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1. 发明申请

US20020068674A1 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced configuration 失效
公开(公告)号：US20020068674A1
公开(公告)日：2002-06-06
申请号：US10005431
申请日：2001-11-02
申请人： Gambro, Inc.
发明人： Dennis J. Hlavinka , Thomas J. Felt
IPC分类号： B04B007/12 , B04B009/00
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, several fluid flow channels and at least two separated component collection areas defined therein. A composite fluid to be separated is delivered to the fluid containment area from which it travels through an inlet channel to a substantially circumferential fluid separation channel where under centrifugal forces the composite fluid is separated into components which each then travel to distinct first and second separated fluid outlet channels, and thence on to exit therefrom into the respective collection areas. The first and second fluid outlet channels also have respective first and second heights which are related to each other so as to provide a balanced fluid pressure relationship for the respective separated component fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred fluid pressure balance relationship is null2g2h2nullnull3g3h3 wherein the first height of the first outlet channel is h2, and the second height of the second outlet channel is h3, wherein g2 and g3 are gravitational or centrifugal acceleration values and null2 and null3 represent the respective densities of the separated fluids in the first and second outlet channels. A similar, continuously forward flow drive relationship involves also the height h1, of the inlet channel and the density null1 of the fluid therein such that null1g1h1>null2g2h2 or null1g1h1>null3g3h3 . The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus available herefrom. A disposable bag and tubing system is also disclosed for use with preferably reusable rotor devices.

2. 发明申请

US20020068675A1 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach 有权
公开(公告)号：US20020068675A1
公开(公告)日：2002-06-06
申请号：US10008989
申请日：2001-11-02
申请人： Gambro, Inc.
发明人： Thomas J. Felt , Dennis J. Hlavinka
IPC分类号： B04B007/12 , B04B009/00
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal separation device for use in a fluid separation system to centrifugally separate a composite fluid into the composite components thereof. This centrifugal separation device includes a centrifugal rotor housing and a rotor which is disposed in a freely rotatable disposition within the housing, the rotor having a fluid receiving area and several fluid flow channels defined therein. A composite fluid to be separated is delivered to the fluid receiving area from which it travels through a radial fluid transport channel to a circumferential fluid separation channel where it is subjected to substantial centrifugal forces which separate the composite fluid into components which each then travel to distinct first and second separated fluid outlet channels. The separated fluids then exit from these outlet channels and are then moved from the separation device to a collection bag for storage or may then be returned to the donor. The first and second fluid outlet channels also have respective first and second lengths which are related to each other so as to provide a substantial hydraulic pressure balance for the respective separated fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred relationship of the respective first and second lengths of said first and second separated fluid outlet channels to each other which provides the hydraulic balance is null3gh3nullnull3gh3 wherein the first length of the first outlet channel is h3, and the second length of the second outlet channel is h3, wherein g is a gravitational acceleration value and null3 represents the density of the fluids in the first outlet channel and null3 represents the density of the fluids in the second outlet channel. The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus useful herein.

3. 发明申请

US20020043051A1 Container and method of sealing 审中-公开
标题翻译：容器和密封方法
公开(公告)号：US20020043051A1
公开(公告)日：2002-04-18
申请号：US09982298
申请日：2001-10-16
申请人： Gambro, Inc
发明人： Keith Manica , Dennis J. Hlavinka , Frank Corbin III
IPC分类号： B65B003/04
CPC分类号： A61J1/10 , A61J1/1475 , A61L2/0076 , A61L2/0082 , A61L2/088 , A61L2/16 , A61L2202/18 , A61L2202/22 , B29C65/04 , B29C65/18 , B29C65/30 , B29C66/05 , B29C66/1122 , B29C66/431 , B29C66/43121 , B29C66/4742 , B29C66/71 , B29C66/80 , B29C66/81263 , B29C66/81422 , B29C66/83221 , B29C66/861 , B29C66/98 , B29L2031/7148 , B29K2027/06 , B29K2023/12 , B29K2023/06 , B29K2023/00
摘要： A method and apparatus for use in inactivating pathogens in fluids such as blood or blood components. The apparatus includes a container having a main body portion, a plurality of openings into the main body portion of the container, and at least one weld which partially surrounds at least one opening into the main body portion of the container. The method includes flowing fluid into the container via at least one of the plurality of openings and sealing at least one opening closed by extending the partially surrounding weld so that it completely surrounds the opening.
摘要翻译：用于灭活诸如血液或血液成分的流体中的病原体的方法和装置。该装置包括容器，该容器具有主体部分，进入容器主体部分的多个开口以及部分地围绕至少一个开口进入容器主体部分的焊缝。该方法包括通过多个开口中的至少一个将流体流入容器，并通过延伸部分环绕的焊缝来密封至少一个开口，使其完全包围开口。

