ready-to-use dialysis fluid expressed in millimoles per litre (mM).
摘要翻译：本发明提供了包含乳酸盐和钙离子的第一浓缩物，所述第一浓缩物在约+ 4℃的温度下具有提高的抗沉淀稳定性，所述第一浓缩物可用于制备即用型通过将所述第一浓缩物与水以及任选的包含葡萄糖的第二浓缩物混合来制备透析液，其中所述浓缩物的乳酸盐浓度L sub（以摩尔每升M表示）满足条件：a）L _{conc ＆gt; 0.8米; 和b）L _{conc （1.9-0.4×Ca准备好）M; 并且其中准备好的是即用型透析液的钙浓度，以毫摩尔每升（mM）表示。}}

8. 发明申请

WO2014177630A1 A MULTIPART FLUID SYSTEM AND A SYSTEM FOR CITRATE ANTICOAGUALATION IN AN EXTRACORPOREAL BLOOD CIRCUIT 审中-公开
标题翻译：多流体液体系统和一种用于在超声波血液循环中进行抗原反应的系统
公开(公告)号：WO2014177630A1
公开(公告)日：2014-11-06
申请号：PCT/EP2014/058853
申请日：2014-04-30
申请人： GAMBRO LUNDIA AB
发明人： ÅHL, Petra , GODALY, Gabriela , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61K31/194 , A61K31/7004 , A61K33/10 , A61K33/14 , A61K33/42 , A61P7/08 , A61K9/08 , A61M1/34
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/0026 , A61K31/194 , A61K31/225 , A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/10 , A61K33/14 , A61K47/02 , A61M1/1654 , A61M1/1672 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61K2300/00
摘要： The present invention concerns a multipart fluid system for dialysis therapy, wherein the multipart fluid system comprises an anticoagulation fluid and at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids. According to the invention the anticoagulation fluid comprises 15-40 mM citrate; and the at least one treatment fluid comprises 1.5-8 mM citrate and ≥ 10 mM bicarbonate. The present invention further concerns a system for citrate anticoagulation in an extracorporeal blood circuit.
摘要翻译：本发明涉及一种用于透析治疗的多部分流体系统，其中所述多部分流体系统包括抗凝血液体和至少一种来自由透析液和输注液体组成的组的治疗液。根据本发明，抗凝液体包含15-40mM柠檬酸盐; 并且所述至少一种处理流体包含1.5-8mM柠檬酸盐和≥10mM碳酸氢盐。本发明还涉及体外血液回路中的柠檬酸盐抗凝系统。

9. 发明申请

WO2011161064A1 PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL 审中-公开
标题翻译：从粉末材料制备医疗解决方案
公开(公告)号：WO2011161064A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060255
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
发明人： JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
IPC分类号： A61J1/20 , A61M1/16
CPC分类号： A61J1/20 , A61J1/2093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/167 , A61M1/287 , B65D31/14 , B65D81/18 , B65D81/20 , B65D81/2007 , B65D81/2023 , B65D81/2046
摘要： A package has a transport/storage state for storing powdery material which is to be mixed with a solvent to form a medical solution, e.g. for use in dialysis treatment. The package comprises a compartment (6) which is at least partially defined by two opposing wall portions, and a connector (10). In the transport/storage state, the compartment contains the powdery material in the form of at least two distinct sets (2A-2D) of powdery material of different compositions, where the opposing wall portions are brought into engagement with the powdery material so as to immobilize the sets of powdery material (2A-2D). When used for preparation of the medical solution, a fluid is selectively admitted into the package via the connector (10) so as to expand the compartment (6) and enable mixing of the sets (2A-2D) of powdery material with the solvent in the compartment (6).
摘要翻译：包装具有用于储存待与溶剂混合以形成医用溶液的粉末状材料的运输/储存状态，用于透析治疗。该包装件包括至少部分地由两个相对的壁部分限定的隔室（6）和连接器（10）。在运输/储存状态下，隔室含有至少两种不同组成的粉末材料组（2A-2D）形式的粉状材料，其中相对的壁部分与粉末材料接合，以便固定一组粉状材料（2A-2D）。当用于制备医用溶液时，通过连接器（10）将流体选择性地进入包装中，以便使隔室（6）膨胀，并使粉末材料组（2A-2D）与溶剂的组合隔室（6）。

10. 发明申请

WO2011161055A1 DIALYSIS PRECURSOR COMPOSITION 审中-公开
标题翻译： DIALYSIS前身组成
公开(公告)号：WO2011161055A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060231
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , CARLSSON, Ola , LINDEN, Torbjörn , JÖNSSON, Lennart , WIESLANDER, Anders
发明人： CARLSSON, Ola , LINDEN, Torbjörn , JÖNSSON, Lennart , WIESLANDER, Anders
IPC分类号： A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/14 , A61K9/00
CPC分类号： A61K33/14 , A61K9/0029 , A61K9/0095 , A61K31/19 , A61K31/191 , A61K31/194 , A61K31/198 , A61K31/366 , A61K31/385 , A61K31/7004 , A61K33/00 , A61K33/06 , A61M1/287 , A61K2300/00
摘要： The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consist of powder components comprising sodium chloride, at least one dry acid and at least one magnesium salt, and optionally potassium salt, calcium salt, and glucose. According to the invention said at least one magnesium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.
摘要翻译：本发明涉及一种透析酸前体组合物，用于制备透析酸浓缩液，并与水和含碳酸氢盐的浓缩液混合成即用型透析溶液。所述透析酸前体组合物由包含氯化钠，至少一种干酸和至少一种镁盐，以及任选的钾盐，钙盐和葡萄糖的粉末组分组成。根据本发明，所述至少一种镁盐和所述任选的葡萄糖以所述透析酸前体组合物中的无水组分存在。

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