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1. 发明申请

US20020032110A1 Array centrifuge 失效
标题翻译：阵列离心机
公开(公告)号：US20020032110A1
公开(公告)日：2002-03-14
申请号：US09989760
申请日：2001-11-20
申请人： Genomic Instrumentation Services, Inc.
发明人： Scott P. Hunicke-Smith , Carl Buice , Benjamin Riepe , Theodore Rogers
IPC分类号： B04B005/00 , B04B009/00
CPC分类号： B01L3/5085 , B01J2219/00691 , B01L3/0217 , B01L2400/0409 , B04B5/0407 , B04B5/10 , B04B9/00 , B04B2011/046 , G01N35/0099 , G01N35/028 , G01N35/1065 , G01N35/1067 , G01N35/1074 , G01N2035/00495 , G01N2035/1069
摘要： A microcentrifuge apparatus has a plurality of rotors for simultaneously spinning a plurality of samples; a retainer for retaining each of the rotors on a bearing surface; and at least one source of motive power, coupled to the rotors by a coupling means, for causing each of the rotors to spin at substantially the same rate. The source of motive power can be a motor, engine, or electromagnetic power. The coupling means can be a drive belt, gears, or friction drive. Another embodiment of the microcentrifuge has a plurality of disposable rotors for simultaneously spinning a plurality of samples; a retainer for retaining each of the rotors on a bearing surface; and a source of motive power, coupled to the rotors, causing each of the rotors to spin at substantially the same rate.
摘要翻译：微量离心机具有多个用于同时旋转多个样品的转子; 用于将每个转子保持在支承表面上的保持器; 以及至少一个动力源，通过联接装置联接到转子，用于使每个转子以基本上相同的速率旋转。动力源可以是电动机，发动机或电磁力。联接装置可以是传动带，齿轮或摩擦传动。微量离心机的另一个实施例具有多个一次性转子，用于同时旋转多个样品; 用于将每个转子保持在支承表面上的保持器; 以及耦合到转子的动力源，使得每个转子以基本上相同的速率旋转。

2. 发明申请

US20030013592A1 Centrifuge with clutch mechanism for synchronous blade and bowl rotation 有权
公开(公告)号：US20030013592A1
公开(公告)日：2003-01-16
申请号：US10234296
申请日：2002-09-03
发明人： Jeffery N. Beattey
IPC分类号： B04B009/00
CPC分类号： B04B11/08 , B04B9/08 , B04B11/043 , B04B2011/086
摘要： An improved centrifuge apparatus comprising a spindle with an affixed bowl and a drive shaft passing through the spindle with a plurality of scraper blades affixed which rotate within the bowl. The spindle is driven by a pulley with a belt attached to a motor. The centrifuge has a clutch mechanism which provides a positive lock to insure synchronous blade and bowl rotation during processing. The clutch mechanism comprises a shifting coupling attached to the drive shaft with a bottom set of teeth and a top set of teeth. The bottom set of teeth interlockingly engage a matching set of teeth located on either the pulley or the top of the spindle. The top set of teeth interlockingly engage a matching set of teeth that are either immovably attached to a plate or attached to a sprocket which is rotatably attached to the plate. The scraper blades have recesses in their front face to allow a variable cutting edge geometry and the mixing and matching of cutting edge geometry while permitting the use of the same base blade. The centrifuge has a tangential outlet and an annular housing to minimize spray and misting in the exiting centrifuged liquid.

3. 发明申请

US20030195106A1 Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics platform 失效
标题翻译：使用向心加速度驱动微流体平台上的流体运动的装置和方法
公开(公告)号：US20030195106A1
公开(公告)日：2003-10-16
申请号：US10414536
申请日：2003-04-15
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob
IPC分类号： B04B009/00
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译：本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。

4. 发明申请

US20030036470A1 Rotor locator 有权
标题翻译：转子定位器
公开(公告)号：US20030036470A1
公开(公告)日：2003-02-20
申请号：US10271137
申请日：2002-10-15
申请人： Gentra Systems, Inc.
发明人： Glenn M. Campbell JR. , Douglas J. Kluge , Glenn M. Campbell SR. , Ellen M. Heath , Ruth Shuman
IPC分类号： B04B009/00 , B04B013/00
CPC分类号： B04B7/02 , B04B5/0421 , B04B7/00 , B04B2007/005
摘要： A rotor locator and centrifuge body locator includes a pair of locator arms that close about the rotor shaft and an aligmuent pin to center the rotor shaft. A registration mechanism rotates the rotor shaft and the centrifuge body until it reaches a known home position. A method of consistently registering the centrifuge body includes centering a rotor shaft of the body along a known center line and aligning the body to a home position both before and after centrifugation.
摘要翻译：转子定位器和离心机本体定位器包括一对定位器臂，其围绕转子轴和用于使转子轴定心的通用销。配准机构使转子轴和离心机体旋转，直到达到已知的原位。一直记录离心机主体的方法包括沿着已知的中心线对准身体的转子轴，并且在离心之前和之后将身体对准到原位。

