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1. 发明授权

US06913697B2 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：US06913697B2
公开(公告)日：2005-07-05
申请号：US10338654
申请日：2003-01-09
申请人： Gabriel P. Lopez , Steven R. Brueck , Linnea K. Ista
发明人： Gabriel P. Lopez , Steven R. Brueck , Linnea K. Ista
IPC分类号： B01D11/00 , B01D61/14
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译：本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

2. 发明授权

US07465381B2 Electrokinetic molecular separation in nanoscale fluidic channels 有权
标题翻译：纳米流体通道中的电动分子分离
公开(公告)号：US07465381B2
公开(公告)日：2008-12-16
申请号：US10958113
申请日：2004-10-04
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista , Anthony L. Garcia , Dimiter N. Petsev , Paul Bisong , Michael J. O'Brien
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista , Anthony L. Garcia , Dimiter N. Petsev , Paul Bisong , Michael J. O'Brien
IPC分类号： G01N27/447
CPC分类号： C07K1/26 , Y10S977/924 , Y10S977/962
摘要： A method for separation of mixtures in fluidic systems through electrokinetic transport by use of nanochannels when the fluidic systems approach the size of an electrical double layer, thereby allowing separation based on charge. The disclosed apparatus comprises a T-chip with a nanochannel section. The method and apparatus are useful for separation of many molecular species, including peptides, proteins, and DNA.
摘要翻译：当流体系统接近电双层的尺寸时，通过使用纳米通道的电动运输来分离流体系统中的混合物的方法，从而允许基于电荷的分离。所公开的装置包括具有纳米通道部分的T芯片。该方法和装置可用于分离许多分子物质，包括肽，蛋白质和DNA。

3. 再颁专利

USRE42249E1 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：USRE42249E1
公开(公告)日：2011-03-29
申请号：US12217114
申请日：2008-07-01
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
IPC分类号： B01D21/00
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nonostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the subtrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures. A fluidic device for separating particles according to size is provided including a fluidic channel, and a matrix comprising a plurality of protrusions within the fluidic channel, wherein the device provides a driving force to the particles being separated through the fluidic channel; and wherein a flow of the driving force from between the protrusions is divided unequally into a major flow component and a minor flow component, each component flowing between subsequent protrusions in the matrix, such that the average direction of the major flow component is not parallel to the average direction of the driving force, and, when particles are introduced into the matrix, particles having a size less than a predetermined critical size are transported generally in the average direction of the driving force, and particles having a size at least that of the critical size are transported generally in the average direction of the major flow component, thereby separating the particles according to size. Methods for separating particles including steps of separation based on size and affinity are also provided.
摘要翻译：本发明提供一种非结构化装置，其包括其中包括纳入通道的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述缓冲液包含纳米结构，并且其中所述脂质双层包含至少一个膜相关的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。提供了一种用于根据尺寸分离颗粒的流体装置，包括流体通道和在流体通道内包括多个突起的基体，其中该装置为通过流体通道分离的颗粒提供驱动力; 并且其中来自所述突起之间的驱动力的流动不均匀地分成主流动分量和小流动分量，每个分量在所述基体中的后续突起之间流动，使得主流动分量的平均方向不平行于驱动力的平均方向，并且当颗粒被引入到基质中时，尺寸小于预定临界尺寸的颗粒通常沿驱动力的平均方向传送，并且尺寸至少大于临界尺寸通常沿主流体组分的平均方向输送，从而根据尺寸分离颗粒。还提供了基于尺寸和亲和力分离包括分离步骤的颗粒的方法。

4. 发明申请

US20120271023A1 MATERIALS INCORPORATING ANTIMICROBIAL POLYMERS 有权
标题翻译：包含抗微生物聚合物的材料
公开(公告)号：US20120271023A1
公开(公告)日：2012-10-25
申请号：US13503067
申请日：2010-10-12
申请人： David G. Whitten , Linnea K. Ista , Thomas S. Corbitt , Motokatsu Ogawa , Kirk S. Schanze , Gabriel P. Lopez , Ramanathan Nagarajan
发明人： David G. Whitten , Linnea K. Ista , Thomas S. Corbitt , Motokatsu Ogawa , Kirk S. Schanze , Gabriel P. Lopez , Ramanathan Nagarajan
IPC分类号： C08G83/00
CPC分类号： A01N43/90 , D06M13/513 , D06M14/02 , D06M14/04 , D06M14/06 , D06M14/08 , D06M15/227 , D06M16/00 , D06M23/005 , D06M2400/01 , Y10T442/20 , Y10T442/2525 , A01N25/10 , A01N25/34
摘要： The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.
摘要翻译：本公开描述了软表面的制造和使用，例如带有表面接枝的抗微生物聚合物的织物。

5. 再颁专利

USRE42315E1 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：USRE42315E1
公开(公告)日：2011-05-03
申请号：US11825298
申请日：2007-07-05
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
IPC分类号： B01D15/34
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译：本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

