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1. 发明授权

US08652464B2 Method of treatment using nanoparticulate compositions having lysozyme as a surface stabilizer 有权
标题翻译：使用具有溶菌酶作为表面稳定剂的纳米颗粒组合物的处理方法
公开(公告)号：US08652464B2
公开(公告)日：2014-02-18
申请号：US13693858
申请日：2012-12-04
申请人： Alkermes Pharma Irland Limited
发明人： Christian F. Wertz , Niels P. Ryde
IPC分类号： A61K38/48 , A61K8/368 , A01N57/08 , A61K31/585 , B82B3/00 , A01N47/08 , A01N43/02 , A61K31/19 , A61K31/045 , A01N31/04
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.
摘要翻译：本发明涉及包含溶菌酶作为表面稳定剂的纳米颗粒活性剂组合物。本发明还包括包含本发明的纳米颗粒活性剂组合物的药物组合物以及制备和使用这些纳米颗粒和药物组合物的方法。

2. 发明申请

US20030102263A1 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：US20030102263A1
公开(公告)日：2003-06-05
申请号：US10338654
申请日：2003-01-09
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
IPC分类号： B01D061/14
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译：本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

3. 发明公开

EP1734937A1 NANOPARTICLE FORMULATIONS OF PLATINUM COMPOUNDS 审中-公开
标题翻译：纳米颗粒制剂铂化合物
公开(公告)号：EP1734937A1
公开(公告)日：2006-12-27
申请号：EP05716377.6
申请日：2005-03-24
申请人： Cell Therapeutics Europe S.R.L. , Nanovector S.r.l.
发明人： GASCO, Maria, Rosa , GASCO, Paolo , BERNAREGGI, Alberto
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , Y10S977/717 , Y10S977/911
摘要： Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a first microemulsion by mixing a molten lipid, a surfactant, and optionally a co-surfactant and the platinum compound acqueous solution; b) preparing a solution by mixing a surfactant and optionally a co-surfactant in water, heating to complete solution, preferably at the same melting temperature of the lipid used in a) and adding a co-surfactant; c) dispersing the microemulsion obtained in a) into the solution obtained in b) obtaining a multiple microemulsion c); d) dispersing the microemulsion obtained in c) in aqueous medium at a temperature ranging from 0.5°C to 4°C obtaining a dispersion of solid lipid microspheres; e) washing with aqueous medium through ultrafiltration the obtained lipid microspheres obtained in d) and lyophilizing, optionally in the presence of a bulking agent and of a cryoprotecting agent.

4. 发明授权

US08323641B2 Nanoparticulate compositions having lysozyme as a surface stabilizer 有权
标题翻译：具有溶菌酶作为表面稳定剂的纳米颗粒组合物
公开(公告)号：US08323641B2
公开(公告)日：2012-12-04
申请号：US12292091
申请日：2008-11-12
申请人： Christian F. Wertz , Niels P. Ryde
发明人： Christian F. Wertz , Niels P. Ryde
IPC分类号： C12Q1/34 , A61K9/26 , B82B3/00 , A61K38/47 , A61K39/40
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention.
摘要翻译：本发明涉及包含溶菌酶作为表面稳定剂的纳米颗粒活性剂组合物。本发明还包括包含本发明的纳米颗粒活性剂组合物的药物组合物。

5. 再颁专利

USRE42249E1 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：USRE42249E1
公开(公告)日：2011-03-29
申请号：US12217114
申请日：2008-07-01
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
IPC分类号： B01D21/00
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nonostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the subtrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures. A fluidic device for separating particles according to size is provided including a fluidic channel, and a matrix comprising a plurality of protrusions within the fluidic channel, wherein the device provides a driving force to the particles being separated through the fluidic channel; and wherein a flow of the driving force from between the protrusions is divided unequally into a major flow component and a minor flow component, each component flowing between subsequent protrusions in the matrix, such that the average direction of the major flow component is not parallel to the average direction of the driving force, and, when particles are introduced into the matrix, particles having a size less than a predetermined critical size are transported generally in the average direction of the driving force, and particles having a size at least that of the critical size are transported generally in the average direction of the major flow component, thereby separating the particles according to size. Methods for separating particles including steps of separation based on size and affinity are also provided.
摘要翻译：本发明提供一种非结构化装置，其包括其中包括纳入通道的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述缓冲液包含纳米结构，并且其中所述脂质双层包含至少一个膜相关的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。提供了一种用于根据尺寸分离颗粒的流体装置，包括流体通道和在流体通道内包括多个突起的基体，其中该装置为通过流体通道分离的颗粒提供驱动力; 并且其中来自所述突起之间的驱动力的流动不均匀地分成主流动分量和小流动分量，每个分量在所述基体中的后续突起之间流动，使得主流动分量的平均方向不平行于驱动力的平均方向，并且当颗粒被引入到基质中时，尺寸小于预定临界尺寸的颗粒通常沿驱动力的平均方向传送，并且尺寸至少大于临界尺寸通常沿主流体组分的平均方向输送，从而根据尺寸分离颗粒。还提供了基于尺寸和亲和力分离包括分离步骤的颗粒的方法。