5. 发明申请

US20020147100A1 Blood centrifuge with an enhanced internal drive assembly 有权
标题翻译：血液离心机具有增强的内部驱动组件
公开(公告)号：US20020147100A1
公开(公告)日：2002-10-10
申请号：US09832730
申请日：2001-04-09
发明人： David Malcolm , Victor D. Dolecek
IPC分类号： B04B009/00
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： A blood centrifuge with a drive assembly for transmitting an input rotation speed to a rotor with a sample reservoir at a desired rotation ratio. The drive assembly includes a base and an outer shell mounted to the base to rotate at an input rate. A bottom pulley is rigidly mounted to the base and attached to the outer shell with bearings. A top pulley is mounted to a center shaft of the outer shell to rotate with the outer shell about the central axis of the centrifuge. An internal drive belt is provided to transmit the rotation to the top pulley via a pair of transversely mounted idler pulleys that rotate with the outer shell. The top pulley is thus rotated at twice the input rate but in the same direction. A rotor assembly with the sample reservoir is attached to the top pulley to separate blood components.
摘要翻译：一种具有驱动组件的血液离心机，用于以期望的旋转比将具有输入转速的输入转速传送到具有样品容器的转子。驱动组件包括底座和外壳，安装到底座以以输入速率旋转。底部滑轮刚性地安装到基座并且用轴承附接到外壳。顶部滑轮安装到外壳的中心轴上，与外壳围绕离心机的中心轴线旋转。内部传动带设置成通过与外壳一起旋转的一对横向安装的惰轮将传递旋转传递到顶部皮带轮。因此，顶部滑轮以两倍的输入速率旋转，但是在相同的方向上旋转。具有样品储存器的转子组件附接到顶部滑轮以分离血液成分。

6. 发明申请

US20020068675A1 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach 有权
公开(公告)号：US20020068675A1
公开(公告)日：2002-06-06
申请号：US10008989
申请日：2001-11-02
申请人： Gambro, Inc.
发明人： Thomas J. Felt , Dennis J. Hlavinka
IPC分类号： B04B007/12 , B04B009/00
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal separation device for use in a fluid separation system to centrifugally separate a composite fluid into the composite components thereof. This centrifugal separation device includes a centrifugal rotor housing and a rotor which is disposed in a freely rotatable disposition within the housing, the rotor having a fluid receiving area and several fluid flow channels defined therein. A composite fluid to be separated is delivered to the fluid receiving area from which it travels through a radial fluid transport channel to a circumferential fluid separation channel where it is subjected to substantial centrifugal forces which separate the composite fluid into components which each then travel to distinct first and second separated fluid outlet channels. The separated fluids then exit from these outlet channels and are then moved from the separation device to a collection bag for storage or may then be returned to the donor. The first and second fluid outlet channels also have respective first and second lengths which are related to each other so as to provide a substantial hydraulic pressure balance for the respective separated fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred relationship of the respective first and second lengths of said first and second separated fluid outlet channels to each other which provides the hydraulic balance is null3gh3nullnull3gh3 wherein the first length of the first outlet channel is h3, and the second length of the second outlet channel is h3, wherein g is a gravitational acceleration value and null3 represents the density of the fluids in the first outlet channel and null3 represents the density of the fluids in the second outlet channel. The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus useful herein.

7. 发明申请

US20040192532A1 Driving system for a separator 有权
标题翻译：分离器的驱动系统
公开(公告)号：US20040192532A1
公开(公告)日：2004-09-30
申请号：US10809858
申请日：2004-03-26
申请人： Westfalia Separator AG
发明人： Wilfried Mackel , Helga Tietz
IPC分类号： B04B009/00
CPC分类号： F16C35/12 , B04B9/12 , F16C19/54 , F16C23/086
摘要： A driving system for a separator having a centrifugal drum with a vertical axis of rotation. The driving system includes a vertically aligned driving spindle-configured to accommodate a centrifugal drum. The driving spindle is arranged by a neck bearing and a footstep bearing in an opening of a drive housing. The neck bearing is supported in an axially rigid and radially resilient manner on the machine housing. The neck bearing is constructed as an angular ball bearing and supports the centrifugal-drum on a spherical-shaped supporting surface of the machine housing.
摘要翻译：一种用于具有垂直旋转轴的离心鼓的分离器的驱动系统。驱动系统包括垂直对准的驱动心轴 - 构造成容纳离心鼓。驱动主轴由颈部轴承和脚踏轴承布置在驱动器壳体的开口中。颈部轴承以轴向刚性和径向弹性的方式支撑在机器壳体上。颈部轴承构造为角球轴承，并将离心鼓支撑在机壳的球形支撑表面上。