6. 发明授权

US08598053B2 Materials incorporating antimicrobial polymers 有权
标题翻译：掺入抗菌聚合物的材料
公开(公告)号：US08598053B2
公开(公告)日：2013-12-03
申请号：US13503067
申请日：2010-10-12
申请人： David G. Whitten , Linnea K. Ista , Thomas S. Corbitt , Motokatsu Ogawa , Kirk S. Schanze , Gabriel P. Lopez , Ramanathan Nagarajan
发明人： David G. Whitten , Linnea K. Ista , Thomas S. Corbitt , Motokatsu Ogawa , Kirk S. Schanze , Gabriel P. Lopez , Ramanathan Nagarajan
IPC分类号： B32B5/02
CPC分类号： A01N43/90 , D06M13/513 , D06M14/02 , D06M14/04 , D06M14/06 , D06M14/08 , D06M15/227 , D06M16/00 , D06M23/005 , D06M2400/01 , Y10T442/20 , Y10T442/2525 , A01N25/10 , A01N25/34
摘要： The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.
摘要翻译：本公开描述了软表面的制造和使用，例如带有表面接枝的抗微生物聚合物的织物。

7. 再颁专利

USRE41762E1 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：USRE41762E1
公开(公告)日：2010-09-28
申请号：US12215893
申请日：2008-06-30
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
IPC分类号： C02F1/00
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译：本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

8. 发明授权

US06685841B2 Nanostructured devices for separation and analysis 有权
标题翻译：用于分离和分析的纳米结构设备
公开(公告)号：US06685841B2
公开(公告)日：2004-02-03
申请号：US10073935
申请日：2002-02-14
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista , Michael O'Brien , Stephen D Hersee
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista , Michael O'Brien , Stephen D Hersee
IPC分类号： B01D5700
CPC分类号： B01L3/502746 , B01L3/502753 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2300/0896 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N27/44791 , G01N30/02 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T137/2224 , Y10T428/249953 , Y10T428/249961 , Y10T436/2575 , B01D15/3833 , B01D15/327 , B01D15/3804 , B01D15/34
摘要： The present invention provides a matrix comprising an array of nanostructures that exhibit a variation (gradient) in physical properties (such as size or pitch) in at least one direction of the plane containing said array. A method for forming an array having a gradient property is also provided. In addition, a separation method is provided comprising the steps of: providing a matrix comprising an array of nanostructures arranged so that the array has the property of a gradient; and conducting at least one biomolecule separation process to separate biomolecules in a composition containing a plurality of biomolecules using the matrix.
摘要翻译：本发明提供一种包含纳米结构阵列的矩阵，其在包含所述阵列的平面的至少一个方向上表现出物理性质（例如尺寸或间距）的变化（梯度）。还提供了一种形成具有梯度特性的阵列的方法。另外，提供了一种分离方法，其包括以下步骤：提供包括纳米结构阵列的矩阵，所述纳米结构的阵列被布置成使得阵列具有梯度的性质; 并进行至少一个生物分子分离过程以使用该基质分离含有多个生物分子的组合物中的生物分子。

9. 发明申请

US20140336062A1 Multinode acoustic focusing for parallel flow cytometry analysis applications 有权
标题翻译：用于并行流式细胞仪分析应用的多节点声聚焦
公开(公告)号：US20140336062A1
公开(公告)日：2014-11-13
申请号：US14339820
申请日：2014-07-24
申请人： Steven W. Graves , Robert W. Applegate, JR. , Gabriel P. Lopez , Menake Eranda Piyasena
发明人： Steven W. Graves , Robert W. Applegate, JR. , Gabriel P. Lopez , Menake Eranda Piyasena
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1459 , G01N2015/142
摘要： An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.
摘要翻译：提供了诸如流式细胞仪的分析装置，其中流过通道的流体样品通过延伸穿过通道的声波场聚焦成多个平行的颗粒流。然后将每个流提供给单独的检测器，以允许多个流的同时询问，从而对流体样品进行高通量分析。

10. 发明授权

US08465983B1 Detection and delivery systems utilizing supported lipid bilayers 有权
标题翻译：利用支持的脂双层的检测和递送系统
公开(公告)号：US08465983B1
公开(公告)日：2013-06-18
申请号：US11466046
申请日：2006-08-21
申请人： Gabriel P. Lopez , Reema Zeineldin , Menake E. Piyasena , Sireesha Chemburu
发明人： Gabriel P. Lopez , Reema Zeineldin , Menake E. Piyasena , Sireesha Chemburu
IPC分类号： G01N21/00
CPC分类号： G01N21/00 , C12Q1/18 , G01N33/542 , G01N33/54313 , G01N33/5432 , G01N33/554
摘要： The invention relates to lipid bilayer coated beads and methods of using those beads in delivery systems, in immunoassays, in analytical assays and the like.
摘要翻译：本发明涉及脂双层包被的珠粒以及在递送系统中，在免疫测定，分析测定等中使用那些珠粒的方法。

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