6. 发明申请

US20090170118A1 Formation and Encapsulation of Molecular Bilayer and Monolayer Membranes 有权
标题翻译：分子双层和单层膜的形成和封装
公开(公告)号：US20090170118A1
公开(公告)日：2009-07-02
申请号：US12083410
申请日：2006-10-13
申请人： Jacob J. Schmidt , Noah Malmstadt , Tae-joon Jeon , Jason Poulos
发明人： Jacob J. Schmidt , Noah Malmstadt , Tae-joon Jeon , Jason Poulos
IPC分类号： G01N33/53 , B29C39/10 , B28B1/54
CPC分类号： G01N33/5432 , Y10S977/713 , Y10S977/717 , Y10S977/756 , Y10T436/255 , Y10T436/2575
摘要： Disclosed herein are compositions, methods, and devices related to bilayer and monolayer membranes, their encapsulation in a hydrogel, and their formation. Methods of using the disclose compositions and devices are also disclosed.
摘要翻译：本文公开了与双层和单层膜相关的组合物，方法和装置，它们在水凝胶中的包封及其形成。还公开了使用公开的组合物和装置的方法。

7. 发明申请

US20130224123A1 NANOPARTICULATE COMPOSITIONS HAVING LYSOZYME AS A SURFACE STABILIZER 有权
标题翻译：具有LYSOZYME作为表面稳定剂的纳米颗粒组合物
公开(公告)号：US20130224123A1
公开(公告)日：2013-08-29
申请号：US13693858
申请日：2012-12-04
申请人： Alkermes Pharma Ireland Limited
发明人： Christian F. Wertz , Niels P. Ryde
IPC分类号： A61K47/42 , A61K31/496 , A61K31/573 , A61K31/58 , A61K49/04 , A61K31/045 , A61K31/327 , A61K31/337 , A61K33/04 , A61K31/569 , A61K31/192 , A61K31/047
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.
摘要翻译：本发明涉及包含溶菌酶作为表面稳定剂的纳米颗粒活性剂组合物。本发明还包括包含本发明的纳米颗粒活性剂组合物的药物组合物以及制备和使用这些纳米颗粒和药物组合物的方法。

8. 再颁专利

USRE41762E1 Nanostructured separation and analysis devices for biological membranes 有权
标题翻译：用于生物膜的纳米结构分离和分析装置
公开(公告)号：USRE41762E1
公开(公告)日：2010-09-28
申请号：US12215893
申请日：2008-06-30
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista
IPC分类号： C02F1/00
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译：本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

9. 发明申请

US20030185869A1 Nanoparticulate compositions having lysozyme as a surface stabilizer 有权
公开(公告)号：US20030185869A1
公开(公告)日：2003-10-02
申请号：US10357514
申请日：2003-02-04
申请人： Elan Pharma International Ltd.
发明人： Christian F. Wertz , Niels P. Ryde
IPC分类号： A61K007/42 , A61K007/06 , A61K007/11 , A61K038/47 , A01N025/00
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.

10. 发明公开

EP1471887A2 NANOPARTICULATE COMPOSITIONS HAVING LYSOZYME AS A SURFACE STABILIZER 有权转让
标题翻译：与表面稳定溶菌酶的药物纳米颗粒
公开(公告)号：EP1471887A2
公开(公告)日：2004-11-03
申请号：EP03737537.5
申请日：2003-02-04
申请人： Elan Pharma International Limited
发明人： WERTZ, Christian F. , RYDE, Niels P.
IPC分类号： A61K9/14
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.

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