4. 发明申请

US20040164032A1 Fluid Separation Methods Using a Fluid Pressure Driven and/or Balanced Approach 有权
标题翻译：使用流体压力驱动和/或平衡方法的流体分离方法
公开(公告)号：US20040164032A1
公开(公告)日：2004-08-26
申请号：US10708856
申请日：2004-03-29
申请人： GAMBRO, INC.
发明人： Thomas J. Felt , Dennis J. Hlavinka
IPC分类号： C02F001/00
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： The method separates a composite fluid, such as blood, into the components thereof in a centrifugal separation device. The fluid is delivered to a fluid receiving area in a rotor from which area the fluid travels through a radial inlet channel having an inlet channel height to a proximal end of a circumferential fluid separation channel. Near a distal end of the separation channel, fluid components travel into distinct first and second outlet channels. The height of the first channel is greater than the height of the more distal second channel. The inlet channel height is greater than the height of the first channel. The rotor may be balanced by axially symmetrical sets of inlet channels, separation channels and outlet channels or by a balance channel connected to the separation channel but displaced from the outlet channels.
摘要翻译：该方法将离心分离装置中的诸如血液的复合流体分离成其组分。流体被输送到转子中的流体接收区域，流体从该区域流过具有到周向流体分离通道的近端的入口通道高度的径向入口通道。在分离通道的远端附近，流体组分行进到不同的第一和第二出口通道。第一通道的高度大于较远端第二通道的高度。入口通道高度大于第一通道的高度。转子可以通过轴向对称的入口通道，分离通道和出口通道组合或通过连接到分离通道但从出口通道移位的平衡通道来平衡。

5. 发明申请

US20030195104A1 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
公开(公告)号：US20030195104A1
公开(公告)日：2003-10-16
申请号：US10413890
申请日：2003-04-14
申请人： Gambro, Inc.
发明人： Dennis J. Hlavinka , William G. Palsulich , Thomas J. Felt , Frank Corbin III
IPC分类号： B04B005/02 , B04B011/00
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.

6. 发明申请

US20040185998A1 Method for Fluid Separation Devices Using A Fluid Pressure Balanced Configuration 失效
标题翻译：使用流体压力平衡配置的流体分离装置的方法
公开(公告)号：US20040185998A1
公开(公告)日：2004-09-23
申请号：US10709079
申请日：2004-04-12
申请人： GAMBRO, INC.
发明人： Dennis J. Hlavinka , Thomas J. Felt
IPC分类号： C02F001/38
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A method for separating a composite fluid into components in a centrifugal fluid separation system. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.
摘要翻译：一种将复合流体分离成离心流体分离系统中的组分的方法。该系统包括具有复合流体容纳区域，入口通道，周边分离通道，出口通道和分离的部件收集区域的转子，它们一起形成处理区域。分离通道可以是半螺旋的。入口通道可以连接到分离通道的中心，并且出口通道可以连接到分离通道的每一端。出口通道具有不同的高度。分离通道的端部可以具有不同的高度。分离通道可以具有扩展。转子可以具有多个处理区域。收集区域可以是径向向外和向下倾斜的袋。电动机可以产生与转子中的磁反应性材料共同作用的旋转磁场。可以在转子的处理区域中使用一次性袋和管道系统。

7. 发明申请

US20030214874A1 Container or bag mixing apparatuses and/or methods 有权
标题翻译：容器或袋混合装置和/或方法
公开(公告)号：US20030214874A1
公开(公告)日：2003-11-20
申请号：US10425281
申请日：2003-04-28
申请人： Gambro, Inc.
发明人： Dennis J. Hlavinka , Michael A. Martinez
IPC分类号： B01F011/00
CPC分类号： B01F5/0682 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2202/22 , A61M1/025 , A61M1/0277 , A61M1/3683 , B01F5/0683 , B01F5/0688 , B01F9/0014 , B01F11/0065 , B01F13/0001 , B01F13/001
摘要： A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.
摘要翻译：混合系统，装置和/或方法。病原体减少和/或将储存溶液混合到血液或血液成分中是有用的。压缩或拍打装置可以用于激活混合过程，如旋转装置或横向可移动，旋转和/或轨道装置。收缩元件也可用于产生有用的涡流混合动作。可以提供光引发剂，同时组分继续混合在一起用于血液或血液成分的病原体减少。

8. 发明申请

US20020138066A1 Multiple compartment bag with openable closure assembly 审中-公开
标题翻译：具有可打开的封闭组件的多隔间袋
公开(公告)号：US20020138066A1
公开(公告)日：2002-09-26
申请号：US10104766
申请日：2002-03-21
申请人： Gambro, Inc.
发明人： Keith Manica , Dennis J. Hlavinka , Jeannie M. Woods
IPC分类号： A61B019/00 , A61M037/00 , B65D035/22
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2034 , A61M1/3681 , A61M1/3683
摘要： A container for pathogen inactivating and storing blood or blood components, which includes multiple sub-compartments fluidly interconnected by an openable closure assembly. Each sub-compartment may contain a component necessary for pathogen inactivation or blood storage. Upon opening the openable closure assembly, the sub-compartments become one compartment and the components contained within each sub-compartment may be mixed together to form a combined solution for pathogen inactivation and/or storage of blood or blood components.
摘要翻译：用于病原体灭活和储存血液或血液成分的容器，其包括通过可打开的封闭组件流体互连的多个子隔室。每个子室可以含有病原体灭活或血液储存所必需的组分。在打开可打开的封闭组件时，子隔间变成一个隔室，并且每个子室中包含的组分可以混合在一起以形成用于病原体灭活和/或储存血液或血液成分的组合溶液。

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