8. 发明申请

US20040063561A1 Handheld and hand-powered centrifuge device 失效
标题翻译：手持式和手动离心机
公开(公告)号：US20040063561A1
公开(公告)日：2004-04-01
申请号：US10608003
申请日：2003-06-30
发明人： Anthony G. Gutierrez
IPC分类号： B04B005/02 , B04B009/00
CPC分类号： B01L99/00 , B01L3/508 , B01L2400/0409 , B04B5/0414 , B04B9/00 , G01N2001/2846
摘要： This invention relates to a handheld, hand-powered centrifuge device. The device preferably includes a centrifuge body and a sample-holding member connected to a tether. The device centrifuges the sample by a user physically spinning the member preferably in a vertical arc. The device preferably includes a pull handle which allows a user to shorten the length of the tether to reduce the circumference of the arc, thereby increasing the speed of rotation and centrifugal force on the sample. The device also preferable includes a brake to prevent the member from contacting the handheld centrifuge body. The centrifuge body may have a storage cavity for storing the pull handle when not in use, wherein the member serves to seal the storage cavity when not in use.
摘要翻译：本发明涉及一种手持式手动离心机装置。该装置优选地包括连接到系绳的离心机主体和样品保持部件。该装置通过使用者优选地在垂直弧中物理地旋转构件来离心样品。该装置优选地包括拉手柄，其允许使用者缩短系绳的长度以减小电弧的周长，从而增加样品上的旋转速度和离心力。该装置还优选包括制动器以防止构件接触手持离心机主体。离心机主体可以具有用于在不使用时存储拉手的存储腔，其中该构件用于在不使用时密封储存腔。

9. 发明申请

US20020147101A1 Miniaturized blood centrifuge having side mounted motor with belt drive 失效
公开(公告)号：US20020147101A1
公开(公告)日：2002-10-10
申请号：US09833232
申请日：2001-04-09
发明人： Victor D. Dolecek
IPC分类号： B04B009/00
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , A61M2205/3368 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： A belt-driven blood centrifuge with side-mounted drive motor for rotating the centrifuge at a rotation speed selected to separate blood components. The centrifuge includes a drive shaft assembly rotated at an input rotation speed and a rotor assembly rotatably linked to the drive shaft assembly rotated at an output rotation speed twice the input rotational speed. A drive motor is provided with a drive pulley to drive a belt, a chain, and the like to provide the motive force to rotate the drive shaft at the input rotation speed. In one embodiment, a belt is provided to contact both the pulley of the drive motor and an outer surface of a rotatable shell of the drive shaft assembly. A base is included in the centrifuge upon which the drive shaft assembly is mounted. The drive motor is positioned adjacent the drive shaft assembly and mounted on the base.

10. 发明申请

US20020068674A1 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced configuration 失效
公开(公告)号：US20020068674A1
公开(公告)日：2002-06-06
申请号：US10005431
申请日：2001-11-02
申请人： Gambro, Inc.
发明人： Dennis J. Hlavinka , Thomas J. Felt
IPC分类号： B04B007/12 , B04B009/00
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, several fluid flow channels and at least two separated component collection areas defined therein. A composite fluid to be separated is delivered to the fluid containment area from which it travels through an inlet channel to a substantially circumferential fluid separation channel where under centrifugal forces the composite fluid is separated into components which each then travel to distinct first and second separated fluid outlet channels, and thence on to exit therefrom into the respective collection areas. The first and second fluid outlet channels also have respective first and second heights which are related to each other so as to provide a balanced fluid pressure relationship for the respective separated component fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred fluid pressure balance relationship is null2g2h2nullnull3g3h3 wherein the first height of the first outlet channel is h2, and the second height of the second outlet channel is h3, wherein g2 and g3 are gravitational or centrifugal acceleration values and null2 and null3 represent the respective densities of the separated fluids in the first and second outlet channels. A similar, continuously forward flow drive relationship involves also the height h1, of the inlet channel and the density null1 of the fluid therein such that null1g1h1>null2g2h2 or null1g1h1>null3g3h3 . The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus available herefrom. A disposable bag and tubing system is also disclosed for use with preferably reusable rotor devices.

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